ENSG00000132405


Homo sapiens

Features
Gene ID: ENSG00000132405
  
Biological name :TBC1D14
  
Synonyms : Q9P2M4 / TBC1D14 / TBC1 domain family member 14
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 4
Strand: 1
Band: p16.1
Gene start: 6909242
Gene end: 7033118
  
Corresponding Affymetrix probe sets: 224622_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000404041
Ensembl peptide - ENSP00000389082
Ensembl peptide - ENSP00000405875
Ensembl peptide - ENSP00000414951
Ensembl peptide - ENSP00000411760
Ensembl peptide - ENSP00000386343
Ensembl peptide - ENSP00000386921
Ensembl peptide - ENSP00000388886
NCBI entrez gene - 57533     See in Manteia.
OMIM - 614855
RefSeq - XM_017008480
RefSeq - NM_001286805
RefSeq - NM_001330638
RefSeq - NM_020773
RefSeq - XM_005247986
RefSeq - XM_006713895
RefSeq - XM_011513507
RefSeq - XM_011513508
RefSeq - XM_011513513
RefSeq - XM_017008477
RefSeq - XM_017008478
RefSeq - XM_017008479
RefSeq - NM_001113361
RefSeq - NM_001113363
RefSeq Peptide - NP_001106834
RefSeq Peptide - NP_001273734
RefSeq Peptide - NP_001317567
RefSeq Peptide - NP_065824
RefSeq Peptide - NP_001106832
swissprot - B9A071
swissprot - C9JP26
swissprot - C9J541
swissprot - F5GXK4
swissprot - H7BZD7
swissprot - Q9P2M4
Ensembl - ENSG00000132405
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 tbc1d14ENSDARG00000003520Danio rerio
 TBC1D14ENSGALG00000015546Gallus gallus
 Tbc1d14ENSMUSG00000029192Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
O60347 / TBC1D12 / TBC1 domain family member 12ENSG0000010823952
Q86TI0 / TBC1D1 / TBC1 domain family member 1ENSG0000006588220
Q9Y3P9 / RABGAP1 / RAB GTPase activating protein 1ENSG0000001145419
O60343 / TBC1D4 / TBC1 domain family member 4ENSG0000013611119
B7ZAP0 / Q5R372 / RABGAP1L / RAB GTPase activating protein 1 likeENSG0000015206118
EVI5 / O60447 / ecotropic viral integration site 5ENSG0000006720814
EVI5L / Q96CN4 / ecotropic viral integration site 5 likeENSG0000014245913


Protein motifs (from Interpro)
Interpro ID Name
 IPR000195  Rab-GTPase-TBC domain
 IPR035969  Rab-GTPase-TBC domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006886 intracellular protein transport IBA
 biological_processGO:0010507 negative regulation of autophagy IMP
 biological_processGO:0031338 regulation of vesicle fusion IBA
 biological_processGO:0071955 recycling endosome to Golgi transport IMP
 biological_processGO:0090630 activation of GTPase activity IBA
 biological_processGO:2000785 regulation of autophagosome assembly IMP
 cellular_componentGO:0005654 nucleoplasm IDA
 cellular_componentGO:0005776 autophagosome IDA
 cellular_componentGO:0005794 Golgi apparatus IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0043231 intracellular membrane-bounded organelle IDA
 cellular_componentGO:0055037 recycling endosome TAS
 molecular_functionGO:0005096 GTPase activator activity IBA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0017137 Rab GTPase binding IBA
 molecular_functionGO:0019901 protein kinase binding IPI


Pathways (from Reactome)
Pathway description
TBC/RABGAPs


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000103769 P62491 / RAB11A / RAB11A, member RAS oncogene family  / complex / reaction
 ENSG00000185236 Q15907 / RAB11B / RAB11B, member RAS oncogene family  / reaction / complex
 ENSG00000177169 ULK1 / O75385 / unc-51 like autophagy activating kinase 1  / complex / reaction






 

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