ENSG00000198055


Homo sapiens

Features
Gene ID: ENSG00000198055
  
Biological name :GRK6
  
Synonyms : G protein-coupled receptor kinase 6 / GRK6 / P43250
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 5
Strand: 1
Band: q35.3
Gene start: 177403204
Gene end: 177442901
  
Corresponding Affymetrix probe sets: 202848_s_at (Human Genome U133 Plus 2.0 Array)   202849_x_at (Human Genome U133 Plus 2.0 Array)   210981_s_at (Human Genome U133 Plus 2.0 Array)   211543_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000421055
Ensembl peptide - ENSP00000433511
Ensembl peptide - ENSP00000427581
Ensembl peptide - ENSP00000425391
Ensembl peptide - ENSP00000423174
Ensembl peptide - ENSP00000422873
Ensembl peptide - ENSP00000422342
Ensembl peptide - ENSP00000347655
Ensembl peptide - ENSP00000348230
Ensembl peptide - ENSP00000377204
NCBI entrez gene - 2870     See in Manteia.
OMIM - 600869
RefSeq - XM_011534537
RefSeq - NM_001004105
RefSeq - NM_001004106
RefSeq - NM_002082
RefSeq - XM_006714858
RefSeq - XM_006714859
RefSeq Peptide - NP_001004106
RefSeq Peptide - NP_002073
RefSeq Peptide - NP_001004105
swissprot - D6RDA3
swissprot - D6RC88
swissprot - D6R9V4
swissprot - D6RHC7
swissprot - H0Y967
swissprot - F8W9W2
swissprot - P43250
swissprot - D6RHX8
Ensembl - ENSG00000198055
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 grk6ENSDARG00000032157Danio rerio
 GRK6ENSGALG00000014054Gallus gallus
 Grk6ENSMUSG00000074886Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
GRK5 / P34947 / G protein-coupled receptor kinase 5ENSG0000019887369
GRK4 / P32298 / G protein-coupled receptor kinase 4ENSG0000012538864
GRK1 / Q15835 / G protein-coupled receptor kinase 1ENSG0000018597445
GRK7 / Q8WTQ7 / G protein-coupled receptor kinase 7ENSG0000011412442
GRK2 / P25098 / G protein-coupled receptor kinase 2ENSG0000017302036
GRK3 / P35626 / G protein-coupled receptor kinase 3ENSG0000010007736


Protein motifs (from Interpro)
Interpro ID Name
 IPR000239  GPCR kinase
 IPR000719  Protein kinase domain
 IPR000961  AGC-kinase, C-terminal
 IPR008271  Serine/threonine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily
 IPR016137  RGS domain
 IPR017441  Protein kinase, ATP binding site
 IPR036305  RGS domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007186 G-protein coupled receptor signaling pathway TAS
 biological_processGO:0008277 regulation of G-protein coupled receptor protein signaling pathway TAS
 biological_processGO:0016055 Wnt signaling pathway IEA
 biological_processGO:0016310 phosphorylation IEA
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0016020 membrane IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004674 protein serine/threonine kinase activity IEA
 molecular_functionGO:0004703 G-protein coupled receptor kinase activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0047696 beta-adrenergic receptor kinase activity IMP


Pathways (from Reactome)
Pathway description
G alpha (s) signalling events


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000169252 ADRB2 / P07550 / adrenoceptor beta 2  / complex / reaction






 

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