ENSG00000198873


Homo sapiens

Features
Gene ID: ENSG00000198873
  
Biological name :GRK5
  
Synonyms : G protein-coupled receptor kinase 5 / GRK5 / P34947
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 10
Strand: 1
Band: q26.11
Gene start: 119207589
Gene end: 119459742
  
Corresponding Affymetrix probe sets: 1557729_at (Human Genome U133 Plus 2.0 Array)   204395_s_at (Human Genome U133 Plus 2.0 Array)   204396_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000376609
NCBI entrez gene - 2869     See in Manteia.
OMIM - 600870
RefSeq - XM_005269708
RefSeq - NM_005308
RefSeq - XM_005269707
RefSeq Peptide - NP_005299
swissprot - P34947
Ensembl - ENSG00000198873
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 grk5ENSDARG00000032801Danio rerio
 grk5lENSDARG00000078815Danio rerio
 GRK5ENSGALG00000009403Gallus gallus
 Grk5ENSMUSG00000003228Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
GRK6 / P43250 / G protein-coupled receptor kinase 6ENSG0000019805569
GRK4 / P32298 / G protein-coupled receptor kinase 4ENSG0000012538865
GRK1 / Q15835 / G protein-coupled receptor kinase 1ENSG0000018597444
GRK7 / Q8WTQ7 / G protein-coupled receptor kinase 7ENSG0000011412441
GRK3 / P35626 / G protein-coupled receptor kinase 3ENSG0000010007734
GRK2 / P25098 / G protein-coupled receptor kinase 2ENSG0000017302034


Protein motifs (from Interpro)
Interpro ID Name
 IPR000239  GPCR kinase
 IPR000719  Protein kinase domain
 IPR000961  AGC-kinase, C-terminal
 IPR011009  Protein kinase-like domain superfamily
 IPR016137  RGS domain
 IPR017441  Protein kinase, ATP binding site
 IPR036305  RGS domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0006915 apoptotic process IEA
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007186 G-protein coupled receptor signaling pathway TAS
 biological_processGO:0007188 adenylate cyclase-modulating G-protein coupled receptor signaling pathway TAS
 biological_processGO:0007217 tachykinin receptor signaling pathway IDA
 biological_processGO:0008277 regulation of G-protein coupled receptor protein signaling pathway TAS
 biological_processGO:0008284 positive regulation of cell proliferation IMP
 biological_processGO:0016055 Wnt signaling pathway IEA
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0043066 negative regulation of apoptotic process IDA
 biological_processGO:0045444 fat cell differentiation IEA
 biological_processGO:0046777 protein autophosphorylation IDA
 biological_processGO:0051726 regulation of cell cycle IMP
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005737 cytoplasm TAS
 cellular_componentGO:0005829 cytosol IDA
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016607 nuclear speck IDA
 cellular_componentGO:0031965 nuclear membrane IDA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004674 protein serine/threonine kinase activity IDA
 molecular_functionGO:0004703 G-protein coupled receptor kinase activity IEA
 molecular_functionGO:0005080 protein kinase C binding TAS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0005543 phospholipid binding TAS
 molecular_functionGO:0008289 lipid binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0047696 beta-adrenergic receptor kinase activity IMP


Pathways (from Reactome)
Pathway description
G alpha (q) signalling events
G alpha (s) signalling events


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000088256 GNA11 / P29992 / G protein subunit alpha 11  / complex / reaction
 ENSG00000060558 GNA15 / P30679 / G protein subunit alpha 15  / reaction / complex
 ENSG00000156052 GNAQ / P50148 / G protein subunit alpha q  / complex / reaction
 ENSG00000169252 ADRB2 / P07550 / adrenoceptor beta 2  / complex / reaction
 ENSG00000156049 GNA14 / O95837 / G protein subunit alpha 14  / complex / reaction






 

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