ENSDARG00000027397


Danio rerio

Features
Gene ID: ENSDARG00000027397
  
Biological name :vangl2
  
Synonyms : Q8UVJ6 / vangl2 / VANGL planar cell polarity protein 2
  
Possible biological names infered from orthology : Q91ZD4 / Q9ULK5 / VANGL planar cell polarity 2
  
Species: Danio rerio
  
Chr. number: 7
Strand: -1
Band:
Gene start: 5324061
Gene end: 5375214
  
Corresponding Affymetrix probe sets: Dr.14661.1.S1_at (Zebrafish Array)   Dr.17360.1.S1_at (Zebrafish Array)   
  
Cross references: Ensembl peptide - ENSDARP00000031546
NCBI entrez gene - 245949     See in Manteia.
swissprot - Q8UVJ6
ZFIN ID - ZDB-GENE-020507-3
Ensembl - ENSDARG00000027397
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 VANGL2ENSGALG00000030643Gallus gallus
 Q9ULK5ENSG00000162738Homo sapiens
 Q91ZD4ENSMUSG00000026556Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
vangl1 / VANGL planar cell polarity protein 1 / Q80Z96* / Q8TAA9* / VANGL planar cell polarity 1*ENSDARG0000000430561


Protein motifs (from Interpro)
Interpro ID Name
 IPR009539  Vang-like protein


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000132 establishment of mitotic spindle orientation IMP
 biological_processGO:0000902 cell morphogenesis IMP
 biological_processGO:0001654 eye development IGI
 biological_processGO:0001736 establishment of planar polarity IMP
 biological_processGO:0001756 somitogenesis IGI
 biological_processGO:0001764 neuron migration IMP
 biological_processGO:0001839 neural plate morphogenesis IMP
 biological_processGO:0001841 neural tube formation IMP
 biological_processGO:0003401 axis elongation IGI
 biological_processGO:0007015 actin filament organization IMP
 biological_processGO:0007163 establishment or maintenance of cell polarity IMP
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0007369 gastrulation IEA
 biological_processGO:0007399 nervous system development IEA
 biological_processGO:0014812 muscle cell migration IMP
 biological_processGO:0016055 Wnt signaling pathway IEA
 biological_processGO:0021535 cell migration in hindbrain IMP
 biological_processGO:0021915 neural tube development IMP
 biological_processGO:0030010 establishment of cell polarity IMP
 biological_processGO:0030111 regulation of Wnt signaling pathway IMP
 biological_processGO:0030154 cell differentiation IEA
 biological_processGO:0030198 extracellular matrix organization IMP
 biological_processGO:0030903 notochord development IMP
 biological_processGO:0033564 anterior/posterior axon guidance IMP
 biological_processGO:0035844 cloaca development IMP
 biological_processGO:0035845 photoreceptor cell outer segment organization IGI
 biological_processGO:0036342 post-anal tail morphogenesis IMP
 biological_processGO:0042074 cell migration involved in gastrulation IMP
 biological_processGO:0044782 cilium organization IMP
 biological_processGO:0045813 positive regulation of Wnt signaling pathway, calcium modulating pathway IMP
 biological_processGO:0048048 embryonic eye morphogenesis IMP
 biological_processGO:0048570 notochord morphogenesis IMP
 biological_processGO:0048840 otolith development IMP
 biological_processGO:0055002 striated muscle cell development IMP
 biological_processGO:0060026 convergent extension IPI
 biological_processGO:0060027 convergent extension involved in gastrulation IMP
 biological_processGO:0060028 convergent extension involved in axis elongation IMP
 biological_processGO:0060030 dorsal convergence IMP
 biological_processGO:0060070 canonical Wnt signaling pathway IMP
 biological_processGO:0060071 Wnt signaling pathway, planar cell polarity pathway IGI
 biological_processGO:0060271 cilium assembly IMP
 biological_processGO:0060972 left/right pattern formation IMP
 biological_processGO:0071679 commissural neuron axon guidance IMP
 biological_processGO:0097475 motor neuron migration IMP
 cellular_componentGO:0005886 plasma membrane IDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane NAS
 molecular_functionGO:0005515 protein binding IPI


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000001 Kupffer s vesicle Kupffers vesicle ciliated cell oriented towards Kupffers vesicle anterior region, abnormal
Kupffers vesicle increased size , abnormal
Kupffers vesicle decreased functionality , abnormal
Kupffers vesicle motile cilium movement quality , abnormal
Kupffers vesicle nucleus increased distance Kupffers vesicle apical plasma membrane, abnormal
Kupffers vesicle motile cilium decreased length , abnormal
Kupffers vesicle motile cilium decreased amount , abnormal
Kupffers vesicle ciliary basal body detached from Kupffers vesicle apical plasma membrane, abnormal
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 ZFA:0000003 adaxial cell adaxial cell shape , abnormal
Show

 ZFA:0000008 brain brain hydrocephalic , abnormal
brain ventral region condensed , abnormal
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 ZFA:0000012 central nervous system central nervous system degenerate , abnormal
central nervous system ventral region decreased size , abnormal
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 ZFA:0000016 ectoderm ectoderm cell shape , abnormal
ectoderm cell orientation ectoderm , abnormal
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 ZFA:0000022 floor plate floor plate distended , abnormal
floor plate ciliated cell increased amount , abnormal
floor plate increased width , abnormal
floor plate quality , abnormal
floor plate motile cilium disoriented , abnormal
floor plate establishment of planar polarity process quality , abnormal
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 ZFA:0000029 hindbrain hindbrain motor neuron migration process quality , abnormal
Show

 ZFA:0000054 pericardium pericardium edematous , abnormal
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 ZFA:0000069 rhombomere 6 rhombomere 6 lacks all parts of type branchiomotor neuron , abnormal
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 ZFA:0000075 spinal cord spinal cord duplicated , abnormal
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 ZFA:0000084 yolk yolk shape , abnormal
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 ZFA:0000091 axial chorda mesoderm axial chorda mesoderm decreased length , abnormal
axial chorda mesoderm increased width , abnormal
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 ZFA:0000092 axis axis decreased length , abnormal
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 ZFA:0000106 extension extension decreased length , abnormal
extension increased width , abnormal
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 ZFA:0000107 eye eye fused with eye , abnormal
eye decreased distance eye , abnormal
eye decreased width , abnormal
eye adjacent to eye , abnormal
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 ZFA:0000110 fourth ventricle fourth ventricle duplicated , abnormal
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 ZFA:0000131 neural keel neural keel shape , abnormal
neural keel increased thickness , abnormal
neural keel increased width , abnormal
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 ZFA:0000132 neural plate neural plate increased width , abnormal
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 ZFA:0000133 neural rod neural rod increased thickness , abnormal
neural rod increased width , abnormal
neural rod morphology , abnormal
Show

 ZFA:0000135 notochord notochord quality , abnormal
notochord morphology , abnormal
notochord increased width , abnormal
notochord cell circular , abnormal
notochord decreased length , abnormal
notochord undulate , abnormal
notochord cell shape , abnormal
notochord cell orientation notochord , abnormal
notochord shape , abnormal
Show

 ZFA:0000150 pronephric duct pronephric duct multi-ciliated epithelial cell disorganized , abnormal
pronephric duct ciliated cell oriented towards pronephric duct anterior region, abnormal
pronephric duct cilium disorganized , abnormal
pronephric duct cilium decreased functionality , abnormal
Show

 ZFA:0000151 pronephros pronephros cystic , abnormal
pronephros ciliated cell decreased amount , abnormal
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 ZFA:0000155 somite somite decreased length , abnormal
somite increased width , abnormal
somite flat , abnormal
somite condensed , abnormal
somite shape , abnormal
somite size , abnormal
somite fused with somite , abnormal
somite morphology , abnormal
somite filamentous actin disorganized , abnormal
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 ZFA:0000206 facial nerve motor nucleus facial nerve motor nucleus motor neuron mislocalised , abnormal
facial nerve motor nucleus mislocalised , abnormal
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 ZFA:0000208 gall bladder gall bladder left side of whole organism , abnormal
gall bladder mislocalised laterally , abnormal
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 ZFA:0000217 inner ear inner ear altered number of otolith , abnormal
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 ZFA:0000255 paraxial mesoderm paraxial mesoderm increased width , abnormal
paraxial mesoderm decreased length , abnormal
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 ZFA:0000279 segmental plate segmental plate decreased length , abnormal
segmental plate increased width , abnormal
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 ZFA:0000330 cloacal chamber cloacal chamber malformed , abnormal
cloacal chamber ciliated cell decreased amount , abnormal
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 ZFA:0000570 optic primordium optic primordium morphology , abnormal
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 ZFA:0000641 cranial nerve cranial nerve hypoplastic , abnormal
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 ZFA:0000737 cranium cranium cartilage element shortened , abnormal
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 ZFA:0000823 rhombomere 5 rhombomere 5 lacks all parts of type branchiomotor neuron , abnormal
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 ZFA:0000949 rhombomere 7 rhombomere 7 lacks all parts of type branchiomotor neuron , abnormal
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 ZFA:0001032 rhombomere 4 rhombomere 4 branchiomotor neuron mislocalised , abnormal
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 ZFA:0001056 myotome myotome disorganized , abnormal
myotome decreased length , abnormal
Show

 ZFA:0001064 rhombomere rhombomere condensed , abnormal
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 ZFA:0001070 presumptive pronephric mesoderm presumptive pronephric mesoderm mislocalised laterally , abnormal
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 ZFA:0001094 whole organism whole organism decreased length , abnormal
whole organism anterior-posterior axis shortened , abnormal
whole organism anterior-posterior axis decreased length , abnormal
whole organism lethal (sensu genetics) , abnormal
whole organism increased curvature , abnormal
whole organism morphology , abnormal
whole organism shape , abnormal
whole organism bent , abnormal
whole organism viability , abnormal
whole organism curved , abnormal
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 ZFA:0001114 head head hydrocephalic , abnormal
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 ZFA:0001115 trunk trunk curved , abnormal
trunk decreased length , abnormal
trunk increased curvature , abnormal
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 ZFA:0001117 post-vent region post-vent region quality , abnormal
post-vent region notochord folded , abnormal
post-vent region curved ventral , abnormal
post-vent region morphology , abnormal
post-vent region truncated , abnormal
post-vent region decreased length , abnormal
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 ZFA:0001135 neural tube neural tube increased thickness , abnormal
neural tube increased width , abnormal
neural tube quality , abnormal
Show

 ZFA:0001205 Meckel s cartilage Meckels cartilage displaced , abnormal
Meckels cartilage deformed , abnormal
Show

 ZFA:0001321 neurocranial trabecula neurocranial trabecula detached from neurocranium posterior region, abnormal
Show

 ZFA:0001400 ceratohyal cartilage ceratohyal cartilage displaced , abnormal
ceratohyal cartilage deformed , abnormal
Show

 ZFA:0001405 ethmoid cartilage ethmoid cartilage decreased width , abnormal
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 ZFA:0001460 pharyngeal arch cartilage pharyngeal arch cartilage deformed , abnormal
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 ZFA:0001516 ceratobranchial cartilage ceratobranchial cartilage decreased amount , abnormal
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 ZFA:0001557 pronephric glomerulus pronephric glomerulus unfused from pronephric glomerulus , abnormal
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 ZFA:0001617 otolith otolith amount , abnormal
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 ZFA:0005175 CoPA CoPA axon misrouted , abnormal
CoPA axon mislocalised posteriorly , abnormal
CoPA anterior/posterior axon guidance decreased process quality , abnormal
CoPA dorsal spinal cord interneuron anterior axon guidance decreased process quality , abnormal
Show

 ZFA:0005731 branchiomotor neuron branchiomotor neuron cell projection lateral orientation , abnormal
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 ZFA:0009000 cell cell extracellular matrix decreased size , abnormal
cell extracellular matrix organization quality , abnormal
Show

 ZFA:0009032 ciliated cell ciliated cell mitotic spindle increased angle to pronephros apical-basal axis relative to substrate, abnormal
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 ZFA:0009116 slow muscle cell slow muscle cell disoriented , abnormal
slow muscle cell disorganized , abnormal
slow muscle cell decreased amount , abnormal
slow muscle cell decreased length , abnormal
slow muscle cell mislocalised , abnormal
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 ZFA:0009117 fast muscle cell fast muscle cell morphology , abnormal
Show

 ZFA:0009306 neuroepithelial cell neuroepithelial cell mislocalised , abnormal
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 ZFA:0009367 neuromast hair cell neuromast hair cell disoriented , abnormal
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Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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