ENSDARG00000010515


Danio rerio

Features
Gene ID: ENSDARG00000010515
  
Biological name :dvl1a
  
Synonyms : dishevelled segment polarity protein 1a / dvl1a
  
Possible biological names infered from orthology : dishevelled segment polarity protein 1 / DVL1 / O14640 / P51141 / Segment polarity DVL-1
  
Species: Danio rerio
  
Chr. number: 23
Strand: 1
Band:
Gene start: 29966466
Gene end: 29992458
  
Corresponding Affymetrix probe sets:
  
Cross references: Ensembl peptide - ENSDARP00000033205
Ensembl peptide - ENSDARP00000120421
swissprot - E7FAJ8
swissprot - F1QBS2
ZFIN ID - ZDB-GENE-090312-40
Ensembl - ENSDARG00000010515
  
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 DVL1ENSGALG00000001600Gallus gallus
 DVL1ENSG00000107404Homo sapiens
 Dvl1ENSMUSG00000029071Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
dvl1b / dishevelled segment polarity protein 1b / DVL1* / P51141* / O14640* / Segment polarity DVL-1 * / dishevelled segment polarity protein 1*ENSDARG0000005555279
dvl3b / dishevelled segment polarity protein 3bENSDARG0000010346259
dvl2 / dishevelled segment polarity protein 2 / O14641* / Q60838* / Segment polarity DVL-2 *ENSDARG0000005618456
dvl3a / dishevelled segment polarity protein 3aENSDARG0000001570753
dixdc1b / DIX domain containing 1b / Q80Y83* / Dixin * / DIXDC1* / Q155Q3* / DIX domain containing 1*ENSDARG000000562679
dixdc1a / DIX domain containing 1a / Q80Y83* / Dixin * / DIXDC1* / Q155Q3* / DIX domain containing 1*ENSDARG000000253028
si:ch73-236e11.2 / DVL1* / O14640* / P51141* / Segment polarity DVL-1 * / dishevelled segment polarity protein 1*ENSDARG000000959190


Protein motifs (from Interpro)
Interpro ID Name
 IPR000591  DEP domain
 IPR001478  PDZ domain
 IPR003351  Dishevelled protein domain
 IPR008339  Dishevelled family
 IPR008340  Dishevelled-1
 IPR011991  ArsR-like helix-turn-helix domain
 IPR015506  Dishevelled-related protein
 IPR024580  Dishevelled C-terminal


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0016055 Wnt signaling pathway IEA
 biological_processGO:0035556 intracellular signal transduction IEA
 biological_processGO:0060070 canonical Wnt signaling pathway IBA
 biological_processGO:0090179 planar cell polarity pathway involved in neural tube closure IBA
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005829 cytosol IBA
 molecular_functionGO:0005109 frizzled binding IBA


Pathways (from Reactome)
Pathway description
WNT mediated activation of DVL
PCP/CE pathway
Degradation of DVL
Disassembly of the destruction complex and recruitment of AXIN to the membrane
RHO GTPases Activate Formins


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000006508 pip5k1bb / phosphatidylinositol-4-phosphate 5-kinase, type I, beta b / O14986* / P70181* / PIP5K1B* / phosphatidylinositol-4-phosphate 5-kinase type 1 beta*  / complex / reaction
 ENSDARG00000017803 gsk3b / glycogen synthase kinase 3 beta / P49841* / Q9WV60*  / reaction / complex
 ENSDARG00000102964 axin1 / O15169*  / reaction / complex
 ENSDARG00000052468 si:dkeyp-80c12.7 / GSK3B (1 of many) / GSK3B* / P49841* / Q9WV60* / glycogen synthase kinase 3 beta*  / reaction / complex
 ENSDARG00000055554 wnt1 / P24257 / wingless-type MMTV integration site family, member 1 / P04628* / P04426* / Wnt family member 1*  / complex
 ENSDARG00000045150 csnk1e / casein kinase 1, epsilon / P49674* / Q9JMK2* / Z98749.3* / Casein kinase I isoform epsilon *  / reaction
 ENSDARG00000044295 pip5k1ba / phosphatidylinositol-4-phosphate 5-kinase, type I, beta a / O14986* / P70181* / PIP5K1B* / phosphatidylinositol-4-phosphate 5-kinase type 1 beta*  / reaction / complex
 ENSDARG00000004291 hecw1b / HECT, C2 and WW domain containing E3 ubiquitin protein ligase 1b / HECW1* / Q8K4P8* / Q76N89* / E3 ubiquitin-protein ligase HECW1 * / HECT, C2 and WW domain containing E3 ubiquitin...  / complex / reaction
 ENSDARG00000106062 fzd1 / frizzled class receptor 1 / Q9UP38*  / complex






 

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