ENSG00000128011


Homo sapiens

Features
Gene ID: ENSG00000128011
  
Biological name :LRFN1
  
Synonyms : leucine rich repeat and fibronectin type III domain containing 1 / LRFN1 / Q9P244
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 19
Strand: -1
Band: q13.2
Gene start: 39306568
Gene end: 39315336
  
Corresponding Affymetrix probe sets: 232486_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000248668
NCBI entrez gene - 57622     See in Manteia.
OMIM - 612807
RefSeq - XM_017027033
RefSeq - NM_020862
RefSeq - XM_005259102
RefSeq Peptide - NP_065913
swissprot - Q9P244
Ensembl - ENSG00000128011
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 lrfn1ENSDARG00000027602Danio rerio
 Lrfn1ENSMUSG00000030600Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
LRFN2 / Q9ULH4 / leucine rich repeat and fibronectin type III domain containing 2ENSG0000015656447
LRFN5 / Q96NI6 / leucine rich repeat and fibronectin type III domain containing 5ENSG0000016537946
LRFN3 / Q9BTN0 / leucine rich repeat and fibronectin type III domain containing 3ENSG0000012624345
LRFN4 / Q6PJG9 / leucine rich repeat and fibronectin type III domain containing 4ENSG0000017362141
LINGO3 / P0C6S8 / leucine rich repeat and Ig domain containing 3ENSG0000022000819
LRRC4B / Q9NT99 / leucine rich repeat containing 4BENSG0000013140919
LINGO2 / Q7L985 / leucine rich repeat and Ig domain containing 2ENSG0000017448219
LINGO1 / Q96FE5 / leucine rich repeat and Ig domain containing 1ENSG0000016978318
LRRN2 / O75325 / leucine rich repeat neuronal 2ENSG0000017038218
LRRC4C / Q9HCJ2 / leucine rich repeat containing 4CENSG0000014894817
LRRC4 / Q9HBW1 / leucine rich repeat containing 4ENSG0000012859417
LRRN3 / Q9H3W5 / leucine rich repeat neuronal 3ENSG0000017311417
LRRN1 / Q6UXK5 / leucine rich repeat neuronal 1ENSG0000017592816
LINGO4 / Q6UY18 / leucine rich repeat and Ig domain containing 4ENSG0000021317115


Protein motifs (from Interpro)
Interpro ID Name
 IPR000483  Cysteine-rich flanking region, C-terminal
 IPR001611  Leucine-rich repeat
 IPR003591  Leucine-rich repeat, typical subtype
 IPR003598  Immunoglobulin subtype 2
 IPR003599  Immunoglobulin subtype
 IPR003961  Fibronectin type III
 IPR007110  Immunoglobulin-like domain
 IPR013098  Immunoglobulin I-set
 IPR013783  Immunoglobulin-like fold
 IPR032675  Leucine-rich repeat domain superfamily
 IPR036116  Fibronectin type III superfamily
 IPR036179  Immunoglobulin-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007409 axonogenesis IBA
 cellular_componentGO:0005615 extracellular space IBA
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0009986 cell surface IEA
 cellular_componentGO:0014069 postsynaptic density IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0030054 cell junction IEA
 cellular_componentGO:0045202 synapse IEA
 cellular_componentGO:0045211 postsynaptic membrane IEA
 molecular_functionGO:0005515 protein binding IEA


Pathways (from Reactome)
Pathway description
Synaptic adhesion-like molecules


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000156564 LRFN2 / Q9ULH4 / leucine rich repeat and fibronectin type III domain containing 2  / reaction / complex
 ENSG00000128011 LRFN1 / Q9P244 / leucine rich repeat and fibronectin type III domain containing 1  / reaction / complex
 ENSG00000082458 DLG3 / Q92796 / discs large MAGUK scaffold protein 3  / complex / reaction
 ENSG00000075711 DLG1 / Q12959 / discs large MAGUK scaffold protein 1  / reaction / complex
 ENSG00000132535 DLG4 / P78352 / discs large MAGUK scaffold protein 4  / complex / reaction
 ENSG00000105464 GRIN2D / O15399 / glutamate ionotropic receptor NMDA type subunit 2D  / complex / reaction
 ENSG00000155511 GRIA1 / P42261 / glutamate ionotropic receptor AMPA type subunit 1  / reaction / complex
 ENSG00000152578 GRIA4 / P48058 / glutamate ionotropic receptor AMPA type subunit 4  / complex / reaction
 ENSG00000161509 GRIN2C / Q14957 / glutamate ionotropic receptor NMDA type subunit 2C  / complex / reaction
 ENSG00000173621 LRFN4 / Q6PJG9 / leucine rich repeat and fibronectin type III domain containing 4  / reaction / complex
 ENSG00000183454 GRIN2A / Q12879 / glutamate ionotropic receptor NMDA type subunit 2A  / complex / reaction
 ENSG00000176884 GRIN1 / Q05586 / glutamate ionotropic receptor NMDA type subunit 1  / reaction / complex
 ENSG00000125675 GRIA3 / P42263 / glutamate ionotropic receptor AMPA type subunit 3  / complex / reaction
 ENSG00000273079 GRIN2B / Q13224 / glutamate ionotropic receptor NMDA type subunit 2B  / reaction / complex






 

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