ENSMUSG00000027860


Mus musculus

Features
Gene ID: ENSMUSG00000027860
  
Biological name :Vangl1
  
Synonyms : Q80Z96 / Vangl1 / VANGL planar cell polarity 1
  
Possible biological names infered from orthology : Q8TAA9 / VANGL planar cell polarity protein 1
  
Species: Mus musculus
  
Chr. number: 3
Strand: -1
Band: F2.2
Gene start: 102153583
Gene end: 102204693
  
Corresponding Affymetrix probe sets: 10500736 (MoGene1.0st)   1427234_at (Mouse Genome 430 2.0 Array)   1441097_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000124874
Ensembl peptide - ENSMUSP00000126254
Ensembl peptide - ENSMUSP00000125484
Ensembl peptide - ENSMUSP00000125043
Ensembl peptide - ENSMUSP00000029453
Ensembl peptide - ENSMUSP00000124642
NCBI entrez gene - 229658     See in Manteia.
MGI - MGI:2159344
RefSeq - XM_017319549
RefSeq - NM_177545
RefSeq - XM_006501395
RefSeq Peptide - NP_808213
swissprot - E0CX72
swissprot - A0A140T8S8
swissprot - Q80Z96
swissprot - A0A0H2UH25
swissprot - F7BWJ0
swissprot - Q3UXU7
Ensembl - ENSMUSG00000027860
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 vangl1ENSDARG00000004305Danio rerio
 VANGL1ENSGALG00000015025Gallus gallus
 Q8TAA9ENSG00000173218Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q91ZD4 / Vangl2 / VANGL planar cell polarity 2 / Q9ULK5* / VANGL planar cell polarity protein 2*ENSMUSG0000002655671


Protein motifs (from Interpro)
Interpro ID Name
 IPR009539  Vang-like protein


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0043473 pigmentation IMP
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0016328 lateral plasma membrane IDA
 molecular_functionGO:0005515 protein binding IPI


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000031 abnormal cochlea morphology "any anomaly, deformity, malformation, impairment or dysfunction of the cochlea" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, cml:Cathleen M. Lutz , Mouse Genome Informatics Curator, J:21484]
Show

Allelic Composition: Vangl1Gt(XL802)Byg/Vangl1+,Vangl2Lp/Vangl2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * LPT/LeJ

 MP:0000592 short tail "reduced length of tail compared to control " [J:55583]
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Allelic Composition: Vangl2tm1.2Yy/Vangl2tm1.2Yy
Genetic Background: involves: C57BL/6 * CBA

 MP:0001144 fused vaginal opening "condition in which the external vaginal opening is closed by the adherence of the epithelium of the vagina" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Vangl1Gt(XL802)Byg/Vangl1Gt(XL802)Byg,Vangl2Lp/Vangl2+
Genetic Background: involves: 129P2/OlaHsd * A

 MP:0001700 abnormal embryo turning "atypical axial rotation of the germ layers of the embryo during the primitive streak/early somite stage (Mus:E8.5-E9.5) such that the curvature of the entire trunk region is reversed and the neural ectoderm moves to the convex region and the midgut region becomes located in the concave region" [The Atlas of Mouse Development:ISBN 0-12-402035-6, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Vangl1Gt(XL802)Byg/Vangl1Gt(XL802)Byg,Vangl2tm1.2Yy/Vangl2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

 MP:0001926 female infertility "inability of female to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:34193]
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Allelic Composition: Vangl1Gt(XL802)Byg/Vangl1Gt(XL802)Byg,Vangl2Lp/Vangl2+
Genetic Background: involves: 129P2/OlaHsd * A

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Vangl1Gt(XL802)Byg/Vangl1+,Vangl2ska17/Vangl2+
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6J

Allelic Composition: Vangl1tm1.1Nat/Vangl1tm1.1Nat
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0002758 long tail "increased length of tail relative to average of a given strain" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:82849]
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Allelic Composition: Vangl1Gt(XL802)Byg/Vangl1Gt(XL802)Byg,Vangl2Lp/Vangl2+
Genetic Background: involves: 129P2/OlaHsd * A

 MP:0002825 abnormal notochord "malformation or absence of the axial fibrocellular cord in embryos around which develops the vertebral primordia" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Vangl1Gt(XL802)Byg/Vangl1Gt(XL802)Byg,Vangl2tm1.2Yy/Vangl2tm1.2Yy
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

 MP:0003051 curly tail "a loop or corkscrew-like curl in the tail" [csmith:Cynthia L. Smith, Mouse Genome Informatics Curator]
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Allelic Composition: Vangl1Gt(XL802)Byg/Vangl1+,Vangl2Lp/Vangl2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * LPT/LeJ

 MP:0003178 left pulmonary isomerism "bilaterally symmetric left lung pattern (or altered asymmetric patterning of the lung)" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:93051]
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Allelic Composition: Vangl1Gt(XL802)Byg/Vangl1Gt(XL802)Byg,Vangl2tm1.2Yy/Vangl2tm1.2Yy
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

 MP:0004133 heterotaxia "abnormal arrangement of organs or parts of the body in relation to each other" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
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Allelic Composition: Vangl1Gt(XL802)Byg/Vangl1Gt(XL802)Byg,Vangl2tm1.2Yy/Vangl2tm1.2Yy
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

 MP:0004160 retroesophageal right subclavian artery "the subclavian artery aberrantly originates from the aortic arch distal to the origin of the left subclavian artery, i.e., it is the last branch of the aortic arch" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
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Allelic Composition: Vangl1Gt(XL802)Byg/Vangl1+,Vangl2Lp/Vangl2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * LPT/LeJ

 MP:0004251 failure of looping morphogenesis "failure of the primitive heart tube to initiate or complete looping" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Vangl1Gt(XL802)Byg/Vangl1Gt(XL802)Byg,Vangl2tm1.2Yy/Vangl2tm1.2Yy
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

 MP:0004393 abnormal cochlear inner hair cell morphology "any structural abnormality in the sensory cells of the organ of Corti which are in synaptic contact with sensory as well as efferent fibers of the auditory nerve; there is a single row of flask-shaped inner hair cells tightly surrounded by supporting interphalangeal cells; the apical end of each cell is anchored to the cuticular plate and about 100 stereocilia arranged in a more or less linear (or shallow) U-shaped pattern extend from the cell s surface through the cuticular plate into the endolymphic space inferior to the tectorial membrane" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Vangl1Gt(XL802)Byg/Vangl1Gt(XL802)Byg,Vangl2Lp/Vangl2+
Genetic Background: involves: 129P2/OlaHsd * A

Allelic Composition: Vangl1Gt(XL802)Byg/Vangl1Gt(XL802)Byg,Vangl2tm1.2Yy/Vangl2tm1.2Yy
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

 MP:0004399 abnormal cochlear outer hair cell morphology "any structural abnormality in the sensory cells of the organ of Corti which are in synaptic contact with sensory as well as efferent fibers of the auditory nerve; there are three rows of columnar outer hair cells largely surrounded by cortilymph and supporting phalangeal cells; the apical end of each cell is anchored to the cuticular plate and about 100 stereocilia arranged in a V-shaped pattern extend from the cell s surface through the cuticular plate into the tectorial membrane" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Vangl1Gt(XL802)Byg/Vangl1Gt(XL802)Byg,Vangl2Lp/Vangl2+
Genetic Background: involves: 129P2/OlaHsd * A

Allelic Composition: Vangl1Gt(XL802)Byg/Vangl1Gt(XL802)Byg,Vangl2tm1.2Yy/Vangl2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

Allelic Composition: Vangl1Gt(XL802)Byg/Vangl1Gt(XL802)Byg,Vangl2tm1.2Yy/Vangl2tm1.2Yy
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

 MP:0004491 abnormal orientation of outer hair cell stereociliary bundles "misorientation or rotation of outer hair cell (OHC) stereociliary bundles, resulting in defective planar cell polarity of the inner ear sensory epithelium " [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Vangl1Gt(XL802)Byg/Vangl1+,Vangl2Lp/Vangl2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * LPT/LeJ

 MP:0004492 abnormal orientation of inner hair cell stereociliary bundles "misorientation or rotation of inner hair cell (IHC) stereociliary bundles, resulting in defective planar cell polarity of the inner ear sensory epithelium" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Vangl1Gt(XL802)Byg/Vangl1+,Vangl2Lp/Vangl2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * LPT/LeJ

 MP:0004521 abnormal cochlear hair cell stereociliary bundle morphology "any structural anomaly or disruption of the typical pattern of arrangement of mechanosensitive hair bundles which are composed of thick long microvilli (stereocilia) and are located at the apical end of cochlear inner and outer hair cells" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Vangl1Gt(XL802)Byg/Vangl1+,Vangl2Lp/Vangl2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * LPT/LeJ

 MP:0004522 abnormal orientation of cochlear hair cell stereociliary bundles "misorientation or rotation of inner and/or outer hair cell stereociliary bundles, resulting in defective planar cell polarity of the inner ear sensory epithelium" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: X/SryAKR/J,Tht/Tht+
Genetic Background: involves: AKR/J * C57BL/6J

 MP:0005561 increased mean corpuscular hemoglobin "greater than the average levels of hemoglobin contained in an erythrocyte" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Kmt5btm1a(KOMP)Wtsi/Kmt5btm1a(KOMP)Wtsi
Genetic Background: B6JTyr;B6N-Kmt5btm1a(KOMP)Wtsi/Wtsi

 MP:0008784 craniorachischisis "congenital fissure of the skull and vertebral column" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Vangl1Gt(XL802)Byg/Vangl1+,Vangl2Lp/Vangl2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * LPT/LeJ

 MP:0008933 abnormal embryonic cilium physiology "any functional anomaly of the earliest cilia of the mouse embryo found on the cells of the embryonic node" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Vangl1Gt(XL802)Byg/Vangl1Gt(XL802)Byg,Vangl2tm1.2Yy/Vangl2tm1.2Yy
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

 MP:0010123 increased bone mineral content "elevation in the amount (usually in grams/cm) of bone mineral divided by a bone-scanned area" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Kmt5btm1a(KOMP)Wtsi/Kmt5btm1a(KOMP)Wtsi
Genetic Background: B6JTyr;B6N-Kmt5btm1a(KOMP)Wtsi/Wtsi

 MP:0010866 abnormal prenatal body size "anomaly in the average body weight, height and/or length of an organism compared to controls at anytime prior to birth" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Vangl1Gt(XL802)Byg/Vangl1Gt(XL802)Byg,Vangl2tm1.2Yy/Vangl2tm1.2Yy
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

 MP:0011090 partial perinatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the perinatal period (Mus: E18.5 through postnatal day 1)" [MGI:csmith]
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Allelic Composition: Vangl1Gt(XL802)Byg/Vangl1+,Vangl2Lp/Vangl2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * LPT/LeJ

 MP:0012027 abnormal embryonic cilium location or orientation "embryonic cilia are displaced from the normal position and/or do not orient in a typical pattern" [MGI:csmith]
Show

Allelic Composition: Vangl1Gt(XL802)Byg/Vangl1Gt(XL802)Byg,Vangl2tm1.2Yy/Vangl2tm1.2Yy
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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