ENSDARG00000067920


Danio rerio

Features
Gene ID: ENSDARG00000067920
  
Biological name :rab8a
  
Synonyms : rab8a / RAB8A, member RAS oncogene family
  
Possible biological names infered from orthology : P55258 / P61006
  
Species: Danio rerio
  
Chr. number: 2
Strand: -1
Band:
Gene start: 55270566
Gene end: 55298075
  
Corresponding Affymetrix probe sets:
  
Cross references: Ensembl peptide - ENSDARP00000125104
Ensembl peptide - ENSDARP00000149394
NCBI entrez gene - 571897     See in Manteia.
swissprot - A4FVK4
ZFIN ID - ZDB-GENE-070424-36
Ensembl - ENSDARG00000067920
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 RAB8AENSGALG00000028851Gallus gallus
 RAB8AENSG00000167461Homo sapiens
 Rab8aENSMUSG00000003037Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
rab8b / RAB8B, member RAS oncogene family / P61028* / Q92930*ENSDARG0000006862883
megf8 / multiple EGF-like-domains 8ENSDARG0000010393474
rab10 / RAB10, member RAS oncogene family / P61026*ENSDARG0000004610668
rab13 / Q7T3A4 / RAB13, member RAS oncogene family / Q9DD03* / P51153* / Ras-related protein Rab-13 *ENSDARG0000003477165
rab3c / RAB3C, member RAS oncogene familyENSDARG0000001446251
rab15 / RAB15, member RAS oncogene family / P59190*ENSDARG0000002648447
rab3da / RAB3D, member RAS oncogene family, a / RAB3D* / P35276* / O95716* / RAB3D, member RAS oncogene family*ENSDARG0000001810747
rab3aa / RAB3A, member RAS oncogene family, a / RAB3A* / P63011* / P20336* / RAB3A, member RAS oncogene family*ENSDARG0000005634747
rab3ab / RAB3A, member RAS oncogene family, b / RAB3A* / P63011* / P20336* / RAB3A, member RAS oncogene family*ENSDARG0000004383546
rab3b / RAB3B, member RAS oncogene family / RAB3C* / Q9CZT8* / P20337* / P62823* / Q96E17* / RAB3C, member RAS oncogene family*ENSDARG0000011479745
rab3db / RAB3D, member RAS oncogene family, b / RAB3D* / P35276* / O95716* / RAB3D, member RAS oncogene family*ENSDARG0000010153444
rab12 / RAB12, member RAS oncogene family / Q6IQ22*ENSDARG0000008942843
rab27a / RAB27A, member RAS oncogene family / P51159*ENSDARG0000010393540
A5WW21 / zgc:162879ENSDARG0000007416339
rab44 / RAB44, member RAS oncogene family / Q8CB87* / Ras-related protein Rab-44 *ENSDARG0000002838939
rab27b / RAB27B, member RAS oncogene family / O00194* / Q99P58*ENSDARG0000008776239
rasef / RAS and EF-hand domain containing / Q5RI75* / Q8IZ41* / Ras and EF-hand domain-containing protein homolog *ENSDARG0000007625035


Protein motifs (from Interpro)
Interpro ID Name
 IPR001806  Small GTPase superfamily
 IPR005225  Small GTP-binding protein domain
 IPR027417  P-loop containing nucleoside triphosphate hydrolase


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0032402 melanosome transport IMP
 biological_processGO:0035845 photoreceptor cell outer segment organization IMP
 cellular_componentGO:0005622 intracellular IEA
 molecular_functionGO:0003924 GTPase activity IEA
 molecular_functionGO:0005525 GTP binding IEA


Pathways (from Reactome)
Pathway description
Regulation of PLK1 Activity at G2/M Transition
Anchoring of the basal body to the plasma membrane
VxPx cargo-targeting to cilium
TBC/RABGAPs
RAB geranylgeranylation
RAB GEFs exchange GTP for GDP on RABs


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000047 peripheral olfactory organ peripheral olfactory organ cilium decreased length , abnormal
Show

 ZFA:0000150 pronephric duct pronephric duct cystic , abnormal
Show

 ZFA:0001117 post-vent region post-vent region curved ventral , abnormal
Show

 ZFA:0009154 eye photoreceptor cell eye photoreceptor cell photoreceptor outer segment decreased length , abnormal
Show

 ZFA:0009275 retinal rod cell retinal rod cell photoreceptor outer segment decreased length , abnormal
retinal rod cell photoreceptor outer segment malformed , abnormal
Show

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000002193 rho / P35359 / rhodopsin / P08100*  / complex
 ENSDARG00000058471 plk1 / polo-like kinase 1 (Drosophila) / P53350* / Q07832* / polo like kinase 1*  / reaction
 ENSDARG00000070666 rhol / rhodopsin, like / RHO* / P15409* / P08100* / rhodopsin*  / complex
 ENSDARG00000056122 gdi1 / GDP dissociation inhibitor 1 / P31150* / P50396* / Rab GDP dissociation inhibitor alpha *  / complex
 ENSDARG00000005927 tbc1d17 / TBC1 domain family, member 17 / Q8BYH7* / Q9HA65*  / reaction / complex
 ENSDARG00000100436 cnga2 / cyclic nucleotide gated channel alpha 2 / Q16280*  / complex
 ENSDARG00000102968 cnga5 / cyclic nucleotide gated channel alpha 5 / CNGA2* / Q62398* / Q16280* / cyclic nucleotide gated channel alpha 2* / Cyclic nucleotide-gated olfactory channel *  / complex






 

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