ENSG00000174871


Homo sapiens

Features
Gene ID: ENSG00000174871
  
Biological name :CNIH2
  
Synonyms : CNIH2 / cornichon family AMPA receptor auxiliary protein 2 / Q6PI25
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 11
Strand: 1
Band: q13.2
Gene start: 66278190
Gene end: 66285301
  
Corresponding Affymetrix probe sets: 230070_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000310003
Ensembl peptide - ENSP00000435537
Ensembl peptide - ENSP00000433896
Ensembl peptide - ENSP00000432177
NCBI entrez gene - 254263     See in Manteia.
OMIM - 611288
RefSeq - NM_182553
RefSeq Peptide - NP_872359
swissprot - E9PJQ8
swissprot - E9PIT8
swissprot - E9PS15
swissprot - Q6PI25
Ensembl - ENSG00000174871
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 cnih2ENSDARG00000043662Danio rerio
 2 ENSMUSG00000024873Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
CNIH3 / Q8TBE1 / cornichon family AMPA receptor auxiliary protein 3ENSG0000014378680
CNIH1 / O95406 / cornichon family AMPA receptor auxiliary protein 1ENSG0000010052865
CNIH4 / Q9P003 / cornichon family AMPA receptor auxiliary protein 4ENSG0000014377126


Protein motifs (from Interpro)
Interpro ID Name
 IPR003377  Cornichon
 IPR033466  Cornichon, conserved site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006888 ER to Golgi vesicle-mediated transport TAS
 biological_processGO:0016192 vesicle-mediated transport IEA
 biological_processGO:0035249 synaptic transmission, glutamatergic IEA
 biological_processGO:0042391 regulation of membrane potential IEA
 biological_processGO:0048208 COPII vesicle coating TAS
 biological_processGO:0051668 localization within membrane IEA
 biological_processGO:1902684 negative regulation of receptor localization to synapse IEA
 biological_processGO:1903743 negative regulation of anterograde synaptic vesicle transport IEA
 biological_processGO:2000310 regulation of NMDA receptor activity IEA
 biological_processGO:2000311 regulation of AMPA receptor activity IEA
 cellular_componentGO:0000139 Golgi membrane IEA
 cellular_componentGO:0005783 endoplasmic reticulum IEA
 cellular_componentGO:0005789 endoplasmic reticulum membrane TAS
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0012507 ER to Golgi transport vesicle membrane TAS
 cellular_componentGO:0014069 postsynaptic density ISS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0030054 cell junction IEA
 cellular_componentGO:0030425 dendrite ISS
 cellular_componentGO:0032281 AMPA glutamate receptor complex IEA
 cellular_componentGO:0033116 endoplasmic reticulum-Golgi intermediate compartment membrane TAS
 cellular_componentGO:0042995 cell projection IEA
 cellular_componentGO:0043197 dendritic spine ISS
 cellular_componentGO:0043198 dendritic shaft IEA
 cellular_componentGO:0045202 synapse IEA
 cellular_componentGO:0045211 postsynaptic membrane ISS
 molecular_functionGO:0005515 protein binding IPI


Pathways (from Reactome)
Pathway description
COPII-mediated vesicle transport
Cargo concentration in the ER


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000155511 GRIA1 / P42261 / glutamate ionotropic receptor AMPA type subunit 1  / complex / reaction






 

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