ENSG00000125388


Homo sapiens

Features
Gene ID: ENSG00000125388
  
Biological name :GRK4
  
Synonyms : G protein-coupled receptor kinase 4 / GRK4 / P32298
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 4
Strand: 1
Band: p16.3
Gene start: 2963608
Gene end: 3040747
  
Corresponding Affymetrix probe sets: 1560543_at (Human Genome U133 Plus 2.0 Array)   208365_s_at (Human Genome U133 Plus 2.0 Array)   210600_s_at (Human Genome U133 Plus 2.0 Array)   241989_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000264764
Ensembl peptide - ENSP00000381129
Ensembl peptide - ENSP00000421650
Ensembl peptide - ENSP00000427445
Ensembl peptide - ENSP00000381128
NCBI entrez gene - 2868     See in Manteia.
OMIM - 137026
RefSeq - XM_017008066
RefSeq - NM_001004056
RefSeq - NM_001004057
RefSeq - NM_005307
RefSeq - NM_182982
RefSeq - XM_017008059
RefSeq - XM_017008060
RefSeq - XM_017008061
RefSeq - XM_017008062
RefSeq - XM_017008063
RefSeq - XM_017008064
RefSeq - XM_005247962
RefSeq - XM_006713880
RefSeq - XM_011513447
RefSeq - XM_011513448
RefSeq - XM_011513449
RefSeq - XM_011513450
RefSeq - XM_011513451
RefSeq - XM_011513452
RefSeq - XM_011513453
RefSeq - XM_011513454
RefSeq - XM_011513455
RefSeq - XM_011513456
RefSeq - XM_017008052
RefSeq - XM_017008053
RefSeq - XM_017008054
RefSeq - XM_017008055
RefSeq - XM_017008056
RefSeq - XM_017008057
RefSeq - XM_017008058
RefSeq Peptide - NP_001004056
RefSeq Peptide - NP_001004057
RefSeq Peptide - NP_005298
RefSeq Peptide - NP_892027
swissprot - P32298
swissprot - D6REW5
Ensembl - ENSG00000125388
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 grk4ENSDARG00000070448Danio rerio
 GRK4ENSGALG00000015645Gallus gallus
 Grk4ENSMUSG00000052783Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
GRK5 / P34947 / G protein-coupled receptor kinase 5ENSG0000019887366
GRK6 / P43250 / G protein-coupled receptor kinase 6ENSG0000019805565
GRK1 / Q15835 / G protein-coupled receptor kinase 1ENSG0000018597446
GRK7 / Q8WTQ7 / G protein-coupled receptor kinase 7ENSG0000011412444
GRK3 / P35626 / G protein-coupled receptor kinase 3ENSG0000010007735
GRK2 / P25098 / G protein-coupled receptor kinase 2ENSG0000017302034


Protein motifs (from Interpro)
Interpro ID Name
 IPR000239  GPCR kinase
 IPR000719  Protein kinase domain
 IPR000961  AGC-kinase, C-terminal
 IPR008271  Serine/threonine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily
 IPR016137  RGS domain
 IPR017441  Protein kinase, ATP binding site
 IPR036305  RGS domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002029 desensitization of G-protein coupled receptor protein signaling pathway IEA
 biological_processGO:0002031 G-protein coupled receptor internalization IEA
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0008277 regulation of G-protein coupled receptor protein signaling pathway TAS
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0022400 regulation of rhodopsin mediated signaling pathway TAS
 biological_processGO:0031623 receptor internalization IDA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0005938 cell cortex IEA
 cellular_componentGO:0030425 dendrite IEA
 cellular_componentGO:0043025 neuronal cell body IEA
 cellular_componentGO:0097381 photoreceptor disc membrane TAS
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004674 protein serine/threonine kinase activity IEA
 molecular_functionGO:0004703 G-protein coupled receptor kinase activity IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0050254 rhodopsin kinase activity TAS


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000163914 RHO / P08100 / rhodopsin  / reaction






 

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