ENSG00000161021


Homo sapiens

Features
Gene ID: ENSG00000161021
  
Biological name :MAML1
  
Synonyms : MAML1 / mastermind like transcriptional coactivator 1 / Q92585
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 5
Strand: 1
Band: q35.3
Gene start: 179732850
Gene end: 179777286
  
Corresponding Affymetrix probe sets: 202360_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000292599
NCBI entrez gene - 9794     See in Manteia.
OMIM - 605424
RefSeq - NM_014757
RefSeq Peptide - NP_055572
swissprot - Q92585
Ensembl - ENSG00000161021
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 maml1ENSDARG00000076466Danio rerio
 MAML1ENSGALG00000005929Gallus gallus
 Maml1ENSMUSG00000050567Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
MAML3 / Q96JK9 / mastermind like transcriptional coactivator 3ENSG0000019678234
MAML2 / Q8IZL2 / mastermind like transcriptional coactivator 2ENSG0000018438425


Protein motifs (from Interpro)
Interpro ID Name
 IPR019082  Neurogenic mastermind-like, N-terminal


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0003162 atrioventricular node development ISS
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006367 transcription initiation from RNA polymerase II promoter TAS
 biological_processGO:0006468 protein phosphorylation IDA
 biological_processGO:0007219 Notch signaling pathway TAS
 biological_processGO:0007221 positive regulation of transcription of Notch receptor target IEA
 biological_processGO:0010831 positive regulation of myotube differentiation IEA
 biological_processGO:0045445 myoblast differentiation IEA
 biological_processGO:0045747 positive regulation of Notch signaling pathway TAS
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IDA
 biological_processGO:0051149 positive regulation of muscle cell differentiation IEA
 biological_processGO:0060928 atrioventricular node cell development IEA
 cellular_componentGO:0002193 MAML1-RBP-Jkappa- ICN1 complex IDA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0016607 nuclear speck IEA
 cellular_componentGO:0043231 intracellular membrane-bounded organelle IDA
 molecular_functionGO:0003713 transcription coactivator activity IDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0019901 protein kinase binding IPI
 molecular_functionGO:0042605 peptide antigen binding IPI


Pathways (from Reactome)
Pathway description
Pre-NOTCH Transcription and Translation
Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells
NOTCH1 Intracellular Domain Regulates Transcription
NOTCH2 intracellular domain regulates transcription
Constitutive Signaling by NOTCH1 PEST Domain Mutants
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
Notch-HLH transcription pathway
RUNX3 regulates NOTCH signaling
NOTCH3 Intracellular Domain Regulates Transcription
NOTCH4 Intracellular Domain Regulates Transcription


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000134250 NOTCH2 / Q04721  / reaction / complex
 ENSG00000100603 SNW1 / Q13573 / SNW domain containing 1  / complex
 ENSG00000074181 NOTCH3 / Q9UM47  / reaction / complex
 ENSG00000100393 EP300 / Q09472 / E1A binding protein p300  / complex / reaction
 ENSG00000115415 STAT1 / P42224 / signal transducer and activator of transcription 1  / reaction / complex
 ENSG00000118260 CREB1 / P16220 / cAMP responsive element binding protein 1  / complex / reaction
 ENSG00000204301 NOTCH4 / Q99466  / complex / reaction
 ENSG00000114166 KAT2B / Q92831 / lysine acetyltransferase 2B  / complex
 ENSG00000168214 RBPJ / Q06330 / recombination signal binding protein for immunoglobulin kappa J region  / reaction / complex
 ENSG00000112237 CCNC / P24863 / cyclin C  / reaction / complex
 ENSG00000132964 CDK8 / P49336 / cyclin dependent kinase 8  / complex / reaction






 

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