ENSMUSG00000045005


Mus musculus

Features
Gene ID: ENSMUSG00000045005
  
Biological name :Fzd5
  
Synonyms : Frizzled-5 / Fzd5 / Q9EQD0
  
Possible biological names infered from orthology : frizzled class receptor 5 / Q13467
  
Species: Mus musculus
  
Chr. number: 1
Strand: -1
Band: C2
Gene start: 64730558
Gene end: 64737751
  
Corresponding Affymetrix probe sets: 10355152 (MoGene1.0st)   1422937_at (Mouse Genome 430 2.0 Array)   1455604_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000067783
Ensembl peptide - ENSMUSP00000111828
NCBI entrez gene - 14367     See in Manteia.
MGI - MGI:108571
RefSeq - NM_001042659
RefSeq - NM_022721
RefSeq Peptide - NP_001036124
RefSeq Peptide - NP_073558
swissprot - Q9EQD0
Ensembl - ENSMUSG00000045005
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 fzd5ENSDARG00000025420Danio rerio
 FZD5ENSGALG00000034101Gallus gallus
 FZD5ENSG00000163251Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Fzd8 / Q61091 / Frizzled-8 / Q9H461* / frizzled class receptor 8*ENSMUSG0000003690469
Fzd2 / Q9JIP6 / Frizzled-2 / Q14332* / frizzled class receptor 2*ENSMUSG0000005028847
Fzd7 / Q61090 / Frizzled-7 / O75084* / frizzled class receptor 7*ENSMUSG0000004107546
Fzd1 / O70421 / Frizzled-1 / Q9UP38* / frizzled class receptor 1*ENSMUSG0000004467446
Fzd10 / Q8BKG4 / Frizzled-10 / Q9ULW2* / frizzled class receptor 10*ENSMUSG0000008168343
Fzd9 / Q9R216 / Frizzled-9 / O00144* / frizzled class receptor 9*ENSMUSG0000004955141
Fzd4 / Q61088 / Frizzled-4 / Q9ULV1* / frizzled class receptor 4*ENSMUSG0000004979139
Fzd3 / Q61086 / Frizzled-3 / Q9NPG1* / frizzled class receptor 3*ENSMUSG0000000798936
Fzd6 / Q61089 / Frizzled-6 / O60353* / frizzled class receptor 6*ENSMUSG0000002229735
Smo / P56726 / smoothened, frizzled class receptor / Q99835*ENSMUSG0000000176125
Sfrp4 / Q9Z1N6 / secreted frizzled-related protein 4 / Q6FHJ7*ENSMUSG0000002131917
Frzb / P97401 / Secreted frizzled-related protein 3 / Q92765* / frizzled related protein*ENSMUSG0000002700415
Sfrp5 / secreted frizzled-related sequence protein 5 / Q5T4F7* / secreted frizzled related protein 5*ENSMUSG0000001882213
Sfrp1 / Q8C4U3 / Secreted frizzled-related protein 1 / Q8N474*ENSMUSG0000003154812
Sfrp2 / P97299 / secreted frizzled-related protein 2 / Q96HF1*ENSMUSG0000002799612


Protein motifs (from Interpro)
Interpro ID Name
 IPR000539  Frizzled/Smoothened, transmembrane domain
 IPR015526  Frizzled/secreted frizzled-related protein
 IPR017981  GPCR, family 2-like
 IPR020067  Frizzled domain
 IPR036790  Frizzled cysteine-rich domain superfamily
 IPR037441  Frizzled-5, CRD domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000578 embryonic axis specification ISO
 biological_processGO:0001525 angiogenesis IMP
 biological_processGO:0001944 vasculature development IMP
 biological_processGO:0002726 positive regulation of T cell cytokine production ISO
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007166 cell surface receptor signaling pathway IEA
 biological_processGO:0007186 G-protein coupled receptor signaling pathway IEA
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0008285 negative regulation of cell proliferation IMP
 biological_processGO:0008595 anterior/posterior axis specification, embryo ISO
 biological_processGO:0016055 Wnt signaling pathway IGI
 biological_processGO:0030154 cell differentiation IEA
 biological_processGO:0031076 embryonic camera-type eye development IMP
 biological_processGO:0031077 post-embryonic camera-type eye development IMP
 biological_processGO:0032729 positive regulation of interferon-gamma production ISO
 biological_processGO:0033077 T cell differentiation in thymus IMP
 biological_processGO:0035567 non-canonical Wnt signaling pathway IBA
 biological_processGO:0043507 positive regulation of JUN kinase activity IDA
 biological_processGO:0044332 Wnt signaling pathway involved in dorsal/ventral axis specification ISO
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II ISO
 biological_processGO:0048469 cell maturation IMP
 biological_processGO:0048596 embryonic camera-type eye morphogenesis IMP
 biological_processGO:0050718 positive regulation of interleukin-1 beta secretion IGI
 biological_processGO:0060061 Spemann organizer formation ISO
 biological_processGO:0060070 canonical Wnt signaling pathway ISO
 biological_processGO:0060561 apoptotic process involved in morphogenesis IMP
 biological_processGO:0060670 branching involved in labyrinthine layer morphogenesis IMP
 biological_processGO:0060715 syncytiotrophoblast cell differentiation involved in labyrinthine layer development IMP
 biological_processGO:0060716 labyrinthine layer blood vessel development IMP
 biological_processGO:0060718 chorionic trophoblast cell differentiation IMP
 biological_processGO:0060828 regulation of canonical Wnt signaling pathway IMP
 biological_processGO:0071219 cellular response to molecule of bacterial origin ISO
 biological_processGO:1901382 regulation of chorionic trophoblast cell proliferation IMP
 biological_processGO:1903146 regulation of autophagy of mitochondrion ISO
 biological_processGO:1903955 positive regulation of protein targeting to mitochondrion ISO
 biological_processGO:1904469 positive regulation of tumor necrosis factor secretion IGI
 biological_processGO:2000810 regulation of bicellular tight junction assembly IMP
 cellular_componentGO:0000139 Golgi membrane IEA
 cellular_componentGO:0005769 early endosome IDA
 cellular_componentGO:0005794 Golgi apparatus IDA
 cellular_componentGO:0005886 plasma membrane IDA
 cellular_componentGO:0005887 integral component of plasma membrane ISO
 cellular_componentGO:0005923 bicellular tight junction IDA
 cellular_componentGO:0009986 cell surface ISO
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IBA
 cellular_componentGO:0030054 cell junction IEA
 cellular_componentGO:0030424 axon IEA
 cellular_componentGO:0030425 dendrite IEA
 cellular_componentGO:0042995 cell projection IEA
 cellular_componentGO:0043204 perikaryon IEA
 cellular_componentGO:0045202 synapse IEA
 cellular_componentGO:0048471 perinuclear region of cytoplasm IDA
 cellular_componentGO:0106003 amyloid-beta complex ISO
 molecular_functionGO:0001540 amyloid-beta binding ISO
 molecular_functionGO:0004871 obsolete signal transducer activity IEA
 molecular_functionGO:0004888 transmembrane signaling receptor activity IEA
 molecular_functionGO:0004930 G-protein coupled receptor activity IBA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008289 lipid binding IEA
 molecular_functionGO:0017147 Wnt-protein binding ISO
 molecular_functionGO:0019901 protein kinase binding ISO
 molecular_functionGO:0031625 ubiquitin protein ligase binding ISO
 molecular_functionGO:0042813 Wnt-activated receptor activity ISO


Pathways (from Reactome)
Pathway description
Ca2+ pathway
Asymmetric localization of PCP proteins
Disassembly of the destruction complex and recruitment of AXIN to the membrane
Regulation of FZD by ubiquitination
WNT5A-dependent internalization of FZD2, FZD5 and ROR2


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000832 abnormal thalamus morphology "malformation or absence of the large ovoid mass of paired bodies containing mostly gray matter and forming part of the lateral wall of the third ventricle of the brain" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Fzd5tm1Nat/Fzd5tm2Nat,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA * SJL

Allelic Composition: Fzd5tm1Nat/Fzd5tm2Nat,Gt(ROSA)26Sortm1(cre/ERT)Nat/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA * SJL

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
Show

Allelic Composition: Fzd5tm1Nat/Fzd5tm2Nat,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA * SJL

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
Show

Allelic Composition: Fzd5tm1Nat/Fzd5tm1Nat
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0001326 retinal degeneration "pathological change in the thin layer of neural tissue lining the back of the eyeball, which contains visual receptors and can result in the impairment or cessation of retinal neural function" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, NMF:Stephanie Pretel, Neuroscience Mutagenesis Facility Curator]
Show

Allelic Composition: Fzd5tm1Nat/Fzd5tm2Nat,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA * SJL

 MP:0001405 impaired coordination "reduced ability to execute integrated movements of muscle" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Fzd5tm1Nat/Fzd5tm2Nat,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA * SJL

 MP:0001718 abnormal yolk sac "malformed extraembryonic tissue which contributes to hematopoietic circulation" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:12623]
Show

Allelic Composition: Engtm1Hma/Engtm1Hma
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0001722 pale yolk sac "bloodless yolk sac" [J:62571]
Show

Allelic Composition: Engtm1Hma/Engtm1Hma
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0001723 disorganized vascular plexus 
Show

Allelic Composition: Engtm1Hma/Engtm1Hma
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0001914 hemorrhage "loss of blood from the vascular compartment to the exterior or into nonvascular body space as a result of rupture or severance of the blood vessels" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Engtm1Hma/Engtm1Hma
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0004076 abnormal vitelline vascular remodelling "anomaly in the conversion of the primary (honeycomb-like) vascular plexus of the yolk sac into a mature vascular network" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Engtm1Hma/Engtm1Hma
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0008803 abnormal placental labyrinth vasculature morphology "any structural anomaly in blood vessels of the layer of the placenta where embryonic and maternal blood vessels interdigitate" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Engtm1Hma/Engtm1Hma
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0011091 complete prenatal lethality "death of all organisms of a given genotype in a population between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith]
Show

Allelic Composition: Engtm1Hma/Engtm1Hma
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: Fzd5tm1Nat/Fzd5tm1Nat
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0014077 ectopic Paneth cells "abnormal position of the large secretory cells containing coarse granules normally confined to the base of the crypts of Lieberkuhn in the small intestine" [MGI:Anna]
Show

Allelic Composition: Dvl1tm1Awb/Dvl1tm1Awb,Dvl2tm1Awb/Dvl2tm1Awb,Tg(Dvl2*K446M/EGFP)5Awb/?
Genetic Background: involves: 129S6/SvEvTac

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000021994 Wnt5a / P22725 / wingless-type MMTV integration site family, member 5A / P41221* / Wnt family member 5A*  / complex / reaction






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr