ENSDARG00000045444


Danio rerio

Features
Gene ID: ENSDARG00000045444
  
Biological name :fzd8a
  
Synonyms : frizzled class receptor 8a / fzd8a
  
Possible biological names infered from orthology : Frizzled-8 / frizzled class receptor 8 / FZD8 / Q61091 / Q9H461
  
Species: Danio rerio
  
Chr. number: 24
Strand: -1
Band:
Gene start: 4447635
Gene end: 4450238
  
Corresponding Affymetrix probe sets: Dr.23451.1.S1_s_at (Zebrafish Array)   Dr.8830.1.S1_at (Zebrafish Array)   NM_130918_at (Zebrafish Genome Array with custom cdf files)   
  
Cross references: Ensembl peptide - ENSDARP00000066834
NCBI entrez gene - 58073     See in Manteia.
RefSeq - NM_130918
RefSeq Peptide - NP_570993
swissprot - Q9YI00
ZFIN ID - ZDB-GENE-000328-3
Ensembl - ENSDARG00000045444
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 FZD8ENSGALG00000039999Gallus gallus
 FZD8ENSG00000177283Homo sapiens
 Fzd8ENSMUSG00000036904Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
fzd8b / frizzled class receptor 8b / FZD8* / Q61091* / Q9H461* / Frizzled-8 * / frizzled class receptor 8*ENSDARG0000003856978
fzd5 / frizzled class receptor 5 / Q13467* / Q9EQD0* / Frizzled-5 *ENSDARG0000002542070
fzd1 / frizzled class receptor 1 / Q9UP38*ENSDARG0000010606248
fzd2 / frizzled class receptor 2 / Q14332* / Q9JIP6* / Frizzled-2 *ENSDARG0000005443847
fzd7a / frizzled class receptor 7a / FZD7* / O75084* / Q61090* / Frizzled-7 * / frizzled class receptor 7*ENSDARG0000006000447
fzd7b / frizzled class receptor 7b / FZD7* / O75084* / Q61090* / Frizzled-7 * / frizzled class receptor 7*ENSDARG0000002758946
fzd10 / frizzled class receptor 10 / Q8BKG4* / Q9ULW2* / Frizzled-10 *ENSDARG0000006821343
fzd9a / frizzled class receptor 9a / FZD9* / O00144* / Q9R216* / Frizzled-9 * / frizzled class receptor 9*ENSDARG0000003518540
fzd9b / frizzled class receptor 9b / FZD9* / O00144* / Q9R216* / Frizzled-9 * / frizzled class receptor 9*ENSDARG0000001467340
fzd3b / frizzled class receptor 3bENSDARG0000005869235
fzd3a / frizzled class receptor 3a / FZD3* / Q61086* / Q9NPG1* / Frizzled-3 * / frizzled class receptor 3*ENSDARG0000002166434
CABZ01088508.1 / FZD6* / O60353* / frizzled class receptor 6*ENSDARG0000010487432
smo / smoothened, frizzled class receptor / P56726* / Q99835*ENSDARG0000000295224
sfrp5 / secreted frizzled-related protein 5 / Q5T4F7* / secreted frizzled-related sequence protein 5*ENSDARG0000003904113
sfrp1a / secreted frizzled-related protein 1a / SFRP1* / Q8C4U3* / Q8N474* / secreted frizzled related protein 1*ENSDARG0000003552113
sfrp2 / secreted frizzled-related protein 2 / P97299* / Q96HF1*ENSDARG0000007005013
frzb / frizzled related protein / P97401* / Q92765* / Secreted frizzled-related protein 3 *ENSDARG0000001838313
sfrp1b / secreted frizzled-related protein 1b / SFRP1* / Q8C4U3* / Q8N474* / secreted frizzled related protein 1*ENSDARG0000005767812
FP102169.1ENSDARG0000011096711
CZQB01095947.1ENSDARG0000008956311


Protein motifs (from Interpro)
Interpro ID Name
 IPR000539  Frizzled/Smoothened, transmembrane domain
 IPR015526  Frizzled/secreted frizzled-related protein
 IPR017981  GPCR, family 2-like
 IPR020067  Frizzled domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007166 cell surface receptor signaling pathway IEA
 biological_processGO:0007186 G-protein coupled receptor signaling pathway IEA
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0016055 Wnt signaling pathway IEA
 biological_processGO:0021529 spinal cord oligodendrocyte cell differentiation IMP
 biological_processGO:0021531 spinal cord radial glial cell differentiation IMP
 biological_processGO:0021879 forebrain neuron differentiation IMP
 biological_processGO:0035567 non-canonical Wnt signaling pathway IBA
 biological_processGO:0060070 canonical Wnt signaling pathway IGI
 biological_processGO:0060898 eye field cell fate commitment involved in camera-type eye formation IGI
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IBA
 molecular_functionGO:0004888 transmembrane signaling receptor activity IEA
 molecular_functionGO:0004930 G-protein coupled receptor activity IBA
 molecular_functionGO:0017147 Wnt-protein binding IBA
 molecular_functionGO:0042813 Wnt-activated receptor activity IBA


Pathways (from Reactome)
Pathway description
Asymmetric localization of PCP proteins
Regulation of FZD by ubiquitination


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000075 spinal cord spinal cord glioblast (sensu Vertebrata) decreased amount , abnormal
spinal cord radial glial cell disorganized , abnormal
spinal cord radial glial cell decreased amount , abnormal
spinal cord glioblast (sensu Vertebrata) absent , abnormal
spinal cord secondary motor neuron decreased amount , abnormal
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 ZFA:0000101 diencephalon diencephalon dopaminergic neuron increased amount , abnormal
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 ZFA:0001106 pharyngeal pouch pharyngeal pouch malformed , abnormal
pharyngeal pouch protein localization to plasma membrane decreased occurrence , abnormal
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 ZFA:0001516 ceratobranchial cartilage ceratobranchial cartilage malformed , abnormal
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Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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