ENSMUSG00000074886


Mus musculus

Features
Gene ID: ENSMUSG00000074886
  
Biological name :Grk6
  
Synonyms : G protein-coupled receptor kinase 6 / Grk6 / O70293
  
Possible biological names infered from orthology : P43250
  
Species: Mus musculus
  
Chr. number: 13
Strand: 1
Band: B1
Gene start: 55445072
Gene end: 55460927
  
Corresponding Affymetrix probe sets: 10405464 (MoGene1.0st)   1437436_s_at (Mouse Genome 430 2.0 Array)   1450480_a_at (Mouse Genome 430 2.0 Array)   1451672_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000153344
Ensembl peptide - ENSMUSP00000152968
Ensembl peptide - ENSMUSP00000153623
Ensembl peptide - ENSMUSP00000153668
Ensembl peptide - ENSMUSP00000001115
Ensembl peptide - ENSMUSP00000097081
NCBI entrez gene - 26385     See in Manteia.
MGI - MGI:1347078
RefSeq - XM_006517251
RefSeq - NM_001038018
RefSeq - NM_001112711
RefSeq - NM_001286063
RefSeq - NM_001286064
RefSeq - NM_001286065
RefSeq - NM_001286066
RefSeq - NM_011938
RefSeq Peptide - NP_001272993
RefSeq Peptide - NP_001272994
RefSeq Peptide - NP_001272995
RefSeq Peptide - NP_036068
RefSeq Peptide - NP_001272992
RefSeq Peptide - NP_001033107
RefSeq Peptide - NP_001106182
swissprot - O70293
swissprot - A0A286YDA5
swissprot - A0A286YE10
swissprot - A0A286YDZ5
swissprot - Q9EP84
Ensembl - ENSMUSG00000074886
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 grk6ENSDARG00000032157Danio rerio
 GRK6ENSGALG00000014054Gallus gallus
 GRK6ENSG00000198055Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Grk5 / Q8VEB1 / G protein-coupled receptor kinase 5 / P34947*ENSMUSG0000000322869
Grk4 / O70291 / G protein-coupled receptor kinase 4 / P32298*ENSMUSG0000005278361
Grk1 / G protein-coupled receptor kinase 1 / Q15835*ENSMUSG0000003145045
Grk3 / Q3UYH7 / Beta-adrenergic receptor kinase 2 / P35626* / G protein-coupled receptor kinase 3*ENSMUSG0000004224936
Grk2 / Q99MK8 / G protein-coupled receptor kinase 2 / P25098*ENSMUSG0000002485836


Protein motifs (from Interpro)
Interpro ID Name
 IPR000239  GPCR kinase
 IPR000719  Protein kinase domain
 IPR000961  AGC-kinase, C-terminal
 IPR008271  Serine/threonine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily
 IPR016137  RGS domain
 IPR017441  Protein kinase, ATP binding site
 IPR036305  RGS domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0016055 Wnt signaling pathway IEA
 biological_processGO:0016310 phosphorylation IEA
 cellular_componentGO:0016020 membrane IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004674 protein serine/threonine kinase activity IEA
 molecular_functionGO:0004703 G-protein coupled receptor kinase activity IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0047696 beta-adrenergic receptor kinase activity ISO


Pathways (from Reactome)
Pathway description
G alpha (s) signalling events


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000691 enlarged spleen "increased spleen size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Gria2tm1.1Bvis/Gria2tm1.1Bvis,Tg(Camk2a-cre)T29-1Stl/0
Genetic Background: 129S6.Cg-Gria2tm1.1Bvis Tg(Camk2a-cre)T29-1Stl

 MP:0001399 hyperactivity "general restlessness or excessive movement; more frequent movement from one place to another" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409, J:57125]
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Allelic Composition: Itgaltm1Bll/Itgaltm1Bll
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

Allelic Composition: Grk6tm1.1Mca/Grk6+
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0001798 impaired macrophage phagocytosis "reduced ability of these phagocytic cells to internalize particulate matter" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Gria2tm1.1Bvis/Gria2tm1.1Bvis,Tg(Camk2a-cre)T29-1Stl/0
Genetic Background: 129S6.Cg-Gria2tm1.1Bvis Tg(Camk2a-cre)T29-1Stl

 MP:0002444 abnormal T cell physiology "anomalous response of T lymphocytes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Itgaltm1Bll/Itgaltm1Bll
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0002459 abnormal B cell physiology "abnormal function of B lymphocytes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Itgaltm1Bll/Itgaltm1Bll
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0002493 increased IgG "greater than normal immunoglobulin class G level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Gria2tm1.1Bvis/Gria2tm1.1Bvis,Tg(Camk2a-cre)T29-1Stl/0
Genetic Background: 129S6.Cg-Gria2tm1.1Bvis Tg(Camk2a-cre)T29-1Stl

 MP:0002743 glomerulonephritis "glomerular disease characterized by diffuse inflammatory reaction that is not the acute response to infection of the kidneys" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Gria2tm1.1Bvis/Gria2tm1.1Bvis,Tg(Camk2a-cre)T29-1Stl/0
Genetic Background: 129S6.Cg-Gria2tm1.1Bvis Tg(Camk2a-cre)T29-1Stl

 MP:0003944 abnormal T cell subpopulation ratio "deviation from the standard ratios of T cell subpopulations (e.g. double positive to single positive ratio) compared to control samples" [mberry:Melissa Berry, Genetics Resources Curator]
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Allelic Composition: Gria2tm1.1Bvis/Gria2tm1.1Bvis,Tg(Camk2a-cre)T29-1Stl/0
Genetic Background: 129S6.Cg-Gria2tm1.1Bvis Tg(Camk2a-cre)T29-1Stl

 MP:0004762 increased anti-double stranded DNA antibody level "increase in the level of antibodies that recognize double stranded DNA" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Gria2tm1.1Bvis/Gria2tm1.1Bvis,Tg(Camk2a-cre)T29-1Stl/0
Genetic Background: 129S6.Cg-Gria2tm1.1Bvis Tg(Camk2a-cre)T29-1Stl

 MP:0004952 increased spleen weight "greater than average weight of the organ that functions to filter blood and to store red corpuscles and platelets" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Gria2tm1.1Bvis/Gria2tm1.1Bvis,Tg(Camk2a-cre)T29-1Stl/0
Genetic Background: 129S6.Cg-Gria2tm1.1Bvis Tg(Camk2a-cre)T29-1Stl

 MP:0008049 increased memory T cell number "greater number of the set of long-lived T cells differentiated from T cells activated by a specific antigen encountered during a past immune response" [adiehl:Alex Diehl_MGI GO curator, Biology-Online.org:http://www.biology-online.org/, MGI:rbabiuk "Randall Babiuk, Mouse Genome Informatics Curator"]
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Allelic Composition: Gria2tm1.1Bvis/Gria2tm1.1Bvis,Tg(Camk2a-cre)T29-1Stl/0
Genetic Background: 129S6.Cg-Gria2tm1.1Bvis Tg(Camk2a-cre)T29-1Stl

 MP:0008079 decreased CD8-positive T cell number "reduction in the number of the regulatory subset of T lymphocytes that are involved in MHC class I restricted interactions" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Gria2tm1.1Bvis/Gria2tm1.1Bvis,Tg(Camk2a-cre)T29-1Stl/0
Genetic Background: 129S6.Cg-Gria2tm1.1Bvis Tg(Camk2a-cre)T29-1Stl

 MP:0008478 increased spleen white pulp amount "increase in the quantity of the parenchymatous tissue of the spleen that surrounds splenic blood vessels, consists of compact masses of lymphatic cells and is where foreign material removed from the blood is used to initiate an immune reaction that results in the production of antibodies" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Gria2tm1.1Bvis/Gria2tm1.1Bvis,Tg(Camk2a-cre)T29-1Stl/0
Genetic Background: 129S6.Cg-Gria2tm1.1Bvis Tg(Camk2a-cre)T29-1Stl

 MP:0008809 increased spleen iron level "increase in the amount of iron present in the spleen tissue" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Gria2tm1.1Bvis/Gria2tm1.1Bvis,Tg(Camk2a-cre)T29-1Stl/0
Genetic Background: 129S6.Cg-Gria2tm1.1Bvis Tg(Camk2a-cre)T29-1Stl

 MP:0009338 increased splenocyte number "increase in the expected number of cells of the spleen" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Gria2tm1.1Bvis/Gria2tm1.1Bvis,Tg(Camk2a-cre)T29-1Stl/0
Genetic Background: 129S6.Cg-Gria2tm1.1Bvis Tg(Camk2a-cre)T29-1Stl

 MP:0009749 enhanced behavioral response to addictive substance "increased sensitivity to an addictive substance capable of inducing the appearance of behavioral response, such as induced hyperactivity or stereotypic behavior, or decreased dosage threshold for the appearance of the behavioral response" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Itgaltm1Bll/Itgaltm1Bll
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

Allelic Composition: Grk6tm1.1Mca/Grk6+
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0009754 enhanced behavioral response to cocaine "increased sensitivity to cocaine resulting in a behavioral response, such as induced hyperactivity or stereotypic behavior, or decreased dosage threshold for the appearance of the behavioral response" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Itgaltm1Bll/Itgaltm1Bll
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

Allelic Composition: Grk6tm1.1Mca/Grk6+
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0011339 abnormal glomerular mesangium morphology "any structural anomaly of the inner layer of the glomerulus within the basement membrane surrounding the glomerular capillaries that contain the intraglomerular mesangial cells" [MGI:csmith]
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Allelic Composition: Gria2tm1.1Bvis/Gria2tm1.1Bvis,Tg(Camk2a-cre)T29-1Stl/0
Genetic Background: 129S6.Cg-Gria2tm1.1Bvis Tg(Camk2a-cre)T29-1Stl

 MP:0013435 decreased CD8-positive, naive alpha-beta T cell number "reduction in the number of the naïve regulatory subset of T lymphocytes that are involved in MHC class I restricted interactions with a CD44-low CD62L+ phenotype" [IMPC:Saran]
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Allelic Composition: Gria2tm1.1Bvis/Gria2tm1.1Bvis,Tg(Camk2a-cre)T29-1Stl/0
Genetic Background: 129S6.Cg-Gria2tm1.1Bvis Tg(Camk2a-cre)T29-1Stl

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000045730 Adrb2 / P18762 / Beta-2 adrenergic receptor / P07550* / adrenoceptor beta 2*  / complex / reaction






 

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