ENSDARG00000058533


Danio rerio

Features
Gene ID: ENSDARG00000058533
  
Biological name :pole
  
Synonyms : pole / polymerase (DNA directed), epsilon
  
Possible biological names infered from orthology : DNA polymerase epsilon, catalytic subunit / Q07864 / Q9WVF7
  
Species: Danio rerio
  
Chr. number: 5
Strand: 1
Band:
Gene start: 12743640
Gene end: 12804906
  
Corresponding Affymetrix probe sets:
  
Cross references: Ensembl peptide - ENSDARP00000075852
NCBI entrez gene - 553405     See in Manteia.
RefSeq - NM_001128523
RefSeq Peptide - NP_001121995
swissprot - B0V351
ZFIN ID - ZDB-GENE-070705-557
Ensembl - ENSDARG00000058533
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ENSGALG00000039384Gallus gallus
 ENSGALG00000007665Gallus gallus
 POLEENSG00000177084Homo sapiens
 PoleENSMUSG00000007080Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR006133  DNA-directed DNA polymerase, family B, exonuclease domain
 IPR006134  DNA-directed DNA polymerase, family B, multifunctional domain
 IPR006172  DNA-directed DNA polymerase, family B
 IPR012337  Ribonuclease H-like superfamily
 IPR013697  DNA polymerase epsilon, catalytic subunit A, C-terminal
 IPR023211  DNA polymerase, palm domain superfamily
 IPR029703  DNA polymerase epsilon catalytic subunit


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000278 mitotic cell cycle IBA
 biological_processGO:0006260 DNA replication IEA
 biological_processGO:0006272 leading strand elongation IBA
 biological_processGO:0006281 DNA repair IEA
 biological_processGO:0006287 base-excision repair, gap-filling IBA
 biological_processGO:0006297 nucleotide-excision repair, DNA gap filling IBA
 biological_processGO:0045004 DNA replication proofreading IBA
 biological_processGO:0071897 DNA biosynthetic process IEA
 biological_processGO:0090305 nucleic acid phosphodiester bond hydrolysis IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0008622 epsilon DNA polymerase complex IBA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0003676 nucleic acid binding IEA
 molecular_functionGO:0003677 DNA binding IBA
 molecular_functionGO:0003887 DNA-directed DNA polymerase activity IBA
 molecular_functionGO:0008270 zinc ion binding IEA
 molecular_functionGO:0008310 single-stranded DNA 3"-5" exodeoxyribonuclease activity IBA


Pathways (from Reactome)
Pathway description
Recognition of DNA damage by PCNA-containing replication complex
Telomere C-strand synthesis initiation
PCNA-Dependent Long Patch Base Excision Repair
Termination of translesion DNA synthesis
HDR through Homologous Recombination (HRR)
Gap-filling DNA repair synthesis and ligation in GG-NER
Dual Incision in GG-NER
Dual incision in TC-NER
Gap-filling DNA repair synthesis and ligation in TC-NER
DNA replication initiation
Activation of the pre-replicative complex


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000052721 prim2 / DNA primase subunit 2 / P33610* / P49643* / DNA primase large subunit *  / complex / reaction
 ENSDARG00000013016 pole4 / polymerase (DNA-directed), epsilon 4, accessory subunit / Q9CQ36* / Q9NR33* / DNA polymerase epsilon 4, accessory subunit* / polymerase (DNA-directed), epsilon 4 (p12 subunit)*  / complex
 ENSDARG00000015070 pola2 / polymerase (DNA directed), alpha 2 / P33611* / Q14181* / DNA polymerase alpha 2, accessory subunit*  / reaction / complex
 ENSDARG00000008551 pole3 / polymerase (DNA directed), epsilon 3 (p17 subunit) / Q9NRF9* / DNA polymerase epsilon 3, accessory subunit*  / complex
 ENSDARG00000045308 pola1 / polymerase (DNA directed), alpha 1 / P09884* / P33609* / DNA polymerase alpha 1, catalytic subunit*  / reaction / complex






 

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