ENSMUSG00000025478


Mus musculus

Features
Gene ID: ENSMUSG00000025478
  
Biological name :Dpysl4
  
Synonyms : dihydropyrimidinase like 4 / Dpysl4
  
Possible biological names infered from orthology : O14531
  
Species: Mus musculus
  
Chr. number: 7
Strand: 1
Band: F4
Gene start: 139086001
Gene end: 139102704
  
Corresponding Affymetrix probe sets: 10558481 (MoGene1.0st)   1418297_at (Mouse Genome 430 2.0 Array)   1418298_s_at (Mouse Genome 430 2.0 Array)   1418299_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000112896
Ensembl peptide - ENSMUSP00000117764
Ensembl peptide - ENSMUSP00000026551
NCBI entrez gene - 26757     See in Manteia.
MGI - MGI:1349764
RefSeq - XM_006536192
RefSeq - XM_006536193
RefSeq - NM_011993
RefSeq Peptide - NP_036123
swissprot - Q3TMU8
swissprot - D3Z360
swissprot - A0A0R4J1N0
Ensembl - ENSMUSG00000025478
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 dpysl4ENSDARG00000103490Danio rerio
 DPYSL4ENSGALG00000010490Gallus gallus
 DPYSL4ENSG00000151640Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Dpysl2 / O08553 / Dihydropyrimidinase-related protein 2 / Q16555* / dihydropyrimidinase like 2*ENSMUSG0000002204874
Dpysl3 / Q62188 / Dihydropyrimidinase-related protein 3 / Q14195* / dihydropyrimidinase like 3*ENSMUSG0000002450169
Crmp1 / P97427 / Dihydropyrimidinase-related protein 1 / Q14194* / collapsin response mediator protein 1*ENSMUSG0000002912168
Dpys / Q9EQF5 / Dihydropyrimidinase / Q14117*ENSMUSG0000002230452
Dpysl5 / Q9EQF6 / Mus musculus dihydropyrimidinase-like 5 (Dpysl5), transcript variant 2, mRNA. / Q9BPU6* / dihydropyrimidinase like 5*ENSMUSG0000002916849


Protein motifs (from Interpro)
Interpro ID Name
 IPR006680  Amidohydrolase-related
 IPR011059  Metal-dependent hydrolase, composite domain superfamily
 IPR011778  Hydantoinase/dihydropyrimidinase
 IPR030612  Dihydropyrimidinase-related protein 4
 IPR032466  Metal-dependent hydrolase


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0070997 neuron death IEA
 biological_processGO:0097485 neuron projection guidance IEA
 cellular_componentGO:0005737 cytoplasm IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0016810 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds IEA
 molecular_functionGO:0031005 filamin binding IEA


Pathways (from Reactome)
Pathway description
CRMPs in Sema3A signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001473 reduced long term potentiation "less than the normal persistent robust synaptic response induced by synchronous stimulation of pre- and postsynaptic cells " [Principles of Neural Science:ISBN 0-8385-8034-3]
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Allelic Composition: Ednrbtm1.1Yko/Ednrbtm1.1Yko
Genetic Background: involves: 129P2/OlaHsd * Bkl:BKW * C57BL/6 * SJL

 MP:0001900 impaired synaptic plasticity "decreased or inability of the nervous system to change its reactivity as a result of successive activations " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ednrbtm1.1Yko/Ednrbtm1.1Yko
Genetic Background: involves: 129P2/OlaHsd * Bkl:BKW * C57BL/6 * SJL

 MP:0008263 abnormal hippocampus CA1 region morphology 
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Allelic Composition: Ednrbtm1.1Yko/Ednrbtm1.1Yko
Genetic Background: involves: 129P2/OlaHsd * Bkl:BKW * C57BL/6 * SJL

 MP:0008284 abnormal hippocampus pyramidal cell layer 
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Allelic Composition: Ednrbtm1.1Yko/Ednrbtm1.1Yko
Genetic Background: involves: 129P2/OlaHsd * Bkl:BKW * C57BL/6 * SJL

 MP:0009940 abnormal hippocampus pyramidal cell morphology "any structural anomaly of the projection neuron in the pyramidal layer of the hippocampus" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ednrbtm1.1Yko/Ednrbtm1.1Yko
Genetic Background: involves: 129P2/OlaHsd * Bkl:BKW * C57BL/6 * SJL

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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