ENSDARG00000078815


Danio rerio

Features
Gene ID: ENSDARG00000078815
  
Biological name :grk5l
  
Synonyms : G protein-coupled receptor kinase 5 like / grk5l
  
Possible biological names infered from orthology : G protein-coupled receptor kinase 5 / GRK5 / P34947 / Q8VEB1
  
Species: Danio rerio
  
Chr. number: 8
Strand: 1
Band:
Gene start: 44623540
Gene end: 44695260
  
Corresponding Affymetrix probe sets:
  
Cross references: Ensembl peptide - ENSDARP00000114075
Ensembl peptide - ENSDARP00000145343
Ensembl peptide - ENSDARP00000157508
NCBI entrez gene - 567452     See in Manteia.
swissprot - F1R6F6
ZFIN ID - ZDB-GENE-081105-95
Ensembl - ENSDARG00000078815
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 GRK5ENSGALG00000009403Gallus gallus
 GRK5ENSG00000198873Homo sapiens
 Grk5ENSMUSG00000003228Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
grk6 / G protein-coupled receptor kinase 6 / P43250*ENSDARG0000003215770
grk4 / G protein-coupled receptor kinase 4 / O70291* / P32298*ENSDARG0000007044869
grk5 / G protein-coupled receptor kinase 5 / P34947* / Q8VEB1*ENSDARG0000003280159
grk1a / G protein-coupled receptor kinase 1 a / GRK1* / Q15835* / G protein-coupled receptor kinase 1*ENSDARG0000005880345
grk1b / G protein-coupled receptor kinase 1 bENSDARG0000010468544
grk7a / Q49HM9 / G protein-coupled receptor kinase 7a / GRK7* / Q8WTQ7* / G protein-coupled receptor kinase 7*ENSDARG0000002060243
grk7b / Q1XHL7 / G protein-coupled receptor kinase 7b / GRK7* / Q8WTQ7* / G protein-coupled receptor kinase 7*ENSDARG0000005553442
grk3 / G protein-coupled receptor kinase 3 / P35626* / Q3UYH7* / Beta-adrenergic receptor kinase 2 *ENSDARG0000010409433


Protein motifs (from Interpro)
Interpro ID Name
 IPR000239  GPCR kinase
 IPR000719  Protein kinase domain
 IPR000961  AGC-kinase, C-terminal
 IPR008271  Serine/threonine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily
 IPR016137  RGS domain
 IPR017441  Protein kinase, ATP binding site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001947 heart looping IMP
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007368 determination of left/right symmetry IMP
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0032007 negative regulation of TOR signaling IMP
 biological_processGO:0035469 determination of pancreatic left/right asymmetry IMP
 biological_processGO:1902017 regulation of cilium assembly IMP
 cellular_componentGO:0005886 plasma membrane IDA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004674 protein serine/threonine kinase activity IEA
 molecular_functionGO:0004703 G-protein coupled receptor kinase activity IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA


Pathways (from Reactome)
Pathway description
G alpha (s) signalling events


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000001 Kupffer s vesicle Kupffers vesicle motile cilium increased length , abnormal
Show

 ZFA:0000101 diencephalon diencephalon bilateral symmetry , abnormal
Show

 ZFA:0000114 heart heart bilateral symmetry , abnormal
heart edematous , abnormal
heart dilated , abnormal
heart malformed , abnormal
Show

 ZFA:0000150 pronephric duct pronephric duct motile cilium increased length , abnormal
Show

 ZFA:0000254 pancreas primordium pancreas primordium mislocalised , abnormal
Show

 ZFA:0001117 post-vent region post-vent region curled , abnormal
Show

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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