ENSMUSG00000034867


Mus musculus

Features
Gene ID: ENSMUSG00000034867
  
Biological name :Ankrd27
  
Synonyms : Ankrd27 / Ankyrin repeat domain-containing protein 27 / Q3UMR0
  
Possible biological names infered from orthology : ankyrin repeat domain 27 / Q96NW4
  
Species: Mus musculus
  
Chr. number: 7
Strand: 1
Band: B2
Gene start: 35586244
Gene end: 35639226
  
Corresponding Affymetrix probe sets: 10552210 (MoGene1.0st)   1425112_at (Mouse Genome 430 2.0 Array)   1454717_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000139753
Ensembl peptide - ENSMUSP00000146118
Ensembl peptide - ENSMUSP00000145969
Ensembl peptide - ENSMUSP00000145817
Ensembl peptide - ENSMUSP00000140848
Ensembl peptide - ENSMUSP00000140554
Ensembl peptide - ENSMUSP00000140259
Ensembl peptide - ENSMUSP00000041751
NCBI entrez gene - 245886     See in Manteia.
MGI - MGI:2444103
RefSeq - XM_017322266
RefSeq - NM_145633
RefSeq - NM_178263
RefSeq - XM_006539985
RefSeq - XM_006539986
RefSeq - XM_017322264
RefSeq Peptide - NP_839994
RefSeq Peptide - NP_663608
swissprot - A0A0U1RP40
swissprot - A0A0R4J2C4
swissprot - A0A087WS06
swissprot - A0A087WPF2
swissprot - Q3UMR0
swissprot - A0A0U1RPG1
swissprot - A0A0U1RPT7
Ensembl - ENSMUSG00000034867
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ankrd27ENSDARG00000089207Danio rerio
 ANKRD27ENSGALG00000004671Gallus gallus
 Q96NW4ENSG00000105186Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Trpa1 / Q8BLA8 / Transient receptor potential cation channel subfamily A member 1 / O75762*ENSMUSG0000003276913


Protein motifs (from Interpro)
Interpro ID Name
 IPR002110  Ankyrin repeat
 IPR003123  VPS9 domain
 IPR020683  Ankyrin repeat-containing domain
 IPR036770  Ankyrin repeat-containing domain superfamily
 IPR037191  VPS9 domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0010976 positive regulation of neuron projection development IEA
 biological_processGO:0015031 protein transport IEA
 biological_processGO:0035544 negative regulation of SNARE complex assembly ISO
 biological_processGO:0035646 endosome to melanosome transport IDA
 biological_processGO:0043547 positive regulation of GTPase activity IBA
 biological_processGO:0045022 early endosome to late endosome transport IBA
 biological_processGO:0048812 neuron projection morphogenesis IMP
 biological_processGO:0050775 positive regulation of dendrite morphogenesis IMP
 biological_processGO:0065009 regulation of molecular function IEA
 biological_processGO:1990126 retrograde transport, endosome to plasma membrane IBA
 cellular_componentGO:0005764 lysosome ISO
 cellular_componentGO:0005768 endosome IEA
 cellular_componentGO:0005769 early endosome IBA
 cellular_componentGO:0005770 late endosome IBA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0005886 plasma membrane IBA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0030133 transport vesicle IDA
 cellular_componentGO:0030659 cytoplasmic vesicle membrane IEA
 cellular_componentGO:0031410 cytoplasmic vesicle IEA
 cellular_componentGO:0042470 melanosome IEA
 cellular_componentGO:0043005 neuron projection IDA
 cellular_componentGO:0097422 tubular endosome IBA
 molecular_functionGO:0000149 SNARE binding IDA
 molecular_functionGO:0005085 guanyl-nucleotide exchange factor activity IBA
 molecular_functionGO:0005096 GTPase activator activity IEA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0017137 Rab GTPase binding ISO


Pathways (from Reactome)
Pathway description
RAB GEFs exchange GTP for GDP on RABs


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000219 increased neutrophil count "greater than normal neutrophil numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Ankrd11tm1b(EUCOMM)Wtsi/Ankrd11+
Genetic Background: C57BL/6N-Ankrd11tm1b(EUCOMM)Wtsi/Ics

 MP:0002066 abnormal motor capabilities/coordination/movement "altered ability to coordinate voluntary movement or repetitive, compulsive movements" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Ankrd11tm1b(EUCOMM)Wtsi/Ankrd11+
Genetic Background: C57BL/6N-Ankrd11tm1b(EUCOMM)Wtsi/Ics

 MP:0002764 short tibia " reduced length of the medial and larger bone of the lower leg" [J:12736, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Ankrd11tm1b(EUCOMM)Wtsi/Ankrd11+
Genetic Background: C57BL/6N-Ankrd11tm1b(EUCOMM)Wtsi/Ics

 MP:0011965 decreased total retina thickness "decreased width of the retina through the center plane" [MGI:csmith]
Show

Allelic Composition: Ankrd11tm1b(EUCOMM)Wtsi/Ankrd11+
Genetic Background: C57BL/6N-Ankrd11tm1b(EUCOMM)Wtsi/Ics

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000020132 Rab21 / P35282 / RAB21, member RAS oncogene family / Q9UL25*  / reaction
 ENSMUSG00000078185 Chml / choroideremia-like / P26374* / CHM like, Rab escort protein 2*  / reaction
 ENSMUSG00000025531 Chm / choroidermia (RAB escort protein 1) / P24386* / CHM, Rab escort protein 1*  / reaction
 ENSMUSG00000021218 Gdi2 / Q61598 / Rab GDP dissociation inhibitor beta / P50395* / GDP dissociation inhibitor 2*  / reaction
 ENSMUSG00000015291 Gdi1 / P50396 / Rab GDP dissociation inhibitor alpha / P31150* / GDP dissociation inhibitor 1*  / reaction






 

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