ENSG00000114124


Homo sapiens

Features
Gene ID: ENSG00000114124
  
Biological name :GRK7
  
Synonyms : G protein-coupled receptor kinase 7 / GRK7 / Q8WTQ7
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 3
Strand: 1
Band: q23
Gene start: 141778148
Gene end: 141818490
  
Corresponding Affymetrix probe sets: 1552929_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000264952
NCBI entrez gene - 131890     See in Manteia.
OMIM - 606987
RefSeq - NM_139209
RefSeq - XM_017005717
RefSeq Peptide - NP_631948
swissprot - Q8WTQ7
Ensembl - ENSG00000114124
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 grk7aENSDARG00000020602Danio rerio
 grk7bENSDARG00000055534Danio rerio
 GRK7ENSGALG00000002800Gallus gallus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
GRK1 / Q15835 / G protein-coupled receptor kinase 1ENSG0000018597446
GRK4 / P32298 / G protein-coupled receptor kinase 4ENSG0000012538846
GRK6 / P43250 / G protein-coupled receptor kinase 6ENSG0000019805544
GRK5 / P34947 / G protein-coupled receptor kinase 5ENSG0000019887344
GRK3 / P35626 / G protein-coupled receptor kinase 3ENSG0000010007731
GRK2 / P25098 / G protein-coupled receptor kinase 2ENSG0000017302030


Protein motifs (from Interpro)
Interpro ID Name
 IPR000239  GPCR kinase
 IPR000719  Protein kinase domain
 IPR000961  AGC-kinase, C-terminal
 IPR008271  Serine/threonine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily
 IPR016137  RGS domain
 IPR017441  Protein kinase, ATP binding site
 IPR036305  RGS domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007601 visual perception IEA
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0022400 regulation of rhodopsin mediated signaling pathway TAS
 biological_processGO:0046777 protein autophosphorylation IMP
 biological_processGO:0050896 response to stimulus IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0097381 photoreceptor disc membrane TAS
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004674 protein serine/threonine kinase activity IEA
 molecular_functionGO:0004703 G-protein coupled receptor kinase activity IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0050254 rhodopsin kinase activity IEA


Pathways (from Reactome)
Pathway description
Inactivation, recovery and regulation of the phototransduction cascade


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000163914 RHO / P08100 / rhodopsin  / reaction






 

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