ENSDARG00000015070


Danio rerio

Features
Gene ID: ENSDARG00000015070
  
Biological name :pola2
  
Synonyms : pola2 / polymerase (DNA directed), alpha 2
  
Possible biological names infered from orthology : DNA polymerase alpha 2, accessory subunit / P33611 / Q14181
  
Species: Danio rerio
  
Chr. number: 8
Strand: -1
Band:
Gene start: 17174796
Gene end: 17184482
  
Corresponding Affymetrix probe sets: Dr.4879.1.S1_at (Zebrafish Array)   NM_199581_at (Zebrafish Genome Array with custom cdf files)   
  
Cross references: Ensembl peptide - ENSDARP00000002618
NCBI entrez gene - 322059     See in Manteia.
RefSeq - NM_199581
RefSeq Peptide - NP_955875
swissprot - B0S687
ZFIN ID - ZDB-GENE-030131-778
Ensembl - ENSDARG00000015070
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 POLA2ENSG00000014138Homo sapiens
 Pola2ENSMUSG00000024833Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR007185  DNA polymerase alpha/epsilon, subunit B
 IPR013627  DNA polymerase alpha, subunit B N-terminal
 IPR016722  DNA polymerase alpha, subunit B


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006260 DNA replication IEA
 biological_processGO:0006270 DNA replication initiation IBA
 biological_processGO:0071897 DNA biosynthetic process IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005658 alpha DNA polymerase:primase complex IBA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003887 DNA-directed DNA polymerase activity IEA
 molecular_functionGO:0046982 protein heterodimerization activity IBA


Pathways (from Reactome)
Pathway description
Inhibition of replication initiation of damaged DNA by RB1/E2F1
Polymerase switching on the C-strand of the telomere
Telomere C-strand synthesis initiation
DNA replication initiation
Activation of the pre-replicative complex
Polymerase switching
Removal of the Flap Intermediate
Processive synthesis on the lagging strand


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000052721 prim2 / DNA primase subunit 2 / P33610* / P49643* / DNA primase large subunit *  / reaction / complex
 ENSDARG00000011404 fen1 / Q6TNU4 / flap structure-specific endonuclease 1 / P39748*  / reaction
 ENSDARG00000008551 pole3 / polymerase (DNA directed), epsilon 3 (p17 subunit) / Q9NRF9* / DNA polymerase epsilon 3, accessory subunit*  / complex / reaction
 ENSDARG00000013016 pole4 / polymerase (DNA-directed), epsilon 4, accessory subunit / Q9CQ36* / Q9NR33* / DNA polymerase epsilon 4, accessory subunit* / polymerase (DNA-directed), epsilon 4 (p12 subunit)*  / reaction / complex
 ENSDARG00000045308 pola1 / polymerase (DNA directed), alpha 1 / P09884* / P33609* / DNA polymerase alpha 1, catalytic subunit*  / complex / reaction
 ENSDARG00000058533 pole / polymerase (DNA directed), epsilon / Q07864* / Q9WVF7* / DNA polymerase epsilon, catalytic subunit*  / reaction / complex
 ENSDARG00000015070 pola2 / polymerase (DNA directed), alpha 2 / P33611* / Q14181* / DNA polymerase alpha 2, accessory subunit*  / reaction
 ENSDARG00000078759 dna2 / DNA replication helicase/nuclease 2 / P51530* / Q6ZQJ5* / DNA replication ATP-dependent helicase/nuclease DNA2 DNA replication nuclease DNA2 DNA replication ATP-dependent helicase DNA2*  / reaction / complex
 ENSDARG00000054155 pcna / Q9PTP1 / proliferating cell nuclear antigen / P17918* / P12004* / Pcna-ps2*  / complex / reaction
 ENSDARG00000003938 rpa1 / Q6NY74 / replication protein A1 / Q8VEE4* / P27694* / Replication protein A 70 kDa DNA-binding subunit *  / complex / reaction
 ENSDARG00000027689 pold1 / polymerase (DNA directed), delta 1, catalytic subunit / P28340* / P52431* / DNA polymerase delta 1, catalytic subunit*  / reaction / complex
 ENSDARG00000037188 rpa2 / replication protein A2 / RPA4* / Q13156* / P15927* / replication protein A4*  / reaction / complex
 ENSDARG00000079632 si:dkey-28b4.7 / POLD4* / Q9CWP8* / Q9HCU8* / AP003419.1* / polymerase (DNA-directed), delta 4* / DNA polymerase delta 4, accessory subunit*  / reaction / complex






 

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