ENSDARG00000098936


Danio rerio

Features
Gene ID: ENSDARG00000098936
  
Biological name :kif5aa
  
Synonyms : kif5aa / kinesin family member 5A, a
  
Possible biological names infered from orthology : KIF5A / kinesin family member 5A / Kinesin heavy chain isoform 5A / P33175 / Q12840
  
Species: Danio rerio
  
Chr. number: 9
Strand: -1
Band:
Gene start: 265988
Gene end: 296169
  
Corresponding Affymetrix probe sets: Dr.7098.1.A1_at (Zebrafish Array)   
  
Cross references: Ensembl peptide - ENSDARP00000139080
NCBI entrez gene - 566086     See in Manteia.
RefSeq - NM_001199776
RefSeq Peptide - NP_001186705
swissprot - A0A0R4IWI7
ZFIN ID - ZDB-GENE-070912-141
Ensembl - ENSDARG00000098936
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 KIF5AENSG00000155980Homo sapiens
 Kif5aENSMUSG00000074657Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
kif5ab / kinesin family member 5A, b / KIF5A* / P33175* / Q12840* / kinesin family member 5A* / Kinesin heavy chain isoform 5A *ENSDARG0000005981867
kif5ba / kinesin family member 5B, a / KIF5B* / Q61768* / P33176* / Kinesin-1 heavy chain * / kinesin family member 5B*ENSDARG0000007413161
kif5ba / kif5bb / kinesin family member 5B, b / KIF5B* / P33176* / kinesin family member 5B*ENSDARG0000010339461
kif5c / kinesin family member 5C / O60282* / P28738* / Kinesin heavy chain isoform 5C *ENSDARG0000007602760
kif21a / kinesin family member 21A / Q7Z4S6* / Q9QXL2* / Kinesin-like protein KIF21A *ENSDARG0000006113123
kif7 / kinesin family member 7 / Q2M1P5*ENSDARG0000003309922
kif4 / kinesin family member 4 / KIF4A* / KIF4B* / Q2VIQ3* / O95239* / P33174* / kinesin family member 4A* / kinesin family member 4B* / Chromosome-associated kinesin KIF4 *ENSDARG0000000546222
kif21b / kinesin family member 21B / O75037*ENSDARG0000000973322
kif11 / kinesin family member 11 / P52732* / Q6P9P6* / Kinesin-like protein KIF11 *ENSDARG0000001094821
kif17 / kinesin family member 17 / Q99PW8* / Q9P2E2* / Kinesin-like protein KIF17 *ENSDARG0000005523821
kif15 / kinesin family member 15 / Q6P9L6* / Q9NS87* / Kinesin-like protein KIF15 *ENSDARG0000001207321
kif3ca / kinesin family member 3Ca / KIF3C* / O14782* / kinesin family member 3C*ENSDARG0000001716220
kif3b / kinesin family member 3B / O15066* / Q61771* / Kinesin-like protein KIF3B Kinesin-like protein KIF3B, N-terminally processed*ENSDARG0000010112020
cenpe / centromere protein E / Q02224*ENSDARG0000006338520
kif3a / kinesin family member 3A / P28741* / Q9Y496* / Kinesin-like protein KIF3A *ENSDARG0000008753820
kif3cb / kinesin family member 3Cb / KIF3C* / O14782* / O35066* / kinesin family member 3C* / Kinesin-like protein KIF3C *ENSDARG0000007950019
CABZ01066312.1ENSDARG000001006242


Protein motifs (from Interpro)
Interpro ID Name
 IPR001752  Kinesin motor domain
 IPR019821  Kinesin motor domain, conserved site
 IPR027417  P-loop containing nucleoside triphosphate hydrolase


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007018 microtubule-based movement IEA
 biological_processGO:0019896 axonal transport of mitochondrion IMP
 biological_processGO:1990535 neuron projection maintenance IMP
 cellular_componentGO:1904115 axon cytoplasm IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0003774 motor activity IEA
 molecular_functionGO:0003777 microtubule motor activity IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0008017 microtubule binding IEA


Pathways (from Reactome)
Pathway description
RHO GTPases activate KTN1
Kinesins


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000008 brain brain decreased amount , abnormal
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 ZFA:0000024 retinal ganglion cell layer retinal ganglion cell layer decreased amount , abnormal
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 ZFA:0000076 swim bladder swim bladder morphology , abnormal
swim bladder uninflated , abnormal
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 ZFA:0000175 posterior lateral line nerve posterior lateral line nerve decreased length , abnormal
posterior lateral line nerve decreased thickness , abnormal
posterior lateral line nerve axon degeneration , abnormal
posterior lateral line nerve axon decreased size , abnormal
posterior lateral line nerve axon has fewer parts of type posterior lateral line nerve mitochondrion, abnormal
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 ZFA:0000435 cranial nerve II cranial nerve II anterograde axonal transport of mitochondrion decreased occurrence , abnormal
cranial nerve II anterograde trans-synaptic signaling decreased occurrence , abnormal
cranial nerve II collateral sprouting increased occurrence , abnormal
cranial nerve II collateral sprouting decreased occurrence , abnormal
cranial nerve II axonogenesis involved in innervation delayed , abnormal
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 ZFA:0000445 optic tectum optic tectum increased amount , abnormal
optic tectum increased distribution , abnormal
optic tectum dendrite decreased amount , abnormal
optic tectum anterograde trans-synaptic signaling decreased occurrence , abnormal
optic tectum neuron decreased amount , abnormal
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 ZFA:0001058 caudal fin caudal fin has fewer parts of type caudal fin axon, abnormal
caudal fin axon has fewer parts of type neuron mitochondrion, abnormal
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 ZFA:0001094 whole organism whole organism increased pigmentation , abnormal
whole organism increased amount , abnormal
whole organism decreased amount , abnormal
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 ZFA:0009091 melanocyte melanocyte black , abnormal
melanocyte melanosome distended , abnormal
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 ZFA:0009248 neuron neuron mitochondrion mobility , abnormal
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 ZFA:0009310 retinal ganglion cell retinal ganglion cell axon terminus has fewer parts of type retinal ganglion cell mitochondrion, abnormal
retinal ganglion cell anterograde axonal transport of mitochondrion decreased occurrence , abnormal
retinal ganglion cell axon decreased amount , abnormal
retinal ganglion cell axon terminus increased branchiness , abnormal
retinal ganglion cell axon terminus decreased branchiness , abnormal
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Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000009796 klc1a / kinesin light chain 1a / KLC1* / Q07866* / AL139300.1* / kinesin light chain 1* / kinesin light chain 1 isoform 1G *  / complex / reaction
 ENSDARG00000004301 rhogb / ras homolog family member Gb / RHOG* / P84095* / P84096* / ras homolog family member G*  / complex / reaction
 ENSDARG00000044573 cdc42 / cell division cycle 42 / P60766* / P60953* / Cell division control *  / reaction / complex
 ENSDARG00000032802 ktn1 / kinectin 1 / Q86UP2*  / reaction / complex
 ENSDARG00000098936 kif5aa / kinesin family member 5A, a / KIF5A* / Q12840* / kinesin family member 5A*  / complex / reaction
 ENSDARG00000094673 rhoab / Q6DHM9 / ras homolog gene family, member Ab / RHOA* / Q9QUI0* / P61586* / ras homolog family member A*  / complex / reaction
 ENSDARG00000068653 rhoga / ras homolog family member Ga / RHOG* / P84095* / P84096* / ras homolog family member G*  / complex / reaction






 

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