ENSMUSG00000026304


Mus musculus

Features
Gene ID: ENSMUSG00000026304
  
Biological name :Rab17
  
Synonyms : P35292 / Rab17 / Ras-related protein Rab-17
  
Possible biological names infered from orthology : Q9H0T7 / RAB17, member RAS oncogene family
  
Species: Mus musculus
  
Chr. number: 1
Strand: -1
Band: D
Gene start: 90958133
Gene end: 90969661
  
Corresponding Affymetrix probe sets: 10356568 (MoGene1.0st)   1422178_a_at (Mouse Genome 430 2.0 Array)   1450516_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000027529
Ensembl peptide - ENSMUSP00000114240
Ensembl peptide - ENSMUSP00000122178
NCBI entrez gene - 19329     See in Manteia.
MGI - MGI:104640
RefSeq - XM_006529263
RefSeq - NM_001159725
RefSeq - NM_008998
RefSeq Peptide - NP_001153197
RefSeq Peptide - NP_033024
swissprot - P35292
swissprot - Q0PD39
swissprot - D3YVQ6
Ensembl - ENSMUSG00000026304
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 RAB17ENSGALG00000003899Gallus gallus
 RAB17ENSG00000124839Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Rab5c / P35278 / RAB5C, member RAS oncogene family / P51148*ENSMUSG0000001917343
Rab5a / Q9CQD1 / Ras-related protein Rab-5A / P20339* / RAB5A, member RAS oncogene family*ENSMUSG0000001783142
Rab5b / P61021 / RAB5B, member RAS oncogene family / P61020*ENSMUSG0000000071138
Rab21 / P35282 / RAB21, member RAS oncogene family / Q9UL25*ENSMUSG0000002013236
Rab31 / RAB31, member RAS oncogene family / Q13636*ENSMUSG0000005651535
P35285 / Rab22a / RAB22A, member RAS oncogene family / Q9UL26*ENSMUSG0000002751933
Rab20 / P35295 / Ras-related protein Rab-20 / Q9NX57* / RAB20, member RAS oncogene family*ENSMUSG0000003150429
Q8CFP6 / Dnajc27 / DnaJ homolog subfamily C member 27 / Q9NZQ0* / DnaJ heat shock protein family (Hsp40) member C27*ENSMUSG0000002065727


Protein motifs (from Interpro)
Interpro ID Name
 IPR001806  Small GTPase superfamily
 IPR005225  Small GTP-binding protein domain
 IPR027417  P-loop containing nucleoside triphosphate hydrolase


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002415 immunoglobulin transcytosis in epithelial cells mediated by polymeric immunoglobulin receptor IMP
 biological_processGO:0015031 protein transport IEA
 biological_processGO:0032401 establishment of melanosome localization IMP
 biological_processGO:0032402 melanosome transport IMP
 biological_processGO:0032456 endocytic recycling IMP
 biological_processGO:0045056 transcytosis IMP
 biological_processGO:0046847 filopodium assembly IMP
 biological_processGO:0050773 regulation of dendrite development IMP
 biological_processGO:0051489 regulation of filopodium assembly IMP
 biological_processGO:0051963 regulation of synapse assembly IMP
 biological_processGO:0060271 cilium assembly ISO
 cellular_componentGO:0005622 intracellular ISO
 cellular_componentGO:0005768 endosome IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016323 basolateral plasma membrane IDA
 cellular_componentGO:0016324 apical plasma membrane IDA
 cellular_componentGO:0030139 endocytic vesicle ISO
 cellular_componentGO:0030425 dendrite IEA
 cellular_componentGO:0042470 melanosome IEA
 cellular_componentGO:0042995 cell projection IEA
 cellular_componentGO:0043025 neuronal cell body IDA
 cellular_componentGO:0055037 recycling endosome IDA
 cellular_componentGO:0055038 recycling endosome membrane IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0003924 GTPase activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005525 GTP binding IEA
 molecular_functionGO:0019003 GDP binding ISO


Pathways (from Reactome)
Pathway description
RAB geranylgeranylation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000334 decreased granulocyte number "fewer than expected number of leukocytes that have abundant granules in the cytoplasm: basophils, neutrophils, or eosinophils" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ptpn12tm1b(NCOM)Mfgc/Ptpn12tm1b(NCOM)Mfgc
Genetic Background: C57BL/6N-Ptpn12tm1b(NCOM)Mfgc/Tcp

 MP:0005014 increased B cell number "greater than normal B cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ptpn12tm1b(NCOM)Mfgc/Ptpn12tm1b(NCOM)Mfgc
Genetic Background: C57BL/6N-Ptpn12tm1b(NCOM)Mfgc/Tcp

 MP:0008097 increased plasma cell number "greater number of terminally differentiated, post-mitotic, short-lived cells of the B cell lineage devoted to producing large amounts of immunoglobulin" [CL:0000786, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ptpn12tm1b(NCOM)Mfgc/Ptpn12tm1b(NCOM)Mfgc
Genetic Background: C57BL/6N-Ptpn12tm1b(NCOM)Mfgc/Tcp

 MP:0010851 decreased effector memory CD8-positive, alpha-beta T cell number "reduced number of CD8-positive, alpha beta memory T cells with the phenotype CCR7-negative, CD127-positive, CD45RO-positive, and CD25-negative" [CL:0000913, GO_REF:0000031, GOC:add, GOC:pam, PMID:20146720]
Show

Allelic Composition: Ptpn12tm1b(NCOM)Mfgc/Ptpn12tm1b(NCOM)Mfgc
Genetic Background: C57BL/6N-Ptpn12tm1b(NCOM)Mfgc/Tcp

 MP:0011816 decreased pre-pro B cell number "reduced number of pro-B cells that are CD45R/B220-positive, CD43-positive, HSA-low, BP-1-negative and Ly6c-negative; this cell type is also described as being lin-negative, AA4-positive, Kit-positive, IL7Ra-positive and CD45R-positive" [CL:0002045, MGI:csmith]
Show

Allelic Composition: Ptpn12tm1b(NCOM)Mfgc/Ptpn12tm1b(NCOM)Mfgc
Genetic Background: C57BL/6N-Ptpn12tm1b(NCOM)Mfgc/Tcp

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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