ENSG00000131409


Homo sapiens

Features
Gene ID: ENSG00000131409
  
Biological name :LRRC4B
  
Synonyms : leucine rich repeat containing 4B / LRRC4B / Q9NT99
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 19
Strand: -1
Band: q13.33
Gene start: 50516892
Gene end: 50568045
  
Corresponding Affymetrix probe sets: 239320_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000472528
Ensembl peptide - ENSP00000373853
Ensembl peptide - ENSP00000471502
NCBI entrez gene - 94030     See in Manteia.
RefSeq - XM_011527520
RefSeq - NM_001080457
RefSeq - NM_001348568
RefSeq - XM_005259429
RefSeq - XM_006723506
RefSeq Peptide - NP_001335497
RefSeq Peptide - NP_001073926
swissprot - M0R2G0
swissprot - Q9NT99
swissprot - A0A024R4I8
Ensembl - ENSG00000131409
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 lrrc4baENSDARG00000004597Danio rerio
 lrrc4bbENSDARG00000014792Danio rerio
 Lrrc4bENSMUSG00000047085Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
LRRC4C / Q9HCJ2 / leucine rich repeat containing 4CENSG0000014894857
LRRC4 / Q9HBW1 / leucine rich repeat containing 4ENSG0000012859452
LINGO3 / P0C6S8 / leucine rich repeat and Ig domain containing 3ENSG0000022000823
LINGO2 / Q7L985 / leucine rich repeat and Ig domain containing 2ENSG0000017448222
LINGO1 / Q96FE5 / leucine rich repeat and Ig domain containing 1ENSG0000016978322
LRFN2 / Q9ULH4 / leucine rich repeat and fibronectin type III domain containing 2ENSG0000015656421
LINGO4 / Q6UY18 / leucine rich repeat and Ig domain containing 4ENSG0000021317121
LRRN2 / O75325 / leucine rich repeat neuronal 2ENSG0000017038220
LRFN1 / Q9P244 / leucine rich repeat and fibronectin type III domain containing 1ENSG0000012801120
LRRN3 / Q9H3W5 / leucine rich repeat neuronal 3ENSG0000017311420
LRRN1 / Q6UXK5 / leucine rich repeat neuronal 1ENSG0000017592819
LRFN4 / Q6PJG9 / leucine rich repeat and fibronectin type III domain containing 4ENSG0000017362119
LRFN5 / Q96NI6 / leucine rich repeat and fibronectin type III domain containing 5ENSG0000016537918
LRFN3 / Q9BTN0 / leucine rich repeat and fibronectin type III domain containing 3ENSG0000012624317


Protein motifs (from Interpro)
Interpro ID Name
 IPR000372  Leucine-rich repeat N-terminal domain
 IPR000483  Cysteine-rich flanking region, C-terminal
 IPR001611  Leucine-rich repeat
 IPR003591  Leucine-rich repeat, typical subtype
 IPR003598  Immunoglobulin subtype 2
 IPR003599  Immunoglobulin subtype
 IPR007110  Immunoglobulin-like domain
 IPR013098  Immunoglobulin I-set
 IPR013783  Immunoglobulin-like fold
 IPR026883  Leucine-rich repeat-containing protein 4B
 IPR032675  Leucine-rich repeat domain superfamily
 IPR036179  Immunoglobulin-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006469 negative regulation of protein kinase activity IBA
 biological_processGO:0019221 cytokine-mediated signaling pathway IBA
 biological_processGO:0046426 negative regulation of JAK-STAT cascade IBA
 biological_processGO:0051965 positive regulation of synapse assembly ISS
 cellular_componentGO:0005737 cytoplasm IBA
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0030054 cell junction IEA
 cellular_componentGO:0042734 presynaptic membrane IEA
 cellular_componentGO:0044300 cerebellar mossy fiber IEA
 cellular_componentGO:0045202 synapse IEA
 molecular_functionGO:0004860 protein kinase inhibitor activity IBA
 molecular_functionGO:0005102 signaling receptor binding IEA
 molecular_functionGO:0005515 protein binding IEA


Pathways (from Reactome)
Pathway description
Receptor-type tyrosine-protein phosphatases


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000105426 PTPRS / Q13332 / protein tyrosine phosphatase, receptor type S  / complex / reaction
 ENSG00000153707 PTPRD / P23468 / protein tyrosine phosphatase, receptor type D  / reaction / complex
 ENSG00000142949 PTPRF / P10586 / protein tyrosine phosphatase, receptor type F  / complex / reaction






 

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