ENSDARG00000056184


Danio rerio

Features
Gene ID: ENSDARG00000056184
  
Biological name :dvl2
  
Synonyms : dishevelled segment polarity protein 2 / dvl2
  
Possible biological names infered from orthology : O14641 / Q60838 / Segment polarity DVL-2
  
Species: Danio rerio
  
Chr. number: 7
Strand: 1
Band:
Gene start: 20260172
Gene end: 20295432
  
Corresponding Affymetrix probe sets: Dr.24920.1.S1_at (Zebrafish Array)   Dr.3137.1.A1_at (Zebrafish Array)   Dr.5398.1.A1_at (Zebrafish Array)   
  
Cross references: Ensembl peptide - ENSDARP00000021237
swissprot - F1QM97
ZFIN ID - ZDB-GENE-041118-20
Ensembl - ENSDARG00000056184
  
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 DVL2ENSG00000004975Homo sapiens
 Dvl2ENSMUSG00000020888Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
dvl3b / dishevelled segment polarity protein 3bENSDARG0000010346265
dvl3a / dishevelled segment polarity protein 3aENSDARG0000001570757
dvl1b / dishevelled segment polarity protein 1b / DVL1* / P51141* / O14640* / Segment polarity DVL-1 * / dishevelled segment polarity protein 1*ENSDARG0000005555255
dvl1a / dishevelled segment polarity protein 1a / DVL1* / P51141* / O14640* / Segment polarity DVL-1 * / dishevelled segment polarity protein 1*ENSDARG0000001051543
dixdc1b / DIX domain containing 1b / Q80Y83* / Dixin * / DIXDC1* / Q155Q3* / DIX domain containing 1*ENSDARG0000005626711
si:ch73-236e11.2 / DVL1* / O14640* / P51141* / Segment polarity DVL-1 * / dishevelled segment polarity protein 1*ENSDARG0000009591911
dixdc1a / DIX domain containing 1a / Q80Y83* / Dixin * / DIXDC1* / Q155Q3* / DIX domain containing 1*ENSDARG000000253029


Protein motifs (from Interpro)
Interpro ID Name
 IPR000591  DEP domain
 IPR001158  DIX domain
 IPR001478  PDZ domain
 IPR003351  Dishevelled protein domain
 IPR008339  Dishevelled family
 IPR008341  Dishevelled-2
 IPR011991  ArsR-like helix-turn-helix domain
 IPR015506  Dishevelled-related protein
 IPR024580  Dishevelled C-terminal
 IPR029071  Ubiquitin-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0016055 Wnt signaling pathway IEA
 biological_processGO:0021535 cell migration in hindbrain IMP
 biological_processGO:0035556 intracellular signal transduction IEA
 biological_processGO:0036342 post-anal tail morphogenesis IGI
 biological_processGO:0060028 convergent extension involved in axis elongation IGI
 biological_processGO:0060070 canonical Wnt signaling pathway IBA
 biological_processGO:0060322 head development IMP
 biological_processGO:0090179 planar cell polarity pathway involved in neural tube closure IBA
 cellular_componentGO:0005819 spindle IDA
 cellular_componentGO:0005829 cytosol IBA
 cellular_componentGO:0005938 cell cortex IDA
 molecular_functionGO:0005109 frizzled binding IBA


Pathways (from Reactome)
Pathway description
WNT mediated activation of DVL
Signaling by Hippo
PCP/CE pathway
Asymmetric localization of PCP proteins
Degradation of DVL
Disassembly of the destruction complex and recruitment of AXIN to the membrane
WNT5A-dependent internalization of FZD4
RHO GTPases Activate Formins
Cargo recognition for clathrin-mediated endocytosis
Clathrin-mediated endocytosis


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000008 brain brain apoptotic process increased occurrence , abnormal
brain cell proliferation decreased occurrence , abnormal
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 ZFA:0000075 spinal cord spinal cord duplicated , abnormal
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 ZFA:0000155 somite somite increased width , abnormal
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 ZFA:0001094 whole organism whole organism has extra parts of type post-vent region , abnormal
whole organism decreased length , abnormal
Show

 ZFA:0001114 head head decreased size , abnormal
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 ZFA:0001117 post-vent region post-vent region deformed , abnormal
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Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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