ENSDARG00000098211


Danio rerio

Features
Gene ID: ENSDARG00000098211
  
Biological name :wrn
  
Synonyms : Werner syndrome / wrn
  
Possible biological names infered from orthology : O09053 / Q14191 / Werner syndrome RecQ like helicase
  
Species: Danio rerio
  
Chr. number: 10
Strand: -1
Band:
Gene start: 7483545
Gene end: 7555660
  
Corresponding Affymetrix probe sets:
  
Cross references: Ensembl peptide - ENSDARP00000133164
Ensembl peptide - ENSDARP00000139077
Ensembl peptide - ENSDARP00000146097
NCBI entrez gene - 569495     See in Manteia.
swissprot - A0A0R4IHR6
swissprot - A0A0R4IT14
ZFIN ID - ZDB-GENE-070702-2
Ensembl - ENSDARG00000098211
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 WRNENSGALG00000040909Gallus gallus
 WRNENSG00000165392Homo sapiens
 WrnENSMUSG00000031583Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
blm / Bloom syndrome, RecQ helicase-like / P54132* / O88700* / Bloom syndrome protein homolog * / Bloom syndrome RecQ like helicase*ENSDARG0000007708916
recql4 / RecQ helicase-like 4 / RecQ like helicase 4*ENSDARG0000007751614
recql5 / RecQ helicase-like 5 / Q8VID5* / O94762* / RecQ like helicase 5* / ATP-dependent DNA helicase Q5 *ENSDARG0000005955613
recql / RecQ helicase-like / Q9Z129* / P46063* / RecQ protein-like* / RecQ like helicase*ENSDARG0000000717512


Protein motifs (from Interpro)
Interpro ID Name
 IPR001650  Helicase, C-terminal
 IPR002121  HRDC domain
 IPR002562  3"-5" exonuclease domain
 IPR004589  DNA helicase, ATP-dependent, RecQ type
 IPR010997  HRDC-like superfamily
 IPR011545  DEAD/DEAH box helicase domain
 IPR011991  ArsR-like helix-turn-helix domain
 IPR012337  Ribonuclease H-like superfamily
 IPR014001  Helicase superfamily 1/2, ATP-binding domain
 IPR018982  RQC domain
 IPR027417  P-loop containing nucleoside triphosphate hydrolase
 IPR029491  Helicase Helix-turn-helix domain
 IPR032284  ATP-dependent DNA helicase RecQ, zinc-binding domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006139 nucleobase-containing compound metabolic process IEA
 biological_processGO:0006260 DNA replication IEA
 biological_processGO:0006281 DNA repair IEA
 biological_processGO:0006310 DNA recombination IEA
 biological_processGO:0032508 DNA duplex unwinding IEA
 biological_processGO:0044237 cellular metabolic process IEA
 biological_processGO:0090305 nucleic acid phosphodiester bond hydrolysis IEA
 cellular_componentGO:0005622 intracellular IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0003676 nucleic acid binding IEA
 molecular_functionGO:0003824 catalytic activity IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0008026 ATP-dependent helicase activity IEA
 molecular_functionGO:0008408 3"-5" exonuclease activity IEA
 molecular_functionGO:0043140 ATP-dependent 3"-5" DNA helicase activity IEA


Pathways (from Reactome)
Pathway description
SUMOylation of DNA damage response and repair proteins
HDR through Single Strand Annealing (SSA)
HDR through Homologous Recombination (HRR)
Resolution of D-loop Structures through Holliday Junction Intermediates
Homologous DNA Pairing and Strand Exchange
Processing of DNA double-strand break ends
Presynaptic phase of homologous DNA pairing and strand exchange
Regulation of TP53 Activity through Phosphorylation
G2/M DNA damage checkpoint


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000003938 rpa1 / Q6NY74 / replication protein A1 / Q8VEE4* / P27694* / Replication protein A 70 kDa DNA-binding subunit *  / complex / reaction
 ENSDARG00000037188 rpa2 / replication protein A2 / RPA4* / Q13156* / P15927* / replication protein A4*  / complex / reaction
 ENSDARG00000043480 rbbp8 / F1R983 / retinoblastoma binding protein 8 / Q80YR6* / Q99708* / RB binding protein 8, endonuclease* / retinoblastoma binding protein 8, endonuclease*  / complex / reaction
 ENSDARG00000063076 atrip / ATR interacting protein / Q8BMG1* / Q8WXE1*  / reaction / complex
 ENSDARG00000074410 brip1 / BRCA1 interacting protein C-terminal helicase 1 / Q5SXJ3* / Q9BX63* / Fanconi anemia group J protein homolog *  / complex / reaction
 ENSDARG00000078759 dna2 / DNA replication helicase/nuclease 2 / P51530* / Q6ZQJ5* / DNA replication ATP-dependent helicase/nuclease DNA2 DNA replication nuclease DNA2 DNA replication ATP-dependent helicase DNA2*  / complex
 ENSDARG00000007438 ube2ib / Q9W6H5 / ubiquitin-conjugating enzyme E2Ib / UBE2I* / P63279* / ubiquitin conjugating enzyme E2 I*  / reaction
 ENSDARG00000044267 sumo1 / Q7SZR5 / small ubiquitin-like modifier 1 / P63166* / P63165* / Small ubiquitin-related modifier 1 *  / complex / reaction
 ENSDARG00000038917 rad50 / RAD50 homolog, double strand break repair protein / Q92878* / AC116366.3* / RAD50 double strand break repair protein*  / complex / reaction
 ENSDARG00000052649 Q9DDJ0 / ube2ia / ubiquitin-conjugating enzyme E2Ia / UBE2I* / P63280* / P63279* / ubiquitin conjugating enzyme E2 I*  / reaction
 ENSDARG00000040303 nbn / nibrin / Q5I2W8 / O60934* / Q9R207*  / reaction / complex
 ENSDARG00000105014 mre11a / MRE11 homolog A, double strand break repair nuclease / MRE11* / P49959* / MRE11 homolog, double strand break repair nuclease*  / complex / reaction
 ENSDARG00000002385 atm / ATM serine/threonine kinase / Q13315* / Q62388* / Serine-protein kinase ATM *  / reaction / complex






 

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