Manteia - Molecule gene

ENSMUSG00000036904

Mus musculus

Features

Gene ID:	ENSMUSG00000036904

Biological name :	Fzd8

Synonyms :	Frizzled-8 / Fzd8 / Q61091

Possible biological names infered from orthology :	frizzled class receptor 8 / Q9H461

Species:	Mus musculus

Chr. number:	18
Strand:	1
Band:	A1
Gene start:	9212856
Gene end:	9216201

Corresponding Affymetrix probe sets:	10453738 (MoGene1.0st) 1423348_at (Mouse Genome 430 2.0 Array) 1445815_at (Mouse Genome 430 2.0 Array)

Cross references:	Ensembl peptide - ENSMUSP00000039660 NCBI entrez gene - 14370 See in Manteia. MGI - MGI:108460 RefSeq - NM_008058 RefSeq Peptide - NP_032084 swissprot - Q61091 Ensembl - ENSMUSG00000036904

See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed

Ortholog prediction (from Ensembl)

Ortholog name	ID	Species
fzd8a	ENSDARG00000045444	Danio rerio
fzd8b	ENSDARG00000038569	Danio rerio
FZD8	ENSGALG00000039999	Gallus gallus
FZD8	ENSG00000177283	Homo sapiens

Paralog prediction (from Ensembl)

Paralog name	ID	Similarity(%)
Fzd5 / Q9EQD0 / Frizzled-5 / Q13467* / frizzled class receptor 5*	ENSMUSG00000045005	59
Fzd2 / Q9JIP6 / Frizzled-2 / Q14332* / frizzled class receptor 2*	ENSMUSG00000050288	41
Fzd1 / O70421 / Frizzled-1 / Q9UP38* / frizzled class receptor 1*	ENSMUSG00000044674	40
Fzd7 / Q61090 / Frizzled-7 / O75084* / frizzled class receptor 7*	ENSMUSG00000041075	39
Fzd10 / Q8BKG4 / Frizzled-10 / Q9ULW2* / frizzled class receptor 10*	ENSMUSG00000081683	37
Fzd9 / Q9R216 / Frizzled-9 / O00144* / frizzled class receptor 9*	ENSMUSG00000049551	35
Fzd4 / Q61088 / Frizzled-4 / Q9ULV1* / frizzled class receptor 4*	ENSMUSG00000049791	34
Fzd6 / Q61089 / Frizzled-6 / O60353* / frizzled class receptor 6*	ENSMUSG00000022297	29
Fzd3 / Q61086 / Frizzled-3 / Q9NPG1* / frizzled class receptor 3*	ENSMUSG00000007989	29
Smo / P56726 / smoothened, frizzled class receptor / Q99835*	ENSMUSG00000001761	22
Sfrp4 / Q9Z1N6 / secreted frizzled-related protein 4 / Q6FHJ7*	ENSMUSG00000021319	13
Frzb / P97401 / Secreted frizzled-related protein 3 / Q92765* / frizzled related protein*	ENSMUSG00000027004	12
Sfrp2 / P97299 / secreted frizzled-related protein 2 / Q96HF1*	ENSMUSG00000027996	11
Sfrp5 / secreted frizzled-related sequence protein 5 / Q5T4F7* / secreted frizzled related protein 5*	ENSMUSG00000018822	11
Sfrp1 / Q8C4U3 / Secreted frizzled-related protein 1 / Q8N474*	ENSMUSG00000031548	10

Protein motifs (from Interpro)

Interpro ID	Name
IPR000539	Frizzled/Smoothened, transmembrane domain
IPR015526	Frizzled/secreted frizzled-related protein
IPR017981	GPCR, family 2-like
IPR020067	Frizzled domain
IPR036790	Frizzled cysteine-rich domain superfamily

Gene Ontology (GO)

Type	GO ID	Term	Ev.Code
biological_process	GO:0000122	negative regulation of transcription by RNA polymerase II	IDA
biological_process	GO:0001525	angiogenesis	IDA
biological_process	GO:0001934	positive regulation of protein phosphorylation	IMP
biological_process	GO:0007165	signal transduction	IEA
biological_process	GO:0007166	cell surface receptor signaling pathway	IEA
biological_process	GO:0007186	G-protein coupled receptor signaling pathway	IEA
biological_process	GO:0007275	multicellular organism development	IEA
biological_process	GO:0016055	Wnt signaling pathway	IDA
biological_process	GO:0033077	T cell differentiation in thymus	IMP
biological_process	GO:0035567	non-canonical Wnt signaling pathway	IBA
biological_process	GO:0043507	positive regulation of JUN kinase activity	IDA
biological_process	GO:0045944	positive regulation of transcription by RNA polymerase II	IDA
biological_process	GO:0060070	canonical Wnt signaling pathway	IEA
cellular_component	GO:0005576	extracellular region	TAS
cellular_component	GO:0005794	Golgi apparatus	IEA
cellular_component	GO:0005886	plasma membrane	IDA
cellular_component	GO:0016020	membrane	IEA
cellular_component	GO:0016021	integral component of membrane	IBA
cellular_component	GO:1990851	Wnt-Frizzled-LRP5/6 complex	IPI
molecular_function	GO:0004871	obsolete signal transducer activity	IEA
molecular_function	GO:0004888	transmembrane signaling receptor activity	IEA
molecular_function	GO:0004930	G-protein coupled receptor activity	IBA
molecular_function	GO:0005102	signaling receptor binding	IPI
molecular_function	GO:0005515	protein binding	IPI
molecular_function	GO:0017147	Wnt-protein binding	IPI
molecular_function	GO:0030165	PDZ domain binding	IPI
molecular_function	GO:0031625	ubiquitin protein ligase binding	IEA
molecular_function	GO:0042813	Wnt-activated receptor activity	IEA

Pathways (from Reactome)

Pathway description

Asymmetric localization of PCP proteins

Regulation of FZD by ubiquitination

Phenotype (from MGI, Zfin or HPO)

ID	Phenotype	Definition	Genetic BG
MP:0000527	abnormal kidney development	"anomalous differentiation of the paired organs responsible for urine secretion" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Fzd8^tm1Nat/Fzd8^tm1Nat Genetic Background: involves: 129S1/Sv * 129X1/SvJ
MP:0002169	no phenotype detected	"normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Sele^tm1Alb/Sele^tm1Alb Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J Allelic Composition: Fzd8^tm1Nat/Fzd8^tm1Nat Genetic Background: involves: 129S1/Sv * 129X1/SvJ
MP:0002989	small kidney	"reduced physical bulk one or both of the organs responsible for urine secretion" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Fzd4^tm1Nat/Fzd4^tm1Nat,Fzd8^tm1Nat/Fzd8^tm1Nat Genetic Background: involves: 129S1/Sv * 129X1/SvJ Allelic Composition: Fzd4^tm1Nat/Fzd4^tm1Nat,Fzd8^tm1Nat/Fzd8⁺ Genetic Background: involves: 129S1/Sv * 129X1/SvJ
MP:0004936	abnormal ureteric bud branching morphogenesis	"partial or complete failure of the ureteric bud to repeatedly divide into lobules during development of the kidney" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Fzd4^tm1Nat/Fzd4^tm1Nat,Fzd8^tm1Nat/Fzd8^tm1Nat Genetic Background: involves: 129S1/Sv * 129X1/SvJ
MP:0011111	complete lethality during fetal growth through weaning	"the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between the completion of organogenesis and weaning age (Mus: E14 to approximately 3 weeks of age)" [MGI:csmith]	Show Allelic Composition: Fzd4^tm1Nat/Fzd4^tm1Nat,Fzd8^tm1Nat/Fzd8^tm1Nat Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Interacting proteins (from Reactome)

Interactor ID	Name	Interaction type
ENSMUSG00000021994	Wnt5a / P22725 / wingless-type MMTV integration site family, member 5A / P41221* / Wnt family member 5A*	/ complex / reaction

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		© Olivier Tassy / Olivier Pourquie 2007-2024 contact: otassy@igbmc.fr