ENSMUSG00000036104


Mus musculus

Features
Gene ID: ENSMUSG00000036104
  
Biological name :Rab3gap1
  
Synonyms : Q80UJ7 / Rab3gap1 / Rab3 GTPase-activating protein catalytic subunit
  
Possible biological names infered from orthology : Q15042 / RAB3 GTPase activating protein catalytic subunit 1
  
Species: Mus musculus
  
Chr. number: 1
Strand: 1
Band: E3
Gene start: 127868773
Gene end: 127943868
  
Corresponding Affymetrix probe sets: 10349453 (MoGene1.0st)   1455922_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000148357
Ensembl peptide - ENSMUSP00000042070
NCBI entrez gene - 226407     See in Manteia.
MGI - MGI:2445001
RefSeq - NM_178690
RefSeq - XM_006529405
RefSeq Peptide - NP_848805
swissprot - A0A1D5RLG3
swissprot - Q80UJ7
Ensembl - ENSMUSG00000036104
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 rab3gap1ENSDARG00000098079Danio rerio
 RAB3GAP1ENSGALG00000012214Gallus gallus
 Q15042ENSG00000115839Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR026147  Rab3 GTPase-activating protein catalytic subunit


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007420 brain development IEA
 biological_processGO:0010628 positive regulation of gene expression IDA
 biological_processGO:0010807 regulation of synaptic vesicle priming TAS
 biological_processGO:0021854 hypothalamus development IEA
 biological_processGO:0032483 regulation of Rab protein signal transduction ISS
 biological_processGO:0034389 lipid particle organization IEA
 biological_processGO:0043010 camera-type eye development IEA
 biological_processGO:0043087 regulation of GTPase activity IEA
 biological_processGO:0043547 positive regulation of GTPase activity IEA
 biological_processGO:0048172 regulation of short-term neuronal synaptic plasticity IMP
 biological_processGO:0048489 synaptic vesicle transport NAS
 biological_processGO:0050821 protein stabilization IC
 biological_processGO:0060079 excitatory postsynaptic potential IMP
 biological_processGO:0060325 face morphogenesis IEA
 biological_processGO:0061646 positive regulation of glutamate neurotransmitter secretion in response to membrane depolarization IMP
 biological_processGO:0097051 establishment of protein localization to endoplasmic reticulum membrane IEA
 biological_processGO:1903061 positive regulation of protein lipidation IEA
 biological_processGO:1903233 regulation of calcium ion-dependent exocytosis of neurotransmitter IMP
 biological_processGO:1903373 positive regulation of endoplasmic reticulum tubular network organization IEA
 biological_processGO:2000786 positive regulation of autophagosome assembly IEA
 cellular_componentGO:0005737 cytoplasm ISS
 cellular_componentGO:0005794 Golgi apparatus IEA
 cellular_componentGO:0005811 lipid droplet IEA
 cellular_componentGO:0032991 protein-containing complex IEA
 cellular_componentGO:0045202 synapse IEA
 cellular_componentGO:0071782 endoplasmic reticulum tubular network IEA
 cellular_componentGO:0098794 postsynapse IEA
 molecular_functionGO:0005096 GTPase activator activity IEA
 molecular_functionGO:0017112 Rab guanyl-nucleotide exchange factor activity IEA
 molecular_functionGO:0017137 Rab GTPase binding IEA


Pathways (from Reactome)
Pathway description
COPI-independent Golgi-to-ER retrograde traffic
RAB GEFs exchange GTP for GDP on RABs


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0002910 abnormal excitatory postsynaptic currents "defect in the size or duration of currents detected in postsynaptic cells when an excitatory impulse arrives at the synapse causing depolarization" [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
Show

Allelic Composition: Mavstm1Zjc/Mavs+
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0002919 enhanced paired-pulse facilitation "increase in the response of central synapses when activated twice in rapid succession; indicative of defects in short-term plasticity due to greater increase of neurotransmitter release at the second stimulus" [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
Show

Allelic Composition: Mavstm1Zjc/Mavs+
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0005445 abnormal neurotransmitter release "aberration in the secretion of endogenous signaling molecules normally secreted by neurons that alter the behavior of neurons or effector cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Mavstm1Zjc/Mavs+
Genetic Background: involves: 129/Sv * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000073639 Rab18 / P35293 / RAB18, member RAS oncogene family / Q9NP72*  / reaction / complex
 ENSMUSG00000078185 Chml / choroideremia-like / P26374* / CHM like, Rab escort protein 2*  / reaction
 ENSMUSG00000015291 Gdi1 / P50396 / Rab GDP dissociation inhibitor alpha / P31150* / GDP dissociation inhibitor 1*  / reaction
 ENSMUSG00000025531 Chm / choroidermia (RAB escort protein 1) / P24386* / CHM, Rab escort protein 1*  / reaction
 ENSMUSG00000021218 Gdi2 / Q61598 / Rab GDP dissociation inhibitor beta / P50395* / GDP dissociation inhibitor 2*  / reaction
 ENSMUSG00000039318 Rab3gap2 / RAB3 GTPase activating non-catalytic protein subunit 2 / Q9H2M9*  / complex






 

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