ENSDARG00000054320


Danio rerio

Features
Gene ID: ENSDARG00000054320
  
Biological name :ap2a1
  
Synonyms : adaptor-related protein complex 2, alpha 1 subunit / ap2a1
  
Possible biological names infered from orthology : adaptor related protein complex 2 alpha 2 subunit / AP2A2 / Mus musculus adaptor-related protein complex 2, alpha 2 subunit (Ap2a2), transcript variant 1, mRNA. / O94973 / P17427
  
Species: Danio rerio
  
Chr. number: 3
Strand: 1
Band:
Gene start: 32365811
Gene end: 32401481
  
Corresponding Affymetrix probe sets: Dr.1096.1.A1_at (Zebrafish Array)   
  
Cross references: Ensembl peptide - ENSDARP00000127794
Ensembl peptide - ENSDARP00000128936
Ensembl peptide - ENSDARP00000128168
Ensembl peptide - ENSDARP00000129796
NCBI entrez gene - 558153     See in Manteia.
RefSeq - XM_009299568
RefSeq - XM_005164063
swissprot - X1WD71
swissprot - X1WC51
swissprot - X1WFD2
swissprot - X1WHT2
ZFIN ID - ZDB-GENE-090302-2
Ensembl - ENSDARG00000054320
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 AP2A2ENSGALG00000006799Gallus gallus
 AP2A2ENSG00000183020Homo sapiens
 Ap2a2ENSMUSG00000002957Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR002553  Clathrin/coatomer adaptor, adaptin-like, N-terminal
 IPR003164  Clathrin adaptor, alpha-adaptin, appendage, C-terminal subdomain
 IPR008152  Clathrin adaptor, alpha/beta/gamma-adaptin, appendage, Ig-like subdomain
 IPR009028  Coatomer/calthrin adaptor appendage, C-terminal subdomain
 IPR011989  Armadillo-like helical
 IPR013041  Clathrin adaptor, appendage, Ig-like subdomain superfamily
 IPR016024  Armadillo-type fold
 IPR017104  Adaptor protein complex AP-2, alpha subunit


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006886 intracellular protein transport IEA
 biological_processGO:0006897 endocytosis IEA
 biological_processGO:0009950 dorsal/ventral axis specification IMP
 biological_processGO:0009953 dorsal/ventral pattern formation IMP
 biological_processGO:0015031 protein transport IEA
 biological_processGO:0016192 vesicle-mediated transport IEA
 biological_processGO:0060218 hematopoietic stem cell differentiation IMP
 biological_processGO:0072583 clathrin-dependent endocytosis IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005905 clathrin-coated pit IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0030117 membrane coat IEA
 cellular_componentGO:0030131 clathrin adaptor complex IEA
 molecular_functionGO:0008565 protein transporter activity IEA
 molecular_functionGO:0035615 clathrin adaptor activity IEA


Pathways (from Reactome)
Pathway description
Retrograde neurotrophin signalling
MHC class II antigen presentation
Trafficking of GluR2-containing AMPA receptors
Recycling pathway of L1
WNT5A-dependent internalization of FZD4
WNT5A-dependent internalization of FZD2, FZD5 and ROR2
Neutrophil degranulation
Cargo recognition for clathrin-mediated endocytosis
Clathrin-mediated endocytosis
VLDLR internalisation and degradation
LDL clearance


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000016 ectoderm ectoderm delaminated , abnormal
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 ZFA:0000084 yolk yolk protruding out of ball , abnormal
Show

 ZFA:0001094 whole organism whole organism dead , abnormal
whole organism broken , abnormal
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 ZFA:0005028 ventral wall of dorsal aorta ventral wall of dorsal aorta hematopoietic stem cell decreased amount , abnormal
ventral wall of dorsal aorta decreased amount , abnormal
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Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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