ENSG00000100603


Homo sapiens

Features
Gene ID: ENSG00000100603
  
Biological name :SNW1
  
Synonyms : Q13573 / SNW1 / SNW domain containing 1
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 14
Strand: -1
Band: q24.3
Gene start: 77717599
Gene end: 77761207
  
Corresponding Affymetrix probe sets: 201575_at (Human Genome U133 Plus 2.0 Array)   215424_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000451129
Ensembl peptide - ENSP00000452059
Ensembl peptide - ENSP00000452473
Ensembl peptide - ENSP00000261531
Ensembl peptide - ENSP00000451741
NCBI entrez gene - 22938     See in Manteia.
OMIM - 603055
RefSeq - XM_005267413
RefSeq - NM_001318844
RefSeq - NM_012245
RefSeq Peptide - NP_001305773
RefSeq Peptide - NP_036377
swissprot - G3V3A4
swissprot - G3V5R3
swissprot - G3V4X8
swissprot - G3V4E0
swissprot - Q13573
Ensembl - ENSG00000100603
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 snw1ENSDARG00000091563Danio rerio
 SNW1ENSGALG00000010501Gallus gallus
 Snw1ENSMUSG00000021039Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR004015  SKI-interacting protein SKIP, SNW domain
 IPR017862  SKI-interacting protein, SKIP


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IDA
 biological_processGO:0000350 generation of catalytic spliceosome for second transesterification step IBA
 biological_processGO:0000398 mRNA splicing, via spliceosome IEA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006357 regulation of transcription by RNA polymerase II TAS
 biological_processGO:0006367 transcription initiation from RNA polymerase II promoter TAS
 biological_processGO:0006397 mRNA processing IEA
 biological_processGO:0007219 Notch signaling pathway TAS
 biological_processGO:0007221 positive regulation of transcription of Notch receptor target TAS
 biological_processGO:0008380 RNA splicing IEA
 biological_processGO:0014010 Schwann cell proliferation IEA
 biological_processGO:0016032 viral process IEA
 biological_processGO:0030511 positive regulation of transforming growth factor beta receptor signaling pathway IDA
 biological_processGO:0042771 intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator IMP
 biological_processGO:0043923 positive regulation by host of viral transcription IMP
 biological_processGO:0045747 positive regulation of Notch signaling pathway TAS
 biological_processGO:0045892 negative regulation of transcription, DNA-templated IDA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II TAS
 biological_processGO:0048026 positive regulation of mRNA splicing, via spliceosome IMP
 biological_processGO:0048384 retinoic acid receptor signaling pathway IDA
 biological_processGO:0048385 regulation of retinoic acid receptor signaling pathway IDA
 biological_processGO:0050769 positive regulation of neurogenesis ISS
 biological_processGO:0051571 positive regulation of histone H3-K4 methylation IMP
 biological_processGO:0070562 regulation of vitamin D receptor signaling pathway IDA
 biological_processGO:0070564 positive regulation of vitamin D receptor signaling pathway IDA
 biological_processGO:0071300 cellular response to retinoic acid IDA
 cellular_componentGO:0000785 chromatin IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm IDA
 cellular_componentGO:0005681 spliceosomal complex IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0008024 cyclin/CDK positive transcription elongation factor complex IDA
 cellular_componentGO:0016363 nuclear matrix IDA
 cellular_componentGO:0016604 nuclear body IDA
 cellular_componentGO:0016607 nuclear speck IDA
 cellular_componentGO:0071007 U2-type catalytic step 2 spliceosome IDA
 cellular_componentGO:0071013 catalytic step 2 spliceosome IDA
 cellular_componentGO:0071014 post-mRNA release spliceosomal complex IBA
 cellular_componentGO:0071141 SMAD protein complex IEA
 molecular_functionGO:0003713 transcription coactivator activity IDA
 molecular_functionGO:0003714 transcription corepressor activity IDA
 molecular_functionGO:0003723 RNA binding HDA
 molecular_functionGO:0005112 Notch binding IPI
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0019899 enzyme binding IPI
 molecular_functionGO:0035257 nuclear hormone receptor binding IDA
 molecular_functionGO:0042809 vitamin D receptor binding IDA
 molecular_functionGO:0042974 retinoic acid receptor binding IDA
 molecular_functionGO:0046332 SMAD binding IDA
 molecular_functionGO:0050681 androgen receptor binding IPI


Pathways (from Reactome)
Pathway description
Pre-NOTCH Transcription and Translation
Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells
NOTCH1 Intracellular Domain Regulates Transcription
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
Constitutive Signaling by NOTCH1 PEST Domain Mutants
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
Notch-HLH transcription pathway
mRNA Splicing - Major Pathway
RUNX3 regulates NOTCH signaling
NOTCH3 Intracellular Domain Regulates Transcription
NOTCH4 Intracellular Domain Regulates Transcription


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000101892 ATP1B4 / Q9UN42 / ATPase Na+/K+ transporting family member beta 4  / complex / reaction
 ENSG00000196782 MAML3 / Q96JK9 / mastermind like transcriptional coactivator 3  / complex
 ENSG00000161021 MAML1 / Q92585 / mastermind like transcriptional coactivator 1  / complex
 ENSG00000114166 KAT2B / Q92831 / lysine acetyltransferase 2B  / complex
 ENSG00000148400 NOTCH1 / P46531  / complex
 ENSG00000184384 MAML2 / Q8IZL2 / mastermind like transcriptional coactivator 2  / complex
 ENSG00000100393 EP300 / Q09472 / E1A binding protein p300  / complex
 ENSG00000168214 RBPJ / Q06330 / recombination signal binding protein for immunoglobulin kappa J region  / complex
 ENSG00000112237 CCNC / P24863 / cyclin C  / complex / reaction
 ENSG00000132964 CDK8 / P49336 / cyclin dependent kinase 8  / reaction / complex






 

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