ENSMUSG00000026556


Mus musculus

Features
Gene ID: ENSMUSG00000026556
  
Biological name :Vangl2
  
Synonyms : Q91ZD4 / Vangl2 / VANGL planar cell polarity 2
  
Possible biological names infered from orthology : Q9ULK5 / VANGL planar cell polarity protein 2
  
Species: Mus musculus
  
Chr. number: 1
Strand: -1
Band: H3
Gene start: 172000960
Gene end: 172028444
  
Corresponding Affymetrix probe sets: 10360187 (MoGene1.0st)   1419218_at (Mouse Genome 430 2.0 Array)   1436118_at (Mouse Genome 430 2.0 Array)   1455592_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000106895
Ensembl peptide - ENSMUSP00000117736
Ensembl peptide - ENSMUSP00000116522
Ensembl peptide - ENSMUSP00000027837
Ensembl peptide - ENSMUSP00000106894
NCBI entrez gene - 93840     See in Manteia.
MGI - MGI:2135272
RefSeq - XM_017313008
RefSeq - XM_006497051
RefSeq - XM_006497052
RefSeq - XM_006497053
RefSeq - XM_006497054
RefSeq - XM_006497055
RefSeq - NM_033509
RefSeq Peptide - NP_277044
swissprot - D3Z374
swissprot - D3YY75
swissprot - D3Z4X2
swissprot - Q91ZD4
Ensembl - ENSMUSG00000026556
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 Q8UVJ6ENSDARG00000027397Danio rerio
 VANGL2ENSGALG00000030643Gallus gallus
 Q9ULK5ENSG00000162738Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q80Z96 / Vangl1 / VANGL planar cell polarity 1 / Q8TAA9* / VANGL planar cell polarity protein 1*ENSMUSG0000002786072


Protein motifs (from Interpro)
Interpro ID Name
 IPR009539  Vang-like protein


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001569 branching involved in blood vessel morphogenesis TAS
 biological_processGO:0001736 establishment of planar polarity IMP
 biological_processGO:0001843 neural tube closure IMP
 biological_processGO:0001942 hair follicle development IMP
 biological_processGO:0001947 heart looping IMP
 biological_processGO:0003148 outflow tract septum morphogenesis TAS
 biological_processGO:0003149 membranous septum morphogenesis IGI
 biological_processGO:0003150 muscular septum morphogenesis IGI
 biological_processGO:0003347 epicardial cell to mesenchymal cell transition TAS
 biological_processGO:0003402 planar cell polarity pathway involved in axis elongation IGI
 biological_processGO:0007266 Rho protein signal transduction IMP
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0009952 anterior/posterior pattern specification IMP
 biological_processGO:0015012 heparan sulfate proteoglycan biosynthetic process IMP
 biological_processGO:0022007 convergent extension involved in neural plate elongation IMP
 biological_processGO:0030111 regulation of Wnt signaling pathway IMP
 biological_processGO:0032835 glomerulus development IMP
 biological_processGO:0032956 regulation of actin cytoskeleton organization IMP
 biological_processGO:0035019 somatic stem cell population maintenance IMP
 biological_processGO:0035567 non-canonical Wnt signaling pathway IMP
 biological_processGO:0035787 cell migration involved in kidney development IMP
 biological_processGO:0036342 post-anal tail morphogenesis IMP
 biological_processGO:0036514 dopaminergic neuron axon guidance IMP
 biological_processGO:0036515 serotonergic neuron axon guidance IMP
 biological_processGO:0042060 wound healing IGI
 biological_processGO:0043507 positive regulation of JUN kinase activity IGI
 biological_processGO:0045176 apical protein localization IMP
 biological_processGO:0045197 establishment or maintenance of epithelial cell apical/basal polarity IMP
 biological_processGO:0048103 somatic stem cell division IMP
 biological_processGO:0048105 establishment of body hair planar orientation IMP
 biological_processGO:0048546 digestive tract morphogenesis IGI
 biological_processGO:0060028 convergent extension involved in axis elongation IMP
 biological_processGO:0060029 convergent extension involved in organogenesis IGI
 biological_processGO:0060071 Wnt signaling pathway, planar cell polarity pathway IMP
 biological_processGO:0060119 inner ear receptor cell development IGI
 biological_processGO:0060122 inner ear receptor cell stereocilium organization IMP
 biological_processGO:0060488 orthogonal dichotomous subdivision of terminal units involved in lung branching morphogenesis IMP
 biological_processGO:0060489 planar dichotomous subdivision of terminal units involved in lung branching morphogenesis IMP
 biological_processGO:0060490 lateral sprouting involved in lung morphogenesis IMP
 biological_processGO:0060947 cardiac vascular smooth muscle cell differentiation TAS
 biological_processGO:0060993 kidney morphogenesis IMP
 biological_processGO:0061346 planar cell polarity pathway involved in heart morphogenesis IMP
 biological_processGO:0090102 cochlea development IGI
 biological_processGO:0090103 cochlea morphogenesis IMP
 biological_processGO:0090162 establishment of epithelial cell polarity TAS
 biological_processGO:0090175 regulation of establishment of planar polarity IGI
 biological_processGO:0090177 establishment of planar polarity involved in neural tube closure IMP
 biological_processGO:0090179 planar cell polarity pathway involved in neural tube closure IMP
 biological_processGO:1904938 planar cell polarity pathway involved in axon guidance IMP
 biological_processGO:1905515 non-motile cilium assembly IGI
 cellular_componentGO:0001725 stress fiber IDA
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0005911 cell-cell junction IDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0016323 basolateral plasma membrane IDA
 cellular_componentGO:0016324 apical plasma membrane IDA
 cellular_componentGO:0016328 lateral plasma membrane IDA
 cellular_componentGO:0030134 COPII-coated ER to Golgi transport vesicle IDA
 cellular_componentGO:0060187 cell pole IDA
 cellular_componentGO:0071944 cell periphery IDA
 molecular_functionGO:0005515 protein binding IPI


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000026 abnormal inner ear morphology "malformation or malfunction of any components of the labyrinth, including the semicircular canals, vestibule and cochlea" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:1776]
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Allelic Composition: Scn1atm1Wac/Scn1a+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0000031 abnormal cochlea morphology "any anomaly, deformity, malformation, impairment or dysfunction of the cochlea" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, cml:Cathleen M. Lutz , Mouse Genome Informatics Curator, J:21484]
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Allelic Composition: Vangl2Lp/Vangl2Lp
Genetic Background: LPT/LeJ

Allelic Composition: Vangl1Gt(XL802)Byg/Vangl1+,Vangl2Lp/Vangl2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * LPT/LeJ

Allelic Composition: Vangl2tm2.2Mdea/Vangl2tm2.2Mdea
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * SJL

 MP:0000042 abnormal organ of Corti "abnormalities associated with the highly specialized epithelium in the floor of the ductus cochlearis; also referred to a spiral organ (organum spirale), or acoustic papilla" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Lrp8tm3Her/Lrp8tm3Her
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

Allelic Composition: Dvl2tm1Awb/Dvl2tm1Awb,Vangl2Lp/Vangl2+
Genetic Background: involves: 129S6/SvEvTac * LPT/LeJ

Allelic Composition: Vangl2Lp/Vangl2Lp
Genetic Background: LPT/LeJ

 MP:0000111 cleft palate "congenital fissure of the tissues normally uniting to form the palate" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:49840]
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Allelic Composition: Fzd2tm1.1Nat/Fzd2tm1.1Nat,Vangl2Lp/Vangl2+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA * LPT/LeJ

Allelic Composition: Fzd2tm1.1Nat/Fzd2+,Fzd7tm1.1Nat/Fzd7tm1.1Nat,Vangl2Lp/Vangl2+
Genetic Background: involves: 129 * C57BL/6 * LPT/LeJ

Allelic Composition: Fzd7tm1.1Nat/Fzd7tm1.1Nat,Vangl2Lp/Vangl2+
Genetic Background: involves: 129 * C57BL/6 * LPT/LeJ

 MP:0000137 abnormal vertebrae morphology "malformed bony segment of the spinal column" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Scn1atm1Wac/Scn1a+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0000141 abnormal vertebral body morphology "malformed main portion of the vertebra anterior to the vertebral canal" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:55583]
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Allelic Composition: Vangl2Lp/Vangl2Lp
Genetic Background: involves: A

 MP:0000150 abnormal rib morphology "malformed bones forming the bony wall of the chest" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:50311]
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Allelic Composition: Scn1atm1Wac/Scn1a+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0000153 rib bifurcation "forking or division of ribs, may be a result of partial rib fusions" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Vangl2Lp/Vangl2Lp
Genetic Background: involves: A

 MP:0000154 rib fusion "appearance of one or more ribs as a single structure" [J:62022, J:62023]
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Allelic Composition: Nod2tm1Flv/Nod2tm1Flv
Genetic Background: involves: 129S1/Sv * C57BL/6

Allelic Composition: Vangl2Lp/Vangl2Lp
Genetic Background: involves: A

 MP:0000157 abnormal sternum morphology "malformed long flat bone of the chest; articulates with clavicle and first seven rib pairs" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:19212]
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Allelic Composition: Nod2tm1Flv/Nod2tm1Flv
Genetic Background: involves: 129S1/Sv * C57BL/6

Allelic Composition: Vangl2Lp/Vangl2Lp
Genetic Background: involves: A

 MP:0000159 abnormal xiphoid process "malformed posterior tip of the sternum" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:42932]
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Allelic Composition: Vangl2Lp/Vangl2Lp
Genetic Background: involves: A

Allelic Composition: Vangl2Lp/Vangl2+
Genetic Background: involves: A

 MP:0000266 abnormal cardiac morphology "anomalies in the hollow, muscular organ that maintains the circulation of the blood" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Fzd2tm1.1Nat/Fzd2+,Fzd7tm1.1Nat/Fzd7tm1.1Nat,Vangl2Lp/Vangl2+
Genetic Background: involves: 129 * C57BL/6 * LPT/LeJ

Allelic Composition: Fzd7tm1.1Nat/Fzd7tm1.1Nat,Vangl2Lp/Vangl2+
Genetic Background: involves: 129 * C57BL/6 * LPT/LeJ

Allelic Composition: Fzd2tm1.1Nat/Fzd2+,Vangl2Lp/Vangl2+
Genetic Background: involves: 129 * C57BL/6 * LPT/LeJ

 MP:0000267 abnormal cardiac development "aberrant formation or incomplete differentiation of the heart" [MGI:cls, J:53370]
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Allelic Composition: Vangl2Lp/Vangl2Lp
Genetic Background: LPT/LeJ

 MP:0000269 abnormal looping morphogenesis "atypical bending of the primitive heart tube during early development" [J:27443]
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Allelic Composition: Vangl2Lp/Vangl2Lp
Genetic Background: LPT/LeJ

Allelic Composition: Cfl1c5/Cfl1c5,Vangl2Lp/Vangl2Lp
Genetic Background: involves: C57BL/6J * LPT/LeJ

 MP:0000284 double outlet right ventricle "both the aorta and the pulmonary trunk originate from the right ventricle, usually in conjunction with a ventricular septal defect" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:67826]
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Allelic Composition: Vangl2Lp/Vangl2Lp
Genetic Background: LPT/LeJ

 MP:0000436 abnormal head movements "anomalous motion of the portion of the body containing the brain and organs of sight, hearing, taste, and smell " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Lrp8tm3Her/Lrp8tm3Her
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

Allelic Composition: Vangl2Lp/Vangl2+
Genetic Background: involves: A

 MP:0000462 abnormal digestive system morphology "anomalous structure of the system dedicated to the mechanical, chemical, and enzymatic processing of food" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Dact1tm1.1Bnrc/Dact1+,Vangl2Lp/Vangl2+
Genetic Background: B6.Cg-Vangl2Lp Dact1tm1.1Bnrc

Allelic Composition: Dact1tm1.1Bnrc/Dact1tm1.1Bnrc,Vangl2Lp-m1Jus/Vangl2+
Genetic Background: involves: 101/Rl * 129 * C3H/Rl * C57BL/6

 MP:0000538 abnormal urinary bladder morphology "malformation of the inflatable musculomembranous bag for holding urine" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Dact1tm1.1Bnrc/Dact1+,Vangl2Lp/Vangl2+
Genetic Background: B6.Cg-Vangl2Lp Dact1tm1.1Bnrc

Allelic Composition: Dact1tm1.1Bnrc/Dact1tm1.1Bnrc,Vangl2Lp-m1Jus/Vangl2+
Genetic Background: involves: 101/Rl * 129 * C3H/Rl * C57BL/6

 MP:0000585 kinked tail "a sharp bend or zig-zag in the tail" [J:61295]
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Allelic Composition: Lrp8tm3Her/Lrp8tm3Her
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

Allelic Composition: Vangl2Lp-m1Jus/Vangl2+
Genetic Background: involves: 101/Rl * C3H/Rl * C57BL/6J

Allelic Composition: Vangl2ska17/Vangl2ska17
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

Allelic Composition: Vangl2tm1.2Mdea/Vangl2tm1.2Mdea
Genetic Background: B6NCrl.129S6(Cg)-Vangl2tm1.2Mdea

Allelic Composition: Lrp6skax26/Lrp6+,Vangl2Lp/Vangl2+
Genetic Background: involves: A/J * 129S6/SvEvTac * C57BL/6 * C57BL/6J

 MP:0000592 short tail "reduced length of tail compared to control " [J:55583]
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Allelic Composition: Vangl2Lp/Vangl2+
Genetic Background: involves: A

Allelic Composition: Vangl2Lp-2J/Vangl2Lp-2J
Genetic Background: B6.Cg-Vangl2Lp-2J/GrsrJ

Allelic Composition: Vangl2Lp-2J/Vangl2+
Genetic Background: B6.Cg-Vangl2Lp-2J/GrsrJ

Allelic Composition: Vangl1Gt(XL802)Byg/Vangl1Gt(XL802)Byg,Vangl2Lp/Vangl2+
Genetic Background: involves: 129P2/OlaHsd * A

Allelic Composition: Sestd1tm1.1Bnrc/Sestd1tm1.1Bnrc,Vangl2Lp/Vangl2+
Genetic Background: involves: 129S6/SvEvTac * A * C57BL/6NCr

 MP:0000780 abnormal corpus callosum morphology "malformation or absence of a thick bundle of nerve fibers comprising a commissural plate connecting the two cerebral hemispheres; it consists of contralateral axon projections that provides communications between the right and left cerebral hemispheres" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Vangl2Lp/Vangl2+
Genetic Background: involves: A

 MP:0000783 abnormal forebrain morphology "malformed or absent anterior primitive cerebral vesicle; most rostral of three primary vesicles of the embryonic neural tube" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:38857]
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Allelic Composition: Vangl2Lp/Vangl2Lp
Genetic Background: involves: A

 MP:0000807 abnormal hippocampus morphology "absent or malformed deep lying structure of the cerebrum involved with memory storage and spatial navigation" [The Atlas of Mouse Development:ISBN 0-12-402035-6, MGI:Cls, J:38857]
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Allelic Composition: Lrp8tm3Her/Lrp8tm3Her
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

Allelic Composition: Vangl2Lp/Vangl2+
Genetic Background: involves: A

 MP:0000822 abnormal brain ventricle morphology "malformed or absent fluid filled cavities of the cerebrum" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Vangl2Lp/Vangl2+
Genetic Background: involves: A

 MP:0000823 abnormal lateral ventricle morphology "malformation or absence of cavity in each of the cerebral hemispheres derived from the cavity of the embryonic neural tube; they are separated from each other by the septum pellucidum, and each communicates with the third ventricle by the foramen of Monro, through which also the choroid plexuses of the lateral ventricles become continuous with that of the third ventricle" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Lrp8tm3Her/Lrp8tm3Her
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

 MP:0000841 abnormal hindbrain morphology "malformed caudal region of the brain; includes cerebellum, pons and medulla oblongata" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:45302]
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Allelic Composition: Vangl2Lp/Vangl2Lp
Genetic Background: involves: A

 MP:0000847 abnormal metencephalon morphology "any malformation or absence of the anterior part of the rhombencephalon" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Vangl2Lp/Vangl2Lp
Genetic Background: involves: A

 MP:0000897 abnormal midbrain "malformation or malfunction associated with the middle of the three cerebral vesicles of the embryo; this region controls sensory and motor functions, including eye movement and coordination of auditory and visual reflexes" [J:23882, Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
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Allelic Composition: Vangl2Lp/Vangl2Lp
Genetic Background: involves: A

 MP:0000913 abnormal brain development "malformed or incomplete differentiation of the brain" [MGI:cls, J:49840]
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Allelic Composition: Scn1atm1Wac/Scn1a+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0000914 exencephaly "neurocranial defects resulting in exposure or extrusion of the brain" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:49840]
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Allelic Composition: Terctm1Rdp/Terctm1Rdp,Terf1tm1Tdl/Terf1tm1Tdl
Genetic Background: involves: 129S2/SvPas

Allelic Composition: CoblC101/CoblC101,Vangl2Lp/Vangl2+
Genetic Background: involves: 129S2/SvPas * LPT/LeJ

Allelic Composition: Dvl3tm1Awb/Dvl3+,Vangl2Lp/Vangl2+
Genetic Background: involves: 129S6/SvEvTac * A * Black Swiss

Allelic Composition: ScribCrc/Scrib+,Vangl2Lp/Vangl2+
Genetic Background: C3H.Cg-Vangl2Lp ScribCrc

Allelic Composition: Celsr1Crsh/Celsr1+,ScribCrc/Scrib+,Vangl2Lp/Vangl2+
Genetic Background: C3H.Cg-Vangl2Lp ScribCrc Celsr1Crsh

 MP:0000928 incomplete cephalic closure "arrest of the fusion of the cephalic neural folds" [J:12622]
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Allelic Composition: Dvl3tm1Awb/Dvl3+,Vangl2Lp/Vangl2+
Genetic Background: involves: 129S6/SvEvTac * A * Black Swiss

 MP:0000929 open neural tube "incomplete invagination and fusion of the neuroepithelial layer in early development" [MGI:CLS, J:53370, J:62571]
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Allelic Composition: Nod2tm1Flv/Nod2tm1Flv
Genetic Background: involves: 129S1/Sv * C57BL/6

Allelic Composition: Vangl2Lp/Vangl2Lp
Genetic Background: involves: LPT/LeJ

Allelic Composition: Vangl2Lp-m1Jus/Vangl2Lp-m1Jus
Genetic Background: involves: 101/Rl * C3H/Rl * C57BL/6J

Allelic Composition: Vangl2Lp/Vangl2Lp-m1Jus
Genetic Background: involves: 101/Rl * C3H/Rl * C57BL/6J * LPT/LeJ

Allelic Composition: Sfrp1tm1Aksh/Sfrp1tm1Aksh,Sfrp2tm1Aksh/Sfrp2tm1Aksh,Sfrp5tm1Aksh/Sfrp5+,Vangl2Lp/Vangl2+
Genetic Background: involves: 129 * A * C57BL/6 * LPT/LeJ

Allelic Composition: Fzd1tm1.1Nat/Fzd1+,Vangl2Lp/Vangl2+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA * LPT/LeJ

Allelic Composition: Fzd1tm1.1Nat/Fzd1+,Fzd2tm1.1Nat/Fzd2+,Vangl2Lp/Vangl2+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA * LPT/LeJ

Allelic Composition: Fzd2tm1.1Nat/Fzd2tm1.1Nat,Vangl2Lp/Vangl2+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA * LPT/LeJ

Allelic Composition: Vangl2M1Yzcm/Vangl2+
Genetic Background: either: C57BL/6J-Vangl2m1Yzcm or (involves: C3H/HeJ * C57BL/6J)

Allelic Composition: Cfl1c5/Cfl1c5,Vangl2Lp/Vangl2Lp
Genetic Background: involves: C57BL/6J * LPT/LeJ

Allelic Composition: Cfl1tm1.2Wit/Cfl1tm1.2Wit,Vangl2Lp/Vangl2Lp
Genetic Background: involves: 129 * LPT/LeJ

Allelic Composition: Vangl2Lp/Vangl2Lp
Genetic Background: C3H.A(Cg)-Vangl2Lp

 MP:0000955 abnormal spinal cord morphology "malformation or disorganization of the cylindrical tissue of the vertebral canal that extends from the medulla oblongata to the conus medullaris" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Grhl3ct/?,Vangl2Lp/Vangl2+
Genetic Background: involves: A * GFF

 MP:0001144 fused vaginal opening "condition in which the external vaginal opening is closed by the adherence of the epithelium of the vagina" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Vangl2Lp/Vangl2+
Genetic Background: involves: A

Allelic Composition: Vangl2Lp-2J/Vangl2+
Genetic Background: B6.Cg-Vangl2Lp-2J/GrsrJ

Allelic Composition: Vangl1Gt(XL802)Byg/Vangl1Gt(XL802)Byg,Vangl2Lp/Vangl2+
Genetic Background: involves: 129P2/OlaHsd * A

Allelic Composition: Vangl2Lp/Vangl2Lp
Genetic Background: B6.A(Cg)-Vangl2Lp

Allelic Composition: Ankrd6tm1Pche/Ankrd6tm1Pche,Vangl2Lp/Vangl2+
Genetic Background: involves: 129 * LPT/LeJ

Allelic Composition: Vangl2Lp/Vangl2+
Genetic Background: involves: 129 * LPT/LeJ

 MP:0001175 abnormal lung morphology "malformed organ of respiration" [J:35802]
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Allelic Composition: Mecp2tm3.1Bird/Mecp2tm3.1Bird
Genetic Background: involves: 129P2/OlaHsd * BALB/cJ * C57BL/6

 MP:0001178 pulmonary hypoplasia "reduced size of the respiratory organ due to incomplete development of all or part of the organ " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Pathology , 2nd edition:ISBN 0-397-51047-0]
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Allelic Composition: Mecp2tm3.1Bird/Mecp2tm3.1Bird
Genetic Background: involves: 129P2/OlaHsd * BALB/cJ * C57BL/6

 MP:0001302 eyelids open at birth "widely open eyes instead of closed at perinatal stage" [J:51966]
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Allelic Composition: Vangl2tm1.2Mdea/Vangl2tm1.2Mdea
Genetic Background: B6NCrl.129S6(Cg)-Vangl2tm1.2Mdea

 MP:0001340 abnormal eyelid morphology "malformation of the skin folds covering the front of the eyeball" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Celsr1Crsh/Celsr1Crsh
Genetic Background: C3H.Cg-Celsr1Crsh

Allelic Composition: ScribCrc/Scrib+,Vangl2Lp/Vangl2+
Genetic Background: C3H.Cg-Vangl2Lp ScribCrc

 MP:0001391 abnormal tail movements "a change from the normal manner of moving the tail" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Vangl2Lp/Vangl2+
Genetic Background: involves: A

 MP:0001392 abnormal locomotor activity "altered ability or inability to move from place to place" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Nr3c1tm1Gsc/Nr3c1tm1Gsc
Genetic Background: involves: 129P2/OlaHsd

 MP:0001525 impaired balance "reduced ability of an animal to maintain equilibrium" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:64962, J:17123]
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Allelic Composition: Vangl2Lp/Vangl2+
Genetic Background: involves: A

 MP:0001672 abnormal embryogenesis/ development "anomaly in the establishment of the characteristic configuration of the embryonic body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Lrp8tm3Her/Lrp8tm3Her
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

Allelic Composition: Vangl2Lp/Vangl2Lp
Genetic Background: LPT/LeJ

 MP:0001688 abnormal somite development "anomalous formation of any of the paired, metamerically arranged cell masses formed in the embryonic paraxial mesoderm" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Nod2tm1Flv/Nod2tm1Flv
Genetic Background: involves: 129S1/Sv * C57BL/6

Allelic Composition: Sfrp1tm1Aksh/Sfrp1tm1Aksh,Sfrp2tm1Aksh/Sfrp2tm1Aksh,Sfrp5tm1Aksh/Sfrp5+,Vangl2Lp/Vangl2+
Genetic Background: involves: 129 * A * C57BL/6 * LPT/LeJ

Allelic Composition: Cfl1c5/Cfl1c5,Vangl2Lp/Vangl2Lp
Genetic Background: involves: C57BL/6J * LPT/LeJ

Allelic Composition: Cfl1tm1.2Wit/Cfl1tm1.2Wit,Vangl2Lp/Vangl2Lp
Genetic Background: involves: 129 * LPT/LeJ

 MP:0001691 abnormal somite shape "atypical characteristic surface configuration of a segmental mass along the notochord of the developing embryo" [J:37888]
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Allelic Composition: Nod2tm1Flv/Nod2tm1Flv
Genetic Background: involves: 129S1/Sv * C57BL/6

Allelic Composition: Vangl2Lp/Vangl2Lp
Genetic Background: involves: A

 MP:0001698 reduced embryo size "smaller proportions of embryo compared to littermates" [J:61790]
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Allelic Composition: Vangl2Lp/Vangl2Lp
Genetic Background: involves: A

Allelic Composition: Vangl2Lp-m1Jus/Vangl2Lp-m1Jus
Genetic Background: involves: 101/Rl * C3H/Rl * C57BL/6J

Allelic Composition: Cfl1c5/Cfl1c5,Vangl2Lp/Vangl2Lp
Genetic Background: involves: C57BL/6J * LPT/LeJ

Allelic Composition: Cfl1tm1.2Wit/Cfl1tm1.2Wit,Vangl2Lp/Vangl2Lp
Genetic Background: involves: 129 * LPT/LeJ

 MP:0001700 abnormal embryo turning "atypical axial rotation of the germ layers of the embryo during the primitive streak/early somite stage (Mus:E8.5-E9.5) such that the curvature of the entire trunk region is reversed and the neural ectoderm moves to the convex region and the midgut region becomes located in the concave region" [The Atlas of Mouse Development:ISBN 0-12-402035-6, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Vangl2Lp/Vangl2Lp
Genetic Background: involves: A

Allelic Composition: Vangl1Gt(XL802)Byg/Vangl1Gt(XL802)Byg,Vangl2tm1.2Yy/Vangl2tm1.2Yy
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

Allelic Composition: Cfl1c5/Cfl1c5,Vangl2Lp/Vangl2Lp
Genetic Background: involves: C57BL/6J * LPT/LeJ

Allelic Composition: Cfl1tm1.2Wit/Cfl1tm1.2Wit,Vangl2Lp/Vangl2Lp
Genetic Background: involves: 129 * LPT/LeJ

 MP:0001701 incomplete embryo turning "arrest of the axial rotation of the germ layers of the embryo during the primitive streak/early somite stage (E8.5-E9.5)" [J:62571]
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Allelic Composition: Vangl2Lp/Vangl2Lp
Genetic Background: LPT/LeJ

 MP:0001706 abnormal left-right axis patterning "anomaly in the formation or development of the body or a specific organ of the body in relation to the left and right sides of the body or organ" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Cfl1c5/Cfl1c5
Genetic Background: involves: C57BL/6J

Allelic Composition: Celsr1Crsh/Celsr1+,Vangl2Lp/Vangl2+
Genetic Background: C3H.Cg-Vangl2Lp Celsr1Crsh

 MP:0001730 embryonic growth arrest "the cessation of development beyond a particular stage" [J:17509]
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Allelic Composition: Cfl1c5/Cfl1c5
Genetic Background: involves: C57BL/6J

Allelic Composition: Cfl1tm1.2Wit/Cfl1tm1.2Wit,Vangl2Lp/Vangl2Lp
Genetic Background: involves: 129 * LPT/LeJ

 MP:0001914 hemorrhage "loss of blood from the vascular compartment to the exterior or into nonvascular body space as a result of rupture or severance of the blood vessels" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Vangl2Lp/Vangl2Lp
Genetic Background: involves: A

 MP:0001925 male infertility "inability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]
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Allelic Composition: Vangl2ska17/Vangl2ska17
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

Allelic Composition: Vangl2Lp/Vangl2Lp
Genetic Background: B6.A(Cg)-Vangl2Lp

 MP:0001926 female infertility "inability of female to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:34193]
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Allelic Composition: Vangl2Lp/Vangl2+
Genetic Background: involves: A

Allelic Composition: Vangl1Gt(XL802)Byg/Vangl1Gt(XL802)Byg,Vangl2Lp/Vangl2+
Genetic Background: involves: 129P2/OlaHsd * A

Allelic Composition: Ankrd6tm1Pche/Ankrd6tm1Pche,Vangl2Lp/Vangl2+
Genetic Background: involves: 129 * LPT/LeJ

Allelic Composition: Vangl2Lp/Vangl2+
Genetic Background: involves: 129 * LPT/LeJ

 MP:0002066 abnormal motor capabilities/coordination/movement "altered ability to coordinate voluntary movement or repetitive, compulsive movements" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Nr3c1tm1Gsc/Nr3c1tm1Gsc
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Grhl3ct/?,Vangl2Lp/Vangl2+
Genetic Background: involves: A * GFF

 MP:0002084 abnormal developmental patterning "abnormal systematic arrangement of the developing body along an axis" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Celsr1Crsh/Celsr1+,Vangl2Lp/Vangl2+
Genetic Background: C3H.Cg-Vangl2Lp Celsr1Crsh

 MP:0002085 abnormal embryonic tissue morphology "structural abnormality or development of any embryonic tissue resulting in morphological abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Scn1atm1Wac/Scn1a+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Vangl2Lp/Vangl2+
Genetic Background: involves: C57BL/6 * LPT/LeJ

 MP:0002111 abnormal tail morphology "abnormal development of the tail resulting in structural abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Vangl2Lp-2J/Vangl2Lp-2J
Genetic Background: B6.Cg-Vangl2Lp-2J/GrsrJ

Allelic Composition: Celsr1Crsh/Celsr1+,ScribCrc/Scrib+,Vangl2Lp/Vangl2+
Genetic Background: C3H.Cg-Vangl2Lp ScribCrc Celsr1Crsh

 MP:0002135 abnormal kidney morphology "abnormal development of the kidney resulting in structural abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Dact1tm1.1Bnrc/Dact1+,Vangl2Lp/Vangl2+
Genetic Background: B6.Cg-Vangl2Lp Dact1tm1.1Bnrc

Allelic Composition: Dact1tm1.1Bnrc/Dact1tm1.1Bnrc,Vangl2Lp-m1Jus/Vangl2+
Genetic Background: involves: 101/Rl * 129 * C3H/Rl * C57BL/6

 MP:0002151 abnormal neural tube morphology/development "anomalous structure of or development of the embryonic neural tube resulting in structural anomaly" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Scn1atm1Wac/Scn1a+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Dvl3tm1Awb/Dvl3+,Vangl2Lp/Vangl2+
Genetic Background: involves: 129S6/SvEvTac * A * Black Swiss

Allelic Composition: Dvl3tm1Awb/Dvl3tm1Awb,Vangl2Lp/Vangl2+
Genetic Background: involves: 129S6/SvEvTac * A * Black Swiss

Allelic Composition: Vangl2M1Yzcm/Vangl2+
Genetic Background: either: C57BL/6J-Vangl2m1Yzcm or (involves: C3H/HeJ * C57BL/6J)

Allelic Composition: Vangl2tm2.2Mdea/Vangl2tm2.2Mdea
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * SJL

 MP:0002152 abnormal brain morphology "anomalous structure of or abnormal development of the brain, one of the two components of the central nervous system and the center of thought and emotion; controls coordination, bodily activities and the interpretation of information from the senses (sight, hearing, smell, etc.)" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, http://cancerweb.ncl.ac.uk]
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Allelic Composition: Scn1atm1Wac/Scn1a+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Dvl2tm1Awb/Dvl2tm1Awb,Tg(Dvl2/EGFP)2Awb/?,Vangl2Lp/Vangl2+
Genetic Background: involves: 129S6/SvEvTac * LPT/LeJ

Allelic Composition: Vangl1Gt(XL802)Byg/Vangl1+,Vangl2ska17/Vangl2+
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6J

 MP:0002182 abnormal astrocyte morphology "anomalous structure, number or compostion of one of the large neuroglia cells of nervous tissue" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Grhl3ct/?,Vangl2Lp/Vangl2+
Genetic Background: involves: A * GFF

 MP:0002200 abnormal brain ventricle/choroid plexus morphology "malformation or absence of the brain ventricles or their associated choroid plexuses" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Lrp8tm3Her/Lrp8tm3Her
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

 MP:0002231 abnormal primitive streak morphology "anomaly in the midline ridge of the embryonic epiblast that later develops into mesoderm and endoderm" [The Atlas of Mouse Development:ISBN 0-12-402035-6, csmith:Cynthia L. Smith, Mouse Genome Informatics Curator]
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Allelic Composition: Vangl2Lp/Vangl2Lp
Genetic Background: involves: A

 MP:0002428 abnormal semicircular canal "anomaly of the organ of balance composed of three long bony tubes of the labyrinth" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Vangl2Lp/Vangl2Lp
Genetic Background: involves: A

 MP:0002621 delayed neural tube closure "delayed fusion of the neuroepithelial layer in early development" [J:79790, cml:Cathleen M. Lutz , Mouse Genome Informatics Curator]
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Allelic Composition: Lrp8tm3Her/Lrp8tm3Her
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

Allelic Composition: Vangl2Lp/Vangl2+
Genetic Background: involves: C57BL/6 * CBA/Ca * LPT/LeJ

Allelic Composition: Vangl2Lp/Vangl2+
Genetic Background: C3H.A(Cg)-Vangl2Lp

Allelic Composition: Vangl2Lp/Vangl2+
Genetic Background: involves: CBA * LPT/Le

 MP:0002622 abnormal cochlear hair cell morphology "malformation of the sensory epithelial cells of the cochlea; these cells are in synaptic contact with the auditory nerve" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Cthrc1tm1Hssk/Cthrc1+,Vangl2Lp/Vangl2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Fzd2tm1.1Nat/Fzd2tm1.1Nat,Vangl2Lp/Vangl2+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA * LPT/LeJ

Allelic Composition: Vangl2Lp/Vangl2tm1.2Mdea
Genetic Background: involves: 129S/Sv * C57BL/6 * FVB/N * LPT/LeJ * SJL

Allelic Composition: Vangl2tm1.2Mdea/Vangl2tm1.2Mdea
Genetic Background: B6NCrl.129S6(Cg)-Vangl2tm1.2Mdea

Allelic Composition: Ankrd6tm1Pche/Ankrd6tm1Pche,Vangl2Lp/Vangl2+
Genetic Background: involves: 129 * LPT/LeJ

 MP:0002623 abnormal vestibular hair cell morphology "malformation of the sensory epithelial cells of the membraneous labyrinth of the inner ear; these cells are in synaptic contact with the vestibular nerve" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Vangl2Lp/Vangl2tm1.2Mdea
Genetic Background: involves: 129S/Sv * C57BL/6 * FVB/N * LPT/LeJ * SJL

Allelic Composition: Vangl2tm1.2Mdea/Vangl2tm1.2Mdea
Genetic Background: B6NCrl.129S6(Cg)-Vangl2tm1.2Mdea

 MP:0002730 head shaking "compulsive movement of the head in the horizontal plane" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:274]
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Allelic Composition: Vangl2Lp/Vangl2+
Genetic Background: involves: A

 MP:0002757 reduced vertical activity "lesser than average time spent jumping or rearing" [J:82829, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Vangl2Lp/Vangl2+
Genetic Background: involves: A

 MP:0002758 long tail "increased length of tail relative to average of a given strain" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:82849]
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Allelic Composition: Vangl1Gt(XL802)Byg/Vangl1Gt(XL802)Byg,Vangl2Lp/Vangl2+
Genetic Background: involves: 129P2/OlaHsd * A

 MP:0002823 abnormal rib development "anomalous formation of the bones forming the bony wall of the chest" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:84754]
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Allelic Composition: Vangl2Lp/Vangl2Lp
Genetic Background: involves: A

 MP:0002825 abnormal notochord "malformation or absence of the axial fibrocellular cord in embryos around which develops the vertebral primordia" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Nod2tm1Flv/Nod2tm1Flv
Genetic Background: involves: 129S1/Sv * C57BL/6

Allelic Composition: Vangl2Lp/Vangl2Lp
Genetic Background: LPT/LeJ

Allelic Composition: Vangl2Lp/Vangl2Lp
Genetic Background: involves: LPT/LeJ

Allelic Composition: Vangl2Lp/Vangl2Lp
Genetic Background: involves: A

Allelic Composition: Vangl1Gt(XL802)Byg/Vangl1Gt(XL802)Byg,Vangl2tm1.2Yy/Vangl2tm1.2Yy
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

Allelic Composition: Cfl1c5/Cfl1c5,Vangl2Lp/Vangl2Lp
Genetic Background: involves: C57BL/6J * LPT/LeJ

 MP:0003051 curly tail "a loop or corkscrew-like curl in the tail" [csmith:Cynthia L. Smith, Mouse Genome Informatics Curator]
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Allelic Composition: Scarb1Chohd1/Scarb1+
Genetic Background: C3HeB/FeJ-Scarb1Chohd1/Ieg

Allelic Composition: Vangl2Lp-m1Jus/Vangl2+
Genetic Background: involves: 101/Rl * C3H/Rl * C57BL/6J

Allelic Composition: Vangl2Lp/Vangl2+
Genetic Background: involves: A

Allelic Composition: Vangl1Gt(XL802)Byg/Vangl1+,Vangl2Lp/Vangl2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * LPT/LeJ

Allelic Composition: ScribCrc/Scrib+,Vangl2+/Vangl2Lp
Genetic Background: involves: BALB/c * C57BL/6 * CBA/Ca * LPT/LeJ * NMRI * SWR

Allelic Composition: Vangl2Lp/Vangl2+
Genetic Background: involves: C57BL/6 * LPT/LeJ

Allelic Composition: Dact1tm1.1Bnrc/Dact1+,Vangl2Lp/Vangl2+
Genetic Background: B6.Cg-Vangl2Lp Dact1tm1.1Bnrc

Allelic Composition: Dact1tm1.1Bnrc/Dact1tm1.1Bnrc,Vangl2Lp/Vangl2+
Genetic Background: B6.Cg-Vangl2Lp Dact1tm1.1Bnrc

Allelic Composition: Dact1tm1.1Bnrc/Dact1tm1.1Bnrc,Vangl2Lp-m1Jus/Vangl2+
Genetic Background: involves: 101/Rl * 129 * C3H/Rl * C57BL/6

Allelic Composition: Dact1tm1.1Bnrc/Dact1+,Vangl2Lp-m1Jus/Vangl2+
Genetic Background: involves: 101/Rl * 129 * C3H/Rl * C57BL/6

Allelic Composition: Vangl2Lp-2J/Vangl2+
Genetic Background: B6.Cg-Vangl2Lp-2J/GrsrJ

Allelic Composition: Vangl2ska17/Vangl2ska17
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

Allelic Composition: Scribcrn2/Scrib+,Vangl2Lp/Vangl2+
Genetic Background: involves: A/J * FVB/N

Allelic Composition: Vangl2M1Yzcm/Vangl2+
Genetic Background: C57BL/6J-Vangl2M1Yzcm

Allelic Composition: Vangl2M1Yzcm/Vangl2+
Genetic Background: involves: C3H/HeJ * C57BL/6J

Allelic Composition: Sestd1tm1.1Bnrc/Sestd1tm1.1Bnrc,Vangl2Lp/Vangl2+
Genetic Background: involves: 129S6/SvEvTac * A * C57BL/6NCr

Allelic Composition: Sestd1tm1.1Bnrc/Sestd1+,Vangl2Lp/Vangl2+
Genetic Background: involves: 129S6/SvEvTac * A * C57BL/6NCr

Allelic Composition: Lrp6skax26/Lrp6+,Vangl2Lp/Vangl2+
Genetic Background: involves: A/J * 129S6/SvEvTac * C57BL/6 * C57BL/6J

Allelic Composition: Celsr1Crsh/Celsr1+,Vangl2Lp/Vangl2+
Genetic Background: involves: 101/H * BALB/c * C3H/HeH * CBA * LPT/Le

Allelic Composition: ScribCrc/Scrib+,Vangl2Lp/Vangl2+
Genetic Background: C3H.Cg-Vangl2Lp ScribCrc

Allelic Composition: Vangl2Lp/Vangl2+
Genetic Background: C3H.A(Cg)-Vangl2Lp

Allelic Composition: Vangl2Lp/Vangl2+
Genetic Background: involves: CBA * LPT/Le

 MP:0003052 omphalocele "protrusion of abdominal viscera at the base of the umbilical cord, with a covering membranous sac of peritoneum-amnion" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8, MeSH:National Library of Medicine - Medical Subject Headings, 2003, ava:Anna V. Anagnostopoulos, Mouse Genome Informatics Curator]
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Allelic Composition: Vangl2Lp/Vangl2Lp
Genetic Background: involves: A

Allelic Composition: Celsr1Crsh/Celsr1+,Vangl2Lp/Vangl2+
Genetic Background: C3H.Cg-Vangl2Lp Celsr1Crsh

 MP:0003054 spina bifida "common congenital midline defect of fusion of the vertebral arch" [MeSH:National Library of Medicine - Medical Subject Headings, 2003]
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Allelic Composition: ajl10/a
Genetic Background: Not Specified

Allelic Composition: Vangl2Lp/Vangl2+
Genetic Background: involves: A

Allelic Composition: Sfrp1tm1Aksh/Sfrp1tm1Aksh,Sfrp2tm1Aksh/Sfrp2+,Sfrp5tm1Aksh/Sfrp5tm1Aksh,Vangl2Lp/Vangl2+
Genetic Background: involves: 129 * A * C57BL/6 * LPT/LeJ

Allelic Composition: Sfrp1tm1Aksh/Sfrp1tm1Aksh,Sfrp5tm1Aksh/Sfrp5tm1Aksh,Vangl2Lp/Vangl2+
Genetic Background: involves: 129 * A * C57BL/6 * LPT/LeJ

Allelic Composition: ScribCrc/Scrib+,Vangl2+/Vangl2Lp
Genetic Background: involves: BALB/c * C57BL/6 * CBA/Ca * LPT/LeJ * NMRI * SWR

Allelic Composition: Sec24bY613X/Sec24b+,Vangl2Lp/Vangl2+
Genetic Background: involves: A * C3H/He * C57BL/6

Allelic Composition: Vangl2Lp-2J/Vangl2+
Genetic Background: B6.Cg-Vangl2Lp-2J/GrsrJ

Allelic Composition: Ptk7chz/Ptk7+,Vangl2Lp/Vangl2+
Genetic Background: involves: A * BALB/cAnN * C3H/HeH

Allelic Composition: Vangl2ska17/Vangl2ska17
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

Allelic Composition: Vangl2Lp/Vangl2ska17
Genetic Background: involves: 129S6/SvEvTac * A/J * C57BL/6J

Allelic Composition: Vangl2tm1.2Mdea/Vangl2tm1.2Mdea
Genetic Background: B6NCrl.129S6(Cg)-Vangl2tm1.2Mdea

Allelic Composition: Lrp6skax26/Lrp6+,Vangl2Lp/Vangl2+
Genetic Background: involves: A/J * 129S6/SvEvTac * C57BL/6 * C57BL/6J

 MP:0003119 abnormal digestive system development "dysmorphology of the organ system that converts ingested food to nutrients and energy" [smb:Susan M. Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Vangl2Lp/Vangl2Lp
Genetic Background: involves: A

 MP:0003126 abnormal vulva morphology "anomaly in the structure of the external genitalia of the female" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Dact1tm1.1Bnrc/Dact1tm1.1Bnrc,Vangl2Lp/Vangl2+
Genetic Background: B6.Cg-Vangl2Lp Dact1tm1.1Bnrc

Allelic Composition: Dact1tm1.1Bnrc/Dact1tm1.1Bnrc,Vangl2Lp-m1Jus/Vangl2+
Genetic Background: involves: 101/Rl * 129 * C3H/Rl * C57BL/6

 MP:0003148 reduced cochlear coiling "a reduction in cochlear coiling or number of turns; in wild-type mice, the cochlea most commonly exhibits one and three-fourth turns" [J:56294, anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
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Allelic Composition: Vangl2tm2.2Mdea/Vangl2tm2.2Mdea
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * SJL

 MP:0003178 left pulmonary isomerism "bilaterally symmetric left lung pattern (or altered asymmetric patterning of the lung)" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:93051]
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Allelic Composition: Vangl1Gt(XL802)Byg/Vangl1Gt(XL802)Byg,Vangl2tm1.2Yy/Vangl2tm1.2Yy
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

 MP:0003232 abnormal forebrain development "anomaly in the formation or patterning of the anterior primitive cerebral vesicle; most rostral of three primary vesicles of the embryonic neural tube" [J:93081, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Vangl2Lp-m1Jus/Vangl2Lp-m1Jus
Genetic Background: involves: 101/Rl * C3H/Rl * C57BL/6J

 MP:0003257 abnormal abdominal wall "malformation in the margins that enclose the abdominal cavity; the major part is muscular but also includes skin, subcutaneous fat, fascia and the parietal peritoneum" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, ncbi:Matthew Mailman, NCBI request]
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Allelic Composition: ScribCrc/Scrib+,Vangl2Lp/Vangl2+
Genetic Background: C3H.Cg-Vangl2Lp ScribCrc

 MP:0003345 decreased number of ribs "fewer than normal numbers of the pairs of bony structures that make up the body wall" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, ncbi:Matthew Mailman, NCBI request]
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Allelic Composition: Vangl2Lp/Vangl2Lp
Genetic Background: involves: A

 MP:0003384 abnormal ventral body wall "malformation in the anterior portion of a human body or the lower surface of an animal body comprised of ectoderm and mesoderm layers that encloses the body cavity" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
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Allelic Composition: Vangl2Lp/Vangl2Lp
Genetic Background: involves: A

 MP:0003385 abnormal body wall "malformation in the external portion of an animal body comprised of ectoderm and mesoderm layers that encloses the body cavity " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Vangl2Lp/Vangl2Lp
Genetic Background: involves: A

 MP:0003540 imperforate hymen "absence of the normal opening of the thin membrane which may partially occlude the opening of the vagina; here the opening is completely occluded" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, ncbi:Matthew Mailman, NCBI request]
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Allelic Composition: Vangl2ska17/Vangl2ska17
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

 MP:0003641 small lung "reduced size of the lung relative to normal" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:95332]
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Allelic Composition: Mecp2tm3.1Bird/Mecp2tm3.1Bird
Genetic Background: involves: 129P2/OlaHsd * BALB/cJ * C57BL/6

 MP:0003675 kidney cysts "abnormal membranous sacs in any portion of the pair of organs responsible for urine secretion" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Fat4tm1.1Hmc/Fat4tm1.1Hmc,Vangl2Lp/Vangl2+
Genetic Background: involves: 129P2/OlaHsd * A * FVB/N

 MP:0003720 abnormal neural tube closure "abnormal invagination and fusion of the neuroepithelial layer in early development" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator, J:99099]
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Allelic Composition: Vangl2Lp/Vangl2+
Genetic Background: involves: C57BL/6 * CBA/Ca * LPT/LeJ

Allelic Composition: Cthrc1tm1Hssk/Cthrc1+,Vangl2Lp/Vangl2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0003825 abnormal pillar cell morphology "abnormalities of the supporting cells that form the inner and outer walls of the tunnel in the organ of Corti " [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
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Allelic Composition: Myh9tm1.1Dash/Myh9tm1.1Dash
Genetic Background: involves: 129S2/SvPas * C57BL/6 * CBA

 MP:0003864 abnormal midbrain development "anomaly in the formation of or the patterning of the part of the brainstem developing from the middle of the three primary cerebral vesicles of the embryo" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Vangl2Lp/Vangl2Lp
Genetic Background: involves: A

 MP:0003885 abnormal rostro-caudal body axis extension "anomaly in or failure of the long (rostral-caudal) axis of the body to elongate normally once patterning has been established" [brs:Beverly Richards-Smith, Mouse Genome Informatics Curator]
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Allelic Composition: Sfrp1tm1Aksh/Sfrp1tm1Aksh,Sfrp2tm1Aksh/Sfrp2tm1Aksh,Sfrp5tm1Aksh/Sfrp5+,Vangl2Lp/Vangl2+
Genetic Background: involves: 129 * A * C57BL/6 * LPT/LeJ

 MP:0003886 abnormal embryonic epiblast morphology "anomaly in the development/organization of the tissue that gives rise to the ectoderm, endoderm and mesoderm of the embryo proper" [brs:Beverly Richards-Smith, Mouse Genome Informatics Curator]
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Allelic Composition: Prickle1tm1Nue/Prickle1+,Vangl2Lp/Vangl2+
Genetic Background: involves: C57BL/6J * CBA * LPT/LeJ

 MP:0003936 abnormal reproductive system development "developmental anomaly of any of the organs involved in the reproductive system" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Sestd1tm1.1Bnrc/Sestd1tm1.1Bnrc,Vangl2Lp/Vangl2+
Genetic Background: involves: 129S6/SvEvTac * A * C57BL/6NCr

 MP:0003938 abnormal ear development "developmental anomaly of any of the structures involved in the ear or vestibular system" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Vangl2Lp/Vangl2Lp
Genetic Background: involves: A

 MP:0003942 abnormal urinary system development 
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Allelic Composition: Sestd1tm1.1Bnrc/Sestd1tm1.1Bnrc,Vangl2Lp/Vangl2+
Genetic Background: involves: 129S6/SvEvTac * A * C57BL/6NCr

 MP:0004066 abnormal Henson s node morphology "malformation of cells in the small pit at the anterior end of the primitive streak that are important in determining left-right asymmetry" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Cfl1c5/Cfl1c5,Vangl2Lp/Vangl2Lp
Genetic Background: involves: C57BL/6J * LPT/LeJ

 MP:0004073 caudal body truncation "caudal part of body truncated with anterior portion relatively normal" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Dact1tm1.1Bnrc/Dact1tm1.1Bnrc,Vangl2Lp/Vangl2+
Genetic Background: B6.Cg-Vangl2Lp Dact1tm1.1Bnrc

Allelic Composition: Dact1tm1.1Bnrc/Dact1tm1.1Bnrc,Vangl2Lp-m1Jus/Vangl2+
Genetic Background: involves: 101/Rl * 129 * C3H/Rl * C57BL/6

 MP:0004102 abnormal dorsal striatum morphology "any structural abnormality of the regions of the caudate nucleus and the putamen that lie dorsal to the anterior commissure" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Vangl2Lp/Vangl2+
Genetic Background: involves: A

 MP:0004113 abnormal aortic arch morphology "structural anomoly of the portion of the descending aorta proceeding from the arch of the aorta and extending to the diaphragm " [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Vangl2Lp/Vangl2Lp
Genetic Background: LPT/LeJ

 MP:0004133 heterotaxia "abnormal arrangement of organs or parts of the body in relation to each other" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
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Allelic Composition: Vangl1Gt(XL802)Byg/Vangl1Gt(XL802)Byg,Vangl2tm1.2Yy/Vangl2tm1.2Yy
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

Allelic Composition: Cfl1c5/Cfl1c5,Vangl2Lp/Vangl2Lp
Genetic Background: involves: C57BL/6J * LPT/LeJ

 MP:0004158 right aortic arch "the aortic arch lies to the right of the trachea and esophagus; results from persistance of the entire right dorsal arch and involution of a segment of the left arch" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
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Allelic Composition: Vangl2Lp/Vangl2Lp
Genetic Background: LPT/LeJ

 MP:0004159 double aortic arch "defect in which the main aorta tube splits into large left and right branches (right and left aortic arches), encircling the trachea and esophagus, before becoming one tube to go to the lower body " [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
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Allelic Composition: Vangl2Lp/Vangl2Lp
Genetic Background: LPT/LeJ

 MP:0004160 retroesophageal right subclavian artery "the subclavian artery aberrantly originates from the aortic arch distal to the origin of the left subclavian artery, i.e., it is the last branch of the aortic arch" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
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Allelic Composition: Vangl1Gt(XL802)Byg/Vangl1+,Vangl2Lp/Vangl2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * LPT/LeJ

 MP:0004200 reduced fetal size "smaller proportions of a fetus compared to littermates (sensu Mus: from E14 through birth)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Vangl2M1Yzcm/Vangl2+
Genetic Background: either: C57BL/6J-Vangl2m1Yzcm or (involves: C3H/HeJ * C57BL/6J)

 MP:0004201 fetal growth retardation "slow or limited development during the fetal period (sensu Mus: from E14 through birth)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Vangl2M1Yzcm/Vangl2+
Genetic Background: either: C57BL/6J-Vangl2m1Yzcm or (involves: C3H/HeJ * C57BL/6J)

 MP:0004251 failure of looping morphogenesis "failure of the primitive heart tube to initiate or complete looping" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Vangl1Gt(XL802)Byg/Vangl1Gt(XL802)Byg,Vangl2tm1.2Yy/Vangl2tm1.2Yy
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

Allelic Composition: Cfl1c5/Cfl1c5,Vangl2Lp/Vangl2Lp
Genetic Background: involves: C57BL/6J * LPT/LeJ

 MP:0004252 abnormal direction of looping morphogenesis "deviation from the normal rightward direction of cardiac looping" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Cfl1c5/Cfl1c5,Vangl2Lp/Vangl2Lp
Genetic Background: involves: C57BL/6J * LPT/LeJ

 MP:0004261 abnormal embryonic neuroepithelium morphology "any structural anomaly in the epithelial cell layer that lines the neural tube and develops into the nervous system and into the neural crest cells" [ISBN:0838580343 "Kandel ER, et al. Principles of Neural Science, 3rd edition", MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]
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Allelic Composition: Nod2tm1Flv/Nod2tm1Flv
Genetic Background: involves: 129S1/Sv * C57BL/6

Allelic Composition: Vangl2Lp-m1Jus/Vangl2Lp-m1Jus
Genetic Background: involves: 101/Rl * C3H/Rl * C57BL/6J

Allelic Composition: Vangl2M1Yzcm/Vangl2+
Genetic Background: either: C57BL/6J-Vangl2m1Yzcm or (involves: C3H/HeJ * C57BL/6J)

 MP:0004302 abnormal Dieters cell morphology "any structural abnormality in the supporting cells of the spiral organ which are attached to the basement membrane and receive the hair cells between their free extremities" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Myh9tm1.1Dash/Myh9tm1.1Dash
Genetic Background: involves: 129S2/SvPas * C57BL/6 * CBA

 MP:0004322 abnormal sternebra morphology "any structural anomaly of one segments of the primordial sternum of the embryo; these segments fuse to form the body of the adult vertebrate sternum" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Vangl2Lp/Vangl2Lp
Genetic Background: involves: A

 MP:0004391 abnormal respiratory conducting tube "any structural anomaly of the tubes of the respiratory system that allows passage of air from the trachea to the alveoli of the lungs" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Mecp2tm3.1Bird/Mecp2tm3.1Bird
Genetic Background: involves: 129P2/OlaHsd * BALB/cJ * C57BL/6

 MP:0004393 abnormal cochlear inner hair cell morphology "any structural abnormality in the sensory cells of the organ of Corti which are in synaptic contact with sensory as well as efferent fibers of the auditory nerve; there is a single row of flask-shaped inner hair cells tightly surrounded by supporting interphalangeal cells; the apical end of each cell is anchored to the cuticular plate and about 100 stereocilia arranged in a more or less linear (or shallow) U-shaped pattern extend from the cell s surface through the cuticular plate into the endolymphic space inferior to the tectorial membrane" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Dvl2tm1Awb/Dvl2tm1Awb,Vangl2Lp/Vangl2+
Genetic Background: involves: 129S6/SvEvTac * LPT/LeJ

Allelic Composition: Vangl2Lp/Vangl2Lp
Genetic Background: involves: A

Allelic Composition: Cthrc1tm1Hssk/Cthrc1tm1Hssk,Vangl2Lp/Vangl2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Vangl2tm1.2Yy/Vangl2tm1.2Yy
Genetic Background: involves: C57BL/6 * CBA

Allelic Composition: Vangl1Gt(XL802)Byg/Vangl1Gt(XL802)Byg,Vangl2Lp/Vangl2+
Genetic Background: involves: 129P2/OlaHsd * A

Allelic Composition: Vangl1Gt(XL802)Byg/Vangl1Gt(XL802)Byg,Vangl2tm1.2Yy/Vangl2tm1.2Yy
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

Allelic Composition: Vangl2Lp/Vangl2tm1.2Mdea
Genetic Background: involves: 129S/Sv * C57BL/6 * FVB/N * LPT/LeJ * SJL

Allelic Composition: Vangl2tm1.2Mdea/Vangl2tm1.2Mdea
Genetic Background: B6NCrl.129S6(Cg)-Vangl2tm1.2Mdea

 MP:0004399 abnormal cochlear outer hair cell morphology "any structural abnormality in the sensory cells of the organ of Corti which are in synaptic contact with sensory as well as efferent fibers of the auditory nerve; there are three rows of columnar outer hair cells largely surrounded by cortilymph and supporting phalangeal cells; the apical end of each cell is anchored to the cuticular plate and about 100 stereocilia arranged in a V-shaped pattern extend from the cell s surface through the cuticular plate into the tectorial membrane" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Vangl2Lp/Vangl2Lp
Genetic Background: involves: A

Allelic Composition: Vangl2tm1.2Yy/Vangl2tm1.2Yy
Genetic Background: involves: C57BL/6 * CBA

Allelic Composition: Vangl1Gt(XL802)Byg/Vangl1Gt(XL802)Byg,Vangl2Lp/Vangl2+
Genetic Background: involves: 129P2/OlaHsd * A

Allelic Composition: Vangl1Gt(XL802)Byg/Vangl1Gt(XL802)Byg,Vangl2tm1.2Yy/Vangl2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

Allelic Composition: Vangl1Gt(XL802)Byg/Vangl1Gt(XL802)Byg,Vangl2tm1.2Yy/Vangl2tm1.2Yy
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

Allelic Composition: Vangl2Lp/Vangl2tm1.2Mdea
Genetic Background: involves: 129S/Sv * C57BL/6 * FVB/N * LPT/LeJ * SJL

Allelic Composition: Ankrd6tm1Pche/Ankrd6tm1Pche,Vangl2Lp/Vangl2+
Genetic Background: involves: 129 * LPT/LeJ

 MP:0004401 increased cochlear outer hair cell number "increased number (or more than the expected 3 rows) of the columnar outer hair sensory cells of the organ of Corti" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Vangl2Lp/Vangl2tm1.2Mdea
Genetic Background: involves: 129S/Sv * C57BL/6 * FVB/N * LPT/LeJ * SJL

 MP:0004402 decreased cochlear outer hair cell number "decreased number (or less than the expected 3 rows) of the columnar outer hair sensory cells of the organ of Corti" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Dvl3tm1Awb/Dvl3+,Vangl2Lp/Vangl2+
Genetic Background: involves: 129S6/SvEvTac * A * Black Swiss

Allelic Composition: Dvl3tm1Awb/Dvl3tm1Awb,Vangl2Lp/Vangl2+
Genetic Background: involves: 129S6/SvEvTac * A * Black Swiss

 MP:0004406 abnormal cochlear hair cell number "abnormal number of the sensory epithelial cells of the cochlea, which are normally in synaptic contact with the auditory nerve" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Fzd2tm1.1Nat/Fzd2tm1.1Nat,Vangl2Lp/Vangl2+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA * LPT/LeJ

 MP:0004407 increased cochlear hair cell number "increased number of the sensory epithelial cells of the cochlea, which are normally in synaptic contact with the auditory nerve" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Dvl2tm1Awb/Dvl2tm1Awb,Vangl2Lp/Vangl2+
Genetic Background: involves: 129S6/SvEvTac * LPT/LeJ

Allelic Composition: Vangl2Lp/Vangl2Lp
Genetic Background: LPT/LeJ

Allelic Composition: Dvl3tm1Awb/Dvl3+,Vangl2Lp/Vangl2+
Genetic Background: involves: 129S6/SvEvTac * A * Black Swiss

Allelic Composition: Dvl3tm1Awb/Dvl3tm1Awb,Vangl2Lp/Vangl2+
Genetic Background: involves: 129S6/SvEvTac * A * Black Swiss

 MP:0004491 abnormal orientation of outer hair cell stereociliary bundles "misorientation or rotation of outer hair cell (OHC) stereociliary bundles, resulting in defective planar cell polarity of the inner ear sensory epithelium " [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Vangl2Lp/Vangl2Lp
Genetic Background: LPT/LeJ

Allelic Composition: Vangl2Lp/Vangl2+,MkksGt(OST367255)Lex/Mkks+
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J * LPT/LeJ

Allelic Composition: Bbs1Gt1Nk/Bbs1+,Vangl2Lp/Vangl2+
Genetic Background: involves: 129S7/SvEvBrd * LPT/LeJ

Allelic Composition: Vangl1Gt(XL802)Byg/Vangl1+,Vangl2Lp/Vangl2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * LPT/LeJ

Allelic Composition: Fzd2tm1.1Nat/Fzd2tm1.1Nat,Vangl2Lp/Vangl2+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA * LPT/LeJ

Allelic Composition: Vangl2Lp/Vangl2ska17
Genetic Background: involves: 129S6/SvEvTac * A/J * C57BL/6J

Allelic Composition: Vangl2tm1.2Mdea/Vangl2tm1.2Mdea
Genetic Background: B6NCrl.129S6(Cg)-Vangl2tm1.2Mdea

Allelic Composition: Tg(Pax2-cre)1Akg/0,Vangl2tm1.2Mdea/Vangl2tm2.1Mdea
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * SJL

Allelic Composition: Vangl2tm2.2Mdea/Vangl2tm2.2Mdea
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * SJL

Allelic Composition: Lrp6skax26/Lrp6+,Vangl2Lp/Vangl2+
Genetic Background: involves: A/J * 129S6/SvEvTac * C57BL/6 * C57BL/6J

 MP:0004492 abnormal orientation of inner hair cell stereociliary bundles "misorientation or rotation of inner hair cell (IHC) stereociliary bundles, resulting in defective planar cell polarity of the inner ear sensory epithelium" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Vangl2Lp/Vangl2Lp
Genetic Background: LPT/LeJ

Allelic Composition: Vangl1Gt(XL802)Byg/Vangl1+,Vangl2Lp/Vangl2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * LPT/LeJ

Allelic Composition: Tg(Pax2-cre)1Akg/0,Vangl2tm1.2Mdea/Vangl2tm2.1Mdea
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * SJL

Allelic Composition: Vangl2tm2.2Mdea/Vangl2tm2.2Mdea
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * SJL

 MP:0004521 abnormal cochlear hair cell stereociliary bundle morphology "any structural anomaly or disruption of the typical pattern of arrangement of mechanosensitive hair bundles which are composed of thick long microvilli (stereocilia) and are located at the apical end of cochlear inner and outer hair cells" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Vangl1Gt(XL802)Byg/Vangl1+,Vangl2Lp/Vangl2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * LPT/LeJ

 MP:0004522 abnormal orientation of cochlear hair cell stereociliary bundles "misorientation or rotation of inner and/or outer hair cell stereociliary bundles, resulting in defective planar cell polarity of the inner ear sensory epithelium" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Dvl2tm1Awb/Dvl2tm1Awb,Vangl2Lp/Vangl2+
Genetic Background: involves: 129S6/SvEvTac * LPT/LeJ

Allelic Composition: Vangl2Lp/Vangl2+
Genetic Background: involves: A

Allelic Composition: Dvl3tm1Awb/Dvl3+,Vangl2Lp/Vangl2+
Genetic Background: involves: 129S6/SvEvTac * A * Black Swiss

Allelic Composition: Dvl3tm1Awb/Dvl3tm1Awb,Vangl2Lp/Vangl2+
Genetic Background: involves: 129S6/SvEvTac * A * Black Swiss

 MP:0004527 abnormal outer hair cell stereociliary bundle morphology "any structural anomaly or disruption of the typical V or W-like pattern of arrangement of mechanosensitive hair bundles located at the apical end of cochlear OHCs; each hair bundle is normally composed of ~100 nonmotile, actin-filled microvilli (stereocilia) arranged in rows of increasing height and coupled to one another by morphologically distinct links: tip links, horizontal top connectors, shaft connectors, and ankle links; most hair bundles also possess a single motile kinocilium immediately adjacent to the tallest (outermost) row of stereocilia; a fifth link type, the kinocilial link, connects the kinocilium to its neighboring stereocilia" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Vangl2Lp/Vangl2+,MkksGt(OST367255)Lex/Mkks+
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J * LPT/LeJ

Allelic Composition: Bbs1Gt1Nk/Bbs1+,Vangl2Lp/Vangl2+
Genetic Background: involves: 129S7/SvEvBrd * LPT/LeJ

 MP:0004599 abnormal vertebral arch morphology "any structural anomaly of the dorsal part of a vertebra, consisting of a pair of pedicles, a pair of laminae, and seven processes (four articular processes, two transverse processes, and one spinous process)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Vangl2Lp/Vangl2Lp
Genetic Background: involves: A

 MP:0004609 vertebral fusion "the union of one or more vertebrae into a single structure" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Vangl2Lp/Vangl2Lp
Genetic Background: involves: A

 MP:0004613 fusion of vertebral arches "improper union of the dorsal part of adjacent vertebra" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Vangl2Lp/Vangl2Lp
Genetic Background: involves: A

 MP:0004736 abnormal distortion product otoacoustic emission "any abnormality in the sound produced by the cochlea in response to stimulation with 2 simultaneous tones of different frequencies; this measurement is particularly useful in assessing the functional state of OHCs" [eMedicine:http://www.emedicine.com/ent/topic372.htm, MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Tg(Pax2-cre)1Akg/0,Vangl2tm1.2Mdea/Vangl2tm2.1Mdea
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * SJL

 MP:0004738 abnormal brainstem auditory evoked potential "anomaly in the electrical activity generated in response to short tone bursts; may be used to evaluate sensorineural hearing function" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Tg(Pax2-cre)1Akg/0,Vangl2tm1.2Mdea/Vangl2tm2.1Mdea
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * SJL

 MP:0005034 abnormal anus morphology "structural anomaly of the lower opening of the digestive tract" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Dact1tm1.1Bnrc/Dact1+,Vangl2Lp/Vangl2+
Genetic Background: B6.Cg-Vangl2Lp Dact1tm1.1Bnrc

Allelic Composition: Dact1tm1.1Bnrc/Dact1tm1.1Bnrc,Vangl2Lp-m1Jus/Vangl2+
Genetic Background: involves: 101/Rl * 129 * C3H/Rl * C57BL/6

 MP:0005222 abnormal somite size "atypical size of any of the segmental masses along the notochord of the developing embryo" [J:72325]
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Allelic Composition: Vangl2Lp/Vangl2Lp
Genetic Background: involves: LPT/LeJ

Allelic Composition: Vangl2Lp/Vangl2Lp
Genetic Background: involves: A

Allelic Composition: Cfl1c5/Cfl1c5,Vangl2Lp/Vangl2Lp
Genetic Background: involves: C57BL/6J * LPT/LeJ

 MP:0005226 abnormal vertebral arch development "anomalous formation of the posterior projection from the body of a vertebra that encloses the vertebral foramen " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Nod2tm1Flv/Nod2tm1Flv
Genetic Background: involves: 129S1/Sv * C57BL/6

Allelic Composition: Vangl2Lp/Vangl2Lp
Genetic Background: involves: A

 MP:0005657 abnormal neural plate morphology "malformation or absence of the neuroectodermal area of the embryo s dorsal surface that develops into the neural tube and neural crest" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, hdene:Howard Dene , Mouse Genome Informatics Curator, J:68142]
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Allelic Composition: Nod2tm1Flv/Nod2tm1Flv
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0006014 dilated endolymphatic sac "an expansion in the volume of the endolymphatic sac" [smb:Susan M Bello, Mouse Genome Informatics Curator, anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, J:67072:]
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Allelic Composition: Vangl2Lp/Vangl2Lp
Genetic Background: involves: A

 MP:0006026 dilated terminal bronchiole tubes "increased volume of the terminal lung buds" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, smb:Susan M Bello, Mouse Genome Informatics Curator, J:85546]
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Allelic Composition: Mecp2tm3.1Bird/Mecp2tm3.1Bird
Genetic Background: involves: 129P2/OlaHsd * BALB/cJ * C57BL/6

 MP:0006030 abnormal otic vesicle formation "anomalous formation of the simple epithelial sac formed from the otic placode that gives rise to the structures of the inner ear" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:57313:]
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Allelic Composition: Vangl2Lp-m1Jus/Vangl2Lp-m1Jus
Genetic Background: involves: 101/Rl * C3H/Rl * C57BL/6J

 MP:0006126 abnormal outflow tract development "anomaly in the development of the common arterial trunk that forms the aorta and pulmonary artery" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Dvl3tm1Awb/Dvl3tm1Awb,Vangl2Lp/Vangl2+
Genetic Background: involves: 129S6/SvEvTac * A * Black Swiss

 MP:0006286 inner ear hypoplasia "underdevelopment or reduced size of inner ear structures, usually due to decreased cell number" [J:83662, MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Dvl3tm1Awb/Dvl3+,Vangl2Lp/Vangl2+
Genetic Background: involves: 129S6/SvEvTac * A * Black Swiss

Allelic Composition: Dvl3tm1Awb/Dvl3tm1Awb,Vangl2Lp/Vangl2+
Genetic Background: involves: 129S6/SvEvTac * A * Black Swiss

Allelic Composition: Vangl2tm2.2Mdea/Vangl2tm2.2Mdea
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * SJL

 MP:0006382 abnormal lung epithelium morphology "any structural anomaly of the epithelial layer of the lung" [MGI:rbabiuk "Randall Babiuk, Mouse Genome Informatics Curator", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Mecp2tm3.1Bird/Mecp2tm3.1Bird
Genetic Background: involves: 129P2/OlaHsd * BALB/cJ * C57BL/6

 MP:0006394 abnormal vertebral epiphyseal plate morphology "any structural anomaly in the lateral cartilaginous centers of ossification; may be found on the lateral, upper, and/or lower surfaces of the vertebrae at different times during development" [ISBN:0-914294-08-3 "Gray s Anatomy", MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Vangl2Lp/Vangl2Lp
Genetic Background: involves: A

 MP:0008148 abnormal rib-sternum attachment "any anomaly in the in the normal joining of the ribs to the sternum" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Vangl2Lp/Vangl2Lp
Genetic Background: involves: A

 MP:0008149 abnormal rib-vertebral column attachment "any anomaly in the in the normal joining of the ribs to the vertebral column" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Vangl2Lp/Vangl2Lp
Genetic Background: involves: A

 MP:0008277 abnormal sternum ossification "anomaly in the process of the formation of the sternum bone by the replacement of cartilage tissue with mineralized bone" [GO:0001958, MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]
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Allelic Composition: Vangl2Lp/Vangl2Lp
Genetic Background: involves: A

 MP:0008307 short scala media "reduced length of the spirally arranged membranous tube suspended within the cochlea, lying between and separating the scala vestibuli and scala tympani" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Vangl2tm2.2Mdea/Vangl2tm2.2Mdea
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * SJL

 MP:0008535 enlarged lateral ventricles "increased size of the cavity in each of the cerebral hemispheres derived from the cavity of the embryonic neural tube; they are separated from each other by the septum pellucidum, and each communicates with the third ventricle by the foramen of Monro, through which also the choroid plexuses of the lateral ventricles become continuous with that of the third ventricle" [MESH:A08.186.211.276.650, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Lrp8tm3Her/Lrp8tm3Her
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

Allelic Composition: Vangl2Lp/Vangl2+
Genetic Background: involves: A

 MP:0008536 enlarged third ventricle "increased size of the narrow cleft inferior to the corpus callosum, within the diencephalon, between the paired thalami; its floor is formed by the hypothalamus, its anterior wall by the lamina terminalis, and its roof by ependyma; it communicates with the fourth ventricle by the cerebral aqueduct, and with the lateral ventricles by the interventricular foramina" [MESH:A08.186.211.276.840, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Lrp8tm3Her/Lrp8tm3Her
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

 MP:0008540 abnormal cerebrum morphology "any structural anomaly of the largest part of the brain, derived from the telencephalon, and is composed of a right and a left hemisphere each which contains an outer cerebral cortex and a subcortical basal ganglia; cerebral functions include sensorimotor, emotional, and intellectual activities" [MESH:A08.186.211.730.885.287]
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Allelic Composition: Vangl2Lp/Vangl2Lp
Genetic Background: involves: A

 MP:0008784 craniorachischisis "congenital fissure of the skull and vertebral column" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Nod2tm1Flv/Nod2tm1Flv
Genetic Background: involves: 129S1/Sv * C57BL/6

Allelic Composition: Dvl2tm1Awb/Dvl2tm1Awb,Vangl2Lp/Vangl2+
Genetic Background: involves: 129S6/SvEvTac * LPT/LeJ

Allelic Composition: Vangl2Lp/Vangl2Lp
Genetic Background: LPT/LeJ

Allelic Composition: Vangl2Lp/Vangl2Lp
Genetic Background: involves: LPT/LeJ

Allelic Composition: Vangl2Lp/Vangl2Lp
Genetic Background: involves: A

Allelic Composition: Vangl2Lp-m1Jus/Vangl2Lp-m1Jus
Genetic Background: involves: 101/Rl * C3H/Rl * C57BL/6J

Allelic Composition: Vangl2Lp/Vangl2Lp-m1Jus
Genetic Background: involves: 101/Rl * C3H/Rl * C57BL/6J * LPT/LeJ

Allelic Composition: Dvl1tm1Awb/Dvl1+,Dvl2tm1Awb/Dvl2tm1Awb,Vangl2Lp/Vangl2+
Genetic Background: involves: 129S6/SvEvTac * LPT/LeJ

Allelic Composition: Dvl1tm1Awb/Dvl1tm1Awb,Dvl2tm1Awb/Dvl2tm1Awb,Vangl2Lp/Vangl2Lp
Genetic Background: involves: 129S6/SvEvTac * LPT/LeJ

Allelic Composition: Vangl2Lp/Vangl2+
Genetic Background: involves: A

Allelic Composition: Vangl2Lp/Vangl2Lp
Genetic Background: involves: C57BL/6 * CBA/Ca * LPT/LeJ

Allelic Composition: Vangl1Gt(XL802)Byg/Vangl1+,Vangl2Lp/Vangl2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * LPT/LeJ

Allelic Composition: Sfrp1tm1Aksh/Sfrp1tm1Aksh,Sfrp2tm1Aksh/Sfrp2tm1Aksh,Sfrp5tm1Aksh/Sfrp5+,Vangl2Lp/Vangl2+
Genetic Background: involves: 129 * A * C57BL/6 * LPT/LeJ

Allelic Composition: ScribCrc/Scrib+,Vangl2+/Vangl2Lp
Genetic Background: involves: BALB/c * C57BL/6 * CBA/Ca * LPT/LeJ * NMRI * SWR

Allelic Composition: Dvl3tm1Awb/Dvl3+,Vangl2Lp/Vangl2+
Genetic Background: involves: 129S6/SvEvTac * A * Black Swiss

Allelic Composition: Dvl3tm1Awb/Dvl3tm1Awb,Vangl2Lp/Vangl2+
Genetic Background: involves: 129S6/SvEvTac * A * Black Swiss

Allelic Composition: Dact1tm1.1Bnrc/Dact1tm1.1Bnrc,Vangl2Lp/Vangl2Lp
Genetic Background: B6.Cg-Vangl2Lp Dact1tm1.1Bnrc

Allelic Composition: Vangl2tm1.2Yy/Vangl2tm1.2Yy
Genetic Background: involves: C57BL/6 * CBA

Allelic Composition: Ptk7chz/Ptk7+,Vangl2Lp/Vangl2+
Genetic Background: involves: A * BALB/cAnN * C3H/HeH

Allelic Composition: Vangl2Lp/Vangl2Lp
Genetic Background: involves: A * C3H/HeH

Allelic Composition: Vangl2Lp/Vangl2ska17
Genetic Background: involves: 129S6/SvEvTac * A/J * C57BL/6J

Allelic Composition: Scribcrn2/Scrib+,Vangl2Lp/Vangl2+
Genetic Background: involves: A/J * FVB/N

Allelic Composition: Vangl2tm1.2Mdea/Vangl2tm1.2Mdea
Genetic Background: B6NCrl.129S6(Cg)-Vangl2tm1.2Mdea

Allelic Composition: Vangl2Lp/Vangl2Lp
Genetic Background: either: (involves: CBA * LPT/Le) or (involves: LPT/Le * SWR)

Allelic Composition: Celsr1Crsh/Celsr1+,Vangl2Lp/Vangl2+
Genetic Background: involves: 101/H * BALB/c * C3H/HeH * CBA * LPT/Le

Allelic Composition: Vangl2Lp/Vangl2+
Genetic Background: involves: C3H/HeH * C57BL/6 * LPT/Le * NMRI * SWR

Allelic Composition: Celsr1Crsh/Celsr1+,Vangl2Lp/Vangl2+
Genetic Background: C3H.Cg-Vangl2Lp Celsr1Crsh

Allelic Composition: ScribCrc/Scrib+,Vangl2Lp/Vangl2+
Genetic Background: C3H.Cg-Vangl2Lp ScribCrc

Allelic Composition: Celsr1Crsh/Celsr1+,ScribCrc/Scrib+,Vangl2Lp/Vangl2+
Genetic Background: C3H.Cg-Vangl2Lp ScribCrc Celsr1Crsh

 MP:0008933 abnormal embryonic cilium physiology "any functional anomaly of the earliest cilia of the mouse embryo found on the cells of the embryonic node" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Vangl1Gt(XL802)Byg/Vangl1Gt(XL802)Byg,Vangl2tm1.2Yy/Vangl2tm1.2Yy
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

 MP:0009199 abnormal external male genitalia morphology "any structural anomaly of the external masculine genital organs, including the penis and scrotum" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Dact1tm1.1Bnrc/Dact1tm1.1Bnrc,Vangl2Lp/Vangl2+
Genetic Background: B6.Cg-Vangl2Lp Dact1tm1.1Bnrc

Allelic Composition: Dact1tm1.1Bnrc/Dact1tm1.1Bnrc,Vangl2Lp-m1Jus/Vangl2+
Genetic Background: involves: 101/Rl * 129 * C3H/Rl * C57BL/6

 MP:0009264 failure of eyelid fusion "the upper and lower thin folds of skin and muscle that cover the exposed portion of the eye do not fuse together during development" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Vangl2Lp/Vangl2ska17
Genetic Background: involves: 129S6/SvEvTac * A/J * C57BL/6J

Allelic Composition: Vangl2M1Yzcm/Vangl2+
Genetic Background: either: C57BL/6J-Vangl2m1Yzcm or (involves: C3H/HeJ * C57BL/6J)

 MP:0009431 decreased fetal weight "reduced weight of a fetus compared to controls (sensu Mus: from E14 through birth)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Grhl3ct/?,Vangl2Lp/Vangl2+
Genetic Background: involves: A * GFF

 MP:0009929 meningomyelocele "hernial protrusion of the spinal cord and its meninges through an opening or defect in the vertebral column" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Grhl3ct/?,Vangl2Lp/Vangl2+
Genetic Background: involves: A * GFF

 MP:0010402 ventricular septal defect "abnormal communications between the two lower chambers of the heart, including such defects in the perimembranous, inlet, outlet (infundibular), central muscular, marginal muscular, or apical muscular regions" [MESH:C14.240.400.560.540]
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Allelic Composition: Vangl2Lp/Vangl2Lp
Genetic Background: LPT/LeJ

Allelic Composition: Fzd1tm1.1Nat/Fzd1+,Vangl2Lp/Vangl2+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA * LPT/LeJ

Allelic Composition: Fzd1tm1.1Nat/Fzd1+,Fzd2tm1.1Nat/Fzd2+,Vangl2Lp/Vangl2+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA * LPT/LeJ

Allelic Composition: Fzd2tm1.1Nat/Fzd2tm1.1Nat,Vangl2Lp/Vangl2+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA * LPT/LeJ

Allelic Composition: Fzd2tm1.1Nat/Fzd2+,Fzd7tm1.1Nat/Fzd7tm1.1Nat,Vangl2Lp/Vangl2+
Genetic Background: involves: 129 * C57BL/6 * LPT/LeJ

Allelic Composition: Fzd7tm1.1Nat/Fzd7tm1.1Nat,Vangl2Lp/Vangl2+
Genetic Background: involves: 129 * C57BL/6 * LPT/LeJ

Allelic Composition: Fzd2tm1.1Nat/Fzd2+,Vangl2Lp/Vangl2+
Genetic Background: involves: 129 * C57BL/6 * LPT/LeJ

 MP:0010465 aberrant origin of the right subclavian artery "the right subclavian artery arises from an atypical location on the aortic arch or the proximal descending aorta" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Vangl2Lp/Vangl2Lp
Genetic Background: LPT/LeJ

 MP:0010466 vascular ring "the trachea and esophagus are completely encircled by connected segments of the aortic arch and its branches" [http://emedicine.medscape.com]
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Allelic Composition: Vangl2Lp/Vangl2Lp
Genetic Background: LPT/LeJ

 MP:0010488 abnormal left subclavian artery morphology "any structural anomaly of the artery that extends from the aortic arch to the left side of the body" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Vangl2Lp/Vangl2Lp
Genetic Background: LPT/LeJ

 MP:0010589 common truncal valve "a single outflow tract valve that opens into the truncus arteriosus that is frequently present in cases of truncus arteriosus septation defects" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Vangl2Lp/Vangl2Lp
Genetic Background: LPT/LeJ

 MP:0010744 abnormal cervical flexure "anomaly in the ventrally concave flexure of the embryonic brain occurring at the junction of hindbrain and spinal cord" [ISBN:0-12-402035-6 "Kaufman, MH The Atlas of Mouse Development"]
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Allelic Composition: Vangl2Lp/Vangl2Lp
Genetic Background: LPT/LeJ

 MP:0010825 abnormal lung saccule morphology "any structural anomaly of the transient dilations of the developing alveolar (or transient) ducts, which transform into a transitory alveolar duct as soon as it develops further branches; the last transitory saccule formed on each pathway is a terminal saccule that develops into an alveolar sac after birth" [GO:0060430, ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Vangl2Lp/Vangl2Lp
Genetic Background: involves: A * C3H/HeH

 MP:0010866 abnormal prenatal body size "anomaly in the average body weight, height and/or length of an organism compared to controls at anytime prior to birth" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Vangl1Gt(XL802)Byg/Vangl1Gt(XL802)Byg,Vangl2tm1.2Yy/Vangl2tm1.2Yy
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

 MP:0010975 abnormal lung lobe morphology "any structural anomaly of any of the anatomically and functionally distinct subunits (lobes) comprising the left or right lung, where each lobe receives air from its own secondary bronchus and is separated from it neighbors by one or more fissures (walls of connective tissue)" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Vangl2Lp/Vangl2Lp
Genetic Background: involves: A * C3H/HeH

 MP:0010976 small lung lobe "reduced size of any of the anatomically and functionally distinct subunits (lobes) comprising the left or right lung, where each lobe receives air from its own secondary bronchus and is separated from it neighbors by one or more fissures (walls of connective tissue)" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Vangl2Lp/Vangl2Lp
Genetic Background: involves: A * C3H/HeH

 MP:0011024 abnormal branching involved in lung morphogenesis "anomaly in the process in which the branched structure of the respiratory airway tree is generated and organized" [MGI:csmith]
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Allelic Composition: Vangl2Lp/Vangl2Lp
Genetic Background: involves: A * C3H/HeH

 MP:0011032 impaired branching involved in terminal bronchiole morphogenesis 
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Allelic Composition: Vangl2Lp/Vangl2Lp
Genetic Background: involves: A * C3H/HeH

 MP:0011086 partial postnatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
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Allelic Composition: Sec24bY613X/Sec24b+,Vangl2Lp/Vangl2+
Genetic Background: involves: A * C3H/He * C57BL/6

 MP:0011087 complete neonatal lethality "death of all organisms of a given genotype in a population within the neonatal period after birth (Mus: P0)" [MGI:csmith]
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Allelic Composition: Dvl2tm1Awb/Dvl2tm1Awb,Vangl2Lp/Vangl2+
Genetic Background: involves: 129S6/SvEvTac * LPT/LeJ

Allelic Composition: Dvl1tm1Awb/Dvl1+,Dvl2tm1Awb/Dvl2tm1Awb,Vangl2Lp/Vangl2+
Genetic Background: involves: 129S6/SvEvTac * LPT/LeJ

 MP:0011088 partial neonatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the neonatal period after birth (Mus: P0)" [MGI:csmith]
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Allelic Composition: Vangl2Lp-2J/Vangl2+
Genetic Background: B6.Cg-Vangl2Lp-2J/GrsrJ

 MP:0011089 complete perinatal lethality "death of all organisms of a given genotype in a population within the perinatal period (Mus: E18.5 through postnatal day 1)" [MGI:csmith]
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Allelic Composition: Vangl2Lp/Vangl2Lp
Genetic Background: involves: A

 MP:0011090 partial perinatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the perinatal period (Mus: E18.5 through postnatal day 1)" [MGI:csmith]
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Allelic Composition: Vangl1Gt(XL802)Byg/Vangl1+,Vangl2Lp/Vangl2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * LPT/LeJ

 MP:0011091 complete prenatal lethality "death of all organisms of a given genotype in a population between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith]
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Allelic Composition: Vangl2tm2.2Mdea/Vangl2tm2.2Mdea
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * SJL

 MP:0011098 complete embryonic lethality during organogenesis "death of all organisms of a given genotype in a population between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
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Allelic Composition: Vangl2Lp/Vangl2+,MkksGt(OST367255)Lex/Mkks+
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J * LPT/LeJ

Allelic Composition: Cfl1c5/Cfl1c5,Vangl2Lp/Vangl2Lp
Genetic Background: involves: C57BL/6J * LPT/LeJ

Allelic Composition: Cfl1tm1.2Wit/Cfl1tm1.2Wit,Vangl2Lp/Vangl2Lp
Genetic Background: involves: 129 * LPT/LeJ

 MP:0011101 partial prenatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith]
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Allelic Composition: ScribCrc/Scrib+,Vangl2Lp/Vangl2+
Genetic Background: C3H.Cg-Vangl2Lp ScribCrc

 MP:0011108 partial embryonic lethality during organogenesis "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
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Allelic Composition: Bbs1Gt1Nk/Bbs1+,Vangl2Lp/Vangl2+
Genetic Background: involves: 129S7/SvEvBrd * LPT/LeJ

 MP:0011109 partial lethality throughout fetal growth and development "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between the completion of organogenesis and birth (Mus: E14 to approximately E18.5)" [MGI:csmith]
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Allelic Composition: Sec24bY613X/Sec24b+,Vangl2Lp/Vangl2+
Genetic Background: involves: A * C3H/He * C57BL/6

 MP:0011110 partial preweaning lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
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Allelic Composition: Vangl2Lp-2J/Vangl2+
Genetic Background: B6.Cg-Vangl2Lp-2J/GrsrJ

 MP:0011143 thick lung-associated mesenchyme "increased thickness of the mesenchymal cell layer due to delay or failure of the mesenchymal compartment to thin down during the late stages of embryonic lung development" [MGI:anna]
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Allelic Composition: Vangl2Lp/Vangl2Lp
Genetic Background: involves: A * C3H/HeH

 MP:0011172 abnormal otic pit morphology "any structural anomaly of the pair of depressions of thickened otic placode epithelium, that further develops into the otic vesicles" [ISBN:0-683-40008-8]
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Allelic Composition: Vangl2Lp/Vangl2Lp
Genetic Background: involves: A

 MP:0011400 complete lethality "all individuals of a given genotype in a population die before the end of the normal lifespan but time(s) of death are unspecified" [MGI:llw2]
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Allelic Composition: Picalmtm1Towa/Picalmtm1Towa
Genetic Background: involves: C57BL/6J * C57BL/6NCrlj * CBA/JNCrlj

 MP:0011733 fused somites "a defect in which there is an appearance of a single enlarged somite resulting from partial or complete fusion of the two somitic anlage" [MGI:smb]
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Allelic Composition: Vangl2Lp/Vangl2Lp
Genetic Background: involves: A

 MP:0011967 increased or absent threshold for auditory brainstem response "increase in the value at which one or more sound frequencies or broadband clicks first elicits a recordable response generated by electrical activity of neurons in the ascending auditory system, or complete lack of a recordable response at any frequency or broadband click" [MGI:csmith]
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Allelic Composition: Tg(Pax2-cre)1Akg/0,Vangl2tm1.2Mdea/Vangl2tm2.1Mdea
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * SJL

 MP:0012027 abnormal embryonic cilium location or orientation "embryonic cilia are displaced from the normal position and/or do not orient in a typical pattern" [MGI:csmith]
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Allelic Composition: Vangl1Gt(XL802)Byg/Vangl1Gt(XL802)Byg,Vangl2tm1.2Yy/Vangl2tm1.2Yy
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

Allelic Composition: Cfl1c5/Cfl1c5,Vangl2Lp/Vangl2Lp
Genetic Background: involves: C57BL/6J * LPT/LeJ

 MP:0012304 short umbilical cord "decreased average umbilical cord length compared to normal" [MGI:anna]
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Allelic Composition: Vangl2Lp/Vangl2Lp
Genetic Background: involves: A

 MP:0012675 enlarged floor plate "increased size of the specialized glial structure (non-neuronal cells) situated at the ventral midline of the embryonic neural tube; this structure spans the anteroposterior axis from the midbrain to the tail regions, separating the left and right basal plates of the developing neural tube, and serves as an organizer to ventralize tissues in the embryo as well as to guide neuronal positioning and differentiation along the dorsoventral axis of the neural tube" [MGI:anna]
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Allelic Composition: Vangl2Lp-m1Jus/Vangl2Lp-m1Jus
Genetic Background: involves: 101/Rl * C3H/Rl * C57BL/6J

Allelic Composition: Vangl2M1Yzcm/Vangl2+
Genetic Background: either: C57BL/6J-Vangl2m1Yzcm or (involves: C3H/HeJ * C57BL/6J)

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000021464 Ror2 / Q9Z138 / receptor tyrosine kinase-like orphan receptor 2 / Q01974*  / reaction / complex
 ENSMUSG00000007989 Fzd3 / Q61086 / Frizzled-3 / Q9NPG1* / frizzled class receptor 3*  / complex / reaction
 ENSMUSG00000022568 Scrib / Q80U72 / scribbled planar cell polarity protein / Q14160*  / complex / reaction
 ENSMUSG00000021994 Wnt5a / P22725 / wingless-type MMTV integration site family, member 5A / P41221* / Wnt family member 5A*  / reaction / complex






 

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