ENSDARG00000104094


Danio rerio

Features
Gene ID: ENSDARG00000104094
  
Biological name :grk3
  
Synonyms : G protein-coupled receptor kinase 3 / grk3
  
Possible biological names infered from orthology : Beta-adrenergic receptor kinase 2 / P35626 / Q3UYH7
  
Species: Danio rerio
  
Chr. number: 10
Strand: 1
Band:
Gene start: 44057177
Gene end: 44198211
  
Corresponding Affymetrix probe sets:
  
Cross references: Ensembl peptide - ENSDARP00000130118
Ensembl peptide - ENSDARP00000132518
Ensembl peptide - ENSDARP00000157494
NCBI entrez gene - 569403     See in Manteia.
swissprot - A0A0R4IAE1
swissprot - B5LZ08
ZFIN ID - ZDB-GENE-030616-382
Ensembl - ENSDARG00000104094
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 GRK3ENSGALG00000037097Gallus gallus
 GRK3ENSG00000100077Homo sapiens
 Grk3ENSMUSG00000042249Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
grk6 / G protein-coupled receptor kinase 6 / P43250*ENSDARG0000003215730
grk4 / G protein-coupled receptor kinase 4 / O70291* / P32298*ENSDARG0000007044829
grk1b / G protein-coupled receptor kinase 1 bENSDARG0000010468527
grk5l / G protein-coupled receptor kinase 5 like / GRK5* / P34947* / Q8VEB1* / G protein-coupled receptor kinase 5*ENSDARG0000007881527
grk5 / G protein-coupled receptor kinase 5 / P34947* / Q8VEB1*ENSDARG0000003280126
grk1a / G protein-coupled receptor kinase 1 a / GRK1* / Q15835* / G protein-coupled receptor kinase 1*ENSDARG0000005880326
grk7b / Q1XHL7 / G protein-coupled receptor kinase 7b / GRK7* / Q8WTQ7* / G protein-coupled receptor kinase 7*ENSDARG0000005553425
grk7a / Q49HM9 / G protein-coupled receptor kinase 7a / GRK7* / Q8WTQ7* / G protein-coupled receptor kinase 7*ENSDARG0000002060224


Protein motifs (from Interpro)
Interpro ID Name
 IPR000239  GPCR kinase
 IPR000719  Protein kinase domain
 IPR000961  AGC-kinase, C-terminal
 IPR001849  Pleckstrin homology domain
 IPR008271  Serine/threonine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily
 IPR011993  PH-like domain superfamily
 IPR016137  RGS domain
 IPR017441  Protein kinase, ATP binding site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0003315 heart rudiment formation IGI
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007224 smoothened signaling pathway IMP
 biological_processGO:0007507 heart development IMP
 biological_processGO:0008016 regulation of heart contraction IMP
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0043009 chordate embryonic development IMP
 biological_processGO:0055001 muscle cell development IMP
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004672 protein kinase activity IGI
 molecular_functionGO:0004674 protein serine/threonine kinase activity IEA
 molecular_functionGO:0004703 G-protein coupled receptor kinase activity IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA


Pathways (from Reactome)
Pathway description
G alpha (s) signalling events
Cargo recognition for clathrin-mediated endocytosis


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000009 cardiac ventricle cardiac ventricle decreased size , abnormal
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 ZFA:0000028 heart primordium heart primordium decreased size , abnormal
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 ZFA:0000037 anatomical structure anatomical structure absent , abnormal
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 ZFA:0000041 mesoderm mesoderm decreased amount , abnormal
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 ZFA:0000054 pericardium pericardium edematous , abnormal
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 ZFA:0000107 eye eye decreased size , abnormal
eye fused with eye , abnormal
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 ZFA:0000114 heart heart malformed , abnormal
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 ZFA:0000155 somite somite U-shaped , abnormal
somite muscle pioneer decreased amount , abnormal
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 ZFA:0000360 heart tube heart tube elongated , abnormal
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 ZFA:0000471 atrium atrium dilated , abnormal
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 ZFA:0001056 myotome myotome muscle pioneer absent , abnormal
myotome fast muscle cell absent , abnormal
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 ZFA:0001086 muscle pioneer muscle pioneer decreased amount , abnormal
muscle pioneer absent , abnormal
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 ZFA:0001094 whole organism whole organism decreased length , abnormal
whole organism malformed , abnormal
whole organism anterior-posterior axis curved , abnormal
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 ZFA:0001114 head head increased size , abnormal
head decreased size , abnormal
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 ZFA:0001117 post-vent region post-vent region coiled , abnormal
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 ZFA:0001135 neural tube neural tube decreased amount , abnormal
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 ZFA:0009051 interneuron interneuron absent , abnormal
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 ZFA:0009052 motor neuron motor neuron absent , abnormal
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 ZFA:0009116 slow muscle cell slow muscle cell nucleus decreased amount , abnormal
slow muscle cell decreased amount , abnormal
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 ZFA:0009117 fast muscle cell fast muscle cell absent , abnormal
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Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000007436 avpr2aa / arginine vasopressin receptor 2a, duplicate a / AVPR2* / O88721* / P30518* / arginine vasopressin receptor 2*  / reaction






 

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