ENSMUSG00000022304


Mus musculus

Features
Gene ID: ENSMUSG00000022304
  
Biological name :Dpys
  
Synonyms : Dihydropyrimidinase / Dpys / Q9EQF5
  
Possible biological names infered from orthology : Q14117
  
Species: Mus musculus
  
Chr. number: 15
Strand: -1
Band: B3.1
Gene start: 39768487
Gene end: 39857470
  
Corresponding Affymetrix probe sets: 10428338 (MoGene1.0st)   1425688_a_at (Mouse Genome 430 2.0 Array)   1425689_at (Mouse Genome 430 2.0 Array)   1436291_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000022915
Ensembl peptide - ENSMUSP00000105935
Ensembl peptide - ENSMUSP00000114708
NCBI entrez gene - 64705     See in Manteia.
MGI - MGI:1928679
RefSeq - NM_001164466
RefSeq - NM_022722
RefSeq Peptide - NP_001157938
RefSeq Peptide - NP_073559
swissprot - F6ZLZ4
swissprot - Q9EQF5
Ensembl - ENSMUSG00000022304
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 dpysENSDARG00000079543Danio rerio
 DPYSENSGALG00000039011Gallus gallus
 DPYSENSG00000147647Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Dpysl3 / Q62188 / Dihydropyrimidinase-related protein 3 / Q14195* / dihydropyrimidinase like 3*ENSMUSG0000002450158
Dpysl4 / dihydropyrimidinase like 4 / O14531*ENSMUSG0000002547857
Crmp1 / P97427 / Dihydropyrimidinase-related protein 1 / Q14194* / collapsin response mediator protein 1*ENSMUSG0000002912157
Dpysl5 / Q9EQF6 / Mus musculus dihydropyrimidinase-like 5 (Dpysl5), transcript variant 2, mRNA. / Q9BPU6* / dihydropyrimidinase like 5*ENSMUSG0000002916857
Dpysl2 / O08553 / Dihydropyrimidinase-related protein 2 / Q16555* / dihydropyrimidinase like 2*ENSMUSG0000002204857


Protein motifs (from Interpro)
Interpro ID Name
 IPR006680  Amidohydrolase-related
 IPR011059  Metal-dependent hydrolase, composite domain superfamily
 IPR011778  Hydantoinase/dihydropyrimidinase
 IPR032466  Metal-dependent hydrolase


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006208 pyrimidine nucleobase catabolic process ISO
 biological_processGO:0006210 thymine catabolic process ISS
 biological_processGO:0006212 uracil catabolic process ISS
 biological_processGO:0019482 beta-alanine metabolic process ISS
 biological_processGO:0019860 uracil metabolic process IEA
 biological_processGO:0051260 protein homooligomerization ISS
 biological_processGO:0051289 protein homotetramerization ISS
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol ISS
 molecular_functionGO:0002058 uracil binding ISS
 molecular_functionGO:0002059 thymine binding ISS
 molecular_functionGO:0004157 dihydropyrimidinase activity ISS
 molecular_functionGO:0008270 zinc ion binding ISS
 molecular_functionGO:0016597 amino acid binding ISS
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0016810 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds IEA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0051219 phosphoprotein binding IPI


Pathways (from Reactome)
Pathway description
Pyrimidine catabolism


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000022304 Dpys / Q9EQF5 / Dihydropyrimidinase / Q14117*  / complex






 

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