ENSMUSG00000031450


Mus musculus

Features
Gene ID: ENSMUSG00000031450
  
Biological name :Grk1
  
Synonyms : G protein-coupled receptor kinase 1 / Grk1
  
Possible biological names infered from orthology : Q15835
  
Species: Mus musculus
  
Chr. number: 8
Strand: 1
Band: A1.1
Gene start: 13405081
Gene end: 13421951
  
Corresponding Affymetrix probe sets: 10570379 (MoGene1.0st)   1421361_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000033827
Ensembl peptide - ENSMUSP00000147484
NCBI entrez gene - 24013     See in Manteia.
MGI - MGI:1345146
RefSeq - NM_011881
RefSeq Peptide - NP_036011
swissprot - G3X905
Ensembl - ENSMUSG00000031450
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 grk1aENSDARG00000058803Danio rerio
 GRK1ENSG00000185974Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Grk4 / O70291 / G protein-coupled receptor kinase 4 / P32298*ENSMUSG0000005278347
Grk6 / O70293 / G protein-coupled receptor kinase 6 / P43250*ENSMUSG0000007488647
Grk5 / Q8VEB1 / G protein-coupled receptor kinase 5 / P34947*ENSMUSG0000000322846
Grk2 / Q99MK8 / G protein-coupled receptor kinase 2 / P25098*ENSMUSG0000002485832
Grk3 / Q3UYH7 / Beta-adrenergic receptor kinase 2 / P35626* / G protein-coupled receptor kinase 3*ENSMUSG0000004224932


Protein motifs (from Interpro)
Interpro ID Name
 IPR000239  GPCR kinase
 IPR000719  Protein kinase domain
 IPR000961  AGC-kinase, C-terminal
 IPR008271  Serine/threonine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily
 IPR016137  RGS domain
 IPR017441  Protein kinase, ATP binding site
 IPR032965  Rhodopsin kinase
 IPR036305  RGS domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007601 visual perception IEA
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0022400 regulation of rhodopsin mediated signaling pathway IEA
 biological_processGO:0046777 protein autophosphorylation IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004674 protein serine/threonine kinase activity IEA
 molecular_functionGO:0004703 G-protein coupled receptor kinase activity IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0050254 rhodopsin kinase activity IEA


Pathways (from Reactome)
Pathway description
Inactivation, recovery and regulation of the phototransduction cascade


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001004 abnormal photoreceptor morphology "structural or developmental anomaly of the receptors sensitive to light " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Grk1tm1Citb/Grk1tm1Citb,Nrltm1Asw/Nrltm1Asw
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0001005 abnormal rod morphology "structural or developmental anomaly of the photoreceptors that contain rhodopsin" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Il7tm1Hms/Il7tm1Hms
Genetic Background: involves: 129S6/SvEvTac

 MP:0004021 abnormal rod electrophysiology "anomaly in the function of dark adapted vision mediated by the rods" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Il7tm1Hms/Il7tm1Hms
Genetic Background: involves: 129S6/SvEvTac

 MP:0006072 abnormal retinal apoptosis "increase or decrease in the number of cells in the retina undergoing programmed cell death" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:92622:]
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Allelic Composition: Il7tm1Hms/Il7tm1Hms
Genetic Background: involves: 129S6/SvEvTac

 MP:0008450 retinal photoreceptor degeneration "a retrogressive impairment of function or destruction of a cell specialized to detect and transduce light, including rods and cones of the retina" [MESH:A08.663.650.650, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Il7tm1Hms/Il7tm1Hms
Genetic Background: involves: 129S6/SvEvTac

Allelic Composition: Grk1tvrm207/Grk1tvrm207
Genetic Background: B6.Cg-Grk1tvrm207/Pjn

 MP:0008456 abnormal retinal rod cell outer segment morphology "any strucutral anomaly of the retinal rod cell region which contains stacks of membranous discs separate from the outer cell membrane that are rich in the visual pigment rhodopsin" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Il7tm1Hms/Il7tm1Hms
Genetic Background: involves: 129S6/SvEvTac

 MP:0011965 decreased total retina thickness "decreased width of the retina through the center plane" [MGI:csmith]
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Allelic Composition: Grk1tvrm207/Grk1tvrm207
Genetic Background: B6.Cg-Grk1tvrm207/Pjn

 MP:0012029 abnormal electroretinogram waveform feature "any anomaly in the pattern of the graphic record of the integrated ensemble response from many vision related neuronal and glial populations as a consequence of the serial processing within the retina, represented as changes in voltage over time after visual photonic stimulation" [MGI:csmith]
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Allelic Composition: Grk1tvrm207/Grk1tvrm207
Genetic Background: B6.Cg-Grk1tvrm207/Pjn

 MP:0012671 retinal spots "the appearance of roundish lesions on the retina, frequently white, and may be due to inflammation, degeneration, vasculitis, exudates, edema or mineral deposits" [MGI:csmith]
Show

Allelic Composition: Grk1tvrm207/Grk1tvrm207
Genetic Background: B6.Cg-Grk1tvrm207/Pjn

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000020907 Rcvrn / P34057 / recoverin / P35243*  / complex
 ENSMUSG00000030324 Rho / P15409 / Rhodopsin / P08100*  / reaction






 

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