ENSG00000100077


Homo sapiens

Features
Gene ID: ENSG00000100077
  
Biological name :GRK3
  
Synonyms : G protein-coupled receptor kinase 3 / GRK3 / P35626
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 22
Strand: 1
Band: q12.1
Gene start: 25564849
Gene end: 25729294
  
Corresponding Affymetrix probe sets: 204183_s_at (Human Genome U133 Plus 2.0 Array)   204184_s_at (Human Genome U133 Plus 2.0 Array)   228771_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000478925
Ensembl peptide - ENSP00000317578
Ensembl peptide - ENSP00000393688
NCBI entrez gene - 157     See in Manteia.
OMIM - 109636
RefSeq - XM_011529975
RefSeq - NM_005160
RefSeq Peptide - NP_005151
swissprot - A0A024R1D8
swissprot - P35626
swissprot - Q8N433
swissprot - H7C099
Ensembl - ENSG00000100077
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 grk3ENSDARG00000104094Danio rerio
 GRK3ENSGALG00000037097Gallus gallus
 Grk3ENSMUSG00000042249Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
GRK2 / P25098 / G protein-coupled receptor kinase 2ENSG0000017302084
GRK6 / P43250 / G protein-coupled receptor kinase 6ENSG0000019805531
GRK5 / P34947 / G protein-coupled receptor kinase 5ENSG0000019887329
GRK4 / P32298 / G protein-coupled receptor kinase 4ENSG0000012538829
GRK1 / Q15835 / G protein-coupled receptor kinase 1ENSG0000018597426
GRK7 / Q8WTQ7 / G protein-coupled receptor kinase 7ENSG0000011412425


Protein motifs (from Interpro)
Interpro ID Name
 IPR000239  GPCR kinase
 IPR000719  Protein kinase domain
 IPR000961  AGC-kinase, C-terminal
 IPR001849  Pleckstrin homology domain
 IPR008271  Serine/threonine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily
 IPR011993  PH-like domain superfamily
 IPR016137  RGS domain
 IPR017441  Protein kinase, ATP binding site
 IPR036305  RGS domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007186 G-protein coupled receptor signaling pathway TAS
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0031623 receptor internalization IDA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0005886 plasma membrane TAS
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004674 protein serine/threonine kinase activity IEA
 molecular_functionGO:0004703 G-protein coupled receptor kinase activity IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0047696 beta-adrenergic receptor kinase activity TAS


Pathways (from Reactome)
Pathway description
G alpha (s) signalling events
Cargo recognition for clathrin-mediated endocytosis


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000169252 ADRB2 / P07550 / adrenoceptor beta 2  / complex / reaction
 ENSG00000101200 AVP / P01185 / arginine vasopressin  / reaction
 ENSG00000126895 AVPR2 / P30518 / arginine vasopressin receptor 2  / reaction






 

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