ENSMUSG00000008601


Mus musculus

Features
Gene ID: ENSMUSG00000008601
  
Biological name :Rab25
  
Synonyms : Q9WTL2 / Rab25 / RAB25, member RAS oncogene family
  
Possible biological names infered from orthology : P57735
  
Species: Mus musculus
  
Chr. number: 3
Strand: -1
Band: F1
Gene start: 88542029
Gene end: 88548300
  
Corresponding Affymetrix probe sets: 10499412 (MoGene1.0st)   1417738_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000120505
Ensembl peptide - ENSMUSP00000008745
NCBI entrez gene - 53868     See in Manteia.
MGI - MGI:1858203
RefSeq - NM_016899
RefSeq Peptide - NP_058595
swissprot - D3YYB3
swissprot - Q0PD30
swissprot - Q9WTL2
Ensembl - ENSMUSG00000008601
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 rab25aENSDARG00000058800Danio rerio
 rab25bENSDARG00000052954Danio rerio
 ENSGALG00000029812Gallus gallus
 RAB25ENSG00000132698Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
P62492 / Rab11a / RAB11A, member RAS oncogene family / P62491*ENSMUSG0000000477162
P46638 / Rab11b / RAB11B, member RAS oncogene family / Q15907*ENSMUSG0000007745062
Rab4b / Q91ZR1 / RAB4B, member RAS oncogene family / P61018* / RAB4B-EGLN2* / RAB4B-EGLN2 readthrough (NMD candidate)*ENSMUSG0000005329143
Rab14 / Q91V41 / RAB14, member RAS oncogene family / P61106*ENSMUSG0000002687841
Rab4a / P56371 / Ras-related protein Rab-4A / P20338* / RAB4A, member RAS oncogene family*ENSMUSG0000001947841
Rab2a / P53994 / Ras-related protein Rab-2A / P61019* / RAB2A, member RAS oncogene family*ENSMUSG0000004718740
Rab2b / P59279 / RAB2B, member RAS oncogene family / Q8WUD1*ENSMUSG0000002215939
Rab18 / P35293 / RAB18, member RAS oncogene family / Q9NP72*ENSMUSG0000007363937
Q8BHC1 / Rab39b / RAB39B, member RAS oncogene family / Q96DA2*ENSMUSG0000003120236
Rab39 / Q8BHD0 / RAB39, member RAS oncogene family / Q14964* / RAB39A* / RAB39A, member RAS oncogene family*ENSMUSG0000005506935
Rab42 / Q0PD08 / Ras-related protein Rab-42 / Q8N4Z0* / RAB42, member RAS oncogene family*ENSMUSG0000008968734


Protein motifs (from Interpro)
Interpro ID Name
 IPR001806  Small GTPase superfamily
 IPR005225  Small GTP-binding protein domain
 IPR027417  P-loop containing nucleoside triphosphate hydrolase


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0003382 epithelial cell morphogenesis IMP
 biological_processGO:0008284 positive regulation of cell proliferation IEA
 biological_processGO:0010634 positive regulation of epithelial cell migration IEA
 biological_processGO:0015031 protein transport IEA
 biological_processGO:0031268 pseudopodium organization ISO
 biological_processGO:0060627 regulation of vesicle-mediated transport IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0031143 pseudopodium IEA
 cellular_componentGO:0031260 pseudopodium membrane IEA
 cellular_componentGO:0031410 cytoplasmic vesicle ISO
 cellular_componentGO:0042995 cell projection IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0003924 GTPase activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005525 GTP binding IEA
 molecular_functionGO:0031489 myosin V binding IEA


Pathways (from Reactome)
Pathway description
RAB geranylgeranylation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000466 esophageal epithelium hyperplasia "increased cell number in the epithelial layer of the esophagus" [J:47225]
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Allelic Composition: Fgfr2tm1Ewj/Fgfr2+,Tg(EIIa-cre)C5379Lmgd/0
Genetic Background: B6.Cg-Fgfr2tm1Ewj Tg(EIIa-cre)C5379Lmgd

 MP:0000492 abnormal rectum morphology "structural aberration in the terminal portion of the intestinal tube adjacent to the anus" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: ApcMin/Apc+,Rab25tm1Jrgo/Rab25+
Genetic Background: B6.Cg-Rab25tm1Jrgo ApcMin

 MP:0000495 abnormal colon morphology "malformation of the portion of the large intestine between the cecum and the rectum" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: ApcMin/Apc+,Rab25tm1Jrgo/Rab25+
Genetic Background: B6.Cg-Rab25tm1Jrgo ApcMin

 MP:0001140 abnormal vaginal epithelium "malformation of the epithelial layer of the vagina" [J:54637, tc:Teresa Chu , Mouse Genome Informatics Curator]
Show

Allelic Composition: Fgfr2tm1Ewj/Fgfr2+,Tg(EIIa-cre)C5379Lmgd/0
Genetic Background: B6.Cg-Fgfr2tm1Ewj Tg(EIIa-cre)C5379Lmgd

 MP:0002044 colonic adenoma "benign tumors of the large intestine" [J:38772]
Show

Allelic Composition: Fgfr2tm1Ewj/Fgfr2+,Tg(EIIa-cre)C5379Lmgd/0
Genetic Background: B6.Cg-Fgfr2tm1Ewj Tg(EIIa-cre)C5379Lmgd

 MP:0002404 intestinal adenoma "benign tumors of the small and large intestine" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: ApcMin/Apc+,Rab25tm1Jrgo/Rab25tm1Jrgo
Genetic Background: B6.Cg-Rab25tm1Jrgo ApcMin

Allelic Composition: ApcMin/Apc+,Rab25tm1Jrgo/Rab25+
Genetic Background: B6.Cg-Rab25tm1Jrgo ApcMin

 MP:0003269 colonic polyps "abnormal tissue masses that protrude into the lumen of the colon and are tethered to the wall of the colon" [ncbi:Matthew Mailman, NCBI request, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: ApcMin/Apc+,Rab25tm1Jrgo/Rab25tm1Jrgo
Genetic Background: B6.Cg-Rab25tm1Jrgo ApcMin

Allelic Composition: Rab25tm1Jrgo/Rab25tm1Jrgo,Smad3tm1Par/Smad3+
Genetic Background: 129-Rab25tm1Jrgo Smad3tm1Par

 MP:0003276 esophageal atresia "congenital blockage or absence of the lumen of the esophagus" [ncbi:Matthew Mailman, NCBI request, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Fgfr2tm1Ewj/Fgfr2+,Tg(EIIa-cre)C5379Lmgd/0
Genetic Background: B6.Cg-Fgfr2tm1Ewj Tg(EIIa-cre)C5379Lmgd

 MP:0009314 colon adenocarcinoma "malignant neoplasm of epithelial cells in the colon" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Rab25tm1Jrgo/Rab25tm1Jrgo,Smad3tm1Par/Smad3+
Genetic Background: 129-Rab25tm1Jrgo Smad3tm1Par

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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