ENSMUSG00000019173


Mus musculus

Features
Gene ID: ENSMUSG00000019173
  
Biological name :Rab5c
  
Synonyms : P35278 / Rab5c / RAB5C, member RAS oncogene family
  
Possible biological names infered from orthology : P51148
  
Species: Mus musculus
  
Chr. number: 11
Strand: -1
Band: D
Gene start: 100715009
Gene end: 100738215
  
Corresponding Affymetrix probe sets: 10391242 (MoGene1.0st)   1424684_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000117656
Ensembl peptide - ENSMUSP00000123581
Ensembl peptide - ENSMUSP00000019317
Ensembl peptide - ENSMUSP00000102987
NCBI entrez gene - 19345     See in Manteia.
MGI - MGI:105306
RefSeq - NM_001305003
RefSeq - NM_024456
RefSeq Peptide - NP_077776
RefSeq Peptide - NP_001291932
swissprot - A2A5F6
swissprot - Q8C266
swissprot - A2A5F5
swissprot - P35278
swissprot - Q3TJ39
Ensembl - ENSMUSG00000019173
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 rab5cENSDARG00000026712Danio rerio
 RAB5CENSGALG00000003359Gallus gallus
 RAB5CENSG00000108774Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Rab5a / Q9CQD1 / Ras-related protein Rab-5A / P20339* / RAB5A, member RAS oncogene family*ENSMUSG0000001783181
Rab5b / P61021 / RAB5B, member RAS oncogene family / P61020*ENSMUSG0000000071178
P35285 / Rab22a / RAB22A, member RAS oncogene family / Q9UL26*ENSMUSG0000002751941
Rab31 / RAB31, member RAS oncogene family / Q13636*ENSMUSG0000005651541
Rab17 / P35292 / Ras-related protein Rab-17 / Q9H0T7* / RAB17, member RAS oncogene family*ENSMUSG0000002630439
Rab21 / P35282 / RAB21, member RAS oncogene family / Q9UL25*ENSMUSG0000002013236
Rab20 / P35295 / Ras-related protein Rab-20 / Q9NX57* / RAB20, member RAS oncogene family*ENSMUSG0000003150427
Q8CFP6 / Dnajc27 / DnaJ homolog subfamily C member 27 / Q9NZQ0* / DnaJ heat shock protein family (Hsp40) member C27*ENSMUSG0000002065725


Protein motifs (from Interpro)
Interpro ID Name
 IPR001806  Small GTPase superfamily
 IPR005225  Small GTP-binding protein domain
 IPR027417  P-loop containing nucleoside triphosphate hydrolase


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007032 endosome organization IDA
 biological_processGO:0015031 protein transport IEA
 biological_processGO:0030100 regulation of endocytosis IDA
 biological_processGO:0048227 plasma membrane to endosome transport IEA
 cellular_componentGO:0005768 endosome IEA
 cellular_componentGO:0005769 early endosome IBA
 cellular_componentGO:0005811 lipid droplet IEA
 cellular_componentGO:0005886 plasma membrane IBA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0030139 endocytic vesicle IDA
 cellular_componentGO:0031410 cytoplasmic vesicle IEA
 cellular_componentGO:0031901 early endosome membrane IEA
 cellular_componentGO:0042470 melanosome IEA
 cellular_componentGO:0098993 anchored component of synaptic vesicle membrane IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0003924 GTPase activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005525 GTP binding IEA
 molecular_functionGO:0019003 GDP binding IEA


Pathways (from Reactome)
Pathway description
Golgi Associated Vesicle Biogenesis
Neutrophil degranulation
Clathrin-mediated endocytosis
RAB geranylgeranylation
RAB GEFs exchange GTP for GDP on RABs


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0002591 decreased mean corpuscular volume "less than the average amount of space occupied by each red blood cell, calculated from the hematocrit and red cell count, in erythrocyte indices" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Psphtm1a(EUCOMM)Hmgu/Psph+
Genetic Background: C57BL/6N-Psphtm1a(EUCOMM)Hmgu/Wtsi

 MP:0002968 increased circulating alkaline phosphatase level "elevated activity of this enzyme, which hydrolyzes orthophosphoric monoesters, found in the blood" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Psphtm1a(EUCOMM)Hmgu/Psph+
Genetic Background: C57BL/6N-Psphtm1a(EUCOMM)Hmgu/Wtsi

 MP:0005562 decreased mean corpuscular hemoglobin "less than the average levels of hemoglobin contained in an erythrocyte" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Psphtm1a(EUCOMM)Hmgu/Psph+
Genetic Background: C57BL/6N-Psphtm1a(EUCOMM)Hmgu/Wtsi

 MP:0005568 increased circulating total protein level "greater than the average total concentration of these macromolecules in the blood " [RGD:Rat Genome Database submission]
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Allelic Composition: Psphtm1a(EUCOMM)Hmgu/Psph+
Genetic Background: C57BL/6N-Psphtm1a(EUCOMM)Hmgu/Wtsi

 MP:0010087 increased circulating fructosamine level "increase in the concentration in the blood of total non enzymatic glycated proteins in the blood" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Psphtm1a(EUCOMM)Hmgu/Psph+
Genetic Background: C57BL/6N-Psphtm1a(EUCOMM)Hmgu/Wtsi

 MP:0011100 complete preweaning lethality "death of all organisms of a given genotype in a population between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
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Allelic Composition: Psen1tm1.1(KOMP)Vlcg/Psen1tm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Psen1tm1.1(KOMP)Vlcg/J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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