ENSDARG00000058803


Danio rerio

Features
Gene ID: ENSDARG00000058803
  
Biological name :grk1a
  
Synonyms : G protein-coupled receptor kinase 1 a / grk1a
  
Possible biological names infered from orthology : G protein-coupled receptor kinase 1 / GRK1 / Q15835
  
Species: Danio rerio
  
Chr. number: 1
Strand: 1
Band:
Gene start: 245076
Gene end: 258138
  
Corresponding Affymetrix probe sets: Dr.14327.1.A1_at (Zebrafish Array)   
  
Cross references: Ensembl peptide - ENSDARP00000076182
NCBI entrez gene - 564152     See in Manteia.
swissprot - Q1XHM0
ZFIN ID - ZDB-GENE-050823-1
Ensembl - ENSDARG00000058803
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 GRK1ENSG00000185974Homo sapiens
 Grk1ENSMUSG00000031450Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
grk1b / G protein-coupled receptor kinase 1 bENSDARG0000010468565
grk6 / G protein-coupled receptor kinase 6 / P43250*ENSDARG0000003215747
grk4 / G protein-coupled receptor kinase 4 / O70291* / P32298*ENSDARG0000007044847
grk5l / G protein-coupled receptor kinase 5 like / GRK5* / P34947* / Q8VEB1* / G protein-coupled receptor kinase 5*ENSDARG0000007881546
grk7a / Q49HM9 / G protein-coupled receptor kinase 7a / GRK7* / Q8WTQ7* / G protein-coupled receptor kinase 7*ENSDARG0000002060243
grk7b / Q1XHL7 / G protein-coupled receptor kinase 7b / GRK7* / Q8WTQ7* / G protein-coupled receptor kinase 7*ENSDARG0000005553441
grk5 / G protein-coupled receptor kinase 5 / P34947* / Q8VEB1*ENSDARG0000003280140
grk3 / G protein-coupled receptor kinase 3 / P35626* / Q3UYH7* / Beta-adrenergic receptor kinase 2 *ENSDARG0000010409432


Protein motifs (from Interpro)
Interpro ID Name
 IPR000239  GPCR kinase
 IPR000719  Protein kinase domain
 IPR000961  AGC-kinase, C-terminal
 IPR008271  Serine/threonine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily
 IPR016137  RGS domain
 IPR017441  Protein kinase, ATP binding site
 IPR032965  Rhodopsin kinase


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007601 visual perception IEA
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0022400 regulation of rhodopsin mediated signaling pathway IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004674 protein serine/threonine kinase activity IEA
 molecular_functionGO:0004703 G-protein coupled receptor kinase activity IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0050254 rhodopsin kinase activity IEA


Pathways (from Reactome)
Pathway description
Inactivation, recovery and regulation of the phototransduction cascade


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000070666 rhol / rhodopsin, like / RHO* / P15409* / P08100* / rhodopsin*  / reaction
 ENSDARG00000052223 rcvrna / recoverin a / RCVRN* / P35243* / P34057* / recoverin*  / complex
 ENSDARG00000002193 rho / P35359 / rhodopsin / P08100*  / reaction
 ENSDARG00000111827 rcvrnb / recoverin b / RCVRN* / P35243* / recoverin*  / complex






 

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