ENSMUSG00000027630


Mus musculus

Features
Gene ID: ENSMUSG00000027630
  
Biological name :Tbl1xr1
  
Synonyms : F-box-like/WD repeat-containing protein TBL1XR1 / Q8BHJ5 / Tbl1xr1
  
Possible biological names infered from orthology : Q9BZK7 / transducin beta like 1 X-linked receptor 1
  
Species: Mus musculus
  
Chr. number: 3
Strand: 1
Band: A3
Gene start: 22076652
Gene end: 22216594
  
Corresponding Affymetrix probe sets: 10491038 (MoGene1.0st)   10491056 (MoGene1.0st)   1422761_at (Mouse Genome 430 2.0 Array)   1434839_s_at (Mouse Genome 430 2.0 Array)   1442312_at (Mouse Genome 430 2.0 Array)   1450739_at (Mouse Genome 430 2.0 Array)   1455109_at (Mouse Genome 430 2.0 Array)   1457186_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000144138
Ensembl peptide - ENSMUSP00000144602
Ensembl peptide - ENSMUSP00000144547
Ensembl peptide - ENSMUSP00000144436
Ensembl peptide - ENSMUSP00000144340
Ensembl peptide - ENSMUSP00000144301
Ensembl peptide - ENSMUSP00000067164
Ensembl peptide - ENSMUSP00000141363
Ensembl peptide - ENSMUSP00000142184
NCBI entrez gene - 81004     See in Manteia.
MGI - MGI:2441730
RefSeq - XM_017319817
RefSeq - XM_006535580
RefSeq - XM_006535581
RefSeq - XM_011249718
RefSeq - XM_011249719
RefSeq - XM_011249721
RefSeq - XM_011249723
RefSeq - XM_011249724
RefSeq - NM_030732
RefSeq - XM_006535579
RefSeq Peptide - NP_109657
swissprot - A0A0J9YUR3
swissprot - A0A0J9YUE3
swissprot - A0A0J9YUT9
swissprot - A0A0J9YVC9
swissprot - Q8BHJ5
swissprot - A0A0J9YV90
Ensembl - ENSMUSG00000027630
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 tbl1xr1aENSDARG00000058696Danio rerio
 tbl1xr1bENSDARG00000008966Danio rerio
 TBL1XR1ENSGALG00000039182Gallus gallus
 Q9BZK7ENSG00000177565Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Tbl1x / Q9QXE7 / F-box-like/WD repeat-containing protein TBL1X / TBL1Y* / Q9BQ87* / O60907* / transducin beta like 1 X-linked* / transducin beta like 1 Y-linked*ENSMUSG0000002524689
Thoc3 / Q8VE80 / THO complex subunit 3 / Q96J01* / THO complex 3*ENSMUSG0000002587215


Protein motifs (from Interpro)
Interpro ID Name
 IPR001680  WD40 repeat
 IPR006594  LIS1 homology motif
 IPR015943  WD40/YVTN repeat-like-containing domain superfamily
 IPR017986  WD40-repeat-containing domain
 IPR019775  WD40 repeat, conserved site
 IPR020472  G-protein beta WD-40 repeat
 IPR036322  WD40-repeat-containing domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II ISO
 biological_processGO:0002021 response to dietary excess IMP
 biological_processGO:0006325 chromatin organization IEA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0010468 regulation of gene expression IMP
 biological_processGO:0016042 lipid catabolic process IMP
 biological_processGO:0016575 histone deacetylation IBA
 biological_processGO:0030814 obsolete regulation of cAMP metabolic process IMP
 biological_processGO:0035264 multicellular organism growth IMP
 biological_processGO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process IMP
 biological_processGO:0045892 negative regulation of transcription, DNA-templated IMP
 biological_processGO:0045893 positive regulation of transcription, DNA-templated ISO
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II ISO
 biological_processGO:0050872 white fat cell differentiation IMP
 biological_processGO:0060612 adipose tissue development IMP
 biological_processGO:0060613 fat pad development IMP
 biological_processGO:0090207 regulation of triglyceride metabolic process IMP
 biological_processGO:0090263 positive regulation of canonical Wnt signaling pathway ISO
 cellular_componentGO:0000118 histone deacetylase complex ISO
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005876 spindle microtubule ISO
 cellular_componentGO:0017053 transcriptional repressor complex ISO
 molecular_functionGO:0003677 DNA binding IDA
 molecular_functionGO:0003714 transcription corepressor activity ISO
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0008013 beta-catenin binding ISO
 molecular_functionGO:0042393 histone binding ISO
 molecular_functionGO:0044212 transcription regulatory region DNA binding IDA
 molecular_functionGO:0047485 protein N-terminus binding ISO


Pathways (from Reactome)
Pathway description
HDACs deacetylate histones
Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001260 increased body weight "greater than normal average weight " [J:33400]
Show

Allelic Composition: Dnah11b2b2349Clo/Dnah11b2b2349Clo
Genetic Background: C57BL/6J-Dnah11b2b2349Clo

 MP:0002970 abnormal white fat morphology "structural aberration in the connective tissue consisting of fat-storing cells and arranged in lobular groups or along minor blood vessels" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Dnah11b2b2349Clo/Dnah11b2b2349Clo
Genetic Background: C57BL/6J-Dnah11b2b2349Clo

 MP:0005293 impaired glucose tolerance "less than the normal response to oral consumption or intravenous injection of specified amounts of glucose and indicative of insulin resistance; measured by determining whole blood or plasma sugar level in a fasting state before and after taking glucose at specified intervals" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Dnah11b2b2349Clo/Dnah11b2b2349Clo
Genetic Background: C57BL/6J-Dnah11b2b2349Clo

 MP:0005317 increased triglyceride level "higher than normal concentration of triacylglycerols " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Dnah11b2b2349Clo/Dnah11b2b2349Clo
Genetic Background: C57BL/6J-Dnah11b2b2349Clo

 MP:0005331 insulin resistance "diminished effectiveness of insulin in lowering plasma glucose levels" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:84260, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Dnah11b2b2349Clo/Dnah11b2b2349Clo
Genetic Background: C57BL/6J-Dnah11b2b2349Clo

 MP:0005658 susceptibility to diet-induced obesity "more likely to become excessively fat or to increase fat in the subcutaneous connective tissue as a result of consuming a diet geared to increase body fat " [cwg:Carroll-Ann W. Goldsmith, Mouse Genome Informatics curator]
Show

Allelic Composition: Dnah11b2b2349Clo/Dnah11b2b2349Clo
Genetic Background: C57BL/6J-Dnah11b2b2349Clo

 MP:0005666 abnormal adipose tissue physiology "functional anomaly of the connective tissue composed of fat cells enmeshed in areolar tissue" [cwg:Carroll-Ann W. Goldsmith, Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings, 2003]
Show

Allelic Composition: Dnah11b2b2349Clo/Dnah11b2b2349Clo
Genetic Background: C57BL/6J-Dnah11b2b2349Clo

 MP:0005669 increased circulating leptin level "greater than the normal blood concentration of the peptide hormone secreted by white adipocytes and believed to regulate food intake and energy balance" [MeSH:National Library of Medicine - Medical Subject Headings, 2003, J:34751]
Show

Allelic Composition: Dnah11b2b2349Clo/Dnah11b2b2349Clo
Genetic Background: C57BL/6J-Dnah11b2b2349Clo

 MP:0008033 impaired lipolysis "reduction in the rate of the hydrolysis of fat into free fatty acids " [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Dnah11b2b2349Clo/Dnah11b2b2349Clo
Genetic Background: C57BL/6J-Dnah11b2b2349Clo

 MP:0009118 increased white fat cell size "increase in the size of fat cells with light coloration and few mitochondria" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Dnah11b2b2349Clo/Dnah11b2b2349Clo
Genetic Background: C57BL/6J-Dnah11b2b2349Clo

 MP:0009130 increased white fat cell number "increase in the number of fat cells with light coloration and few mitochondria" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Dnah11b2b2349Clo/Dnah11b2b2349Clo
Genetic Background: C57BL/6J-Dnah11b2b2349Clo

 MP:0009286 increased abdominal fat pad weight "greater than average weight of the encapsulated adipose tissue in the abdomen" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Dnah11b2b2349Clo/Dnah11b2b2349Clo
Genetic Background: C57BL/6J-Dnah11b2b2349Clo

 MP:0009292 increased inguinal fat pad weight 
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Allelic Composition: Dnah11b2b2349Clo/Dnah11b2b2349Clo
Genetic Background: C57BL/6J-Dnah11b2b2349Clo

 MP:0009355 increased liver triglyceride level "higher than normal concentration of triacylglycerols in the liver" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Dnah11b2b2349Clo/Dnah11b2b2349Clo
Genetic Background: C57BL/6J-Dnah11b2b2349Clo

 MP:0010024 increased total body fat amount "greater than the normal total amount of connective tissue composed of fat cells within the entire body" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Dnah11b2b2349Clo/Dnah11b2b2349Clo
Genetic Background: C57BL/6J-Dnah11b2b2349Clo

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000022383 Ppara / P23204 / peroxisome proliferator activated receptor alpha / Q07869*  / reaction / complex
 ENSMUSG00000015846 Rxra / P28700 / retinoid X receptor alpha / P19793*  / reaction / complex
 ENSMUSG00000054422 Fabp1 / P12710 / Fatty acid-binding protein, liver / P07148* / fatty acid binding protein 1*  / reaction
 ENSMUSG00000025246 Tbl1x / Q9QXE7 / F-box-like/WD repeat-containing protein TBL1X / TBL1Y* / Q9BQ87* / O60907* / transducin beta like 1 X-linked* / transducin beta like 1 Y-linked*  / reaction / complex






 

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