ENSDARG00000102464


Danio rerio

Features
Gene ID: ENSDARG00000102464
  
Biological name :wnt5b
  
Synonyms : Q92050 / wingless-type MMTV integration site family, member 5b / wnt5b
  
Possible biological names infered from orthology : P22726 / Q9H1J7 / Wnt family member 5B
  
Species: Danio rerio
  
Chr. number: 4
Strand: 1
Band:
Gene start: 8532580
Gene end: 8663117
  
Corresponding Affymetrix probe sets: Dr.389.1.S1_at (Zebrafish Array)   
  
Cross references: Ensembl peptide - ENSDARP00000134193
Ensembl peptide - ENSDARP00000131042
Ensembl peptide - ENSDARP00000152177
NCBI entrez gene - 30105     See in Manteia.
swissprot - B3DI33
swissprot - Q92050
ZFIN ID - ZDB-GENE-980526-87
Ensembl - ENSDARG00000102464
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 WNT5BENSGALG00000012998Gallus gallus
 WNT5BENSG00000111186Homo sapiens
 Wnt5bENSMUSG00000030170Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
wnt5a / wingless-type MMTV integration site family, member 5a / P41221* / Wnt family member 5A*ENSDARG0000010497373
wnt2ba / wingless-type MMTV integration site family, member 2Ba / WNT2B* / Q93097* / Wnt family member 2B*ENSDARG0000000505048
wnt2bb / wingless-type MMTV integration site family, member 2Bb / WNT2B* / Q93097* / O70283* / Wnt family member 2B* / wingless-type MMTV integration site family, member 2B*ENSDARG0000003223448
wnt4a / P47793 / wingless-type MMTV integration site family, member 4a / WNT4* / P56705* / P22724* / Wnt family member 4* / wingless-type MMTV integration site family, member 4*ENSDARG0000007120846
wnt7bb / wingless-type MMTV integration site family, member 7Bb / WNT7B* / P56706* / P28047* / Wnt family member 7B* / wingless-type MMTV integration site family, member 7B*ENSDARG0000007110744
wnt7ba / wingless-type MMTV integration site family, member 7Ba / WNT7B* / P56706* / P28047* / Wnt family member 7B* / wingless-type MMTV integration site family, member 7B*ENSDARG0000002285844
wnt3a / wingless-type MMTV integration site family, member 3A / P56704* / Wnt family member 3A*ENSDARG0000005882244
wnt4b / wingless-type MMTV integration site family, member 4bENSDARG0000004015943
wnt3 / wingless-type MMTV integration site family, member 3 / P17553* / P56703* / Wnt family member 3*ENSDARG0000003899042
wnt2 / Q92048 / wingless-type MMTV integration site family member 2 / P21552* / P09544* / Wnt family member 2*ENSDARG0000004111742
wnt7aa / wingless-type MMTV integration site family, member 7Aa / WNT7A* / P24383* / O00755* / Wnt family member 7A* / wingless-type MMTV integration site family, member 7A*ENSDARG0000004482741
wnt1 / P24257 / wingless-type MMTV integration site family, member 1 / P04628* / P04426* / Wnt family member 1*ENSDARG0000005555440
wnt7ab / wingless-type MMTV integration site family, member 7Ab / WNT7A* / O00755* / Wnt family member 7A*ENSDARG0000000248340
wnt11r / wingless-type MMTV integration site family, member 11, related / WNT11* / P48615* / O96014* / Wnt family member 11* / wingless-type MMTV integration site family, member 11*ENSDARG0000001479639
wnt6b / wingless-type MMTV integration site family, member 6b / WNT6* / Q9Y6F9* / P22727* / Wnt family member 6* / wingless-type MMTV integration site family, member 6*ENSDARG0000007393539
wnt11 / wingless-type MMTV integration site family, member 11ENSDARG0000000425637
wnt16 / wingless-type MMTV integration site family, member 16 / Q9QYS1* / Q9UBV4* / Wnt family member 16*ENSDARG0000009497337
wnt6a / wingless-type MMTV integration site family, member 6aENSDARG0000003828334


Protein motifs (from Interpro)
Interpro ID Name
 IPR005817  Wnt
 IPR018161  Wnt protein, conserved site
 IPR026537  Wnt-5b protein


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001501 skeletal system development IMP
 biological_processGO:0001525 angiogenesis IMP
 biological_processGO:0001667 ameboidal-type cell migration IMP
 biological_processGO:0001946 lymphangiogenesis IMP
 biological_processGO:0002062 chondrocyte differentiation IMP
 biological_processGO:0002574 thrombocyte differentiation IMP
 biological_processGO:0007223 Wnt signaling pathway, calcium modulating pathway IGI
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0008591 regulation of Wnt signaling pathway, calcium modulating pathway IMP
 biological_processGO:0009826 unidimensional cell growth IMP
 biological_processGO:0010172 embryonic body morphogenesis IMP
 biological_processGO:0016055 Wnt signaling pathway IEA
 biological_processGO:0030182 neuron differentiation IBA
 biological_processGO:0031018 endocrine pancreas development IMP
 biological_processGO:0031101 fin regeneration IMP
 biological_processGO:0036342 post-anal tail morphogenesis IMP
 biological_processGO:0042074 cell migration involved in gastrulation IMP
 biological_processGO:0045165 cell fate commitment IBA
 biological_processGO:0048701 embryonic cranial skeleton morphogenesis IMP
 biological_processGO:0048703 embryonic viscerocranium morphogenesis IMP
 biological_processGO:0048840 otolith development IMP
 biological_processGO:0048884 neuromast development IMP
 biological_processGO:0051209 release of sequestered calcium ion into cytosol IDA
 biological_processGO:0060026 convergent extension IGI
 biological_processGO:0060027 convergent extension involved in gastrulation IMP
 biological_processGO:0060028 convergent extension involved in axis elongation IMP
 biological_processGO:0060030 dorsal convergence IMP
 biological_processGO:0060536 cartilage morphogenesis IMP
 biological_processGO:0061053 somite development IGI
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005615 extracellular space IBA
 cellular_componentGO:0005623 cell IEA
 molecular_functionGO:0005102 signaling receptor binding IEA
 molecular_functionGO:0005109 frizzled binding IBA


Pathways (from Reactome)
Pathway description
WNT ligand biogenesis and trafficking
PCP/CE pathway


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000008 brain brain morphology , abnormal
Show

 ZFA:0000018 epiblast epiblast actin cap position , abnormal
Show

 ZFA:0000029 hindbrain hindbrain anterior/posterior pattern specification disrupted , abnormal
hindbrain axon morphology , abnormal
hindbrain axon mislocalised , abnormal
hindbrain radial glial cell morphology , abnormal
hindbrain decreased size , abnormal
Show

 ZFA:0000059 postoptic commissure postoptic commissure morphology , abnormal
postoptic commissure defasciculated , abnormal
postoptic commissure commissural neuron axon guidance disrupted , abnormal
postoptic commissure astrocyte mislocalised , abnormal
Show

 ZFA:0000060 prechordal plate prechordal plate elongated , abnormal
Show

 ZFA:0000075 spinal cord spinal cord has extra parts of type ventricular zone radial glial cell, abnormal
Show

 ZFA:0000077 tail bud tail bud decreased length , abnormal
tail bud morphology , abnormal
tail bud truncated , abnormal
Show

 ZFA:0000091 axial chorda mesoderm axial chorda mesoderm decreased length , abnormal
Show

 ZFA:0000092 axis axis decreased length , abnormal
Show

 ZFA:0000095 pharyngeal arch 3-7 skeleton pharyngeal arch 3-7 skeleton quality , abnormal
pharyngeal arch 3-7 skeleton morphology , abnormal
Show

 ZFA:0000106 extension extension decreased length , abnormal
extension increased thickness , abnormal
extension increased width , abnormal
Show

 ZFA:0000107 eye eye increased distance eye , abnormal
Show

 ZFA:0000109 forebrain forebrain commissural neuron axon guidance disrupted , abnormal
Show

 ZFA:0000117 hypoblast hypoblast cell projection deviation , abnormal
hypoblast cell circular , abnormal
Show

 ZFA:0000132 neural plate neural plate increased width , abnormal
Show

 ZFA:0000135 notochord notochord quality , abnormal
notochord undulate , abnormal
notochord increased width , abnormal
notochord kinked , abnormal
notochord decreased length , abnormal
Show

 ZFA:0000155 somite somite quality , abnormal
somite decreased thickness , abnormal
somite shape , abnormal
somite increased length , abnormal
somite increased width , abnormal
somite condensed , abnormal
somite fused with somite , abnormal
somite morphology , abnormal
Show

 ZFA:0000186 common cardinal vein common cardinal vein morphology , abnormal
Show

 ZFA:0000396 nervous system nervous system apoptotic , abnormal
Show

 ZFA:0000422 retroarticular retroarticular absent , abnormal
Show

 ZFA:0000435 cranial nerve II cranial nerve II absent , abnormal
cranial nerve II decreased size , abnormal
cranial nerve II defasciculated , abnormal
cranial nerve II commissural neuron axon guidance disrupted , abnormal
Show

 ZFA:0000477 posterior cardinal vein posterior cardinal vein vascular lymphangioblast decreased amount , abnormal
Show

 ZFA:0000547 mouth mouth quality , abnormal
mouth morphology , abnormal
Show

 ZFA:0000621 quadrate quadrate absent , abnormal
Show

 ZFA:0000692 symplectic symplectic decreased length , abnormal
symplectic cell decreased amount , abnormal
Show

 ZFA:0000737 cranium cranium shape , abnormal
Show

 ZFA:0000890 floor plate spinal cord region floor plate spinal cord region glial cell (sensu Vertebrata) increased size , abnormal
Show

 ZFA:0000938 central canal central canal bent , abnormal
central canal kinked , abnormal
Show

 ZFA:0000940 posterior lateral line neuromast posterior lateral line neuromast decreased amount , abnormal
Show

 ZFA:0001067 anterior cerebral vein anterior cerebral vein morphology , abnormal
anterior cerebral vein decreased size , abnormal
Show

 ZFA:0001094 whole organism whole organism shape , abnormal
whole organism decreased length , abnormal
whole organism lethal (sensu genetics) , abnormal
whole organism viability , abnormal
whole organism anterior-posterior axis decreased length , abnormal
whole organism left-right axis increased width , abnormal
whole organism anterior region morphology , abnormal
whole organism morphology , abnormal
whole organism bent , abnormal
Show

 ZFA:0001108 anterior commissure anterior commissure morphology , abnormal
anterior commissure defasciculated , abnormal
anterior commissure commissural neuron axon guidance disrupted , abnormal
anterior commissure astrocyte mislocalised , abnormal
Show

 ZFA:0001114 head head increased width , abnormal
head condensed , abnormal
head anterior region flattened , abnormal
head decreased size , abnormal
Show

 ZFA:0001115 trunk trunk nerve truncated , abnormal
trunk decreased length , abnormal
trunk bent , abnormal
trunk somite increased width , abnormal
Show

 ZFA:0001117 post-vent region post-vent region quality , abnormal
post-vent region decreased length , abnormal
post-vent region decreased size , abnormal
post-vent region kinked , abnormal
post-vent region bent , abnormal
post-vent region undulate , abnormal
Show

 ZFA:0001128 pharyngeal pouch 1 pharyngeal pouch 1 decreased object quality , abnormal
Show

 ZFA:0001130 pharyngeal pouch 2 pharyngeal pouch 2 decreased object quality , abnormal
Show

 ZFA:0001205 Meckel s cartilage Meckels cartilage mislocalised ventrally , abnormal
Meckels cartilage mislocalised posteriorly , abnormal
Meckels cartilage decreased size , abnormal
Meckels cartilage dislocated , abnormal
Meckels cartilage shape , abnormal
Meckels cartilage decreased length , abnormal
Meckels cartilage deformed , abnormal
Meckels cartilage shortened , abnormal
Meckels cartilage cartilage morphogenesis process quality , abnormal
Meckels cartilage chondrocyte morphology , abnormal
Meckels cartilage chondrocyte positional polarity , abnormal
Show

 ZFA:0001227 mandibular arch skeleton mandibular arch skeleton chondrocyte morphology , abnormal
mandibular arch skeleton chondrocyte position , abnormal
mandibular arch skeleton decreased size , abnormal
Show

 ZFA:0001239 ceratobranchial 5 bone ceratobranchial 5 bone absent , abnormal
Show

 ZFA:0001285 intersegmental vessel intersegmental vessel morphology , abnormal
Show

 ZFA:0001306 pharyngeal arch pharyngeal arch cell proliferation decreased occurrence , abnormal
pharyngeal arch cartilage development decreased process quality , abnormal
Show

 ZFA:0001329 retinal inner plexiform layer retinal inner plexiform layer disorganized , abnormal
Show

 ZFA:0001400 ceratohyal cartilage ceratohyal cartilage decreased size , abnormal
ceratohyal cartilage increased thickness , abnormal
ceratohyal cartilage dislocated , abnormal
ceratohyal cartilage increased size , abnormal
ceratohyal cartilage mislocalised posteriorly , abnormal
ceratohyal cartilage decreased length , abnormal
ceratohyal cartilage deformed , abnormal
Show

 ZFA:0001405 ethmoid cartilage ethmoid cartilage decreased length , abnormal
Show

 ZFA:0001458 cranial cartilage cranial cartilage decreased length , abnormal
cranial cartilage decreased size , abnormal
cranial cartilage morphology , abnormal
Show

 ZFA:0001460 pharyngeal arch cartilage pharyngeal arch cartilage chondrocyte increased amount , abnormal
pharyngeal arch cartilage chondrocyte decreased size , abnormal
pharyngeal arch cartilage decreased size , abnormal
pharyngeal arch cartilage deformed , abnormal
pharyngeal arch cartilage cartilage element decreased length , abnormal
pharyngeal arch cartilage chondrocyte circular , abnormal
Show

 ZFA:0001516 ceratobranchial cartilage ceratobranchial cartilage malformed , abnormal
Show

 ZFA:0001591 endochondral bone endochondral bone absent , abnormal
Show

 ZFA:0001617 otolith otolith deformed , abnormal
Show

 ZFA:0001652 head muscle head muscle decreased length , abnormal
Show

 ZFA:0001670 notochord posterior region notochord posterior region bent , abnormal
notochord posterior region kinked , abnormal
Show

 ZFA:0005010 mid cerebral vein mid cerebral vein decreased size , abnormal
Show

 ZFA:0005484 quadrate-anguloarticular joint quadrate-anguloarticular joint morphology , abnormal
Show

 ZFA:0005509 palate palate decreased length , abnormal
palate chondrocyte irregular spatial pattern , abnormal
palate chondrocyte decreased size , abnormal
palate decreased width , abnormal
palate chondrocyte size , abnormal
Show

 ZFA:0005605 lymphangioblast cord lymphangioblast cord decreased length , abnormal
Show

 ZFA:0007009 nerve nerve glial cell (sensu Vertebrata) branched , abnormal
Show

 ZFA:0007016 anterior neural plate anterior neural plate increased width , abnormal
Show

 ZFA:0009084 chondrocyte chondrocyte extracellular matrix spatial pattern , abnormal
chondrocyte secretion decreased occurrence , abnormal
chondrocyte microtubule organizing center disorganized , abnormal
Show

 ZFA:0009137 ectodermal cell ectodermal cell circular , abnormal
ectodermal cell cell projection deviation , abnormal
Show

 ZFA:0009323 thrombocyte thrombocyte decreased amount , abnormal
Show

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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