ENSMUSG00000079477


Mus musculus

Features
Gene ID: ENSMUSG00000079477
  
Biological name :Rab7
  
Synonyms : P51150 / Rab7 / RAB7, member RAS oncogene family
  
Possible biological names infered from orthology : P51149 / RAB7A / RAB7A, member RAS oncogene family
  
Species: Mus musculus
  
Chr. number: 6
Strand: -1
Band: D1
Gene start: 87999106
Gene end: 88045270
  
Corresponding Affymetrix probe sets: 10546092 (MoGene1.0st)   10338076 (MoGene1.0st)   10339697 (MoGene1.0st)   10340293 (MoGene1.0st)   10340428 (MoGene1.0st)   10340602 (MoGene1.0st)   10342860 (MoGene1.0st)   10343176 (MoGene1.0st)   10343787 (MoGene1.0st)   10343927 (MoGene1.0st)   10338861 (MoGene1.0st)   10338926 (MoGene1.0st)   10339976 (MoGene1.0st)   10340662 (MoGene1.0st)   10341872 (MoGene1.0st)   10343709 (MoGene1.0st)   1415734_at (Mouse Genome 430 2.0 Array)   1448159_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000145097
Ensembl peptide - ENSMUSP00000109230
Ensembl peptide - ENSMUSP00000145215
Ensembl peptide - ENSMUSP00000092658
Ensembl peptide - ENSMUSP00000109226
Ensembl peptide - ENSMUSP00000109227
Ensembl peptide - ENSMUSP00000109228
NCBI entrez gene - 19349     See in Manteia.
MGI - MGI:105068
RefSeq - NM_001293652
RefSeq - NM_001293653
RefSeq - NM_001293654
RefSeq - NM_001293655
RefSeq - NM_009005
RefSeq Peptide - NP_033031
RefSeq Peptide - NP_001280581
RefSeq Peptide - NP_001280582
RefSeq Peptide - NP_001280583
RefSeq Peptide - NP_001280584
swissprot - Q4FJQ0
swissprot - A0A0N4SVR6
swissprot - A0A0N4SVG9
swissprot - P51150
Ensembl - ENSMUSG00000079477
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 rab7ENSDARG00000020497Danio rerio
 RAB7AENSGALG00000005902Gallus gallus
 RAB7AENSG00000075785Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Rab9b / Q8BHH2 / RAB9B, member RAS oncogene family / Q9NP90*ENSMUSG0000004346351
Rab9 / Q9R0M6 / RAB9, member RAS oncogene family / RAB9A* / P51151* / RAB9A, member RAS oncogene family*ENSMUSG0000007931649
Rab7b / Q8VEA8 / RAB7B, member RAS oncogene family / Q96AH8*ENSMUSG0000005268848
Rab23 / RAB23, member RAS oncogene family / Q9ULC3*ENSMUSG0000000476832
Rab32 / Q9CZE3 / RAB32, member RAS oncogene family / Q13637*ENSMUSG0000001983232
Rab38 / Q8QZZ8 / RAB38, member RAS oncogene family / P57729*ENSMUSG0000003055932
Rab29 / RAB29, member RAS oncogene family / O14966*ENSMUSG0000002643331


Protein motifs (from Interpro)
Interpro ID Name
 IPR001806  Small GTPase superfamily
 IPR005225  Small GTP-binding protein domain
 IPR027417  P-loop containing nucleoside triphosphate hydrolase


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000045 autophagosome assembly ISO
 biological_processGO:0006622 protein targeting to lysosome ISO
 biological_processGO:0006629 lipid metabolic process IEA
 biological_processGO:0006886 intracellular protein transport TAS
 biological_processGO:0006914 autophagy IEA
 biological_processGO:0007174 epidermal growth factor catabolic process ISO
 biological_processGO:0008333 endosome to lysosome transport ISO
 biological_processGO:0015031 protein transport IEA
 biological_processGO:0016042 lipid catabolic process IEA
 biological_processGO:0019076 viral release from host cell ISO
 biological_processGO:0022615 protein to membrane docking ISO
 biological_processGO:0042147 retrograde transport, endosome to Golgi ISO
 biological_processGO:0045022 early endosome to late endosome transport ISO
 biological_processGO:0045453 bone resorption IEA
 biological_processGO:0045732 positive regulation of protein catabolic process ISO
 biological_processGO:0048524 positive regulation of viral process ISO
 biological_processGO:0061724 lipophagy IMP
 biological_processGO:0090383 phagosome acidification ISO
 biological_processGO:0090385 phagosome-lysosome fusion ISO
 biological_processGO:1903542 negative regulation of exosomal secretion ISO
 biological_processGO:1903543 positive regulation of exosomal secretion ISO
 cellular_componentGO:0000421 autophagosome membrane IEA
 cellular_componentGO:0005737 cytoplasm IDA
 cellular_componentGO:0005764 lysosome ISO
 cellular_componentGO:0005765 lysosomal membrane IEA
 cellular_componentGO:0005768 endosome IEA
 cellular_componentGO:0005770 late endosome ISO
 cellular_componentGO:0005794 Golgi apparatus IDA
 cellular_componentGO:0005811 lipid droplet IDA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0010008 endosome membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0030670 phagocytic vesicle membrane IEA
 cellular_componentGO:0030904 retromer complex ISO
 cellular_componentGO:0031410 cytoplasmic vesicle IEA
 cellular_componentGO:0031902 late endosome membrane IDA
 cellular_componentGO:0032419 extrinsic component of lysosome membrane IDA
 cellular_componentGO:0033162 melanosome membrane IEA
 cellular_componentGO:0034045 phagophore assembly site membrane IDA
 cellular_componentGO:0043195 terminal bouton IEA
 cellular_componentGO:0045335 phagocytic vesicle ISS
 cellular_componentGO:0097208 alveolar lamellar body IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0003924 GTPase activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005525 GTP binding IEA
 molecular_functionGO:0019003 GDP binding ISO
 molecular_functionGO:0048365 Rac GTPase binding IEA
 molecular_functionGO:1905394 retromer complex binding ISO


Pathways (from Reactome)
Pathway description
MHC class II antigen presentation
Neutrophil degranulation
TBC/RABGAPs
RAB geranylgeranylation
RAB GEFs exchange GTP for GDP on RABs


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001696 failure to gastrulate "inability to differentiate and invaginate the primary germ layers" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:34458]
Show

Allelic Composition: Pgm1b-m1Ehs/Pgm1b-m1Ehs
Genetic Background: involves: DBA/2J

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Olfr160tm1.1(COP4*/EYFP)Tboz/Olfr160tm1.1(COP4*/EYFP)Tboz
Genetic Background: involves: 129 * C57BL/6

 MP:0002444 abnormal T cell physiology "anomalous response of T lymphocytes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Prdm13tm1.1Tfur/Prdm13tm1.1Tfur,Tg(Dkk3-cre)D9Tfur/0
Genetic Background: involves: C3H * C57BL/6 * C57BL/6J * C57BL/6N

 MP:0003674 oxidative stress "condition characterized by an accumulation of free radical groups in the body, which creates a potentially unstable and damaging cellular environment linked to tissue damage, accelerated aging, and degenerative disease; can result from many factors, including exposure to alcohol, medications, poor nutrition, trauma, cold or toxins; may be indicated by low antioxidant levels measured in blood plasma" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Prdm13tm1.1Tfur/Prdm13tm1.1Tfur,Tg(Dkk3-cre)D9Tfur/0
Genetic Background: involves: C3H * C57BL/6 * C57BL/6J * C57BL/6N

 MP:0003944 abnormal T cell subpopulation ratio "deviation from the standard ratios of T cell subpopulations (e.g. double positive to single positive ratio) compared to control samples" [mberry:Melissa Berry, Genetics Resources Curator]
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Allelic Composition: Prdm13tm1.1Tfur/Prdm13tm1.1Tfur,Tg(Dkk3-cre)D9Tfur/0
Genetic Background: involves: C3H * C57BL/6 * C57BL/6J * C57BL/6N

 MP:0005018 decreased T cell number "fewer than normal T cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Prdm13tm1.1Tfur/Prdm13tm1.1Tfur,Tg(Dkk3-cre)D9Tfur/0
Genetic Background: involves: C3H * C57BL/6 * C57BL/6J * C57BL/6N

 MP:0005095 decreased T cell proliferation "reduced clonal expansion of naive T cells in response to stimuli" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Prdm13tm1.1Tfur/Prdm13tm1.1Tfur,Tg(Dkk3-cre)D9Tfur/0
Genetic Background: involves: C3H * C57BL/6 * C57BL/6J * C57BL/6N

 MP:0008037 abnormal T cell morphology "any structural anomaly of lymphocytes that are responsible for cell-mediated immunity and immune system regulation" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Prdm13tm1.1Tfur/Prdm13tm1.1Tfur,Tg(Dkk3-cre)D9Tfur/0
Genetic Background: involves: C3H * C57BL/6 * C57BL/6J * C57BL/6N

 MP:0008075 decreased CD4-positive T cell number "reduced number of the subset of T lymphocytes that carry the CD4 marker, recognize intravesicular peptides bound to MHC class-II molecules, and turn on antibody production" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Prdm13tm1.1Tfur/Prdm13tm1.1Tfur,Tg(Dkk3-cre)D9Tfur/0
Genetic Background: involves: C3H * C57BL/6 * C57BL/6J * C57BL/6N

 MP:0008079 decreased CD8-positive T cell number "reduction in the number of the regulatory subset of T lymphocytes that are involved in MHC class I restricted interactions" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Prdm13tm1.1Tfur/Prdm13tm1.1Tfur,Tg(Dkk3-cre)D9Tfur/0
Genetic Background: involves: C3H * C57BL/6 * C57BL/6J * C57BL/6N

 MP:0008260 abnormal autophagy "abnormal catabolic process involving the degradation of a cell s own components through the lysosomal machinery" [MGI:honda "Hiraoki Onda, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Prdm13tm1.1Tfur/Prdm13tm1.1Tfur,Tg(Dkk3-cre)D9Tfur/0
Genetic Background: involves: C3H * C57BL/6 * C57BL/6J * C57BL/6N

 MP:0008762 embryonic lethality "death of an animal in the embryonic period (Mus: up to E14)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Braftm1Cpri/Braftm1Cpri,Gnastm3Lsw/Gnastm3Lsw,Tg(TPO-cre)1Shk/0
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * FVB/NCr

 MP:0010831 partial lethality "the appearance of lower than Mendelian ratios of offspring of a given genotype due to death of some, but not all of the organisms" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Prdm13tm1.1Tfur/Prdm13tm1.1Tfur,Tg(Dkk3-cre)D9Tfur/0
Genetic Background: involves: C3H * C57BL/6 * C57BL/6J * C57BL/6N

 MP:0011186 abnormal visceral endoderm morphology "any structural anomaly of the primitive endoderm-derived tissue which remains in contact with and surrounds the extra-embryonic ectoderm and the epiblast and provides signals for the differentiation and patterning of the epiblast; a small number of visceral endoderm cells also contribute to the endoderm of the embryonic gut" [PMID:21123814]
Show

Allelic Composition: Pgm1b-m1Ehs/Pgm1b-m1Ehs
Genetic Background: involves: DBA/2J

 MP:0011630 increased mitochondria size "enlarged the cellular organelles responsible for energy production" [MGI:csmith]
Show

Allelic Composition: Prdm13tm1.1Tfur/Prdm13tm1.1Tfur,Tg(Dkk3-cre)D9Tfur/0
Genetic Background: involves: C3H * C57BL/6 * C57BL/6J * C57BL/6N

 MP:0012685 abnormal primitive streak elongation "any anomaly in the process by which the primitive streak extends anteriorly and elongates towards the distal (cranial) end of the embryo to reach its full length" [MGI:anna]
Show

Allelic Composition: Pgm1b-m1Ehs/Pgm1b-m1Ehs
Genetic Background: involves: DBA/2J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000015291 Gdi1 / P50396 / Rab GDP dissociation inhibitor alpha / P31150* / GDP dissociation inhibitor 1*  / complex
 ENSMUSG00000025531 Chm / choroidermia (RAB escort protein 1) / P24386* / CHM, Rab escort protein 1*  / complex
 ENSMUSG00000038195 Rilp / Q5ND29 / Rab interacting lysosomal protein / Q96NA2*  / complex
 ENSMUSG00000029617 Ccz1 / Q8C1Y8 / Vacuolar fusion / CCZ1B* / P86790* / P86791* / CCZ1 homolog, vacuolar protein trafficking and biogenesis associated* / CCZ1 homolog B, vacuolar protein trafficking and bio...  / reaction
 ENSMUSG00000032583 Mon1a / MON1 homolog A, secretory trafficking associated / Q86VX9*  / reaction
 ENSMUSG00000021218 Gdi2 / Q61598 / Rab GDP dissociation inhibitor beta / P50395* / GDP dissociation inhibitor 2*  / complex
 ENSMUSG00000079477 Rab7 / P51150 / RAB7, member RAS oncogene family / RAB7A* / P51149* / RAB7A, member RAS oncogene family*  / complex
 ENSMUSG00000044252 Q91XL9 / Osbpl1a / Oxysterol-binding protein-related protein 1 / Q9BXW6* / oxysterol binding protein like 1A*  / complex
 ENSMUSG00000078185 Chml / choroideremia-like / P26374* / CHM like, Rab escort protein 2*  / complex






 

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