ENSDARG00000070448


Danio rerio

Features
Gene ID: ENSDARG00000070448
  
Biological name :grk4
  
Synonyms : G protein-coupled receptor kinase 4 / grk4
  
Possible biological names infered from orthology : O70291 / P32298
  
Species: Danio rerio
  
Chr. number: 1
Strand: -1
Band:
Gene start: 11902579
Gene end: 11973341
  
Corresponding Affymetrix probe sets:
  
Cross references: Ensembl peptide - ENSDARP00000133992
Ensembl peptide - ENSDARP00000141465
Ensembl peptide - ENSDARP00000066637
NCBI entrez gene - 560761     See in Manteia.
RefSeq - NM_001079986
RefSeq Peptide - NP_001073455
swissprot - A0A0R4IXX5
swissprot - Q08CJ6
ZFIN ID - ZDB-GENE-060929-1198
Ensembl - ENSDARG00000070448
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 GRK4ENSGALG00000015645Gallus gallus
 GRK4ENSG00000125388Homo sapiens
 Grk4ENSMUSG00000052783Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
grk6 / G protein-coupled receptor kinase 6 / P43250*ENSDARG0000003215772
grk5l / G protein-coupled receptor kinase 5 like / GRK5* / P34947* / Q8VEB1* / G protein-coupled receptor kinase 5*ENSDARG0000007881570
grk5 / G protein-coupled receptor kinase 5 / P34947* / Q8VEB1*ENSDARG0000003280155
grk1a / G protein-coupled receptor kinase 1 a / GRK1* / Q15835* / G protein-coupled receptor kinase 1*ENSDARG0000005880346
grk1b / G protein-coupled receptor kinase 1 bENSDARG0000010468545
grk7a / Q49HM9 / G protein-coupled receptor kinase 7a / GRK7* / Q8WTQ7* / G protein-coupled receptor kinase 7*ENSDARG0000002060243
grk7b / Q1XHL7 / G protein-coupled receptor kinase 7b / GRK7* / Q8WTQ7* / G protein-coupled receptor kinase 7*ENSDARG0000005553441
grk3 / G protein-coupled receptor kinase 3 / P35626* / Q3UYH7* / Beta-adrenergic receptor kinase 2 *ENSDARG0000010409435


Protein motifs (from Interpro)
Interpro ID Name
 IPR000239  GPCR kinase
 IPR000719  Protein kinase domain
 IPR000961  AGC-kinase, C-terminal
 IPR008271  Serine/threonine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily
 IPR016137  RGS domain
 IPR017441  Protein kinase, ATP binding site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0085033 positive regulation by symbiont of host I-kappaB kinase/NF-kappaB cascade IMP
 cellular_componentGO:0005575 cellular_component ND
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004674 protein serine/threonine kinase activity IEA
 molecular_functionGO:0004703 G-protein coupled receptor kinase activity IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA


Pathways (from Reactome)
Pathway description
Inactivation, recovery and regulation of the phototransduction cascade


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000002193 rho / P35359 / rhodopsin / P08100*  / reaction
 ENSDARG00000070666 rhol / rhodopsin, like / RHO* / P15409* / P08100* / rhodopsin*  / reaction






 

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