ENSDARG00000054438


Danio rerio

Features
Gene ID: ENSDARG00000054438
  
Biological name :fzd2
  
Synonyms : frizzled class receptor 2 / fzd2
  
Possible biological names infered from orthology : Frizzled-2 / Q14332 / Q9JIP6
  
Species: Danio rerio
  
Chr. number: 3
Strand: 1
Band:
Gene start: 31621774
Gene end: 31624213
  
Corresponding Affymetrix probe sets: Dr.12607.1.S1_at (Zebrafish Array)   NM_131140_at (Zebrafish Genome Array with custom cdf files)   
  
Cross references: Ensembl peptide - ENSDARP00000071107
NCBI entrez gene - 30370     See in Manteia.
RefSeq - NM_131140
RefSeq Peptide - NP_571215
swissprot - F1QBI2
ZFIN ID - ZDB-GENE-990415-224
Ensembl - ENSDARG00000054438
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 FZD2ENSGALG00000030847Gallus gallus
 FZD2ENSG00000180340Homo sapiens
 Fzd2ENSMUSG00000050288Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
fzd1 / frizzled class receptor 1 / Q9UP38*ENSDARG0000010606273
fzd7a / frizzled class receptor 7a / FZD7* / O75084* / Q61090* / Frizzled-7 * / frizzled class receptor 7*ENSDARG0000006000472
fzd7b / frizzled class receptor 7b / FZD7* / O75084* / Q61090* / Frizzled-7 * / frizzled class receptor 7*ENSDARG0000002758971
fzd8a / frizzled class receptor 8a / FZD8* / Q61091* / Q9H461* / Frizzled-8 * / frizzled class receptor 8*ENSDARG0000004544449
fzd5 / frizzled class receptor 5 / Q13467* / Q9EQD0* / Frizzled-5 *ENSDARG0000002542047
fzd8b / frizzled class receptor 8b / FZD8* / Q61091* / Q9H461* / Frizzled-8 * / frizzled class receptor 8*ENSDARG0000003856947
fzd10 / frizzled class receptor 10 / Q8BKG4* / Q9ULW2* / Frizzled-10 *ENSDARG0000006821344
fzd9a / frizzled class receptor 9a / FZD9* / O00144* / Q9R216* / Frizzled-9 * / frizzled class receptor 9*ENSDARG0000003518543
fzd9b / frizzled class receptor 9b / FZD9* / O00144* / Q9R216* / Frizzled-9 * / frizzled class receptor 9*ENSDARG0000001467342
fzd3a / frizzled class receptor 3a / FZD3* / Q61086* / Q9NPG1* / Frizzled-3 * / frizzled class receptor 3*ENSDARG0000002166441
fzd3b / frizzled class receptor 3bENSDARG0000005869240
CABZ01088508.1 / FZD6* / O60353* / frizzled class receptor 6*ENSDARG0000010487438
smo / smoothened, frizzled class receptor / P56726* / Q99835*ENSDARG0000000295223
frzb / frizzled related protein / P97401* / Q92765* / Secreted frizzled-related protein 3 *ENSDARG0000001838313
sfrp1b / secreted frizzled-related protein 1b / SFRP1* / Q8C4U3* / Q8N474* / secreted frizzled related protein 1*ENSDARG0000005767813
sfrp5 / secreted frizzled-related protein 5 / Q5T4F7* / secreted frizzled-related sequence protein 5*ENSDARG0000003904113
sfrp2 / secreted frizzled-related protein 2 / P97299* / Q96HF1*ENSDARG0000007005013
sfrp1a / secreted frizzled-related protein 1a / SFRP1* / Q8C4U3* / Q8N474* / secreted frizzled related protein 1*ENSDARG0000003552113
FP102169.1ENSDARG0000011096712
CZQB01095947.1ENSDARG0000008956311


Protein motifs (from Interpro)
Interpro ID Name
 IPR000539  Frizzled/Smoothened, transmembrane domain
 IPR015526  Frizzled/secreted frizzled-related protein
 IPR020067  Frizzled domain
 IPR026550  Frizzled-2


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001947 heart looping IMP
 biological_processGO:0003146 heart jogging IMP
 biological_processGO:0007166 cell surface receptor signaling pathway IEA
 biological_processGO:0007186 G-protein coupled receptor signaling pathway IEA
 biological_processGO:0007223 Wnt signaling pathway, calcium modulating pathway IGI
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0007368 determination of left/right symmetry IMP
 biological_processGO:0016055 Wnt signaling pathway IEA
 biological_processGO:0016477 cell migration IMP
 biological_processGO:0031018 endocrine pancreas development IMP
 biological_processGO:0060027 convergent extension involved in gastrulation IMP
 biological_processGO:0060070 canonical Wnt signaling pathway IBA
 biological_processGO:0060271 cilium assembly IMP
 biological_processGO:0061341 non-canonical Wnt signaling pathway involved in heart development IMP
 biological_processGO:0070654 sensory epithelium regeneration IEP
 cellular_componentGO:0005886 plasma membrane IDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IBA
 molecular_functionGO:0004888 transmembrane signaling receptor activity IEA
 molecular_functionGO:0004930 G-protein coupled receptor activity IBA
 molecular_functionGO:0017147 Wnt-protein binding IBA
 molecular_functionGO:0042813 Wnt-activated receptor activity IEA


Pathways (from Reactome)
Pathway description
Ca2+ pathway
Asymmetric localization of PCP proteins
Disassembly of the destruction complex and recruitment of AXIN to the membrane
WNT5A-dependent internalization of FZD2, FZD5 and ROR2


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000001 Kupffer s vesicle Kupffers vesicle cilium decreased length , abnormal
Kupffers vesicle cilium decreased amount , abnormal
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 ZFA:0000022 floor plate floor plate undulate , abnormal
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 ZFA:0000031 hypochord hypochord undulate , abnormal
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 ZFA:0000135 notochord notochord decreased length , abnormal
notochord increased thickness , abnormal
notochord undulate , abnormal
notochord kinked , abnormal
notochord increased width , abnormal
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 ZFA:0000155 somite somite increased width , abnormal
somite condensed , abnormal
somite asymmetrical , abnormal
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 ZFA:0000360 heart tube heart tube inverted , abnormal
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 ZFA:0001069 ventral fin fold ventral fin fold decreased size , abnormal
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 ZFA:0001094 whole organism whole organism oblong , abnormal
whole organism anterior-posterior axis decreased length , abnormal
Show

 ZFA:0001117 post-vent region post-vent region decreased length , abnormal
post-vent region curved ventral , abnormal
post-vent region kinked , abnormal
Show

 ZFA:0001173 dorsal fin dorsal fin decreased size , abnormal
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Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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