ENSDARG00000077089


Danio rerio

Features
Gene ID: ENSDARG00000077089
  
Biological name :blm
  
Synonyms : blm / Bloom syndrome, RecQ helicase-like
  
Possible biological names infered from orthology : Bloom syndrome protein homolog / Bloom syndrome RecQ like helicase / O88700 / P54132
  
Species: Danio rerio
  
Chr. number: 18
Strand: 1
Band:
Gene start: 26428829
Gene end: 26453729
  
Corresponding Affymetrix probe sets: Dr.13183.1.A1_at (Zebrafish Array)   
  
Cross references: Ensembl peptide - ENSDARP00000113634
Ensembl peptide - ENSDARP00000153051
Ensembl peptide - ENSDARP00000147418
Ensembl peptide - ENSDARP00000098087
NCBI entrez gene - 572540     See in Manteia.
RefSeq - XM_696265
swissprot - E9QIQ5
swissprot - E7EZY7
ZFIN ID - ZDB-GENE-070702-5
Ensembl - ENSDARG00000077089
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 BLMENSGALG00000008256Gallus gallus
 BLMENSG00000197299Homo sapiens
 BlmENSMUSG00000030528Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
recql / RecQ helicase-like / Q9Z129* / P46063* / RecQ protein-like* / RecQ like helicase*ENSDARG0000000717516
recql5 / RecQ helicase-like 5 / Q8VID5* / O94762* / RecQ like helicase 5* / ATP-dependent DNA helicase Q5 *ENSDARG0000005955615
wrn / Werner syndrome / O09053* / Q14191* / Werner syndrome RecQ like helicase*ENSDARG0000009821115
recql4 / RecQ helicase-like 4 / RecQ like helicase 4*ENSDARG0000007751614


Protein motifs (from Interpro)
Interpro ID Name
 IPR001650  Helicase, C-terminal
 IPR002121  HRDC domain
 IPR002464  DNA/RNA helicase, ATP-dependent, DEAH-box type, conserved site
 IPR004589  DNA helicase, ATP-dependent, RecQ type
 IPR010997  HRDC-like superfamily
 IPR011545  DEAD/DEAH box helicase domain
 IPR011991  ArsR-like helix-turn-helix domain
 IPR012532  BDHCT
 IPR014001  Helicase superfamily 1/2, ATP-binding domain
 IPR018982  RQC domain
 IPR027417  P-loop containing nucleoside triphosphate hydrolase
 IPR032284  ATP-dependent DNA helicase RecQ, zinc-binding domain
 IPR032437  Bloom syndrome protein, N-terminal domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000724 double-strand break repair via homologous recombination IBA
 biological_processGO:0006260 DNA replication IEA
 biological_processGO:0006281 DNA repair IEA
 biological_processGO:0006310 DNA recombination IEA
 biological_processGO:0032508 DNA duplex unwinding IEA
 biological_processGO:0044237 cellular metabolic process IEA
 biological_processGO:0045950 negative regulation of mitotic recombination IMP
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005634 nucleus IBA
 cellular_componentGO:0005694 chromosome IBA
 cellular_componentGO:0005737 cytoplasm IBA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0003676 nucleic acid binding IEA
 molecular_functionGO:0003677 DNA binding IBA
 molecular_functionGO:0003824 catalytic activity IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0008026 ATP-dependent helicase activity IEA
 molecular_functionGO:0009378 four-way junction helicase activity IBA
 molecular_functionGO:0016818 hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides IEA
 molecular_functionGO:0043140 ATP-dependent 3"-5" DNA helicase activity IBA


Pathways (from Reactome)
Pathway description
SUMOylation of DNA damage response and repair proteins
HDR through Single Strand Annealing (SSA)
HDR through Homologous Recombination (HRR)
Resolution of D-loop Structures through Holliday Junction Intermediates
Homologous DNA Pairing and Strand Exchange
Processing of DNA double-strand break ends
Presynaptic phase of homologous DNA pairing and strand exchange
Regulation of TP53 Activity through Phosphorylation
G2/M DNA damage checkpoint


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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