ENSG00000185236


Homo sapiens

Features
Gene ID: ENSG00000185236
  
Biological name :RAB11B
  
Synonyms : Q15907 / RAB11B / RAB11B, member RAS oncogene family
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 19
Strand: 1
Band: p13.2
Gene start: 8389981
Gene end: 8404434
  
Corresponding Affymetrix probe sets: 217793_at (Human Genome U133 Plus 2.0 Array)   34478_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000473042
Ensembl peptide - ENSP00000333547
Ensembl peptide - ENSP00000471148
Ensembl peptide - ENSP00000472473
NCBI entrez gene - 9230     See in Manteia.
OMIM - 604198
RefSeq - NM_004218
RefSeq Peptide - NP_004209
swissprot - M0R2D0
swissprot - M0R377
swissprot - Q15907
Ensembl - ENSG00000185236
  
Related genetic diseases (OMIM): 617807 - Neurodevelopmental disorder with ataxic gait, absent speech, and decreased cortical white matter, 617807
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 rab11baENSDARG00000041878Danio rerio
 rab11bbENSDARG00000090086Danio rerio
 RAB11BENSGALG00000037802Gallus gallus
 P46638ENSMUSG00000077450Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
P62491 / RAB11A / RAB11A, member RAS oncogene familyENSG0000010376990
RAB25 / P57735 / RAB25, member RAS oncogene familyENSG0000013269858
RAB2B / Q8WUD1 / RAB2B, member RAS oncogene familyENSG0000012947246
RAB2A / P61019 / RAB2A, member RAS oncogene familyENSG0000010438845
RAB4A / P20338 / RAB4A, member RAS oncogene familyENSG0000016811844
RAB4B-EGLN2 / RAB4B-EGLN2 readthrough (NMD candidate)ENSG0000017157044
RAB4B / P61018 / RAB4B, member RAS oncogene familyENSG0000016757844
RAB14 / P61106 / RAB14, member RAS oncogene familyENSG0000011939643
Q96DA2 / RAB39B / RAB39B, member RAS oncogene familyENSG0000015596139
RAB18 / Q9NP72 / RAB18, member RAS oncogene familyENSG0000009924639
Q14964 / RAB39A / RAB39A, member RAS oncogene familyENSG0000017933138
RAB42 / Q8N4Z0 / RAB42, member RAS oncogene familyENSG0000018806011


Protein motifs (from Interpro)
Interpro ID Name
 IPR001806  Small GTPase superfamily
 IPR005225  Small GTP-binding protein domain
 IPR027417  P-loop containing nucleoside triphosphate hydrolase


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001881 receptor recycling ISS
 biological_processGO:0015031 protein transport IEA
 biological_processGO:0032402 melanosome transport ISS
 biological_processGO:0033572 transferrin transport ISS
 biological_processGO:0035773 insulin secretion involved in cellular response to glucose stimulus ISS
 biological_processGO:0043687 post-translational protein modification TAS
 biological_processGO:0044070 regulation of anion transport IMP
 biological_processGO:0045054 constitutive secretory pathway IMP
 biological_processGO:0045055 regulated exocytosis IBA
 biological_processGO:0045056 transcytosis IMP
 biological_processGO:0071468 cellular response to acidic pH IDA
 biological_processGO:0090150 establishment of protein localization to membrane IMP
 biological_processGO:1990126 retrograde transport, endosome to plasma membrane IMP
 biological_processGO:2000008 regulation of protein localization to cell surface IMP
 biological_processGO:2001135 regulation of endocytic recycling ISS
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005739 mitochondrion IEA
 cellular_componentGO:0005768 endosome IEA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0008021 synaptic vesicle ISS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0030054 cell junction IEA
 cellular_componentGO:0030670 phagocytic vesicle membrane IEA
 cellular_componentGO:0030672 synaptic vesicle membrane IEA
 cellular_componentGO:0031410 cytoplasmic vesicle IEA
 cellular_componentGO:0045202 synapse IEA
 cellular_componentGO:0045335 phagocytic vesicle IDA
 cellular_componentGO:0055037 recycling endosome IBA
 cellular_componentGO:0055038 recycling endosome membrane TAS
 cellular_componentGO:0070062 extracellular exosome HDA
 cellular_componentGO:0098993 anchored component of synaptic vesicle membrane IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0003924 GTPase activity IDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005525 GTP binding IDA
 molecular_functionGO:0019003 GDP binding IDA
 molecular_functionGO:0031489 myosin V binding IPI
 molecular_functionGO:0045296 cadherin binding IDA


Pathways (from Reactome)
Pathway description
TBC/RABGAPs
RAB geranylgeranylation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000132405 Q9P2M4 / TBC1D14 / TBC1 domain family member 14  / complex / reaction
 ENSG00000177169 ULK1 / O75385 / unc-51 like autophagy activating kinase 1  / reaction / complex






 

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