ENSMUSG00000026672


Mus musculus

Features
Gene ID: ENSMUSG00000026672
  
Biological name :Optn
  
Synonyms : Mus musculus optineurin (Optn), transcript variant 1, mRNA. / Optn / Q8K3K8
  
Possible biological names infered from orthology : optineurin / Q96CV9
  
Species: Mus musculus
  
Chr. number: 2
Strand: -1
Band: A1
Gene start: 5020642
Gene end: 5064051
  
Corresponding Affymetrix probe sets: 10479833 (MoGene1.0st)   1429778_at (Mouse Genome 430 2.0 Array)   1435679_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000027986
Ensembl peptide - ENSMUSP00000110648
NCBI entrez gene - 71648     See in Manteia.
MGI - MGI:1918898
RefSeq - XM_011238988
RefSeq - NM_001356487
RefSeq - NM_181848
RefSeq - XM_006497547
RefSeq - XM_006497548
RefSeq - XM_011238987
RefSeq - XM_006497546
RefSeq Peptide - NP_862896
RefSeq Peptide - NP_001343416
swissprot - Q8K3K8
Ensembl - ENSMUSG00000026672
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 optnENSDARG00000002663Danio rerio
 OPTNENSGALG00000013738Gallus gallus
 OPTNENSG00000123240Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Ikbkg / O88522 / NF-kappa-B essential modulator / Q9Y6K9* / inhibitor of nuclear factor kappa B kinase subunit gamma*ENSMUSG0000000422121


Protein motifs (from Interpro)
Interpro ID Name
 IPR021063  NF-kappa-B essential modulator NEMO, N-terminal
 IPR032419  NF-kappa-B essential modulator NEMO, CC2-LZ domain
 IPR032939  Optineurin
 IPR034735  NEMO, Zinc finger


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001920 negative regulation of receptor recycling ISO
 biological_processGO:0002376 immune system process IEA
 biological_processGO:0006914 autophagy IEA
 biological_processGO:0007030 Golgi organization ISO
 biological_processGO:0010508 positive regulation of autophagy ISO
 biological_processGO:0016192 vesicle-mediated transport IEA
 biological_processGO:0034067 protein localization to Golgi apparatus IEA
 biological_processGO:0034613 cellular protein localization IMP
 biological_processGO:0034620 cellular response to unfolded protein ISO
 biological_processGO:0043001 Golgi to plasma membrane protein transport ISO
 biological_processGO:0043124 negative regulation of I-kappaB kinase/NF-kappaB signaling IMP
 biological_processGO:0045087 innate immune response IEA
 biological_processGO:0050829 defense response to Gram-negative bacterium ISO
 biological_processGO:0061734 parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization ISO
 biological_processGO:0090161 Golgi ribbon formation IBA
 biological_processGO:1904417 positive regulation of xenophagy ISO
 cellular_componentGO:0005634 nucleus IBA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005768 endosome IEA
 cellular_componentGO:0005776 autophagosome IEA
 cellular_componentGO:0005794 Golgi apparatus IBA
 cellular_componentGO:0005802 trans-Golgi network ISO
 cellular_componentGO:0005829 cytosol ISO
 cellular_componentGO:0031410 cytoplasmic vesicle IBA
 cellular_componentGO:0048471 perinuclear region of cytoplasm IEA
 cellular_componentGO:0055037 recycling endosome IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008022 protein C-terminus binding ISO
 molecular_functionGO:0017137 Rab GTPase binding ISO
 molecular_functionGO:0030674 protein binding, bridging ISO
 molecular_functionGO:0031593 polyubiquitin modification-dependent protein binding ISO
 molecular_functionGO:0042802 identical protein binding ISO
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0070530 K63-linked polyubiquitin modification-dependent protein binding IDA


Pathways (from Reactome)
Pathway description
Regulation of PLK1 Activity at G2/M Transition
TBC/RABGAPs


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000183 decreased circulating LDL cholesterol level "less than average concentration in the blood of low density lipoprotein, which normally transports cholesterol to tissues other than the liver" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Nsun2tm1a(EUCOMM)Wtsi/Nsun2tm1a(EUCOMM)Wtsi
Genetic Background: B6JTyr;B6N-Nsun2tm1a(EUCOMM)Wtsi/Wtsi

 MP:0000186 decreased circulating HDL cholesterol level "lower than average level of high density lipoprotein in blood; this molecule transports cholesterol to the liver for excretion in bile" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Nsun2tm1a(EUCOMM)Wtsi/Nsun2tm1a(EUCOMM)Wtsi
Genetic Background: B6JTyr;B6N-Nsun2tm1a(EUCOMM)Wtsi/Wtsi

 MP:0004129 abnormal respiratory quotient "anomaly in the ratio of the volume of carbon dioxide released to oxygen consumed by a body tissue or an organism" [J:94416]
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Allelic Composition: Myoz1tm1a(EUCOMM)Hmgu/Myoz1tm1a(EUCOMM)Hmgu
Genetic Background: Not Specified

 MP:0005179 decreased total circulating cholesterol level "less than the normal concentration in the blood of these most abundant steroids in animal tissues, and precursors to steroid hormones and bile salts; also components of plasma membranes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Nsun2tm1a(EUCOMM)Wtsi/Nsun2tm1a(EUCOMM)Wtsi
Genetic Background: B6JTyr;B6N-Nsun2tm1a(EUCOMM)Wtsi/Wtsi

 MP:0005628 decreased circulating potassium level "less than the normal concentration in the blood of this alkaline metallic element, the most abundant intracellular ion; anomalies in the extracellular (circulating) concentration have important implications for the function of excitable tissues, such as nerve and muscle" [RGD:Rat Genome Database submission]
Show

Allelic Composition: Nsun2tm1a(EUCOMM)Wtsi/Nsun2tm1a(EUCOMM)Wtsi
Genetic Background: B6JTyr;B6N-Nsun2tm1a(EUCOMM)Wtsi/Wtsi

 MP:0011102 partial embryonic lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the embryonic period prior to organogenesis (Mus: prior to E14)" [MGI:csmith]
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Allelic Composition: Gt(ROSA)26Sortm1.1(Ubc-BCL3)Sbn/Gt(ROSA)26Sor+,Cd79atm1(cre)Reth/Cd79a+
Genetic Background: involves: BALB/c * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000036943 Rab8b / P61028 / RAB8B, member RAS oncogene family / Q92930*  / complex
 ENSMUSG00000003037 Rab8a / P55258 / RAB8A, member RAS oncogene family / P61006*  / complex
 ENSMUSG00000030867 Plk1 / Q07832 / polo like kinase 1 / P53350*  / reaction
 ENSMUSG00000038520 Q8BYH7 / Tbc1d17 / TBC1 domain family, member 17 / Q9HA65*  / complex / reaction






 

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