ENSG00000137955


Homo sapiens

Features
Gene ID: ENSG00000137955
  
Biological name :RABGGTB
  
Synonyms : P53611 / Rab geranylgeranyltransferase beta subunit / RABGGTB
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 1
Strand: 1
Band: p31.1
Gene start: 75786197
Gene end: 75795079
  
Corresponding Affymetrix probe sets: 209180_at (Human Genome U133 Plus 2.0 Array)   209181_s_at (Human Genome U133 Plus 2.0 Array)   213704_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000317473
Ensembl peptide - ENSP00000359862
NCBI entrez gene - 5876     See in Manteia.
OMIM - 179080
RefSeq - NM_004582
RefSeq Peptide - NP_004573
swissprot - P53611
swissprot - Q5T4U8
swissprot - Q6IB63
Ensembl - ENSG00000137955
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 rabggtbENSDARG00000068587Danio rerio
 RABGGTBENSGALG00000011388Gallus gallus
 P53612ENSMUSG00000038975Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
P53609 / PGGT1B / protein geranylgeranyltransferase type I subunit betaENSG0000016421929


Protein motifs (from Interpro)
Interpro ID Name
 IPR001330  PFTB repeat
 IPR008930  Terpenoid cyclases/protein prenyltransferase alpha-alpha toroid
 IPR026873  Geranylgeranyl transferase type-2 subunit beta


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006464 cellular protein modification process NAS
 biological_processGO:0007601 visual perception TAS
 biological_processGO:0018344 protein geranylgeranylation IBA
 biological_processGO:0042981 regulation of apoptotic process TAS
 biological_processGO:0043687 post-translational protein modification TAS
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0005968 Rab-protein geranylgeranyltransferase complex IBA
 molecular_functionGO:0003824 catalytic activity IEA
 molecular_functionGO:0004659 prenyltransferase activity IEA
 molecular_functionGO:0004663 Rab geranylgeranyltransferase activity ISS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008270 zinc ion binding ISS
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0017137 Rab GTPase binding ISS
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain
RAB geranylgeranylation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000203668 CHML / P26374 / CHM like, Rab escort protein 2  / complex / reaction
 ENSG00000100949 Q92696 / RABGGTA / Rab geranylgeranyltransferase alpha subunit  / complex / reaction
 ENSG00000188419 CHM / P24386 / CHM, Rab escort protein 1  / reaction / complex
 ENSG00000184007 PTP4A2 / Q12974 / protein tyrosine phosphatase type IVA, member 2  / reaction / complex






 

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