ENSGALG00000013738


Gallus gallus

Features
Gene ID: ENSGALG00000013738
  
Biological name :OPTN
  
Synonyms : Optineurin / OPTN / Q90Z16
  
Possible biological names infered from orthology : Mus musculus optineurin (Optn), transcript variant 1, mRNA. / Q8K3K8 / Q96CV9
  
Species: Gallus gallus
  
Chr. number: 1
Strand: 1
Band:
Gene start: 6691790
Gene end: 6711192
  
Corresponding Affymetrix probe sets: Gga.4189.1.S1_s_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000022287
NCBI entrez gene - 374079     See in Manteia.
RefSeq - NM_204236
RefSeq Peptide - NP_989567
swissprot - Q90Z16
Ensembl - ENSGALG00000013738
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 optnENSDARG00000002663Danio rerio
 OPTNENSG00000123240Homo sapiens
 OptnENSMUSG00000026672Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR021063  NF-kappa-B essential modulator NEMO, N-terminal
 IPR032419  NF-kappa-B essential modulator NEMO, CC2-LZ domain
 IPR032939  Optineurin


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001920 negative regulation of receptor recycling IEA
 biological_processGO:0006914 autophagy IEA
 biological_processGO:0007030 Golgi organization IEA
 biological_processGO:0010508 positive regulation of autophagy IEA
 biological_processGO:0016192 vesicle-mediated transport IEA
 biological_processGO:0034067 protein localization to Golgi apparatus IEA
 biological_processGO:0034613 cellular protein localization IEA
 biological_processGO:0034620 cellular response to unfolded protein IEA
 biological_processGO:0043001 Golgi to plasma membrane protein transport IEA
 biological_processGO:0043122 regulation of I-kappaB kinase/NF-kappaB signaling IBA
 biological_processGO:0043124 negative regulation of I-kappaB kinase/NF-kappaB signaling IEA
 biological_processGO:0050829 defense response to Gram-negative bacterium IEA
 biological_processGO:0061734 parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization IEA
 biological_processGO:0090161 Golgi ribbon formation IEA
 biological_processGO:1904417 positive regulation of xenophagy IEA
 cellular_componentGO:0005634 nucleus IBA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005768 endosome IEA
 cellular_componentGO:0005776 autophagosome IEA
 cellular_componentGO:0005794 Golgi apparatus IBA
 cellular_componentGO:0005802 trans-Golgi network IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0031410 cytoplasmic vesicle IBA
 cellular_componentGO:0048471 perinuclear region of cytoplasm IEA
 cellular_componentGO:0055037 recycling endosome IEA
 molecular_functionGO:0008022 protein C-terminus binding IEA
 molecular_functionGO:0017137 Rab GTPase binding IEA
 molecular_functionGO:0030674 protein binding, bridging IEA
 molecular_functionGO:0031593 polyubiquitin modification-dependent protein binding IEA
 molecular_functionGO:0042802 identical protein binding IEA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0070530 K63-linked polyubiquitin modification-dependent protein binding IBA


Pathways (from Reactome)
Pathway description
Regulation of PLK1 Activity at G2/M Transition


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSGALG00000003487 RAB8B / RAB8B, member RAS oncogene family / P61028* / Q92930*  / complex
 ENSGALG00000006110 PLK1 / serine/threonine-protein kinase PLK1 / P53350* / Q07832* / polo like kinase 1*  / reaction
 ENSGALG00000028851 RAB8A / Q5F470 / Ras-related protein Rab-8A / P61006* / P55258* / RAB8A, member RAS oncogene family*  / complex






 

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