ENSMUSG00000005677


Mus musculus

Features
Gene ID: ENSMUSG00000005677
  
Biological name :Nr1i3
  
Synonyms : Nr1i3 / Nuclear receptor subfamily 1 group I member 3 / O35627
  
Possible biological names infered from orthology : Q14994
  
Species: Mus musculus
  
Chr. number: 1
Strand: 1
Band: H3
Gene start: 171213970
Gene end: 171220701
  
Corresponding Affymetrix probe sets: 10351533 (MoGene1.0st)   1425392_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000106960
Ensembl peptide - ENSMUSP00000005820
Ensembl peptide - ENSMUSP00000074915
Ensembl peptide - ENSMUSP00000137683
Ensembl peptide - ENSMUSP00000137852
NCBI entrez gene - 12355     See in Manteia.
MGI - MGI:1346307
RefSeq - XM_011238744
RefSeq - NM_001243062
RefSeq - NM_001243063
RefSeq - NM_009803
RefSeq - XM_006496628
RefSeq - XM_006496629
RefSeq - XM_006496630
RefSeq - XM_006496631
RefSeq - XM_006496632
RefSeq - XM_011238743
RefSeq Peptide - NP_033933
RefSeq Peptide - NP_001229991
RefSeq Peptide - NP_001229992
swissprot - M0QWI8
swissprot - O35627
swissprot - Q3UEP1
swissprot - Q5FW96
Ensembl - ENSMUSG00000005677
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 NR1I3ENSG00000143257Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Nr1i2 / O54915 / Nuclear receptor subfamily 1 group I member 2 / O75469*ENSMUSG0000002280944
Vdr / P48281 / vitamin D (1,25-dihydroxyvitamin D3) receptor / P11473* / vitamin D receptor*ENSMUSG0000002247938
Thrb / P37242 / Thyroid hormone receptor beta / P10828*ENSMUSG0000002177929
Nr1h4 / Q60641 / Bile acid receptor / Q96RI1* / nuclear receptor subfamily 1 group H member 4*ENSMUSG0000004763829
Nr1h2 / Q60644 / Oxysterols receptor LXR-beta / P55055* / nuclear receptor subfamily 1 group H member 2*ENSMUSG0000006060129
Rarg / P18911 / Retinoic acid receptor gamma / P13631*ENSMUSG0000000128828
Thra / P63058 / Thyroid hormone receptor alpha / P10827*ENSMUSG0000005875628
Nr1h3 / Q9Z0Y9 / Mus musculus nuclear receptor subfamily 1, group H, member 3 (Nr1h3), transcript variant 3, mRNA. / Q13133* / nuclear receptor subfamily 1 group H member 3*ENSMUSG0000000210828
Rara / P11416 / retinoic acid receptor, alpha / P10276*ENSMUSG0000003799228
Rarb / P22605 / retinoic acid receptor, beta / P10826*ENSMUSG0000001749127
Nr1h5ENSMUSG0000004893826


Protein motifs (from Interpro)
Interpro ID Name
 IPR000536  Nuclear hormone receptor, ligand-binding domain
 IPR001628  Zinc finger, nuclear hormone receptor-type
 IPR001723  Nuclear hormone receptor
 IPR001728  Thyroid hormone receptor
 IPR013088  Zinc finger, NHR/GATA-type
 IPR035500  Nuclear hormone receptor-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006366 transcription by RNA polymerase II IEA
 biological_processGO:0030522 intracellular receptor signaling pathway IEA
 biological_processGO:0043401 steroid hormone mediated signaling pathway IEA
 biological_processGO:0045892 negative regulation of transcription, DNA-templated IDA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II ISO
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm ISO
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol IDA
 cellular_componentGO:0005856 cytoskeleton IEA
 molecular_functionGO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding ISO
 molecular_functionGO:0001228 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding ISO
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003700 DNA-binding transcription factor activity IEA
 molecular_functionGO:0003707 steroid hormone receptor activity IEA
 molecular_functionGO:0004887 thyroid hormone receptor activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008270 zinc ion binding IEA
 molecular_functionGO:0043565 sequence-specific DNA binding IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Nuclear Receptor transcription pathway


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0002644 decreased circulating triglyceride level "lower than normal concentration of triacylglycerols in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Lepob/Lepob
Genetic Background: B6.Cg-Lepob/JBomTac

 MP:0003638 abnormal response/metabolism to endogenous compounds "altered ability or inability to metabolize or respond to substances normally present in the body" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: MipCat-Tohm/Mip+
Genetic Background: DDI

 MP:0005469 abnormal thyroxine level "anomalous concentration of the major hormone dervied from the thryoid gland; it normally affects cellular metabolism" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, J:13923]
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Allelic Composition: Hsf1tm1Anak/Hsf1tm1Anak,Tg(ACTB-HSF1)1Anak/?
Genetic Background: involves: C57BL/6 * CBA * ICR

 MP:0005472 abnormal triiodothyronine level "aberrant concentration of this hormone synthesized and secreted by the thyroid; normally, this is the main thyroid hormone used by the tissues " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Hsf1tm1Anak/Hsf1tm1Anak,Tg(ACTB-HSF1)1Anak/?
Genetic Background: involves: C57BL/6 * CBA * ICR

 MP:0005559 increased circulating glucose level "greater than the normal concentration in the blood of this major monosaccharide of the body; it is an important energy source" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, RGD:Rat Genome Database submission]
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Allelic Composition: Cd83lcd4/Cd83lcd4
Genetic Background: involves: C57BL/6J

 MP:0008873 increased sensitivity to xenobiotics "decrease in the dose or concentration of a foreign compound required to induce a specific level of response" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: MipCat-Tohm/Mip+
Genetic Background: DDI

Allelic Composition: Nr1i3tm1(NR1I3)Arte/Nr1i3tm1(NR1I3)Arte
Genetic Background: involves: C57BL/6

 MP:0008874 decreased sensitivity to xenobiotics "increase in the dose or concentration of a foreign compound required to induce a specific level of response" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: MipCat-Tohm/Mip+
Genetic Background: DDI

Allelic Composition: Nr1i3tm1Dgen/Nr1i3tm1Dgen
Genetic Background: involves: 129/Sv

Allelic Composition: Nr1i3tm1.1Arte/Nr1i3tm1.1Arte
Genetic Background: involves: C57BL/6

Allelic Composition: Nr1i3tm1(NR1I3)Arte/Nr1i3tm1(NR1I3)Arte
Genetic Background: involves: C57BL/6

Allelic Composition: Nr1i2tm3Arte/Nr1i2tm3Arte,Nr1i3tm1.1Arte/Nr1i3tm1.1Arte
Genetic Background: involves: C57BL/6

Allelic Composition: Nr1i2tm1(NR1I2)Arte/Nr1i2tm1(NR1I2)Arte,Nr1i3tm1.1Arte/Nr1i3tm1.1Arte
Genetic Background: involves: C57BL/6

 MP:0008875 abnormal pharmacokinetics of xenobiotics "any anomaly in the absorbtion, distribution, metabolism or elimination of a foreign compound" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Nr1i3tm1(NR1I3)Arte/Nr1i3tm1(NR1I3)Arte
Genetic Background: involves: C57BL/6

 MP:0010180 increased susceptibility to weight loss "greater decrease in body weight over time when compared to the average decrease in weight in response to dietary modification, fasting or caloric restriction" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Nr1i3tm1Dgen/Nr1i3tm1Dgen
Genetic Background: involves: 129/Sv

 MP:0010951 abnormal lipid oxidation "anomaly in the process of removal of one or more electrons from a lipid, with or without the concomitant removal of a proton or protons, by reaction with an electron-accepting substance, by addition of oxygen or by removal of hydrogen" [GO:0034440]
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Allelic Composition: Ldlrtm1Her/Ldlrtm1Her,Nr0b2tm1.1Mjev/Nr0b2tm1.1Mjev
Genetic Background: involves: 129S/SvEvBrd * 129S4/SvJae * 129S7/SvEvBrd * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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