ENSMUSG00000021319


Mus musculus

Features
Gene ID: ENSMUSG00000021319
  
Biological name :Sfrp4
  
Synonyms : Q9Z1N6 / secreted frizzled-related protein 4 / Sfrp4
  
Possible biological names infered from orthology : Q6FHJ7
  
Species: Mus musculus
  
Chr. number: 13
Strand: 1
Band: A2
Gene start: 19623104
Gene end: 19632994
  
Corresponding Affymetrix probe sets: 10403834 (MoGene1.0st)   1451031_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000152498
Ensembl peptide - ENSMUSP00000152850
Ensembl peptide - ENSMUSP00000152511
Ensembl peptide - ENSMUSP00000002883
NCBI entrez gene - 20379     See in Manteia.
MGI - MGI:892010
RefSeq - NM_016687
RefSeq Peptide - NP_057896
swissprot - A0A1Y7VJK6
swissprot - A0A1Y7VK98
swissprot - Q8CAH7
swissprot - Q9Z1N6
Ensembl - ENSMUSG00000021319
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 SFRP4ENSGALG00000031997Gallus gallus
 SFRP4ENSG00000106483Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Frzb / P97401 / Secreted frizzled-related protein 3 / Q92765* / frizzled related protein*ENSMUSG0000002700447
Fzd5 / Q9EQD0 / Frizzled-5 / Q13467* / frizzled class receptor 5*ENSMUSG0000004500528
Fzd1 / O70421 / Frizzled-1 / Q9UP38* / frizzled class receptor 1*ENSMUSG0000004467426
Fzd7 / Q61090 / Frizzled-7 / O75084* / frizzled class receptor 7*ENSMUSG0000004107526
Fzd8 / Q61091 / Frizzled-8 / Q9H461* / frizzled class receptor 8*ENSMUSG0000003690426
Fzd2 / Q9JIP6 / Frizzled-2 / Q14332* / frizzled class receptor 2*ENSMUSG0000005028825
Fzd9 / Q9R216 / Frizzled-9 / O00144* / frizzled class receptor 9*ENSMUSG0000004955125
Fzd10 / Q8BKG4 / Frizzled-10 / Q9ULW2* / frizzled class receptor 10*ENSMUSG0000008168323
Fzd3 / Q61086 / Frizzled-3 / Q9NPG1* / frizzled class receptor 3*ENSMUSG0000000798922
Fzd6 / Q61089 / Frizzled-6 / O60353* / frizzled class receptor 6*ENSMUSG0000002229721
Fzd4 / Q61088 / Frizzled-4 / Q9ULV1* / frizzled class receptor 4*ENSMUSG0000004979121
Smo / P56726 / smoothened, frizzled class receptor / Q99835*ENSMUSG0000000176120
Sfrp1 / Q8C4U3 / Secreted frizzled-related protein 1 / Q8N474*ENSMUSG0000003154815
Sfrp5 / secreted frizzled-related sequence protein 5 / Q5T4F7* / secreted frizzled related protein 5*ENSMUSG0000001882215
Sfrp2 / P97299 / secreted frizzled-related protein 2 / Q96HF1*ENSMUSG0000002799612


Protein motifs (from Interpro)
Interpro ID Name
 IPR001134  Netrin domain
 IPR008993  Tissue inhibitor of metalloproteinases-like, OB-fold
 IPR015526  Frizzled/secreted frizzled-related protein
 IPR018933  Netrin module, non-TIMP type
 IPR020067  Frizzled domain
 IPR026560  Secreted frizzled-related protein 4
 IPR036790  Frizzled cysteine-rich domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002092 positive regulation of receptor internalization IEA
 biological_processGO:0007186 G-protein coupled receptor signaling pathway IEA
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0008285 negative regulation of cell proliferation IEA
 biological_processGO:0010628 positive regulation of gene expression IEA
 biological_processGO:0016055 Wnt signaling pathway IEA
 biological_processGO:0030154 cell differentiation IEA
 biological_processGO:0030510 regulation of BMP signaling pathway IMP
 biological_processGO:0043065 positive regulation of apoptotic process IEA
 biological_processGO:0043433 negative regulation of DNA-binding transcription factor activity IEA
 biological_processGO:0045606 positive regulation of epidermal cell differentiation IEA
 biological_processGO:0055062 phosphate ion homeostasis IEA
 biological_processGO:0060349 bone morphogenesis IEA
 biological_processGO:0090090 negative regulation of canonical Wnt signaling pathway IEA
 biological_processGO:0090263 positive regulation of canonical Wnt signaling pathway IEA
 biological_processGO:1902174 positive regulation of keratinocyte apoptotic process IEA
 biological_processGO:2000051 negative regulation of non-canonical Wnt signaling pathway IMP
 biological_processGO:2000119 negative regulation of sodium-dependent phosphate transport IEA
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005615 extracellular space IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0009986 cell surface IEA
 cellular_componentGO:0016021 integral component of membrane IBA
 molecular_functionGO:0004930 G-protein coupled receptor activity IBA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0017147 Wnt-protein binding IEA
 molecular_functionGO:0042813 Wnt-activated receptor activity IBA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000133 abnormal long bone metaphysis morphology "malformed conical section of bone between the epiphysis and diaphysis of the long bones" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:61295]
Show

Allelic Composition: Del(1Aim2-Ifi205)1Stsn/Del(1Aim2-Ifi205)1Stsn,Trex1tm1Tld/Trex1tm1Tld
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6N

Allelic Composition: Sfrp4tm1.1Blan/Sfrp4tm1.1Blan
Genetic Background: Not Specified

 MP:0000135 reduced cortical bone thickness "thinner than normal superficial layer of compact bone " [J:61509]
Show

Allelic Composition: Del(1Aim2-Ifi205)1Stsn/Del(1Aim2-Ifi205)1Stsn,Trex1tm1Tld/Trex1tm1Tld
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6N

Allelic Composition: Sfrp4tm1.1Blan/Sfrp4tm1.1Blan
Genetic Background: Not Specified

Allelic Composition: Sfrp4tm1.1Lex/Sfrp4+
Genetic Background: Not Specified

Allelic Composition: Sfrp4tm1.1Blan/Sfrp4+
Genetic Background: Not Specified

 MP:0000462 abnormal digestive system morphology "anomalous structure of the system dedicated to the mechanical, chemical, and enzymatic processing of food" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Phbtm1.1Bwo/Phbtm1.1Bwo,Pgrtm2(cre)Lyd/?
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

Allelic Composition: Kltm1Lex/Kltm1Lex,Sfrp4tm1.1Blan/Sfrp4tm1.1Blan
Genetic Background: involves: 129S/SvEvBrd * C57BL/6

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
Show

Allelic Composition: Phbtm1.1Bwo/Phbtm1.1Bwo,Pgrtm2(cre)Lyd/?
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

Allelic Composition: Kltm1Lex/Kltm1Lex,Sfrp4tm1.1Blan/Sfrp4tm1.1Blan
Genetic Background: involves: 129S/SvEvBrd * C57BL/6

 MP:0001566 hyperphosphatemia "abnormally high concentrations of phosphates in the circulating blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Fgf23tm1Blan/Fgf23tm1Blan,Sfrp4tm1.1Blan/Sfrp4tm1.1Blan
Genetic Background: involves: 129 * C57BL/6

Allelic Composition: Kltm1Lex/Kltm1Lex,Sfrp4tm1.1Blan/Sfrp4tm1.1Blan
Genetic Background: involves: 129S/SvEvBrd * C57BL/6

 MP:0001923 reduced female fertility "reduced ability of female to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]
Show

Allelic Composition: Phbtm1.1Bwo/Phbtm1.1Bwo,Pgrtm2(cre)Lyd/?
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0001935 reduced litter size "fewer live born pups in a litter compared to average" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Phbtm1.1Bwo/Phbtm1.1Bwo,Pgrtm2(cre)Lyd/?
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0001958 emphysema "lung disease characterized by increased size of terminal bronchioles with destructive changes in their walls and reduction in number" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:33629]
Show

Allelic Composition: Fgf23tm1Blan/Fgf23tm1Blan,Sfrp4tm1.1Blan/Sfrp4tm1.1Blan
Genetic Background: involves: 129 * C57BL/6

Allelic Composition: Kltm1Lex/Kltm1Lex,Sfrp4tm1.1Blan/Sfrp4tm1.1Blan
Genetic Background: involves: 129S/SvEvBrd * C57BL/6

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Fgf23tm1Blan/Fgf23tm1Blan,Sfrp4tm1.1Blan/Sfrp4tm1.1Blan
Genetic Background: involves: 129 * C57BL/6

Allelic Composition: Kltm1Lex/Kltm1Lex,Sfrp4tm1.1Blan/Sfrp4tm1.1Blan
Genetic Background: involves: 129S/SvEvBrd * C57BL/6

 MP:0002896 abnormal bone mineralization "defect in the process by which minerals are deposited into bone" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Del(1Aim2-Ifi205)1Stsn/Del(1Aim2-Ifi205)1Stsn,Trex1tm1Tld/Trex1tm1Tld
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6N

Allelic Composition: Sfrp4tm1.1Blan/Sfrp4tm1.1Blan
Genetic Background: Not Specified

Allelic Composition: Sfrp4tm1.1Lex/Sfrp4+
Genetic Background: Not Specified

Allelic Composition: Sfrp4tm1.1Blan/Sfrp4+
Genetic Background: Not Specified

 MP:0002998 abnormal bone remodeling "aberrant process of the turnover of bone matrix that involves a balance of resorbtion and formation by osteoclasts and osteoblasts, respectively" [ava:Anna V. Anagnostopoulos , Mouse Genome Informatics Curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Del(1Aim2-Ifi205)1Stsn/Del(1Aim2-Ifi205)1Stsn,Trex1tm1Tld/Trex1tm1Tld
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6N

Allelic Composition: Sfrp4tm1.1Blan/Sfrp4tm1.1Blan
Genetic Background: Not Specified

 MP:0003197 kidney calcification "pathologic deposition of calcium salts in the kidney" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, RGD:Rat Genome Database submission]
Show

Allelic Composition: Fgf23tm1Blan/Fgf23tm1Blan,Sfrp4tm1.1Blan/Sfrp4tm1.1Blan
Genetic Background: involves: 129 * C57BL/6

Allelic Composition: Kltm1Lex/Kltm1Lex,Sfrp4tm1.1Blan/Sfrp4tm1.1Blan
Genetic Background: involves: 129S/SvEvBrd * C57BL/6

 MP:0004984 increased osteoclast cell number "greater than average number of the bone resorpting cells that remove bone tissue by degrading the mineralized matrix" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Del(1Aim2-Ifi205)1Stsn/Del(1Aim2-Ifi205)1Stsn,Trex1tm1Tld/Trex1tm1Tld
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6N

Allelic Composition: Sfrp4tm1.1Blan/Sfrp4tm1.1Blan
Genetic Background: Not Specified

 MP:0004991 decreased bone strength "reduced ability of bone to endure the application of force without yielding or breaking" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Del(1Aim2-Ifi205)1Stsn/Del(1Aim2-Ifi205)1Stsn,Trex1tm1Tld/Trex1tm1Tld
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6N

Allelic Composition: Sfrp4tm1.1Blan/Sfrp4tm1.1Blan
Genetic Background: Not Specified

 MP:0004992 increased bone resorption "greater than average amount of degradation of the organic and inorganic phases of bone by absorption, usually by the abnormal function or number of osteoclasts" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Del(1Aim2-Ifi205)1Stsn/Del(1Aim2-Ifi205)1Stsn,Trex1tm1Tld/Trex1tm1Tld
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6N

Allelic Composition: Sfrp4tm1.1Blan/Sfrp4tm1.1Blan
Genetic Background: Not Specified

 MP:0006133 arterial calcification "pathologic deposition of calcium salts in the arteries" [ncbi:Matthew Mailman, NCBI request, smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Fgf23tm1Blan/Fgf23tm1Blan,Sfrp4tm1.1Blan/Sfrp4tm1.1Blan
Genetic Background: involves: 129 * C57BL/6

Allelic Composition: Kltm1Lex/Kltm1Lex,Sfrp4tm1.1Blan/Sfrp4tm1.1Blan
Genetic Background: involves: 129S/SvEvBrd * C57BL/6

 MP:0008151 increased diameter of long bones "increased width of the cross-sectional distance that extends from one lateral edge of a long bone, through its center and to the opposite lateral edge" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Del(1Aim2-Ifi205)1Stsn/Del(1Aim2-Ifi205)1Stsn,Trex1tm1Tld/Trex1tm1Tld
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6N

Allelic Composition: Sfrp4tm1.1Blan/Sfrp4tm1.1Blan
Genetic Background: Not Specified

 MP:0008271 abnormal bone ossification "any anomaly in the formation of bone or of a bony substance, or the conversion of fibrous tissue or of cartilage into bone or a bony substance" [GO:0001503]
Show

Allelic Composition: Del(1Aim2-Ifi205)1Stsn/Del(1Aim2-Ifi205)1Stsn,Trex1tm1Tld/Trex1tm1Tld
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6N

Allelic Composition: Sfrp4tm1.1Blan/Sfrp4tm1.1Blan
Genetic Background: Not Specified

 MP:0010878 increased trabecular bone volume "increase in the amount of space occupied by trabecular bone tissue in the skeleton" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Del(1Aim2-Ifi205)1Stsn/Del(1Aim2-Ifi205)1Stsn,Trex1tm1Tld/Trex1tm1Tld
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6N

Allelic Composition: Sfrp4tm1.1Blan/Sfrp4tm1.1Blan
Genetic Background: Not Specified

Allelic Composition: Sfrp4tm1.1Lex/Sfrp4+
Genetic Background: Not Specified

Allelic Composition: Sfrp4tm1.1Blan/Sfrp4+
Genetic Background: Not Specified

 MP:0013624 decreased femur compact bone thickness "reduced width of the superficial layer of compact bone at the midpoint of the femur" [MGI:csmith]
Show

Allelic Composition: Del(1Aim2-Ifi205)1Stsn/Del(1Aim2-Ifi205)1Stsn,Trex1tm1Tld/Trex1tm1Tld
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6N

Allelic Composition: Sfrp4tm1.1Blan/Sfrp4tm1.1Blan
Genetic Background: Not Specified

 MP:0020039 increased bone ossification "increase in the formation of bone or of a bony substance, or the conversion of fibrous tissue or of cartilage into bone or a bony substance" [ORCID: orcid.org/0000-0003-4606-0597]
Show

Allelic Composition: Del(1Aim2-Ifi205)1Stsn/Del(1Aim2-Ifi205)1Stsn,Trex1tm1Tld/Trex1tm1Tld
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6N

Allelic Composition: Sfrp4tm1.1Blan/Sfrp4tm1.1Blan
Genetic Background: Not Specified

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

1 s.

 
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