Manteia

ID	Phenotype	Definition	Genetic BG
MP:0000031	abnormal cochlea morphology	"any anomaly, deformity, malformation, impairment or dysfunction of the cochlea" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, cml:Cathleen M. Lutz , Mouse Genome Informatics Curator, J:21484]	Show Allelic Composition: Sp4^tm1Krc/Sp4^tm1Krc Genetic Background: involves: 129S4/SvJae * Black Swiss Allelic Composition: Thrb^tm4Few/Thrb^tm4Few Genetic Background: involves: 129 * C57BL/6 Allelic Composition: Thrb^tm1.1Syc/Thrb^tm1.1Syc Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * NIH Black Swiss
MP:0000042	abnormal organ of Corti	"abnormalities associated with the highly specialized epithelium in the floor of the ductus cochlearis; also referred to a spiral organ (organum spirale), or acoustic papilla" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Tsta3^tm1Jbl/Tsta3⁺ Genetic Background: involves: 129S2/SvPas * C57BL/6J Allelic Composition: Thra^tm1Ven/Thra^tm1Ven,Thrb^tm1Df/Thrb^tm1Df Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * BALB/c * C57BL/6J Allelic Composition: Thrb^tm1.1Syc/Thrb^tm1.1Syc Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * NIH Black Swiss
MP:0000043	organ of Corti degeneration	"a retrogressive impairment of function or destruction of the highly specialized epithelium in the floor of the ductus cochlearis" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Thrb^tm1.1Syc/Thrb^tm1.1Syc Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * NIH Black Swiss
MP:0000066	osteoporosis	"reduction in bone mass or atrophy of skeletal tissue; may lead to skeletal fragility" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:57315]	Show Allelic Composition: Thrb^tm1Olc/Thrb^tm1Olc Genetic Background: involves: 129/Sv
MP:0000081	premature suture closure	"early fusion of the bones of the skull" [J:26513]	Show Allelic Composition: Thrb^tm1.1Syc/Thrb^tm1.1Syc Genetic Background: involves: 129S6/SvEvTac * FVB/N * NIH Black Swiss Allelic Composition: Thrb^tm1.1Syc/Thrb^tm1.1Syc Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * NIH Black Swiss
MP:0000130	abnormal cancellous bone morphology	"structural anomaly of bone that has a latticelike or spongy structure" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Cacna2d2^du/Cacna2d2^du Genetic Background: TKDU
MP:0000135	reduced cortical bone thickness	"thinner than normal superficial layer of compact bone " [J:61509]	Show Allelic Composition: Thrb^tm1Olc/Thrb^tm1Olc Genetic Background: involves: 129/Sv
MP:0000165	abnormal hypertrophic chondrocyte zone	"anomaly of the cartilage cell matrix layer " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:58795]	Show Allelic Composition: Thrb^tm1.1Syc/Thrb^tm1.1Syc Genetic Background: involves: 129S6/SvEvTac * FVB/N * NIH Black Swiss
MP:0000438	abnormal skull morphology	"anomalous structure or development of the cranium" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Suprmam1^BALB/cMed/Suprmam1^BALB/cMed,Trp53^tm1Tyj/Trp53⁺ Genetic Background: involves: 129S2/SvPas * BALB/cMed * C57BL/6 * C57BL/6J
MP:0000478	delayed intestine development	"slowed progression to a structurally mature intestine" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Thra^tm1Jas/Thra^tm1Jas,Thrb^tm1Olc/Thrb^tm1Olc Genetic Background: involves: 129/Sv * 129S1/Sv * 129X1/SvJ
MP:0000496	abnormal small intestine morphology	"structural or developmental anomalies of the intestinum tenue " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Thra^tm1Jas/Thra^tm1Jas,Thrb^tm1Olc/Thrb^tm1Olc Genetic Background: involves: 129/Sv * 129S1/Sv * 129X1/SvJ
MP:0000547	short limbs	"reduced average length of the extremities" [MGI:CLS, J:61509]	Show Allelic Composition: Thrb^tm1Olc/Thrb^tm1Olc Genetic Background: involves: 129/Sv
MP:0000592	short tail	"reduced length of tail compared to control " [J:55583]	Show Allelic Composition: Thrb^tm1Olc/Thrb^tm1Olc Genetic Background: involves: 129/Sv
MP:0000636	enlarged pituitary gland	"increased size of pituitary gland" [J:50053]	Show Allelic Composition: Cr2^tm1Hmo/Cr2^tm1Hmo Genetic Background: B6.129S7-Cr2^tm1Hmo
MP:0000745	tremors	"repetitive, cyclical movements of the body or a body part; usually involuntary, but can also manifest in response to an attempt at movement" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]	Show Allelic Composition: Tcf7^{tm1a(EUCOMM)Wtsi}/Tcf7^{tm1a(EUCOMM)Wtsi} Genetic Background: C57BL/6N-Tcf7^{tm1a(EUCOMM)Wtsi}/Ics
MP:0000852	small cerebellum	"reduced size of cerebellum" [MGI:CLS, J:17203, J:67524]	Show Allelic Composition: Cxadr^tm1Dvst/Cxadr^tm1Dvst Genetic Background: involves: 129X1/SvJ * C57BL/6 Allelic Composition: Thrb^tm2Few/Thrb⁺ Genetic Background: involves: 129X1/SvJ * C57BL/6
MP:0000875	abnormal cerebellar Purkinje cell layer	"any malformation or absence of the cell layer that lies just underneath the molecular layer of the cerebellar cortex; it contains the neuronal cell bodies of the Purkinje cells that are arranged side by side in a single layer, and candelabrum interneurons are vertically oriented between the Purkinje cells" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]	Show Allelic Composition: Cxadr^tm1Dvst/Cxadr^tm1Dvst Genetic Background: involves: 129X1/SvJ * C57BL/6 Allelic Composition: Thrb^tm2Few/Thrb⁺ Genetic Background: involves: 129X1/SvJ * C57BL/6
MP:0000877	abnormal Purkinje cell	"any structural anomaly of the neurons located at the interface of the molecular and internal granule layers of the cerebellar cortex; these inhibitory neurons provide the output of the cerebellar cortex through axons that project into the white matter, and extensive dendritic trees from the Purkinje cells extend upward in a single plane into the molecular layer where they synapse with parallel fibers of granule cells" [J:46140, Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]	Show Allelic Composition: Cxadr^tm1Dvst/Cxadr^tm1Dvst Genetic Background: involves: 129X1/SvJ * C57BL/6 Allelic Composition: Thrb^tm2Few/Thrb⁺ Genetic Background: involves: 129X1/SvJ * C57BL/6
MP:0000880	decreased Purkinje cell number	"fewer than normal neuronal cells that are located in the interface of the molecular and granular layers of the cerebellar cortex" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:45302]	Show Allelic Composition: Cxadr^tm1Dvst/Cxadr^tm1Dvst Genetic Background: involves: 129X1/SvJ * C57BL/6 Allelic Composition: Thrb^tm2Few/Thrb⁺ Genetic Background: involves: 129X1/SvJ * C57BL/6
MP:0000890	thin cerebellar molecular layer	"reduced width of the outer of the three cortical layers of the cerebellum" [J:46854]	Show Allelic Composition: Cxadr^tm1Dvst/Cxadr^tm1Dvst Genetic Background: involves: 129X1/SvJ * C57BL/6 Allelic Composition: Thrb^tm2Few/Thrb⁺ Genetic Background: involves: 129X1/SvJ * C57BL/6
MP:0001006	abnormal cone morphology	"structural or developmental anomaly of the retinal receptors that give rise to color vision" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Dnmt1^tm2Enl/Dnmt1^tm2Enl Genetic Background: involves: 129S4/SvJae Allelic Composition: Thrb^tm3Few/Thrb^tm3Few Genetic Background: involves: 129 * C57BL/6 Allelic Composition: Thrb^tm4Few/Thrb^tm4Few Genetic Background: involves: 129 * C57BL/6
MP:0001258	decreased body length	"decreased crown to tail distance compared to controls" [cwg:Carroll W. Goldsmith, Mouse Genome Informatics Curator]	Show Allelic Composition: Thrb^tm1.1Syc/Thrb^tm1.1Syc Genetic Background: involves: 129S6/SvEvTac * FVB/N * NIH Black Swiss
MP:0001262	decreased body weight	"lower than normal average weight " [J:61295]	Show Allelic Composition: Thra^tm2Ven/Thra^tm3Ven Genetic Background: involves: 129P2/OlaHsd * C57BL/6NCrl Allelic Composition: Thra^tm3Ven/Thra⁺,Thrb^tm1Df/Thrb^tm1Df Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * C57BL/6NCrl Allelic Composition: Thra^tm1Ven/Thra^tm1Ven,Thrb^tm1Df/Thrb^tm1Df Genetic Background: B6.129-Thra^tm1Ven Thrb^tm1Df Allelic Composition: Thrb^tm6.1Few/Thrb^tm6.1Few Genetic Background: involves: 129 * C57BL/6 Allelic Composition: Thrb^tm6.1Few/Thrb⁺ Genetic Background: involves: 129 * C57BL/6 Allelic Composition: Thrb^tm1Olc/Thrb^tm1Olc Genetic Background: involves: 129/Sv Allelic Composition: Thra^tm1Jas/Thra^tm1Jas,Thrb^tm1Olc/Thrb^tm1Olc Genetic Background: involves: 129/Sv * 129S1/Sv * 129X1/SvJ
MP:0001265	reduced body size	"smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]	Show Allelic Composition: Ddb1^tm1Spg/Ddb1^tm1Spg,Trp53^tm1Tyj/Trp53^tm1Tyj,Tg(Nes-cre)1Kln/0 Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6 * SJL Allelic Composition: Thrb^tm1.1Syc/Thrb^tm1.1Syc Genetic Background: involves: 129S6/SvEvTac * FVB/N * NIH Black Swiss
MP:0001399	hyperactivity	"general restlessness or excessive movement; more frequent movement from one place to another" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409, J:57125]	Show Allelic Composition: Fcer1g^tm1Tks/Fcer1g^tm1Tks Genetic Background: involves: C57BL/6J
MP:0001463	abnormal spatial learning	"defects in the abilibity to navigate using behavioraly meaningful locations" [CFG:Center for Functional Genomics , Northwestern University]	Show Allelic Composition: Cxadr^tm1Dvst/Cxadr^tm1Dvst Genetic Background: involves: 129X1/SvJ * C57BL/6 Allelic Composition: Thrb^tm2Few/Thrb⁺ Genetic Background: involves: 129X1/SvJ * C57BL/6
MP:0001473	reduced long term potentiation	"less than the normal persistent robust synaptic response induced by synchronous stimulation of pre- and postsynaptic cells " [Principles of Neural Science:ISBN 0-8385-8034-3]	Show Allelic Composition: Mir34a^tm1.2Arte/Mir34a^tm1.2Arte,Tg(Neurod2-SmoA1)199Jols/0 Genetic Background:* involves: C57BL/6 * C57BL/6N
MP:0001496	audiogenic seizures	"a reflex seizure triggered by loud noises" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Sh3bp2^tm1Bjro/Sh3bp2^tm1Bjro,Tnf^tm1Gkl/Tnf^tm1Gkl Genetic Background: involves: 129S/SvEv * 129S4/SvJae * BALB/cJ * C57BL/6J
MP:0001541	abnormal osteoclast function	"reduced ability or inability of osteoclasts to absorb and remove osseous tissue" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:58795]	Show Allelic Composition: Thrb^tm1Olc/Thrb^tm1Olc Genetic Background: involves: 129/Sv
MP:0001731	abnormal postnatal growth	"anomaly in reaching a developmental stage or stages after birth" [il:Ira Lu, Mouse Genome Informatics Curator]	Show Allelic Composition: Thra^tm3Ven/Thra⁺,Thrb^tm1Df/Thrb⁺ Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * C57BL/6NCrl
MP:0001732	postnatal growth retardation	"slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Thra^tm2Ven/Thra^tm2Ven,Thrb^tm1Df/Thrb^tm1Df Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6J Allelic Composition: Thra^tm2Ven/Thra⁺,Thrb^tm1Df/Thrb^tm1Df Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6J Allelic Composition: Thrb^tm1.1Syc/Thrb^tm1.1Syc Genetic Background: involves: 129S6/SvEvTac * FVB/N * NIH Black Swiss Allelic Composition: Thra^tm1Jas/Thra^tm1Jas,Thrb^tm1Olc/Thrb^tm1Olc Genetic Background: involves: 129/Sv * 129S1/Sv * 129X1/SvJ Allelic Composition: Thra^tm1Jas/Thra⁺,Thrb^tm1Olc/Thrb^tm1Olc Genetic Background: involves: 129/Sv * 129S1/Sv * 129X1/SvJ
MP:0001900	impaired synaptic plasticity	"decreased or inability of the nervous system to change its reactivity as a result of successive activations " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Mir34a^tm1.2Arte/Mir34a^tm1.2Arte,Tg(Neurod2-SmoA1)199Jols/0 Genetic Background:* involves: C57BL/6 * C57BL/6N
MP:0001926	female infertility	"inability of female to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:34193]	Show Allelic Composition: Thra^tm1Ven/Thra^tm1Ven,Thrb^tm1Df/Thrb^tm1Df Genetic Background: B6.129-Thra^tm1Ven Thrb^tm1Df Allelic Composition: Thra^tm1Ven/Thra^tm1Ven,Thrb^tm1Df/Thrb^tm1Df Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * BALB/c * C57BL/6J
MP:0001954	respiratory distress	"physical difficulty or inability to breathe" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:54931]	Show Allelic Composition: Thra^tm1Ven/Thra^tm1Ven,Thrb^tm1Df/Thrb^tm1Df Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6
MP:0001967	deafness	"inability to hear" [J:57651]	Show Allelic Composition: Tsta3^tm1Jbl/Tsta3⁺ Genetic Background: involves: 129S2/SvPas * C57BL/6J Allelic Composition: Thrb^tm1Df/Thrb^tm1Df Genetic Background: either: B6.129S1-Thrb^tm1Df or (involves: 129S1/Sv * C57BL/6J)
MP:0002041	pituitary adenoma	"appearance of benign neoplasms of the pituitary" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:33042]	Show Allelic Composition: Cr2^tm1Hmo/Cr2^tm1Hmo Genetic Background: B6.129S7-Cr2^tm1Hmo
MP:0002083	premature death	"death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Thra^tm1Ven/Thra^tm1Ven,Thrb^tm1Df/Thrb^tm1Df Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6 Allelic Composition: Thrb^tm1.1Syc/Thrb^tm1.1Syc Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * C57BL/6 * C57BL/6J Allelic Composition: Thra^tm1Jas/Thra^tm1Jas,Thrb^tm1Olc/Thrb^tm1Olc Genetic Background: involves: 129/Sv * 129S1/Sv * 129X1/SvJ
MP:0002109	abnormal limb morphology	"abnormal development of limbs resulting in morphological abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Suprmam1^BALB/cMed/Suprmam1^BALB/cMed,Trp53^tm1Tyj/Trp53⁺ Genetic Background: involves: 129S2/SvPas * BALB/cMed * C57BL/6 * C57BL/6J
MP:0002113	abnormal skeleton development	"anomalous differentiation or remodeling of bone tissue resulting in morphological abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Thrb^tm1.1Syc/Thrb^tm1.1Syc Genetic Background: involves: 129S6/SvEvTac * FVB/N * NIH Black Swiss Allelic Composition: Thra^tm1Jas/Thra^tm1Jas,Thrb^tm1Olc/Thrb^tm1Olc Genetic Background: involves: 129/Sv * 129S1/Sv * 129X1/SvJ
MP:0002626	increased heart rate	"greater than average resting heart beats per minute" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]	Show Allelic Composition: Thrb^tm1Olc/Thrb^tm1Olc Genetic Background: involves: 129/Sv
MP:0002674	abnormal sperm motility	"anomalies in the mobility of the spermatozoa" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]	Show Allelic Composition: Thra^tm1Ven/Thra^tm1Ven,Thrb^tm1Df/Thrb^tm1Df Genetic Background: B6.129-Thra^tm1Ven Thrb^tm1Df
MP:0002757	reduced vertical activity	"lesser than average time spent jumping or rearing" [J:82829, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]	Show Allelic Composition: Fcer1g^tm1Tks/Fcer1g^tm1Tks Genetic Background: involves: C57BL/6J
MP:0002764	short tibia	" reduced length of the medial and larger bone of the lower leg" [J:12736, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]	Show Allelic Composition: Thrb^tm1.1Syc/Thrb^tm1.1Syc Genetic Background: involves: 129S6/SvEvTac * FVB/N * NIH Black Swiss Allelic Composition: Thrb^tm1.1Syc/Thrb⁺ Genetic Background: involves: 129S6/SvEvTac * FVB/N * NIH Black Swiss Allelic Composition: Thrb^tm1.1Syc/Thrb^tm1.1Syc Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * NIH Black Swiss Allelic Composition: Thrb^tm1Olc/Thrb^tm1Olc Genetic Background: involves: 129/Sv
MP:0002874	decreased hemoglobin content	"decrease in the total hemoglobin content in the circulating blood" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Tcf7^{tm1a(EUCOMM)Wtsi}/Tcf7^{tm1a(EUCOMM)Wtsi} Genetic Background: C57BL/6N-Tcf7^{tm1a(EUCOMM)Wtsi}/Ics
MP:0002876	abnormal thyroid physiology	"anomalous function of this endocrine gland that normally produces hormones that regulate the metabolic rate of the body " [MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Thrb^tm1Few/Thrb^tm1Few Genetic Background: involves: 129S4/SvJae
MP:0002896	abnormal bone mineralization	"defect in the process by which minerals are deposited into bone" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Thrb^tm1.1Syc/Thrb^tm1.1Syc Genetic Background: involves: 129S6/SvEvTac * FVB/N * NIH Black Swiss Allelic Composition: Thrb^tm1Olc/Thrb^tm1Olc Genetic Background: involves: 129/Sv
MP:0003055	abnormal epiphyseal plate morphology	"malformed or absent cartilagenous center of ossification on the long bones permitting growth of the bone in both directions during development" [MeSH:National Library of Medicine - Medical Subject Headings, 2003]	Show Allelic Composition: Thrb^tm1Olc/Thrb^tm1Olc Genetic Background: involves: 129/Sv Allelic Composition: Thra^tm1Jas/Thra^tm1Jas,Thrb^tm1Olc/Thrb^tm1Olc Genetic Background: involves: 129/Sv * 129S1/Sv * 129X1/SvJ
MP:0003109	short femur	"reduced length of the long bone of the thigh" [ava:Anna V. Anagnostopoulos, Mouse Genome Informatics Curator, Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]	Show Allelic Composition: Thrb^tm1.1Syc/Thrb^tm1.1Syc Genetic Background: involves: 129S6/SvEvTac * FVB/N * NIH Black Swiss Allelic Composition: Thrb^tm1.1Syc/Thrb⁺ Genetic Background: involves: 129S6/SvEvTac * FVB/N * NIH Black Swiss
MP:0003149	abnormal tectorial membrane morphology	"malformation, malfunction or absence of the overlaying membrane of cochlear duct, an extracellular matrix of the inner ear that contacts the stereocilia bundles of specialized sensory hair cells; sound induces movement of these hair cells relative to the tectorial membrane, deflects the stereocilia, and leads to fluctuations in hair cell membrane potential, transducing sound into electrical signals" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, J:77634]	Show Allelic Composition: Thrb^tm4Few/Thrb^tm4Few Genetic Background: involves: 129 * C57BL/6 Allelic Composition: Thra^tm1Ven/Thra^tm1Ven,Thrb^tm1Df/Thrb^tm1Df Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * BALB/c * C57BL/6J Allelic Composition: Thrb^tm1.1Syc/Thrb^tm1.1Syc Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * NIH Black Swiss
MP:0003150	detached tectorial membrane	"tectorial membrane is abnormally detached from the cochlear epithelium or spiral limbus" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, J:77634]	Show Allelic Composition: Thrb^tm1.1Syc/Thrb^tm1.1Syc Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * NIH Black Swiss
MP:0003350	increased circulating levels of thyroid hormone		Show Allelic Composition: Thrb^tm1Mkni/Thrb^tm1Mkni,Hprt^{tm1(TG-cre)1Sasr}/Y Genetic Background: involves: 129/Sv * C57BL/6
MP:0003417	premature endochondral bone ossification	"early onset of bone formation in bones that form from cartilage" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:94631]	Show Allelic Composition: Thrb^tm1.1Syc/Thrb^tm1.1Syc Genetic Background: involves: 129S6/SvEvTac * FVB/N * NIH Black Swiss Allelic Composition: Thrb^tm1.1Syc/Thrb^tm1.1Syc Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * NIH Black Swiss Allelic Composition: Thrb^tm1Olc/Thrb^tm1Olc Genetic Background: involves: 129/Sv
MP:0003418	premature intramembranous bone ossification	"early onset of bone formation in bones that form without a cartilagenous intermediate including the cranium and clavicle" [smb:Susan M Bello, Mouse Genome Informatics Curator]	Show Allelic Composition: Thrb^tm1.1Syc/Thrb^tm1.1Syc Genetic Background: involves: 129S6/SvEvTac * FVB/N * NIH Black Swiss Allelic Composition: Thrb^tm1.1Syc/Thrb^tm1.1Syc Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * NIH Black Swiss
MP:0003442	decreased circulating glycerol level	"lower than normal concentration of glycerol in the blood" [smb:Susan M Bello, Mouse Genome Informatics Curator]	Show Allelic Composition: Tcf7^{tm1a(EUCOMM)Wtsi}/Tcf7^{tm1a(EUCOMM)Wtsi} Genetic Background: C57BL/6N-Tcf7^{tm1a(EUCOMM)Wtsi}/Ics
MP:0003498	thyroid hyperplasia		Show Allelic Composition: Thrb^tm1Df/Thrb^tm1Df Genetic Background: involves: 129S1/Sv * C57BL/6J Allelic Composition: Thrb^tm1.1Syc/Thrb^tm1.1Syc Genetic Background: involves: 129S6/SvEvTac * FVB/N * NIH Black Swiss Allelic Composition: Thrb^tm1Olc/Thrb^tm1Olc Genetic Background: involves: 129/Sv Allelic Composition: Thra^tm1Jas/Thra^tm1Jas,Thrb^tm1Olc/Thrb^tm1Olc Genetic Background: involves: 129/Sv * 129S1/Sv * 129X1/SvJ
MP:0003502	increased activity of thyroid		Show Allelic Composition: Thrb^tm1Df/Thrb^tm1Df Genetic Background: involves: 129S1/Sv * C57BL/6J Allelic Composition: Thrb^tm3Few/Thrb^tm3Few Genetic Background: involves: 129 * C57BL/6 Allelic Composition: Thrb^tm1Olc/Thrb^tm1Olc Genetic Background: involves: 129/Sv
MP:0003638	abnormal response/metabolism to endogenous compounds	"altered ability or inability to metabolize or respond to substances normally present in the body" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Oca2^p-un+J/Oca2^p-un+J Genetic Background: C57BL/6J-Oca2^p-un Allelic Composition: Thrb^tm1Olc/Thrb^tm1Olc Genetic Background: involves: 129/Sv Allelic Composition: Ncoa1^tm1Bwo/Ncoa1^tm1Bwo,Thrb^tm1Olc/Thrb^tm1Olc Genetic Background: B6.129-Ncoa1^tm1Bwo Thrb^tm1Olc Allelic Composition: Thrb^tm3.1Df/Thrb^tm3.1Df Genetic Background: B6J.Cg-Thrb^tm3.1Df
MP:0003662	abnormal proliferative zone	"germinal layer of the epiphyseal plate where cells are actively dividing as well as producing extracellular matrix" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:96254]	Show Allelic Composition: Thrb^tm1.1Syc/Thrb^tm1.1Syc Genetic Background: involves: 129S6/SvEvTac * FVB/N * NIH Black Swiss
MP:0003795	abnormal bone structure		Show Allelic Composition: Thrb^tm1Olc/Thrb^tm1Olc Genetic Background: involves: 129/Sv
MP:0003825	abnormal pillar cell morphology	"abnormalities of the supporting cells that form the inner and outer walls of the tunnel in the organ of Corti " [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]	Show Allelic Composition: Thrb^tm3Few/Thrb^tm3Few Genetic Background: involves: 129 * C57BL/6 Allelic Composition: Thrb^tm4Few/Thrb^tm4Few Genetic Background: involves: 129 * C57BL/6 Allelic Composition: Thra^tm1Ven/Thra^tm1Ven,Thrb^tm1Df/Thrb^tm1Df Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * BALB/c * C57BL/6J
MP:0003965	abnormal pituitary hormone level	"aberration in the blood or tissue concentration of any of the hormones secreted by the pituitary" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Thra^tm1Ven/Thra^tm1Ven,Thrb^tm1Df/Thrb^tm1Df Genetic Background: B6.129-Thra^tm1Ven Thrb^tm1Df Allelic Composition: Thrb^tm1.1Syc/Thrb^tm1.1Syc Genetic Background: involves: 129S6/SvEvTac * 129X1/SvJ * C57BL/6
MP:0004022	abnormal cone electrophysiology	"anomaly in the function of light adapted vision mediated by the cones" [smb:Susan M Bello, Mouse Genome Informatics Curator]	Show Allelic Composition: Dnmt1^tm2Enl/Dnmt1^tm2Enl Genetic Background: involves: 129S4/SvJae
MP:0004148	increased cortical bone thickness	"thicker than normal superficial layer of compact bone" [brs:Beverly Richards-Smith, Mouse Genome Informatics Curator]	Show Allelic Composition: Thrb^tm1Olc/Thrb^tm1Olc Genetic Background: involves: 129/Sv
MP:0004197	abnormal fetal growth/weight/body size	"limited or accelerated growth or development apparent during the fetal period (sensu Mus: from E14 through birth)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Thrb^tm1.1Syc/Thrb^tm1.1Syc Genetic Background: involves: 129S6/SvEvTac * FVB/N * NIH Black Swiss
MP:0004362	cochlear hair cell degeneration	"degeneration or loss of the sensory epithelial cells of the cochlea; these cells are in synaptic contact with the auditory nerve" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Thrb^tm1.1Syc/Thrb^tm1.1Syc Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * NIH Black Swiss
MP:0004402	decreased cochlear outer hair cell number	"decreased number (or less than the expected 3 rows) of the columnar outer hair sensory cells of the organ of Corti" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]	Show Allelic Composition: Thrb^tm4Few/Thrb^tm4Few Genetic Background: involves: 129 * C57BL/6
MP:0004404	cochlear outer hair cell degeneration	"degeneration or loss of the columnar outer hair sensory cells of the organ of Corti" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]	Show Allelic Composition: Thrb^tm3Few/Thrb^tm3Few Genetic Background: involves: 129 * C57BL/6
MP:0004411	decreased endocochlear potential	"reduction of the electrical potential difference between the endolymphatic and perilymphatic compartments of the cochlea" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]	Show Allelic Composition: Thra^tm1Ven/Thra^tm1Ven,Thrb^tm1Df/Thrb^tm1Df Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * BALB/c * C57BL/6J
MP:0004414	decreased cochlear microphonics	"reduction of the bioelectric potentials produced by the hair cells of the organ of Corti in response to sound" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]	Show Allelic Composition: Thrb^tm1Df/Thrb^tm1Mkni,Tg(Pres-cre)1Jnz/0 Genetic Background: involves: 129S1/Sv * C57BL/6J * FVB/NJ
MP:0004415	abnormal cochlear nerve compound action potential	"anomaly in the combined potentials resulting from activation of the auditory division of the eighth cranial nerve; these potentials represent the summed activity of multiple cochlear afferent fibers discharging synchronously and thus assess the combined functional state of OHCs, IHCs, and their primary afferent innervation" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]	Show Allelic Composition: Thrb^tm1Df/Thrb^tm1Mkni,Tg(Pres-cre)1Jnz/0 Genetic Background: involves: 129S1/Sv * C57BL/6J * FVB/NJ
MP:0004433	abnormal cochlear inner hair cell physiology	"anomalies in processes pertinent to the function of cochlear IHCs which constitute the true sensory cell type sending impulses via the cochlear (auditory) nerve" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]	Show Allelic Composition: Thrb^tm1Df/Thrb^tm1Df Genetic Background: involves: 129S1/Sv * C57BL/6J Allelic Composition: Thra^tm1Ven/Thra^tm1Ven,Thrb^tm1Df/Thrb^tm1Df Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * BALB/c * C57BL/6J Allelic Composition: Thrb^tm1Df/Thrb^tm1Df Genetic Background: B6J.129S1-Thrb^tm1Df Allelic Composition: Thrb^tm1Df/Thrb^tm1Mkni,Tg(Pres-cre)1Jnz/0 Genetic Background: involves: 129S1/Sv * C57BL/6J * FVB/NJ
MP:0004434	abnormal cochlear outer hair cell physiology	"anomalies in processes pertinent to the function of cochlear OHCs which are known to enhance the performance of the cochlea, both qualitatively (increased selectivity) and quantitatively (increased sensitivity); in addition to the mechanoelectric transduction required for auditory sensation, OHCs also perform electromechanical transduction, whereby transmembrane voltage drives rapid changes in the length and stiffness of OHCs at audio frequencies in vitro (electromotility)" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]	Show Allelic Composition: Thrb^tm1Df/Thrb^tm1Df Genetic Background: involves: 129S1/Sv * C57BL/6J Allelic Composition: Thra^tm1Ven/Thra^tm1Ven,Thrb^tm1Df/Thrb^tm1Df Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * BALB/c * C57BL/6J
MP:0004437	decreased cochlear outer hair cell electromotility	"reduced motility of the cochlear OHCs in response to electrical stimulation" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]	Show Allelic Composition: Thrb^tm1Df/Thrb^tm1Df Genetic Background: involves: 129S1/Sv * C57BL/6J Allelic Composition: Thra^tm1Ven/Thra^tm1Ven,Thrb^tm1Df/Thrb^tm1Df Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * BALB/c * C57BL/6J
MP:0004465	degeneration of supporting cells	"degeneration or loss of the highly differentiated epithelial cells with distinctive morphological features that surround all hair cells in the organ of Corti" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]	Show Allelic Composition: Thrb^tm4Few/Thrb^tm4Few Genetic Background: involves: 129 * C57BL/6
MP:0004466	short cochlear outer hair cells		Show Allelic Composition: Thrb^tm1Df/Thrb^tm1Df Genetic Background: involves: 129S1/Sv * C57BL/6J
MP:0004591	enlarged tectorial membrane	"increased size of the overlaying membrane of cochlear duct, an extracellular matrix of the inner ear that contacts the stereocilia bundles of specialized sensory hair cells" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]	Show Allelic Composition: Thrb^tm1Df/Thrb^tm1Df Genetic Background: involves: 129S1/Sv * C57BL/6J Allelic Composition: Thrb^tm3Few/Thrb^tm3Few Genetic Background: involves: 129 * C57BL/6 Allelic Composition: Thrb^tm4Few/Thrb^tm4Few Genetic Background: involves: 129 * C57BL/6 Allelic Composition: Thra^tm1Ven/Thra^tm1Ven,Thrb^tm1Df/Thrb^tm1Df Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * BALB/c * C57BL/6J Allelic Composition: Thrb^tm1.1Syc/Thrb^tm1.1Syc Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * NIH Black Swiss Allelic Composition: Thrb^tm1Df/Thrb^tm1Df Genetic Background: involves: 129S1/Sv * C57BL/6J * FVB/NJ
MP:0004664	delayed inner ear development	"slowed progression to structurally mature components of the labyrinth, including the semicircular canals, vestibule and cochlea" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]	Show Allelic Composition: Thrb^tm1Df/Thrb^tm1Df Genetic Background: involves: 129S1/Sv * C57BL/6J Allelic Composition: Thra^tm1Ven/Thra^tm1Ven,Thrb^tm1Df/Thrb^tm1Df Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * BALB/c * C57BL/6J
MP:0004696	abnormal thyroid follicle morphology	"any structural abnormality of the small spherical vesicular components of the thyroid gland that are lined with epithelium and contain a colloid substance that both serves as a reservoir of materials for thyroid hormone production and stores thyroid hormones" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]	Show Allelic Composition: Thrb^tm1Df/Thrb^tm1Df Genetic Background: involves: 129S1/Sv * C57BL/6J Allelic Composition: Thra^tm2Ven/Thra^tm2Ven,Thrb^tm1Df/Thrb^tm1Df Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6J Allelic Composition: Thrb^tm1.1Syc/Thrb⁺ Genetic Background: involves: 129S6/SvEvTac * FVB/N * NIH Black Swiss Allelic Composition: Thrb^tm1Olc/Thrb^tm1Olc Genetic Background: involves: 129/Sv Allelic Composition: Thra^tm1Jas/Thra^tm1Jas,Thrb^tm1Olc/Thrb^tm1Olc Genetic Background: involves: 129/Sv * 129S1/Sv * 129X1/SvJ
MP:0004701	decreased circulating insulin-like growth factor I level	"reduced blood concentration of this polypeptide hormone with growth-regulating, insulin-like, and mitogenic activities" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Thrb^tm1Olc/Thrb^tm1Olc Genetic Background: involves: 129/Sv
MP:0004736	abnormal distortion product otoacoustic emission	"any abnormality in the sound produced by the cochlea in response to stimulation with 2 simultaneous tones of different frequencies; this measurement is particularly useful in assessing the functional state of OHCs" [eMedicine:http://www.emedicine.com/ent/topic372.htm, MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Thrb^tm3Few/Thrb^tm3Few Genetic Background: involves: 129 * C57BL/6 Allelic Composition: Thrb^tm4Few/Thrb^tm4Few Genetic Background: involves: 129 * C57BL/6 Allelic Composition: Thrb^tm1Df/Thrb^tm1Df Genetic Background: involves: 129S1/Sv * C57BL/6J * FVB/NJ
MP:0004737	absent distortion product otoacoustic emissions	"failure to create mechanical distortions in the inner ear when two primary tones are presented, indicating failure of outer hair cells to amplify basilar membrane motion" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]	Show Allelic Composition: Thrb^tm4Few/Thrb^tm4Few Genetic Background: involves: 129 * C57BL/6
MP:0004738	abnormal brainstem auditory evoked potential	"anomaly in the electrical activity generated in response to short tone bursts; may be used to evaluate sensorineural hearing function" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]	Show Allelic Composition: Thra^tm1Ven/Thra^tm1Ven,Thrb^tm1Df/Thrb^tm1Df Genetic Background: B6.129-Thra^tm1Ven Thrb^tm1Df
MP:0004740	sensorineural hearing loss	"a form of progressive hearing loss due to a lesion of the auditory division of cranial nerve VIII or the inner ear" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]	Show Allelic Composition: Thrb^tm3Few/Thrb^tm3Few Genetic Background: involves: 129 * C57BL/6 Allelic Composition: Thrb^tm4Few/Thrb^tm4Few Genetic Background: involves: 129 * C57BL/6
MP:0004852	decreased testis weight	"reduced average weight of the male reproductive glands" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Thra^tm1Ven/Thra^tm1Ven,Thrb^tm1Df/Thrb^tm1Df Genetic Background: B6.129-Thra^tm1Ven Thrb^tm1Df
MP:0004864	spiral ligament degeneration	"degeneration or loss of the thickened periosteal lining of the bony cochlea that forms the outer wall of the cochlear duct to which the basal lamina attaches" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]	Show Allelic Composition: Thrb^tm4Few/Thrb^tm4Few Genetic Background: involves: 129 * C57BL/6
MP:0004984	increased osteoclast cell number	"greater than average number of the bone resorpting cells that remove bone tissue by degrading the mineralized matrix" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Thrb^tm1Olc/Thrb^tm1Olc Genetic Background: involves: 129/Sv
MP:0005119	decreased circulating thyroid-stimulating hormone level	"less than expected blood concentration of the hormone that stimulates the growth and function of the thyroid gland" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Ppargc1a^tm2.1Brsp/Ppargc1a^tm2.1Brsp,Tg(Myog-cre)1Eno/0 Genetic Background: involves: 129 * BALB/c * C57BL/6J * C57BL/6N
MP:0005122	increased circulating thyroid-stimulating hormone level	"greater than expected blood concentration of the hormone that stimulates the growth and function of the thyroid gland" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Dnmt1^tm2Enl/Dnmt1^tm2Enl Genetic Background: involves: 129S4/SvJae Allelic Composition: Thrb^tm3Few/Thrb^tm3Few Genetic Background: involves: 129 * C57BL/6 Allelic Composition: Thrb^tm4Few/Thrb^tm4Few Genetic Background: involves: 129 * C57BL/6 Allelic Composition: Thrb^tm1Few/Thrb^tm1Few Genetic Background: involves: 129S4/SvJae Allelic Composition: Thrb^tm2Few/Thrb^tm2Few Genetic Background: involves: 129X1/SvJ * C57BL/6 Allelic Composition: Thrb^tm2Few/Thrb⁺ Genetic Background: involves: 129X1/SvJ * C57BL/6 Allelic Composition: Thrb^tm5Few/Thrb^tm5Few Genetic Background: involves: 129 * C57BL/6 Allelic Composition: Thrb^tm1.1Syc/Thrb^tm1.1Syc Genetic Background: involves: 129S6/SvEvTac * FVB/N * NIH Black Swiss Allelic Composition: Thrb^tm1.1Syc/Thrb⁺ Genetic Background: involves: 129S6/SvEvTac * FVB/N * NIH Black Swiss Allelic Composition: Thrb^tm1.1Syc/Thrb^tm1.1Syc Genetic Background: involves: 129S6/SvEvTac * 129X1/SvJ * C57BL/6 Allelic Composition: Thra^tm1Ven/Thra^tm1Ven,Thrb^tm1Df/Thrb^tm1Df Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6 Allelic Composition: Thrb^tm1Olc/Thrb^tm1Olc Genetic Background: involves: 129/Sv Allelic Composition: Thra^tm1Jas/Thra^tm1Jas,Thrb^tm1Olc/Thrb^tm1Olc Genetic Background: involves: 129/Sv * 129S1/Sv * 129X1/SvJ Allelic Composition: Ncoa1^tm1Bwo/Ncoa1^tm1Bwo,Thrb^tm1Olc/Thrb^tm1Olc Genetic Background: B6.129-Ncoa1^tm1Bwo Thrb^tm1Olc
MP:0005130	decreased follicle stimulating hormone level	"less than expected concentration of the hormone that, in females, stimulates the graafian follicles of the ovary and assists in follicular maturation and the secretion of estradiol; in the male it stimulates the epithelium of the seminiferous tubules and is partly responsible for spermatogenesis " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Thra^tm1Ven/Thra^tm1Ven,Thrb^tm1Df/Thrb^tm1Df Genetic Background: B6.129-Thra^tm1Ven Thrb^tm1Df
MP:0005132	decreased luteinizing hormone level	"lower than normal concentration of LH " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Thra^tm1Ven/Thra^tm1Ven,Thrb^tm1Df/Thrb^tm1Df Genetic Background: B6.129-Thra^tm1Ven Thrb^tm1Df
MP:0005135	increased thyroid-stimulating hormone level	"less than expected concentration of the hormone that stimulates the growth and function of the thyroid gland" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Tsta3^tm1Jbl/Tsta3⁺ Genetic Background: involves: 129S2/SvPas * C57BL/6J Allelic Composition: Thra^tm1Ven/Thra^tm1Ven,Thrb^tm1Df/Thrb^tm1Df Genetic Background: B6.129-Thra^tm1Ven Thrb^tm1Df Allelic Composition: Thrb^tm1Df/Thrb^tm1Df Genetic Background: either: B6.129S1-Thrb^tm1Df or (involves: 129S1/Sv * C57BL/6J)
MP:0005136	decreased growth hormone level	"less than the expected concentration of the hormone that promotes body growth, fat mobilization, and inhibition of glucose utilization" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Thra^tm1Ven/Thra^tm1Ven,Thrb^tm1Df/Thrb^tm1Df Genetic Background: B6.129-Thra^tm1Ven Thrb^tm1Df
MP:0005138	decreased prolactin level	"less than expected concentration of the hormone that stimulates milk secretion " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Thra^tm1Ven/Thra^tm1Ven,Thrb^tm1Df/Thrb^tm1Df Genetic Background: B6.129-Thra^tm1Ven Thrb^tm1Df
MP:0005355	enlarged thyroid gland	"increased size of the endocrine gland located in the front and to the sides of the upper part of the trachea, and which secretes thyroid hormone and calcitonin " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:85158, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]	Show Allelic Composition: Tsta3^tm1Jbl/Tsta3⁺ Genetic Background: involves: 129S2/SvPas * C57BL/6J Allelic Composition: Thrb^tm3Few/Thrb^tm3Few Genetic Background: involves: 129 * C57BL/6 Allelic Composition: Thrb^tm4Few/Thrb^tm4Few Genetic Background: involves: 129 * C57BL/6 Allelic Composition: Thrb^tm1.1Syc/Thrb^tm1.1Syc Genetic Background: involves: 129S6/SvEvTac * FVB/N * NIH Black Swiss Allelic Composition: Thrb^tm1.1Syc/Thrb⁺ Genetic Background: involves: 129S6/SvEvTac * FVB/N * NIH Black Swiss Allelic Composition: Thrb^tm1Df/Thrb^tm1.1Syc Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * C57BL/6 * C57BL/6J
MP:0005361	small pituitary gland	"reduced size of the pituitary gland, the compound gland suspended from the base of the hypothalamus, which secretes somatotropins, prolactin, TSH (thyroid-stimulating hormone), gonadotropins, adrenal corticotropin" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Thra^tm1Ven/Thra^tm1Ven,Thrb^tm1Df/Thrb^tm1Df Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6
MP:0005418	abnormal circulating hormone level	"anomalous blood concentration of any of the chemical substances that have specific regulatory effects on the activity of a certain organ or organs; originally applied to substances secreted by various endocrine glands and transported in the bloodstream to the target organs, it is sometimes extended to include substances that are not produced by the endocrine glands but that have similar effects" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Thrb^tm1.1Syc/Thrb^tm1.1Syc Genetic Background: involves: 129S6/SvEvTac * FVB/N * NIH Black Swiss
MP:0005468	abnormal thyroid hormone level	"aberrant concentration of any of the hormones secreted by the thryoid gland" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, J:13923, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Thra^tm2Ven/Thra^tm2Ven,Thrb^tm1Df/Thrb^tm1Df Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6J Allelic Composition: Thrb^tm1.1Syc/Thrb^tm1.1Syc Genetic Background: involves: 129S6/SvEvTac * 129X1/SvJ * C57BL/6 Allelic Composition: Thrb^tm1Mkni/Thrb^tm1Mkni,Hprt^{tm1(TG-cre)1Sasr}/Y Genetic Background: involves: 129/Sv * C57BL/6
MP:0005470	increased thyroxine level	"greater than the normal concentration of the major hormone dervied from the thryoid gland; it normally affects cellular metabolism" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Thrb^tm1Few/Thrb^tm1Few Genetic Background: involves: 129S4/SvJae Allelic Composition: Thrb^tm2Few/Thrb^tm2Few Genetic Background: involves: 129X1/SvJ * C57BL/6 Allelic Composition: Thrb^tm2Few/Thrb⁺ Genetic Background: involves: 129X1/SvJ * C57BL/6 Allelic Composition: Thrb^tm1Mkni/Thrb^tm1Mkni,Hprt^{tm1(TG-cre)1Sasr}/Y Genetic Background: involves: 129/Sv * C57BL/6
MP:0005474	increased triiodothyronine level	"greater than the normal concentration of this hormone synthesized and secreted by the thyroid; normally, this is the main thyroid hormone used by the tissues " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Thrb^tm1Few/Thrb^tm1Few Genetic Background: involves: 129S4/SvJae Allelic Composition: Thrb^tm2Few/Thrb^tm2Few Genetic Background: involves: 129X1/SvJ * C57BL/6 Allelic Composition: Thrb^tm2Few/Thrb⁺ Genetic Background: involves: 129X1/SvJ * C57BL/6 Allelic Composition: Thra^tm1Jas/Thra^tm1Jas,Thrb^tm1Olc/Thrb^tm1Olc Genetic Background: involves: 129/Sv * 129S1/Sv * 129X1/SvJ
MP:0005477	increased circulating thyroxine level	"greater than the normal blood concentration of the major hormone dervied from the thryoid gland; it normally affects cellular metabolism" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Tsta3^tm1Jbl/Tsta3⁺ Genetic Background: involves: 129S2/SvPas * C57BL/6J Allelic Composition: Thrb^tm3Few/Thrb^tm3Few Genetic Background: involves: 129 * C57BL/6 Allelic Composition: Thrb^tm5Few/Thrb^tm5Few Genetic Background: involves: 129 * C57BL/6 Allelic Composition: Thrb^tm5Few/Thrb⁺ Genetic Background: involves: 129 * C57BL/6 Allelic Composition: Thrb^tm1Df/Thrb^tm1Df Genetic Background: either: B6.129S1-Thrb^tm1Df or (involves: 129S1/Sv * C57BL/6J) Allelic Composition: Thrb^tm1.1Syc/Thrb^tm1.1Syc Genetic Background: involves: 129S6/SvEvTac * FVB/N * NIH Black Swiss Allelic Composition: Thrb^tm1.1Syc/Thrb⁺ Genetic Background: involves: 129S6/SvEvTac * FVB/N * NIH Black Swiss Allelic Composition: Thrb^tm1.1Syc/Thrb^tm1.1Syc Genetic Background: involves: 129S6/SvEvTac * 129X1/SvJ * C57BL/6 Allelic Composition: Thra^tm1Ven/Thra^tm1Ven,Thrb^tm1Df/Thrb^tm1Df Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6 Allelic Composition: Thrb^tm6.1Few/Thrb^tm6.1Few Genetic Background: involves: 129 * C57BL/6 Allelic Composition: Thrb^tm6.1Few/Thrb⁺ Genetic Background: involves: 129 * C57BL/6 Allelic Composition: Thrb^tm1Olc/Thrb^tm1Olc Genetic Background: involves: 129/Sv Allelic Composition: Thra^tm1Jas/Thra^tm1Jas,Thrb^tm1Olc/Thrb^tm1Olc Genetic Background: involves: 129/Sv * 129S1/Sv * 129X1/SvJ Allelic Composition: Ncoa1^tm1Bwo/Ncoa1^tm1Bwo,Thrb^tm1Olc/Thrb^tm1Olc Genetic Background: B6.129-Ncoa1^tm1Bwo Thrb^tm1Olc Allelic Composition: Thrb^tm1Mkni/Thrb^tm1Mkni,Hprt^{tm1(TG-cre)1Sasr}/Y Genetic Background: involves: 129/Sv * C57BL/6
MP:0005478	decreased circulating thyroxine level	"less than the normal blood concentration of the major hormone dervied from the thryoid gland; it normally affects cellular metabolism" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Tsta3^tm1Jbl/Tsta3⁺ Genetic Background: involves: 129S2/SvPas * C57BL/6J Allelic Composition: Thra^tm2Ven/Thra^tm2Ven,Thrb^tm1Df/Thrb^tm1Df Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6J
MP:0005479	decreased circulating triiodothyronine level	"less than the normal blood concentration of this hormone synthesized and secreted by the thyroid; normally, this is the main thyroid hormone used by the tissues " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Thra^tm2Ven/Thra^tm2Ven,Thrb^tm1Df/Thrb^tm1Df Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6J
MP:0005480	increased circulating triiodothyronine level	"greater than the normal blood concentration of this hormone synthesized and secreted by the thyroid; normally, this is the main thyroid hormone used by the tissues " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Dnmt1^tm2Enl/Dnmt1^tm2Enl Genetic Background: involves: 129S4/SvJae Allelic Composition: Thrb^tm1Df/Thrb^tm1Df Genetic Background: involves: 129S1/Sv * C57BL/6J Allelic Composition: Thrb^tm3Few/Thrb^tm3Few Genetic Background: involves: 129 * C57BL/6 Allelic Composition: Thrb^tm5Few/Thrb^tm5Few Genetic Background: involves: 129 * C57BL/6 Allelic Composition: Thrb^tm1Df/Thrb^tm1Df Genetic Background: either: B6.129S1-Thrb^tm1Df or (involves: 129S1/Sv * C57BL/6J) Allelic Composition: Thrb^tm1.1Syc/Thrb^tm1.1Syc Genetic Background: involves: 129S6/SvEvTac * FVB/N * NIH Black Swiss Allelic Composition: Thrb^tm1.1Syc/Thrb⁺ Genetic Background: involves: 129S6/SvEvTac * FVB/N * NIH Black Swiss Allelic Composition: Thrb^tm1.1Syc/Thrb^tm1.1Syc Genetic Background: involves: 129S6/SvEvTac * 129X1/SvJ * C57BL/6 Allelic Composition: Thra^tm1Ven/Thra^tm1Ven,Thrb^tm1Df/Thrb^tm1Df Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6 Allelic Composition: Thrb^tm6.1Few/Thrb^tm6.1Few Genetic Background: involves: 129 * C57BL/6 Allelic Composition: Thrb^tm6.1Few/Thrb⁺ Genetic Background: involves: 129 * C57BL/6 Allelic Composition: Thrb^tm1Olc/Thrb^tm1Olc Genetic Background: involves: 129/Sv Allelic Composition: Ncoa1^tm1Bwo/Ncoa1^tm1Bwo,Thrb^tm1Olc/Thrb^tm1Olc Genetic Background: B6.129-Ncoa1^tm1Bwo Thrb^tm1Olc
MP:0005646	abnormal pituitary gland physiology	"anmalous function of this unpaired compound gland suspended from the base of the hypothalamus by a short extension of the infundibulum, the infundibular or pituitary stalk" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Thrb^tm3Few/Thrb^tm3Few Genetic Background: involves: 129 * C57BL/6 Allelic Composition: Thrb^tm4Few/Thrb^tm4Few Genetic Background: involves: 129 * C57BL/6 Allelic Composition: Thrb^tm1.1Syc/Thrb^tm1.1Syc Genetic Background: involves: 129S6/SvEvTac * FVB/N * NIH Black Swiss Allelic Composition: Thrb^tm1.1Syc/Thrb⁺ Genetic Background: involves: 129S6/SvEvTac * FVB/N * NIH Black Swiss
MP:0006325	impaired hearing	"reduced ability to percieve auditory stimuli" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]	Show Allelic Composition: Thrb^tm1.1Syc/Thrb^tm1.1Syc Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * NIH Black Swiss
MP:0006395	abnormal epiphyseal plate morphology	"any structural anomaly of the cartilaginous center of ossification on the bones permitting growth of the bone in both directions during development" [MESH:A02.835.232.251.352]	Show Allelic Composition: Thrb^tm1.1Syc/Thrb^tm1.1Syc Genetic Background: involves: 129S6/SvEvTac * FVB/N * NIH Black Swiss
MP:0006396	decreased long bone epiphyseal plate size	"reduced size of the cartilaginous center of ossification on the long bones permitting growth of the bone in both directions during development" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]	Show Allelic Composition: Thrb^tm1Olc/Thrb^tm1Olc Genetic Background: involves: 129/Sv
MP:0008142	decreased small intestinal villus size	"reduced size of the tiny hair-like projections that protrude from the inside of the small intestine that contain blood vessels that capture digested nutrients that are absorbed through the intestinal wall; the villi increase the absorptive surface area of the small intestine by approximately 30-fold" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", MGI:rbabiuk "Randall Babiuk, Mouse Genome Informatics Curator"]	Show Allelic Composition: Thra^tm1Jas/Thra^tm1Jas,Thrb^tm1Olc/Thrb^tm1Olc Genetic Background: involves: 129/Sv * 129S1/Sv * 129X1/SvJ
MP:0008337	increased thyrotroph cell number	"greater number of an anterior pituitary cell that produces thyroid-stimulating hormone" [MESH:A06.407.747.608.968]	Show Allelic Composition: Thrb^tm3Few/Thrb^tm3Few Genetic Background: involves: 129 * C57BL/6 Allelic Composition: Thrb^tm4Few/Thrb^tm4Few Genetic Background: involves: 129 * C57BL/6 Allelic Composition: Thrb^tm1.1Syc/Thrb^tm1.1Syc Genetic Background: involves: 129S6/SvEvTac * FVB/N * NIH Black Swiss
MP:0009346	decreased cancellous bone thickness	"thinner than normal bone with a lattice-like or spongy structure" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]	Show Allelic Composition: Thrb^tm1Olc/Thrb^tm1Olc Genetic Background: involves: 129/Sv
MP:0009766	increased sensitivity to xenobiotic induced morbidity/mortality	"decrease in the amount of a foreign compound required to cause death or diseased state" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]	Show Allelic Composition: Thra^tm1Ven/Thra^tm1Ven,Thrb^tm1Df/Thrb^tm1Df Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * BALB/c * C57BL/6J
MP:0009780	abnormal chondrocyte physiology	"any functional anomaly of nondividing cartilage cells" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]	Show Allelic Composition: Thrb^tm1Olc/Thrb^tm1Olc Genetic Background: involves: 129/Sv
MP:0010346	increased thyroid carcinioma incidence	"greater than the expected number of a malignant epithelial neoplasms of the thyroid gland, occurring in a specific population in a given time period" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Thrb^tm1Df/Thrb^tm1.1Syc Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * C57BL/6 * C57BL/6J Allelic Composition: Thrb^tm1.1Syc/Thrb^tm1.1Syc Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * C57BL/6 * C57BL/6J
MP:0011100	complete preweaning lethality	"death of all organisms of a given genotype in a population between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]	Show Allelic Composition: Thra^tm2Ven/Thra^tm3Ven Genetic Background: involves: 129P2/OlaHsd * C57BL/6NCrl
MP:0011270	decreased excitatory postsynaptic current amplitude	"reduction in the size (height or maximum displacement) of the evoked excitatory postsynaptic current wave" [MGI:csmith]	Show Allelic Composition: Mir34a^tm1.2Arte/Mir34a^tm1.2Arte,Tg(Neurod2-SmoA1)199Jols/0 Genetic Background:* involves: C57BL/6 * C57BL/6N
MP:0011617	abnormal habituation	"anomaly in the process in which there is a progressive decline of behavioral response probability with a repetitive stimulus" [GO:0046959, PMID:16774787]	Show Allelic Composition: Fcer1g^tm1Tks/Fcer1g^tm1Tks Genetic Background: involves: C57BL/6J Allelic Composition: Thrb^tm1.1Syc/Thrb⁺ Genetic Background: involves: 129S6/SvEvTac * NIH Black Swiss
MP:0011967	increased or absent threshold for auditory brainstem response	"increase in the value at which one or more sound frequencies or broadband clicks first elicits a recordable response generated by electrical activity of neurons in the ascending auditory system, or complete lack of a recordable response at any frequency or broadband click" [MGI:csmith]	Show Allelic Composition: Thrb^tm1Df/Thrb^tm1Df Genetic Background: involves: 129S1/Sv * C57BL/6J Allelic Composition: Thrb^tm3Few/Thrb^tm3Few Genetic Background: involves: 129 * C57BL/6 Allelic Composition: Thrb^tm4Few/Thrb^tm4Few Genetic Background: involves: 129 * C57BL/6 Allelic Composition: Thra^tm1Ven/Thra⁺,Thrb^tm1Df/Thrb^tm1Df Genetic Background: B6.129-Thra^tm1Ven Thrb^tm1Df Allelic Composition: Thrb^tm1Df/Thrb^tm1Df Genetic Background: either: B6.129S1-Thrb^tm1Df or (involves: 129S1/Sv * C57BL/6J) Allelic Composition: Thrb^tm1Df/Thrb^tm1Df Genetic Background: B6J.129S1-Thrb^tm1Df Allelic Composition: Thrb^tm1.1Syc/Thrb^tm1.1Syc Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * NIH Black Swiss Allelic Composition: Thrb^tm1Df/Thrb^tm1Mkni,Tg(Pres-cre)1Jnz/0 Genetic Background: involves: 129S1/Sv * C57BL/6J * FVB/NJ Allelic Composition: Thrb^tm1Df/Thrb^tm1Df Genetic Background: involves: 129S1/Sv * C57BL/6J * FVB/NJ
MP:0012315	impaired learning	"impaired ability to aquire lasting change in behavior that is the result of experience" [http:psychology.about.com/od/lindex/g/learning.htm]	Show Allelic Composition: Fcer1g^tm1Tks/Fcer1g^tm1Tks Genetic Background: involves: C57BL/6J Allelic Composition: Thrb^tm1.1Syc/Thrb⁺ Genetic Background: involves: 129S6/SvEvTac * NIH Black Swiss
MP:0014091	abnormal tectorial membrane striated-sheet matrix morphology	"any structural anomaly of the laminated, striated-sheet matrix within which collagen fibrils of the TM are imbedded; the striated sheet matrix is formed by two types of fine-diameter collagen filaments, a light and a dark staining type that lie in parallel within the plane of each sheet and are extensively linked along their length by staggered cross bridges; it originates medially within the sulcal zone, extends to the marginal band and is particularly evident in apical regions of the cochlea, where it has a less compressed appearance" [PMID:18797289, PMID:24363064]	Show Allelic Composition: Thrb^tm1Df/Thrb^tm1Df Genetic Background: involves: 129S1/Sv * C57BL/6J Allelic Composition: Thra^tm1Ven/Thra^tm1Ven,Thrb^tm1Df/Thrb^tm1Df Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * BALB/c * C57BL/6J
MP:0020168	decreased thyroid gland weight	"lower than average weight of the thyroid gland" [GOC:NV]	Show Allelic Composition: Thrb^tm1Mkni/Thrb^tm1Mkni,Hprt^{tm1(TG-cre)1Sasr}/Y Genetic Background: involves: 129/Sv * C57BL/6 Allelic Composition: Thrb^tm1Mkni/Thrb⁺,Hprt^{tm1(TG-cre)1Sasr}/Y Genetic Background: involves: 129/Sv * C57BL/6
MP:0020169	increased thyroid gland weight	"higher than average weight of the thyroid gland" [GOC:NV]	Show Allelic Composition: Thrb^tm5Few/Thrb^tm5Few Genetic Background: involves: 129 * C57BL/6 Allelic Composition: Thrb^tm5Few/Thrb⁺ Genetic Background: involves: 129 * C57BL/6 Allelic Composition: Thrb^tm1.1Syc/Thrb^tm1.1Syc Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * C57BL/6 * C57BL/6J
MP:0030018	increased cardiac cell glucose uptake	"increased ability of the cells of the heart to take in glucose" [MGI:anna]	Show Allelic Composition: Thra^tm1Syc/Thra⁺ Genetic Background: involves: 129S6/SvEvTac
MP:0030389	small fontanelles	"an abnormally decreased size of one or more fontanelles for age-related norms" [HP:0005486, MGI:anna]	Show Allelic Composition: Thrb^tm1.1Syc/Thrb^tm1.1Syc Genetic Background: involves: 129S6/SvEvTac * FVB/N * NIH Black Swiss Allelic Composition: Thrb^tm1Olc/Thrb^tm1Olc Genetic Background: involves: 129/Sv

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